42,267 research outputs found
Dr. Lin Sun, CAU, March 2013
No full textThis video is a conversation with Dr. Lin Sun. Dr. Sun talks about an exhibit at the Woodruff Library titled "At The Boundary." Jordan Moore, AUC Woodruff Library, is the interviewer
Thrombin Induces Expression of Twist and Cell Motility Via the Hypoxia- Inducible Factor-1 Alpha Translational Pathway in Colorectal Cancer Cells
No full textDeep vein thrombosis associated with advanced cancer is known as Trousseaus syndrome. We hypothesized that thrombin, an activator of protease-activated receptor PAR-1 and PAR-4 contributes to tumor metastasis. In this study, we demonstrated that thrombin and the PAR-1 activating peptide AP SFLLRN, but not the PAR-4 AP GYPGKF, induced HIF-1 alpha activities, protein expression, and cell motility in colorectal cancer cells, and these actions were significantly inhibited by the PAR-1 antagonist SCH79797. Moreover, thrombin-induced HIF-1 alpha activity and cell motility were blocked by inhibiting important mediators of signaling transduction, including the ERK, PI3K, and mTOR pathways. These results showed that thrombin induced HIF-1 alpha protein expression through PAR-1 and HIF-1 alpha translational de novo protein synthesis. Twist can regulate epithelial-mesenchymal transition EMT and increase tumor metastasis. However, we observed that thrombin-induced HIF-1 alpha increased Twist mRNA and its protein level was mediated by the modulation of PAR-1 activation and the HIF-1 alpha translational pathway. In addition , Twist could increase N-cadherin but not E-cadherin to promote tumor metastasis. Overexpression of dominant-negative HIF-1 alpha reversed thrombin-mediated Twist and Twist-induced N- cadherin expression. Moreover , siTwist inhibited Twist- induced N-cadherin and Thrombin-induced cell motility. In conclusion, our study showed that thrombin-induced HIF-1 alpha upregulated Twist at the transcriptional level to enhance cell motility. These findings show that thrombin upregulates Twist via HIF-1 alpha to make tumor cells malignant and also establish a link between the coagulation disorder and cancer metastasis
Accessibility Analysis of A-level Lin Pan Scenic Spot in Dayi County Based on Road Network
Full text linkChengdu vigorously promotes the construction and development of Lin Pan. Aiming at the distribution of A-level Lin Pan in Dayi County, this study analyzed the accessibility of A-level Lin Pan by using ArcGIS software, OD cost matrix analysis method and two-step mobile search method, and found that: (1) Accessibility of different A-class Lin Pan varies greatly, and the longest arrival time is almost twice that of the shortest. (2) The A-level Lin Pan scenic spot has A general economic driving effect on the local economy, and it is suggested to increase the construction of Lin Pan scenic spot according to the distribution of Lin Pan
An Analysis of <i>Judge Lin</i>
No full textBiography of Lin Wen Zhong Gong has another way to call, that is Judge Lin. The leading character is Lin Ze-Xu. This book is based on functionary experience of Lin Ze-Xu, with the captivating plots of court case, helping by highly skilled military attach\uc3\ua9s and chivalrous knights, and the history facts of Opium War. It makes Lin Ze-Xu\ue2s Confucian temperament and tragic mood more, also contrasts with author\ue2s sorrow and furiousness for the politics at the time. History, court case, martial arts\ue2\ua6\ue2\ua6etc. are essence of this book and it broadens the way of this writing style.
The topic of the thesis is \ue2An Analysis of Judge Lin\ue2. The following thesis will be divided into six different chapters. The introduction is Chapter one of the thesis, which is including researching motive and purpose, literature review of predecessors, researching version by existing information, raising questions, choosing research methods and arranging chapters. In chapter Two, I discuss the study of characters of Lin Ze-Xu, also makes a deep analysis of author\u27s purpose of writing him. In chapter Three, I analyze supporting actors and actress. Meanwhile, I illustrate author\u27s purpose of writing supporting actress because the author had different manner to describe supporting actress. Moving to the Chapter Four, I mainly focus on the plots of Judge Lin, and organize cases of Lin Ze-Xu and his subordinates to understand features of cases. In Chapter Five, I represent the causes of Opium War. China and England had difference of opinions of opium. Therefore, it is easier to comprehend what the author\u27s purpose is. In the last chapter I summarize the main points of the preceding chapters and confirm particularity of Judge Lin
Pharmaceutical powder dispensing by ultrasonic vibration dosing system
No full textPowder technology is one of the most important parts in manufacturing industry when materials applied in large quantities of solid particles. Dispensing technology for powders can significantly improve operation efficiency in manufacturing processes. The powder dispensing technologies have a broad range of applications. The powders exhibit different flow behaviours due to different physical properties. This project aims to reveal the dispensing mechanism and pharmaceutical powder flow behaviour in a designed dispensing hopper under the ultrasonic mechanical vibration, and to develop a powder dosing system to achieve the precise dispensing of pharmaceutical powders.The experimental work focuses on the dispensing device design and pharmaceutical powder dispensing tests by using ultrasonic vibration dosing system. The experimental results indicate that the ultrasonic vibration dosing system is capable of fast (less than one second) and precise (RSD<5%) pharmaceutical powder dispensing in small-dose (milligram scale) and large-dose (gram scale). A dome-control mechanism is identified in the ultrasonic vibration dispensing process. Powder dome formed in the dispensing hopper as a “valve” of powder flow under the ultrasonic vibration. The dispensing results represent that the parameters of dispensing hopper, i.e. orifice size, hopper angle, and working voltage signal, i.e. vibration duration, are the critical factors for the powder flow rate and dosage uniformity of the dispensing.Additionally, the working voltage signal properties and mechanical vibration performance are investigated in the ultrasonic vibration dispensing device by using the digital oscilloscope and the 3D scanning vibrometer
Antitumor mechanism of evodiamine, a constituent from Chinese herb Evodiae fructus, in human multiple-drug resistant breast cancer NCI/ADR-RES cells in vitro and in vivo
No full textAspidistra albovillosa T. Ding, B. Pan & C. R. Lin 2023, sp. nov.
