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3D Printing Technology-Assisted Magnetic Nano-Diopside Bioceramics Synthesized from Biowaste for Bone Regeneration and Magnetic Hyperthermia Applications
No full textCurrently, synchronous therapy and regeneration for bone defects caused by tumors remain significant challenges. Traditional strategies involving implantation of bone graft materials post-surgery promote bone regeneration but fail to completely eliminate residual tumor cells. The biomedical field continually seeks innovative techniques, especially in bone regeneration and cancer treatment. The incorporation and application of magnetic nanomaterials present a new frontier in biomedical research and therapy, particularly in magnetic hyperthermia. Compared to simple bioceramic materials, the attention is focused on the enhanced hyperthermia capabilities of magnetic composite bioceramics, addressing the needs of bone tissue engineering and osteosarcoma treatment. Simultaneously, with advancements in material science and engineering, 3D printing has emerged as a groundbreaking tool in the biomedical field, offering unprecedented opportunities to redefine tissue engineering and therapeutic approaches.
The primary objective of this study is to bring innovation to the fields of bone regeneration therapy and cancer treatment while emphasizing resource sustainability. Through in-depth research and experimentation involving the synthesis of diopside bioceramics and magnetic nanoparticles from biological waste, coupled with the application of 3D printing technology, we aim to provide new possibilities for the biomedical field, enhancing both patient quality of life and treatment outcomes.
The experimental approach involves the synthesis of diopside through ball milling, followed by the hydrothermal synthesis of MnFe2O4 magnetic nanoparticles. This combination results in the preparation of diopside- MnFe2O4 bioceramics. Material analysis, in vitro biological experiments, and evaluation of magnetic hyperthermia effects will be conducted to identify the most promising diopside- MnFe2O4 composition. Subsequently, Digital Light Processing (DLP) 3D printing technology will be applied to fabricate the Di-10MnFe 3D printing scaffold. Further analyses of the material, in vitro biological experiments, magnetic hyperthermia inhibition of cancer cells, immersion testing in simulated body fluid (SBF), and in vitro animal experiments will comprehensively assess the potential of the Di-10MnFe 3D printing scaffold for bone regeneration and magnetic hyperthermia applications.
Environmental scanning electron microscope (ESEM) results for the Diopside- MnFe2O4 bioceramics demonstrate enhanced density and hardness due to the addition of MnFe2O4 magnetic nanoparticles. In vitro biological tests show good biocompatibility and osteogenic differentiation capabilities for Di-10MnFe and Di-20MnFe. Magnetic hyperthermia tests reveal controllable thermal effects for all samples, with Di-10MnFe exhibiting thermal effects lasting over 10 minutes without exceeding 46\uc2\ub0C, making it the primary material for subsequent research. This material will be combined with DLP 3D printing technology for more in-depth studies on bone regeneration and magnetic hyperthermia. The successful synthesis of the Di-10MnFe 3D printing scaffold, featuring a porous structure with pore sizes larger than 300\uce\ubcm and micropores smaller than 50\uce\ubcm, and a porosity rate of 58.7%, was achieved. Mechanical property experiments show that Di-10MnFe 3D printing scaffold maintains compressive strength between 2.84-6.23 MPa before and after immersion in SBF, within the compressive strength range of human trabecular bone (2-12MPa) . In alkaline phosphatase (ALP) experiments, Di-10MnFe promotes osteogenic cell differentiation, and Alizarin Red S (ARS) staining demonstrates mineralization potential. In magnetic hyperthermia inhibition of cancer cell experiments, Di-10MnFe 3D printing scaffold exhibits controllable magnetic hyperthermia effects, significantly suppressing cancer cells without affecting healthy bone cells, confirming its applicability and safety. In SBF immersion tests, the scaffold surface forms nano-sized hydroxyapatite deposits, maintaining a stable neutral pH value. Animal experiments demonstrate the scaffold was non-cytotoxic when implanted into rats, promoting bone growth and showing potential for bone regeneration.
