112,020 research outputs found
PARRILLO V. ITALY - DONATION OF HUMAN EMBRYOS IN VITRO TO SCIENTIFIC RESEARCH
No full textDiplomsko delo obravnava pravno ureditev raziskav na in vitro zarodkih. Temeljna pozornost je posvečena analizi sodbe Evropskega sodišča za človekove pravice v zadevi Parrillo proti Italiji, v kateri je bilo sodišče postavljeno pred vprašanje, ali je italijanska ureditev, ki je pritožnici onemogočila donacijo in vitro zarodkov v znanstvene namene, v skladu z 8. členom Konvencije o varstvu človekovih pravic in temeljnih svoboščin. Pri tem avtor ugotavlja, da imajo države v obravnavanem primeru široko polje proste presoje, saj se področje doniranja in vitro zarodkov v znanstvene namene dotika občutljivih moralnih in etičnih vprašanj, o navedeni problematiki pa tudi ni evropskega konsenza. V zvezi z dopustnostjo raziskav na in vitro zarodkih mora vsaka država postaviti jasne omejitve in pogoje, lahko pa jih tudi prepove. Prikazana je tudi pravna ureditev področja raziskav na in vitro zarodkih, z vidika ureditve na mednarodnopravni ravni, v posameznih državah in v Republiki Sloveniji.The subject of this thesis is a legal regulation of embryos in vitro research. A particular attention is paid to analysis the judgement of the European Court of Human Rights in case of Parrillo v. Italy. The case concerned a ban under Italian Law no. 40/2004, preventing Ms Parrillo from donating to scientific research embryos obtained from an in vitro fertilisation. Ms Parrillo considered that the prohibition in question amounted to a violation of her right to respect for her private life, protected by Article 8 of the Convention for the Protection of Human Rights and Fundamental Freedoms. The author establishes that The Court considered at the outset that European Countries were to be afforded a wide margin of appreciation in this case, which raised sensitive moral and ethical issues, by the lack of a European consensus on the delicate question of the donation of embryos in vitro. Further on, current legal situation in the international law, in some European Countries and in the Republic of Slovenia is presented
author-bios-SRD-19-0063.R1 – Supplemental material for The Network Structure of Police Misconduct
No full textSupplemental material, author-bios-SRD-19-0063.R1 for The Network Structure of Police Misconduct by George Wood, Daria Roithmayr and Andrew V. Papachristos in Socius</p
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
No full text“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Discursive illusions and manipulations in legal blogs on medically assisted procreation: the case Parrillo v. Italy
No full textThis chapter sets to overview the European Court of Human Rights’ judgment Parrillo v. Italy and its representation in blogs to analyse the phenomena of discursive alterations in legal blogs covering the controversial issue of embryo donation. The study applies the popularisation framework to the transfer of information from the institutionalised context of the court, represented by its final judgment, to the less regulated web-domain of legal blogs, or blawgs.
The general methodological framework is Critical Discourse Analysis. Specifically, the study applies van Dijk’s triangulation approach and the notion of discursive manipulations or illusions, created by subjective reconceptualisation of the perceptions of objective realities.
The aim is to identify the complex mechanisms that shape the discursive illusion and that could lead to readership manipulation in the popularised context of blogs as compared to the institutional settings of judgments. This aim is verified on a small ad hoc created corpus of ten blog posts and the final judgment on the case accompanied by six concurring and dissenting judicial opinions. The study also uses the legal summary of the judgment and the Court’s press release for consultative purposes.
