1,721,013 research outputs found
A simplified approach to capillary electrophoresis separation of DNA fragments and PCR amplified sequences of forensic interest.
No full textA simplified approach to capillary electrophoresis separation of DNA fragments and PCR amplified sequences of forensic interest
Autopsy investigation and bayesian approach to coronary artery disease in victims of motor-vehicle accidents
No full textAnalisi di una traccia mista i cui contribuenti sono legati da un rapporto di parentela.
No full textHigh-resolution analysis of male genomes by the addition of nine biallelic polymorphisms to the classic 8-STR forensic haplotype
No full textDNA typing of male-specific polymorphisms is a well-established procedure of molecular analysis. A haplotype of eight different human male Y-specific short tandem repeats (STRs) has been intensively used for forensic casework. This haplotype has also been effectively used to address specific problems of population genetics. A collection of 50 male genomes from our laboratory previously genotyped for 8-Y-STR has been reinvestigated with a battery of eight single nucleotide polymorphisms (SNPs) mapping to the Y-chromosome. The addition of these biallelic markers provided additional identification power. Population investigation revealed genetic structure in Italy, with notably implications in Forensic Genetics. © 2003, Elsevier Science B.V. All rights reserved
Non-fatherhood or mutation? A probabilistic approach to parental exclusion in paternity testing
No full textThe occurrence of germline mutations at microsatellite loci poses problems in ascertaining non-fatherhood status in paternity testing. We describe the appropriate probabilistic analysis for computing the likelihood ratio in favour of paternity while allowing for mutation, for all 18 relevant combinations of seemingly incompatible parental genotypes. We allow arbitrary and possibly different mutation rates in paternal and maternal germlines. We describe a stationary mutation model for expressing the required allele-specific transition mutation rates in terms of overall mutation rates, and compare the likelihood ratios calculated from this and from other mutation models suggested in the literature. We also show how to derive an upper bound on the likelihood ratio, depending only on the overall mutation rat
Applicazione in ambito medico-legale della carbohydrate deficient transferrin (CDT): un nuovo marker biochimico di abuso cronico di alcool. Sua determinazione mediante elettroforesi capillare.
No full textA cura di De Ferrari F., Cerri N., Conti A., Giuffrè editore
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