The Di-10MnFe 3D printing scaffold from this study holds promise as a novel choice for bone regeneration therapy and cancer treatment, with multifunctional applications. Future research will focus on optimizing 3D printing technology, developing sustainable materials, and conducting clinical trials to ensure safety and practical application effectiveness
The Self-composition and Self-cultivation skills of \ue2Wu Sang Wo (I lose myself)\ue2 in \ue2Zhuangzi\ue2
No full text"I lose myself" is a unique and representative sentence pattern about the theory of cultivation in the text of "Zhuangzi", and its connotation indicates the possibility and significance of the composition and transformation of the individual self in Zhuangzi's thought. This article uses the time-process structure of "transformer-transformation process-transformed" formed by "I lose myself" as a reference to examine the text of "Zhuangzi" such as "Pengkun's Fable", "Heaven's Sound", "Pao Ding" "Jie Niu", "Xin Zhai", "Zi Wang"... and other story scenes or character dialogues involving personal transcendence or self-transformation further integrate the transformation process presented in various narrative methods and bring "I The connotation of "losing myself" is connected and interpreted, and an attempt is made to make "I lose myself" as an important concept and interpretation anchor for the theory of self-cultivation in "Zhuangzi". At the same time, the connection and coexistence between individuals and all things in the world are constantly displayed in practical transformation. It attempts to get rid of the old negative interpretations of "uselessness" and "inaction" in the thoughts of "Zhuangzi". It uses the ideological characteristics of "not being dissatisfied with all things, not condemning right and wrong, and living in harmony with the world" to show its impact on people when they encounter difficulties in life\ue2offering endless potential for redemption
A Study on the Impact of Job Involvement, Perceived Equity of Salary, and Workplace Friendship on Turnover Intention
No full textIn the context of Taiwan's economic prosperity, many companies are facing the dual challenges of inflation and talent shortage. As a result, they choose to adopt high-salary hiring strategies to attract outstanding talents. This study aims to explore the impact of salary equity on employees and further examine whether workplace friendship has a moderating effect on this impact.
The purpose of this study is to investigate the relationship between job involvement, 'distributive justice' in the perception of salary equity, and workplace friendship with turnover intention. To conduct this research, we used a questionnaire survey method and selected four scales developed by renowned scholars and widely accepted as measurement tools.
The subjects of this study were currently employed workers in Taiwan. The questionnaire distribution was conducted in two phases, with 445 responses collected in the first phase and 282 in the second phase, resulting in a total response rate of 63%. After screening and eliminating incomplete and invalid questionnaires, a total of 261 valid questionnaires were obtained. Following statistical data analysis of these collected data, the study reached the following conclusions:
1.Job involvement is negatively correlated with turnover intention.
2.Job involvement is positively correlated with 'distributive justice' in perceived equity of salary.
3.'Distributive justice' in perceived equity of salary is negatively correlated with turnover intention.
4.'Distributive justice' in perceived equity of salary mediates the relationship between job involvement and turnover intention.
5.Workplace friendship is negatively correlated with turnover intention.
6.Workplace friendship indirectly positively moderates the mediating effect of external justice in 'distributive justice' on the relationship between job involvement and turnover intention.
7.Workplace friendship does not moderate the mediating effect of external justice and personal justice in 'distributive justice' on the relationship between job involvement and turnover intention.
Based on these results, this study presents conclusions, managerial implications, limitations, and suggestions for future academic and practical management reference
Digitally Controlled Active Gate Driver for DC-DC Buck Converter With High Efficiency Under Light Load Condition
No full textA DC-DC buck converter must provide high efficiency during light load and
generate low dV /dt oscillation during heavy load operations. This dissertation
demonstrates a DC-DC buck converter with a light load controller that improves the
converter efficiency during light load operations. An active gate driver (AGD) reduces
oscillation at a heavy load condition by decreasing the switching speed. The AGD is
digitally controlled through DPWM for better stability.
A single-clock digital PWM (DPWM) technique is discussed in Chapter 2 for better
stability. The matrix shift array in the proposed design minimizes the effect of clock
skew. Because the matrix\ue2s DFF array is reconfigurable, users can make the trade-off
between clock skew and circuit complexity during the design phase. In addition, the clock
gating technique selects a specific row of DFFs to reduce the power consumption. The
single clock also allows the DPWM to operate at a higher input clock frequency. The chip
measurement confirms the minimum effect of clock skew through the linear relationship
between the selector input and the modulated duty cycle.
