1,292 research outputs found
Dixit Dominus à più Voci // con V.V. Trombe, ed Oboè // del Sig:r D. Pasquale Cafaro
No full textAncien possesseur : France. Intendance des Menus Plaisirs et affaires de la Chambre du roi. Ancien possesseurTitre uniforme : Cafaro, Pasquale (1715-1787). Compositeur. [Dixit Dominus Domino meo]Solistes : alto solo (Ut 3), c[anto] solo (Ut 1). - Choeurs (2) : Ut 1, Ut 3, Ut 4, Fa 4. - Le 2me coeur est désigné comme "parti di rinforzo". - Vl 2, vla, ob 2, cor 2 (en fa, sol, mi bémol), tr 2 (en ré), org, bc. - Cors et trompettes écrits en sons réels. - À la fin : "Finis Laus Deo B.V.M.". - 15 cahiers numérotés de la même main. - P. 104 et [119-120] blanches ; p. [113 bis]-114 collées. - Mêmes main de copiste, papier et rel. que la Messe brève eb fa majeur de Cafaro (F-Pn / D. 1685)Présentation musicale : [Partition]Incipit : Dixit Dominus Domino meoAppartient à l’ensemble documentaire : RISM2Appartient à l’ensemble documentaire : RISMMssPsaumes (musique) -- +* 1700......- 1799......+:18e siècle
Pericyte deficiencies lead to aberrant tumor vascularizaton in the brain of the NG2 null mouse.
No full textTightly regulated crosstalk between endothelial cells and pericytes is required for formation and maintenance of functional blood vessels. When the NG2 proteoglycan is absent from pericyte surfaces, vascularization of syngeneic tumors growing in the C57B1/6 mouse brain is aberrant in several respects, resulting in retardation of tumor progression. In the NG2 null mouse brain, pericyte investment of the tumor vascular endothelium is reduced, causing deficiencies in both pericyte and endothelial cell maturation, as well as reduced basal lamina assembly. While part of this deficit may be due to the previously-identified role of NG2 in 51 integrin-dependent periyte/endothelial cell crosstalk, the ablation of NG2 also appears responsible for loss of collagen VI anchorage, in turn leading to reduced collagen IV deposition. Poor functionality of tumor vessels in NG2 null brain is reflected by reduced vessel patency and increased vessel leakiness, resulting in large increases in tumor hypoxia. These findings demonstrate the importance of NG2-dependent pericyte/endothelial cell interaction in the development and maturation of tumor blood vessels, identifying NG2 as a potential target for anti-angiogenic cancer therapy
EB-NeRD a large-scale dataset for news recommendation
No full textPersonalized content recommendations have been pivotal to the content experience in digital media from video streaming to social networks. However, several domain specific challenges have held back adoption of recommender systems in news publishing. To address these challenges, we introduce the Ekstra Bladet News Recommendation Dataset (EB-NeRD). The dataset encompasses data from over a million unique users and more than 37 million impression logs from Ekstra Bladet. It also includes a collection of over 125, 000 Danish news articles, complete with titles, abstracts, bodies, and metadata, such as categories. EB-NeRD served as the benchmark dataset for the RecSys ’24 Challenge, where it was demonstrated how the dataset can be used to address both technical and normative challenges in designing effective and responsible recommender systems for news publishing. The dataset is available at: https://recsys.eb.dk
AUTHOR CONTRIBUTION
No full textConception or design of the study: Silva AC, Silva LG, Souza ARS, Martins, AKL, Gomes EB. Data collection: Silva AC, Silva LG, Souza ARS. Analysis and interpretation of the data: Silva AC, Silva LG, Souza ARS. Writing of the article or critical review: Silva AC, Gomes EB. Final approval of the version to be published: Silva AC, Martins, AKL, Oliveira CJ, Alencar AMPG, Gomes EB
Supporting safe motherhood : a review of financial trends : summary
No full textAn estimated 500,000 women, 99 percent of them from the developing world, die each year from pregnancy-related causes. About three quarters of these deaths are the direct result of obstetrical complications -- hemorrhage, infection, toxemia, obstructed labor, and abortion (under primitive and illegal conditions). An estimated equivalent number of infants do not survive their mother's death. For surviving mothers, the consequences of pregnancy have a severe impact on health and family economics. The strategy for safe motherhood is based on two approaches. First, the encouragement of activities that indirectly improve maternal health. These include education, policies to improve women's rights and working conditions, health care and nutrition, transportation and communication systems, water and sanitation facilities, and increases in family income and food production. The second approach targets activities to reduce maternal deaths. These activities include reducing unwanted pregnancies through the provision of family planning services, and through national policies that recognize the importance of this issue. A second objective is to reduce the risks of pregnancy through providing community-based family planning and prenatal services to identify high-risk cases'adequate referral services for the complications of pregnancy, and communication and transport systems to support patient referral procedures.Health Monitoring&Evaluation,Health Systems Development&Reform,Gender and Health,Early Child and Children's Health,Agricultural Knowledge&Information Systems
Achard de Saint-Victor métaphysicien. Le "De unitate Dei et pluralitate creaturarum"
