102,357 research outputs found
G. Pettinato,Das altorientalische Menschenbild und die sumerischen und akkadischen Schôpfungsmythen
No full textArnaud Daniel. G. Pettinato,Das altorientalische Menschenbild und die sumerischen und akkadischen Schôpfungsmythen. In: Annales. Economies, sociétés, civilisations. 28ᵉ année, N. 4, 1973. pp. 956-958
G. Pettinato,Das altorientalische Menschenbild und die sumerischen und akkadischen Schôpfungsmythen
No full textArnaud Daniel. G. Pettinato,Das altorientalische Menschenbild und die sumerischen und akkadischen Schôpfungsmythen. In: Annales. Economies, sociétés, civilisations. 28ᵉ année, N. 4, 1973. pp. 956-958
Trace metals and metallothionein in tissues of Caretta caretta from Mediterranean Sea
No full textBiomonitoring of heavy metals in wild marine fauna is an important task due to the toxic effects of these pollutants on organisms at the top of the food chain. Metal homeostasis and bioaccumulation is strictly related to the induction of metallothionein (MT). Our research was advised to investigate the relathionship between trace metal concentration in tissues and their chelation by MT. Cd, Zn, and Cu concentrations were determined by AAS in liver, kidney, muscle, heart, lung and gonads of loggerhead turtle (Caretta caretta) which is the most common turtle in the Mediterranean Sea. Kidney displayed the highest Cd concentration, reaching a maximum of 2.4 μg/g wet weight (w.w.), while the lowest metal level was present in the muscle. The highest Cu concentrations were found in the liver (4.98±0.58 μg/g w.w.); finally highest Zn levels were present in the heart (46.6±5.2 μg/g w.w.). MT was isolated and quantified in the liver and kidney; in the liver MT bound mainly Cu, due to the high metal concentration in the organ, whereas in the kidney Cd co-eluted with MT peak and only a minor percentage of Cu was bound to the protein. Metal levels determined in this research are similar to those reported by other authors for the same species from Mediterranean Sea; in contrast Cd concentrations in loggerhead turtle from other locations were considerably higher than those reported here. Differences in heavy metals concentrations may be explained by differences in the diet and age. The low MT expression in liver and kidney is consistent with a low exposure to the investigated metals
FOXL2 molecular status in adult granulosa cell tumors of the ovary: A study of primary and metastatic cases
No full textGranulosa cell tumors (GCTs) of the ovary are uncommon neoplasms, accounting for ~5% of all malignant ovarian tumors. GCTs are a relatively homogeneous group of tumors, categorized into two distinct subtypes, juvenile GCT and adult GCT (AGCT), likely arising from a limited set of molecular events usually involving the disruption of pathways that regulate granulosa cell proliferation. In the present study, the presence of forkheadbox L2 (FOXL2) c.402C>G mutation was investigated in a series of 42 samples of primary and metastatic AGCT of the ovary. The samples consisted of 37 primary and 5 metastatic ovarian AGCTs from 37 patients. FOXL2 mutational status was evaluated using a pyrosequencing approach on 2.5‐μm sections of formalin‐fixed paraffin‐embedded tissue. FOXL2 c.402C>G mutation was found in 33/37 (89.2%) primary AGCTs and in 4/5 (80.0%) metastases, with the molecular status of the metastases recapitulating that of the primary tumors (4 mutated cases and 1 wild‐type case). Overall, FOXL2 mutation is present in the majority of primary and metastatic AGCTs, and could be used as a valid tool in the diagnosis of the disease and in cases of metastatic lesions from an unknown primary origin. Moreover the concordance of FOXL2 molecular status in primary and associated metastases suggests its early appearance and genomic stability in AGCT tumorigenesis
Alveolar variant of infiltrating lobular carcinoma of the breast with stromal steoclast-like giant cells
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