The findings show that blogs employ a vast array of techniques that could be defined as ideological manipulations or discursive illusions in that bloggers use legitimate information in a selective manner, leading to a one-sided representation of the case. In addition, the blogs provide subjective interpretations, both textual and paratextual, attempting to pass them as objective, and trigger selective appraisal patterns, including through the use of evaluative language, specifically in regard of responsibility attribution
Case Report: Reproductive evaluation of a Murgese stallion with obstructive azoospermia, accumulation of hyaline material in the ampullae ducts, and corpora amylacea in vesicular glands
No full textThis report aims to present a case of obstructive azoospermia in a stud stallion diagnosed with an alkaline phosphatase (SPAP) assessment. A 20-year-old Murgese stallion is referred for acquired azoospermia. History is negative for reproductive disorders, and clinical examinations and ultrasonography of internal and external genitalia do not reveal significant alterations. Semen collection highlights the absence of spermatozoa in the ejaculate and the urinalysis is negative for spermatozoa. SPAP assay is performed on seminal plasma, with a value of 30 IU/L, compatible with obstructive azoospermia. A biopsy is performed, detecting the presence of complete germ lines in both testes. A resolution is attempted endoscopically, gently insufflating ampullae, with negative results, so the stallion is excluded from breeding. Time afterwards, the stallion dies of natural causes, and necropsy and histopathological analyses are performed. Corpora amylacea are highlighted in both seminal vesicles; the right and left ampullae show ectasic lumen, with the diffuse presence of hyaline material. Ampullae obstruction is an uncommon pathology, which can affect stallions and jacks, generally caused by the accumulation of spermatozoa, but, unfortunately, this case was unresponsive to attempted treatments. Interestingly, to the authors' knowledge, this is the first report of corpora amylacea in equine stallion sexual glands
Docosahexaenoic acid and signaling pathways in rabbit colon.
No full textThe effects of one of the main components of fish oil, docosahexaenoic acid (DHA), on prostaglandin (PG) and Ca2+ signaling pathways were examined in intact mucosa and freshly isolated crypt cells of rabbit descending colon. Preincubation of serosal mucosa for 20 min with 1 microM DHA fully suppressed the short-circuit and transepithelial conductance increase induced by serosal addition of 10 microM arachidonic acid (AA). DHA at 1 microM also prevented the Cl- secretion promoted by 10 microM AA, as estimated by unidirectional 36Cl flux measurements (net flux = 0.68 +/- 0.30 versus -1.91 +/- 0.20 microEq/hr/cm2, four experiments, p < 0.001), whereas it did not affect the electrophysiological and ion flux responses to PGE2. Addition of 1 microM DHA to the serosal side of the mucosa also inhibited the PG cascade activation elicited by AA (PG synthesis and second messenger cAMP increase). In vitro assays of colonic cyclooxygenase activity showed that 1 microM DHA inhibited (with a 20-min lag) cyclooxygenase activity to the same extent as 5 microM indomethacin (approximately 82\% and 80\%, respectively). DHA also affected the Ca2+ signaling pathway; in isolated crypt cells, the cytosolic free Ca2+ concentration ([Ca2+]i) dropped by 49 +/- 7.6\% (mean +/- standard error, six experiments) after incubation with 1 microM DHA. The sustained phase of the [Ca2+]i response to 500 nM concentrations of the intracellular Ca(2+)-ATPase inhibitor thapsigargin was also inhibited within 150 sec upon 1 microM DHA addition (141 +/- 5.8 versus 243 +/- 8.2 nM [Ca2+]i mean +/- standard error, eight experiments, p < 0.01). The [Ca2+]i-lowering effect of DHA, which was not achieved by incubation with other free fatty acids, was not prevented by removal of Na+ from the incubation medium (-46 +/- 4.3\% versus -47 +/- 3.8\%, mean +/- standard error, four experiments), nor it was mediated by cAMP-, protein kinase C-, or calmodulin-dependent mechanisms. The incubation of highly purified basolateral membranes of crypt cells with 1 microM DHA for 1 min produced a 5-fold increase (IC50 = 0.25 microM) in the plasma membrane Ca(2+)-ATPase activity (34.3 +/- 2.73 versus 6.02 +/- 0.50 nmol/mg of protein/min, mean +/- standard error, four experiments, p < 0.0001), thus indicating that the DHA effects on the Ca2+ pathway were mediated mainly by an increase in plasma membrane Ca2+ pump activity. These findings suggest that DHA is a powerful modulator of the cellular response to activation of PG and Ca2+ signaling pathways
Antiflammins suppress the A23187- and arachidonic acid-dependent chloride secretion in rabbit distal colonic mucosa
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