No full text<i>Aspidistra albovillosa</i> T. Ding, B. Pan & C.R. Lin, <i>sp. nov.</i> (Figs. 1, 2) <p> <b>Type:</b> — China. Guangxi, Luizhou City, Luijiang District, Luoman Town, Qiaomu Village, in the crevices of the stones on shady, at the foot of the limestone hill, not common, 109°11’ E, 24°22’ N, alt. 130 m, 27 April 2023, <i>Tao Ding</i> & <i>Bo Pan 2703</i> (holotype: IBK!, Isotype: IBK!).</p> <p> <b>Diagnosis:</b> —The new species is morphologically similar to <i>A. ovatifolia</i>, but clearly distinguished by its perianth lobes basely with purplish red appendages, which sometimes white and slightly rolled upwards at apex, tube adaxially densely with white villous, stigma slightly undulate and 6 (or 8) lobed at margin.</p> <p> <b>Herbs</b> perennial, evergreen, rhizomatous. <b>Rhizome</b> creeping, subterete, 6–8 mm thick, covered with scales, nodes dense. <b>Roots</b> numerous. <b>Vagina</b> leaves 4–5, purple-red, 1–10 cm long, enveloping base of petiole, becoming blackbrown when dry. <b>Leaves</b> solitary, ca. 1cm apart; <b>petiole</b> stiff, upright, 12–24 cm long, 2–3 mm thick, adaxially sulcate; <b>leaf blade</b> broad ovate to ovate, 14–17 cm long, 8–13 cm wide, dark green, base cordate to suborbicular, abruptly narrow into petiole, inequilateral, apex cuspidate to acuminate, margin entire. <b>Peduncle</b> decumbent, pale green slightly with purplish red spots, 2–4 cm long, with 4–5 bracts, terminal 1 or 2 close to flower; the <b>bracts</b> at the base of perianth broadly ovate, white with purple spots, ca. 8–10 mm long, 10–12 mm wide, apex subobtuse. <b>Flowers</b> solitary at the top of the peduncle; <b>perianth</b> urceolate, fleshy, slightly 6 (or 8) lobed apically; <b>lobes</b> suberect, triangular, 2–3 mm long and 2–4 mm wide at base, abaxially whitish and slightly purplish mottled, adaxially pale yellow, densely with purplish red speckles at base, each lobe basally with an adaxial, purplish red, toothlike appendage, ca. 2 mm long, 2–4 mm wide, apex with 2–3 denticulate, and sometimes white, slightly rolled upwards, appendages protruding horizontally or obliquely over tube opening and reducing the opening to 2–4 mm; <b>tube</b> 8–10 mm long, greatest 12–15 mm in diam., abaxially white and sometimes slightly with purplish red spots, adaxially deep purple to nearly purplish black, densely white villous. <b>Stamens</b> 6 (or 8), opposite to lobes, inserted at ca. 2mm from the base of perianth tube, positioned conspicuously lower than stigma; <b>anther</b> subsessile, ovate, ca. 2 mm long and ca. 1 mm wide, pollen yellow; <b>Pistil</b> 7–8 mm long, <b>ovary</b> indistinct, <b>style</b> cylindrical, ca. 2 mm long, <b>stigma</b> peltate, enlarge, round, 10–12 cm in diam., 5–6 mm high, upper surface yellow to yellowish white, glabrous, the central part slightly convex with 3 or 4 radial, 2–3 forks lines, <b>slightly</b> undulate and 6 (or 8) lobed at margin, lower surface dark purplish red, with 12 (or 16), alternating large and small longitudinal ribs. Flowering from April to May.</p> <p> <b>Etymology:—</b> The specific epithet ‘ <i>albovillosa</i> ’ is derived from the perianth tube adaxially densely with white villous. The Chinese name is given as ‘ <b>ǝfflÑṞffifi</b> ’(Chinese pinyin: bái máo zhî zhű bào dàn).</p> <p> <b>Distribution and ecology:</b> — <i>Aspidistra albovillosa</i> is currently only known from the type locality in Luijiang District, central Guangxi, China. It grows under broad-leaved evergreen forests, in shaded rocky limestone slopes at elevation range of 120– 240 m. Living plants introduced from the type locality are currently cultivated in Guilin Botanical Garden of Guangxi Institute of Botany.</p> <p> <b>Conservation status:</b> — In the field investigations, <i>Aspidistra albovillosa</i> was only found from the type locality with one populations with about 80 individuals. All discovered individuals were occurring in the natural scenic spot, where the habitat was in good condition. The further detailed investigation of the same habitats is also needed to give a better understanding of its natural distribution and abundance, and the status of new species is currently considered as Data Deficient (DD), following the IUCN Red List Categories and Criteria (IUCN 2022).