No full texte-ISBN: 978-2-503-58826-1.International audienceAprès plus de 800 ans d'oubli paraissait, il y a une treintaine d'années, un chef d'œuvre de la philosophie médiévale — si ce n'est de la pensée occidentale dans son ensemble—, le De unitate Dei et pluralitate creaturarum d'Achard de Saint-Victor, devenu évêque d'Avranches en 1161, dans l'édition et la traduction de son unique exemplaire padouan que procurait Emmanuel Martineau en 1987. C'est pour marquer cette renaissance qu'a été rééditée cette première édition et organisé le colloque dont le présent ouvrage publie les actes. Il rassemble des contributions nécessairement modestes et partielles, mais pionnières, dont le seul but est d'initier à l'explication d'un traité d'une audace, d'une complexité et d'une puissance spéculative exceptionnelles : «génial entrelacs de spiritualité hyper-augustinienne et de métaphysique hyper-platonicienne», où il s'agit de rien de moins que de penser l'uni-distinction essentielle de la Sagesse divine. Puisse ce volume de la collection Ad argumenta. Quaestio Special Issues ouvrir à d'autres études qui donneront à leur tour le goût de cette sagesse sans laquelle la vérité ne saurait être saisie «par elle-même» : ipsa generalis, qua omnes sapiunt, sapientia. [Contient en partie les actes du colloque international le "De unitate Dei et pluralitate creaturarum d'Achard de Saint-Victor" qui s'est tenu les des 9 et 10 avril 2015 à Avranches, à l’Abbaye de la Lucerne et à l’Université de Caen Normandie.]TABLE OF CONTENTSVincent Carraud, Gilles Olivo, Pasquale Porro, Avant-propos. Le goût de la sagesseEmmanuel Martineau, Achard et l’OccidentVéronique Gazeau, Culture et société dans l’ouest de la Normandie. Autour d’Achard de Saint-VictorHugh Feiss, The Trinity in De unitate: Metaphysics and TheologyPascal Massie, Métaphysique de la pluralité premièreMohammad Ilkhani, Achard of Saint-Victor and PhilosophyFrançois Medriane, Unité, pluralité et modalité dans le De unitate : approche du chapitre I.11David Albertson, Ecce Quadratura! An Early Reader of Thierry of Chartres’s Arithmetica CommentaryJean-Louis Poirier, L’adverbe ibi dans le De unitateNicole Reibe, Reconsidering the homo assumptus positionNicole Reibe, Achard of Saint-Victor. A Bibliograph
AUTHOR CONTRIBUTION
No full textConception or design of the study: Silva AC, Silva LG, Souza ARS, Martins, AKL, Gomes EB. Data collection: Silva AC, Silva LG, Souza ARS. Analysis and interpretation of the data: Silva AC, Silva LG, Souza ARS. Writing of the article or critical review: Silva AC, Gomes EB. Final approval of the version to be published: Silva AC, Martins, AKL, Oliveira CJ, Alencar AMPG, Gomes EB
AUTHOR CONTRIBUTION
No full textConception or design of the study: Silva AC, Silva LG, Souza ARS, Martins, AKL, Gomes EB. Data collection: Silva AC, Silva LG, Souza ARS. Analysis and interpretation of the data: Silva AC, Silva LG, Souza ARS. Writing of the article or critical review: Silva AC, Gomes EB. Final approval of the version to be published: Silva AC, Martins, AKL, Oliveira CJ, Alencar AMPG, Gomes EB
An extracellular steric seeding mechanism for Eph-ephrin signaling platform assembly
No full textErythropoetin-producing hepatoma (Eph) receptors are cell-surface protein tyrosine kinases mediating cell-cell communication. Upon activation, they form signaling clusters. We report crystal structures of the full ectodomain of human EphA2 (eEphA2) both alone and in complex with the receptor-binding domain of the ligand ephrinA5 (ephrinA5 RBD). Unliganded eEphA2 forms linear arrays of staggered parallel receptors involving two patches of residues conserved across A-class Ephs. eEphA2-ephrinA5 RBD forms a more elaborate assembly, whose interfaces include the same conserved regions on eEphA2, but rearranged to accommodate ephrinA5 RBD. Cell-surface expression of mutant EphA2s showed that these interfaces are critical for localization at cell-cell contacts and activation-dependent degradation. Our results suggest a 'nucleation' mechanism whereby a limited number of ligand-receptor interactions 'seed' an arrangement of receptors which can propagate into extended signaling arrays
Cek5, a membrane receptor-type tyrosine kinase, is in neurons of the embryonic and postnatal avian brain
No full textCek5 is a recently identified receptor-type tyrosine kinase of the Eph subclass that is nearly ubiquitously expressed during embryonic development (Pasquale, 1991). Cek5 is predominantly expressed in the avian CNS throughout development, and high levels remain apparent in adult neurons. By means of immunofluorescence microscopy and high- resolution immunoelectron microscopy, Cek5 was found to be expressed in many regions of the chicken brain at various developmental stages, most notably in the hippocampus and cerebellum. The highest concentration of Cek5 was observed in the molecular layer of the cerebellum, associated within the axons of mature granule cells (parallel fibers) and with the cell bodies of immature granule cells. In the axons of parallel fibers, Cek5 was concentrated in the fasciculated nonsynaptic portions. This localization, together with the “adhesion” motifs present in the Cek5 extracellular region suggest that Cek5 may interact with other cell surface-associated molecules and be involved in the growth, guidance, and/or bundling of certain unmyelinated axonal processes. Alternatively (or in addition), Cek5 may represent the receptor for a neurotrophic substance, similar to several other neuronal transmembrane tyrosine kinases.</jats:p
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