1,721,081 research outputs found
La riabilitazione delle infrastrutture marittime: il caso delle dighe a gettata. The problem of maintenance of rubble-mound breakwaters
No full textLa riabilitazione delle infrastrutture marittime: il caso delle dighe a gettata. The problem of maintenance of rubble-mound breakwaters
No full text
Rapidly growing intraparotid mass in a young child.
No full textNodular fasciitis (NF) is a pseudosarcomatous lesion typically involving the subcutaneous tissue and fascia; rarely, it has been observed within a parotid gland. We report a case of NF in an 8-year-old boy who presented with a rapidly growing nodule in the right parotid gland. A preoperative fine-needle aspiration
suggested a diagnosis of nodular (pseudosarcomatous) fasciitis. After fine-needle aspiration, the surgical excision of nodule with a conservative approach was made. Intraparotid NF was diagnosed by histopathologic examination confirming the former cytologic diagnosis. This case demonstrates that NF, although rarely may
occur in unusual site as parotid gland, in cases of rapidly growing tumor masses in the parotid, a correct cytologic diagnosis in the fine-needle aspirate might spare unnecessary aggressive surgical treatment
miRNA 34a, 100, and 137 modulate differentiation of mouse embryonic stem cells
No full textMicroRNAs (miRNAs) play an important
role in proper function and differentiation of mouse
embryonic stem cells (ESCs). We performed a systematic
comparison of miRNA expression in undifferentiated
vs. differentiating ESCs. We report that 138 miRNAs
are increased on the induction of differentiation. We
compared the entire list of candidate mRNA targets
of up-regulated miRNAs with that of mRNA downregulated
in ESCs on induction of differentiation.
Among the candidate targets emerging from this analysis,
we found three genes, Smarca5, Jarid1b, and Sirt1,
previously demonstrated to be involved in sustaining
the undifferentiated phenotype in ESCs. On this basis,
we first demonstrated that Smarca5 is a direct target of
miR-100, Jarid1b of miR-137, and we also confirmed
previously published data demonstrating that Sirt1 is a
direct target of miR-34a in a different context. The
suppression of these three miRNAs by anti-miRs caused
the block of ESC differentiation induced by LIF withdrawal.
On the other hand, the overexpression of the
three miRNAs resulted in an altered expression of
differentiation markers. These results demonstrate that
miR-34a, miR-100, and miR-137 are required for
proper differentiation of mouse ESCs, and that they
function in part by targeting Sirt1, Smarca5, and
Jarid1b mRNAs.—Tarantino, C., Paolella, G., Cozzuto,
L., Minopoli, G., Pastore, L., Parisi, S., Russo, T.
miRNA 34a, 100, and 137 modulate differentiation of
mouse embryonic stem cells
Un nuovo ciclo di vita per Punta Pellaro: Il Parco del vento di Reggio Calabria Città Metropolitana
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