A programmable AGD is demonstrated in Chapter 3 which does not rely
on extensive computation from an external microcontroller or FPGA. The AGD is
programmed through reference voltages tuning. Changing the value of the reference
voltages widens the area of Miller plateau detection. The tri-state inverting buffer
generates two distinct driving signals for standard operations and Miller plateau detection.
The feedback-controlled split-path of the AGD generates non-overlapping signals to
prevent shoot-throughs. The proposed AGD generates two distinct signals for Miller plateau detection with better quality of rise time, fall time, and power consumption,
respectively.
Chapter 4 exhibits a DC-DC buck converter with an improved efficiency during the
light load operation. The light load is detected through the output of the Error amplifier
and the reference voltage Vll. The light-load controller shuts down a set of power MOS in
the converter core circuit to minimize excessive power loss. This optimal solution, which
reduces the gate capacitance of the core power MOS, has been derived and analytically
proved
A Study on Taiwan\ue2s Steel Industry Development Strategies in the Face of U.S.-China Trade War
No full textThis study focuses on the challenges and opportunities faced by Taiwan's steel industry in the context of the US-China trade war. Since the 1990s, the trade relationship between the United States and China has become increasingly tense, particularly over issues of trade imbalance and intellectual property rights infringement. This trade war has had a widespread impact on the global economy, particularly affecting Taiwan, which has close trade ties with both the US and China, with the steel industry being notably impacted. To comprehensively analyze this issue, this study employs a combination of qualitative research methods. Qualitative research, through in-depth analysis of policy documents and industry reports, as well as interviews with industry experts, provides a deep understanding of the challenges faced by Taiwan's steel industry in the context of the trade war.
The findings of the study indicate that while the US-China trade war has put certain pressures on Taiwan's steel industry, it also presents opportunities for transformation and upgrading. It is recommended that Taiwan's steel industry, in facing these challenges, should focus on product innovation, efficiency enhancement, and actively seek new markets and cooperative opportunities.
In summary, this research not only enhances understanding of the development status of Taiwan's steel industry under the US-China trade war but also provides practical strategies and suggestions for relevant policymakers and business managers. This assists the Taiwanese steel industry in maintaining competitiveness in the ever-changing global economic environment
Are the Stock Prices of ESG Companies more Resilient - Evidence from the COVID-19 Pandemic in Taiwan
No full textCOVID-19 is the latest global pandemic virus. The epidemic came suddenly and spread quickly throughout the world. The first and most direct impact is the economic impact. All of the above are reflected in the stock price causing the relevant stocks to rise or fall sharply. On the other hand, Taiwanese companies have recently implemented ESG mechanisms, actively implemented internal improvements and promoted the company's good corporate image through ESG. Investors can understand the company's actual operating conditions through ESG, This allows investors to more clearly judge whether the stock is worth investing in.
This article will explore whether investors will still consider ESG ratings as a reference when the world is hit by an epidemic. Use the event study method to analyze whether A-rated companies with high ESG ratings have resisted the decline in stock prices during the outbreak, and whether C-rated companies with low ESG ratings have been strongly negatively affected by this, causing their stock prices to suffer heavy losses. And use daily data to analyze whether there are obvious fluctuations in the stock price in the short term. However, this time it was disrupted by the epidemic for a long time. Therefore, we extend it to weekly data to explore whether the stock market continues to suffer setbacks. Empirical results show that both ESG A-rated companies and C-rated companies experienced a decline in stock prices in the early stages of the epidemic. However, A-rated companies only experienced a slight decline and subsequently rebounded rapidly. On the other hand, C-rated companies experienced a sharp and significant decline in stock prices. Negative abnormal returns and slow recovery in the market. All the above prove that compared with the two, A-grade companies have the ability to withstand declines, while C-grade companies are obviously negatively affected
Looking at the change of one-child policy in mainland China from the perspective of non-traditional security
