1,721,035 research outputs found
A speckle-tracking echocardiographic study on right ventricular function in primary aldosteronism
No full textPrimary aldosteronism represents the most frequent form of secondary arterial hypertension, with prevalence more than 11% in new-onset hypertensive patients. Beyond moderate-severe hypertension, or resistant hypertension, in these patients it is frequent to observe an unfavourable metabolic profile, characterized by higher prevalence of diabetes mellitus, metabolic syndrome, with altered adipokines levels. Several reports described a higher rate of cardiovascular events in primary aldosteronism patients when compared with essential hypertensive patients, independently from blood pressure values and directly related to aldosterone excess.
Previous studies showed that plasma aldosterone (PAC) excess itself, either in primary aldosteronism and in secondary aldosteronism (characterized by lack of arterial hypertension) is correlated with left ventricular enlargement and high prevalence of left ventricular hypertrophy and diastolic dysfunction; whereas subclinical systolic dysfunction, myocardial interstitial fibrosis and increased collagen deposition in the heart are evident only in the presence of PAC excess and hypertension
Response to: Neprilysin inhibitor-angiotensin II receptor blocker combination (sacubitril/valsartan)
No full textnon presente abstrac
Editorial: Endocrine malignancies: from pathophysiology to current clinical and surgical therapeutic approaches
Full text linkEndocrine tumors of the thyroid, parathyroid, and adrenal glands are a significant and
complex medical issue that affects millions of people worldwide. These tumors can lead to a
variety of serious conditions, including hyperthyroidism, hypothyroidism, hyperparathyroidism
(1), and pheochromocytoma (2); moreover endocrine tumors can be benign or malignant, and
their diagnosis and treatment require a multidisciplinary approach involving endocrinologists,
radiologists (3), pathologists, and surgeons. In recent years, significant progress has been made
in our understanding of the pathophysiology of endocrine tumors, as well as in the development
of new diagnostic and therapeutic approaches. Hence, this Research Topic aims to provide an
up-to-date overview of endocrine tumors, from their pathophysiology to current clinical and
surgical therapeutic approaches. The Research Topic includes contributions from leading
experts in the field, covering a broad range of topics related to endocrine tumors. The articles in
this Research Topic cover the variability of development and the importance of the latest
advances in managing thyroid tumors and its debated topics such as lymph node metastasis,
central neck dissection, micrometastasis and ectopic tumors
Pheochromocytoma associated with adrenocortical adenoma in patients with neurofibromatosis type 1
No full textHyperhomocysteinemia: a biochemical link between bone and cardiovascular system diseases?
No full textAssociation between -308 G/A TNF- α polymorphism and appendicular skeletal muscle mass index as a marker of sarcopenia in normal weight obese syndrome
No full textBackground and Aim. Normal weight obese (NWO) syndrome is characterized by normal body mass index (BMI), but high amount of fat mass and reduced lean mass. We evaluated allelic frequency of the G/A -308 TNF-α polymorphism and prevalence of sarcopenia in NWO. Methods. We enrolled 120 Italian healthy women, distinguished into 3 groups: normal weight (NW); NWO, and preobese-obese (PreOB/OB) and evaluated anthropometric parameters, body composition by dual X-ray absorptiometry, blood tests, and genotyping of G/A -308 TNF-α polymorphism. Results. We found a positive association between sarcopenic obesity and -308 TNF-α polymorphism. All obese women were sarcopenic and were no carrier of mutation (G/G). Among all G/G, NWO showed significant differences in lean mass and total body lean mass (TBLean) with respect to NW and PreOB/OB (P < 0.001). Regarding appendicular skeletal muscle mass index values, 4.21% of NW were sarcopenic (50% G/G and 50% G/A); the same percentage was observed in NWO subjects (100% G/G). Moreover, 2.10% of PreOB/OB were sarcopenic and all were G/G. Conclusion. Our study suggests that TNF-α polymorphism contributes to sarcopenic obesity susceptibility, in association with body composition. This is the first study that shows the importance of TNF-α polymorphism to determine TBLean variation in NWO syndrome. © 2013 L. Di Renzo et al
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Adipokines and cardio-metabolic profile in primary hyperaldosteronism
No full textPA subjects independently of BMI an age , have significantly higher circulating resistin and leptin levels
Thrombotic aspects of SARS-CoV-2 infection: indications for treatment
Full text linkSeveral studies highlighted the importance of thrombotic complications during early phases of acute respiratory syn -
drome coronavirus type 2 (S arS-coV-2) as well as long-term complications, until responsible for the high mortality
observed in SARS-CoV-2 infection. The relationship “increased thrombotic risk and COVID-19 infection” justified fur-
ther researchers, especially those undergoing hospitalization for severe coVId-19 infection, presented thrombotic com-
plications during follow-up, after hospital discharge and apparent healing. It was highlighted that SarS-coV-2 infection
mainly affects the upper airways, the access of the virus in the humans, while the complications are systemic, secondary
to extensive endothelial damage, with consequent systemic activation of the immune system and of pro-thrombotic
system. Recent data confirm that prophylactic antithrombotic treatment is useful in hospitalized patients, and in selected
cases it is useful at high therapeutic dos
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