</p> <p> <b>Similar species:—</b> <i>Aspidistra albovillosa</i> is similar to <i>A. ovatifolia</i> Yan Liu & C. R. Lin in Lin <i>et al.</i> (2014: 287, Fig. 3) in the urceolate perianth and ovate leaf blade, but differs by the widerleaf blades (8–13 cm vs. 6–9.5 cm wide), the purplish red (vs. pure white) and slightly rolled upwards at apex (vs. flat) appendages at the base of the perianth lobes, surface of the perianth tube (adaxially densely villous vs. with 8 longitudinal grooves), thre ovate (vs. oblong) anther, structure of the stigma (margin slightly undulate and 6 (or 8) lobed vs. margin bent upwards, with 16 longitudinal ribs). A detailed morphological comparison between the two species is provided in Table 1.</p>Published as part of <i>Ding, Tao, Pan, Bo & Lin, Chun-Rui, 2023, Aspidistra albovillosa (Asparagaceae), a new species from Guangxi, China, pp. 244-250 in Phytotaxa 620 (3)</i> on pages 245-248, DOI: 10.11646/phytotaxa.620.3.5, <a href="http://zenodo.org/record/10012445">http://zenodo.org/record/10012445</a>
A study on the design and concept of Guilin Landscape Building in Shang Kuo based on the Beaux-Arts system
Full text linkThe Beaux-Arts system, once an important international architectural design method, represents a significant and challenging area of research when considering its localization in China. Shang Kuo, a Chinese architect influenced by the Beaux-Arts concept, demonstrates the heritage and development of the Beaux-Arts system through his landscape buildings in Guilin. This study selects six representative cases from Shang Kuo’s landscape buildings in Guilin and analyzes them based on the Beaux-Arts system. The analysis focuses on four aspects: plan composition, spatial composition, facade composition, and the formal aesthetic laws of composition. The research reveals that Shang Kuo’s works exhibit three balanced choices of axis composition in their plans. He innovatively incorporates elements such as residential buildings, garden architecture, traditional Chinese art, and natural elements into the composition of his buildings, while emphasizing the harmonious integration of interiors and facades and adhering to the principles of aesthetic form. This study shows the way of localizing Beaux-Arts architecture through Shang Kuo’s landscape buildings in Guilin and contributes to the understanding of the development of modern Chinese architecture
Genistein Inversely Affects Tubulin-Binding Agent-Induced Apoptosis in Human Breast Cancer Cells
No full textGenistein, a natural isoflavone phytoestrogen present in soybeans, has been extensively studied as a chemopreventive or therapeutic agent in several types of cancer. The traditional Asian diet is rich in soy products may explain in part why the incidence of breast cancer in Asian women is relatively low. To improve therapeutic benefits, we investigated the combination of genistein with chemotherapeutic agents in phenotypically dissimilar human breast cancer cells, MCF-7 and MDA-MB-231, in which estrogen receptor expression is positive and negative, respectively. In the present study, genistein significantly decreased cell apoptosis induced by tubulin-binding agents, paclitaxel and vincristine. FACScan analysis revealed that genistein also diminished the accumulation of the G2/M phase in the cell cycle caused by tubulin-binding agents. In situ staining of microtubules revealed that genistein could decrease paclitaxel-induced tubulin polymerization. However, in vivo tubulin polymerization assay revealed that simultaneous treatment of genistein did not change the tubulin/microtubule dynamic. Genistein reduced Bcl-2 phosphorylation triggered by paclitaxel and vincristine without changing Bax protein expression. p53 and p21 expression, monitored by Western blotting, was not altered by genistein. However, the expression of cyclin B1 and CDC2 kinase was markedly decreased in combination with genistein. In conclusion, genistein inversely affected tubulinbinding agent-induced apoptosis via down-regulation of cyclin B1 / CDC2 kinase expression resulting in reduced Bcl-2 phosphorylation. (C) 2004 Elsevier Inc. All rights reserved
Studies on the utilization of immobilized papain or/and bromelain for beer chillproofing
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