No full textSince the 911 terrorist attacks in 2001, it has highlighted that in addition to traditional national security issues such as military and diplomacy, non-traditional security issues will also threaten the security of countries, regions and even individuals. Later, cross-border incidents such as SARS incident and COVID-19 epidemic occurred Virus contagion has caused human illness and death, and has also made leaders and governing teams of various countries around the world urgently need to face various types of non-traditional security issues in recent years. China's population policy has been promoting family planning since 1979 with the reform and opening up, stipulating that urban residents can only have one child. Why did it announce the abolition of the one-child policy in 2015? This article starts from the perspective of non-traditional security, analyzes the aspects of national security and human security, and tries to understand the one-child policy implemented by China under the Leninist party-state system. Its long-term implementation has led to changes in the social environment and has gradually given rise to many problems, such as The one-child problem, the 421 family structure, the aging population, the disappearance of the demographic dividend, etc. It is estimated that if the policy continues, it will cause serious national security problems, forcing China to change its implementation for decades without encountering traditional security threats. Even if there were factors involved in implementing the policy at the time, under non-traditional security threats, the leader of a country no matter how powerful it is will have to change its policy to resolve possible national security crises in the future
The effects of metaphorical themes on idiom acquisition: A case study on Taiwanese college students
No full textNumerous studies have proposed pedagogical methods incorporating the cognitive linguistics (CL) insights into the teaching of second language idioms since they believed the enhancement of metaphor awareness stimulated by the conceptual inputs can foster the retention of metaphorical-based lexis. One of the teaching approaches inspired by cognitive linguistics involves presenting learners with idioms categorized under metaphorical themes. This study investigates whether such CL-guided presentations have positive impacts on the teaching and learning of idioms associated with the DISEASE metaphor, encompassing source domains such as ENEMY, FIRE, JOURNEY, and NATRAL DISASTER. Two small-scale experiments were conducted to assess if learners receiving explicit CL instruction perform better in memorizing the figurative meanings of given lexis and inferring untaught idiomatic expressions compared to learners without this guidance. In the first experiment, both literal and figurative meanings have been offered, while in the second experiment, the literal meanings were replaced by metaphor interpretations in order to raise learners\ue2 awareness of mappings and metaphor themes. Results of the experiments have confirmed the overall advantages of the cognitive-oriented method on learning idioms, despite some variables (e.g. cultural difference, contextual clues, and individual competence) that might somewhat affect the consequences
Role and Behavioral Analysis of Dummy Accounts in Fraud Cases: An Empirical Study Based on Judicial Judgments
No full textThis study focuses on analyzing the role and behavior of dummy accounts in fraudulent cases, using empirical research based on judicial rulings. The goal is to understand how dummy accounts are specifically used in fraudulent crimes, especially in multi-layered transfers. The study aims to provide practical insights and recommendations for preventing fraudulent activities, particularly those involving dummy accounts. Using literature analysis and text mining techniques, judgments related to the keyword "providing accounts" in January 2023 are examined. The research strives to offer concrete information and actionable suggestions to combat fraudulent crimes, encouraging further exploration and application in related fields
Exploring the Practice of Marketing Strategies of Non-profit Organizations from the Perspective of Integrated Marketing Communications: Take the Media Pioneer Team of M Organization as an Example
No full textDuring the severe pandemic in 2021, the researcher worked as non-full-time staff member in the non-profit organization. The organization's core purpose is to preach the gospel, actively carrying out integrated and contemporary missionary work, and providing multimedia gospel content services through managing social media and video platforms.
The challenges faced by the case organization, in addition to the common difficulties encountered by non-profit organizations such as insufficient funding, lack of organizational visibility, and unclear mission, have been further complicated by the establishment of online evangelism platforms by various churches during the pandemic. This has necessitated a rethinking of the organization's original mission and positioning. Furthermore, the impact of the pandemic has reduced opportunities for communication and cohesion between the organization, volunteers, and believers, making it necessary to strengthen interaction with stakeholders and adapt to the fragmented information landscape of the post-pandemic era. This requires integrating the organization's mission, evangelism content, and other aspects through multi-channel marketing and communication efforts.
This study adopts a qualitative research approach, using case study method, to explore the current development status of M organization's media advance team in terms of their service targets, operations, resources, participants, and services through secondary data analysis and in-depth interviews. The study found that the case organization is facing challenges such as lack of professional manpower, insufficient funds, and difficulties in attracting and training volunteers.
Finally, this study proposes effective marketing strategies for the organization from the perspective of Integrated Marketing Communication: (1) Strengthening organizational goals, (2) Specifying the mission, using actual work results for fundraising, and (3) Focusing on the audience, using differentiation positioning as a communication strategy to address the difficulties they are facing