21 research outputs found
Prevention and treatment for iron-deficiency anemia in obstetrical gynecological practice
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М.S. Selikhova, P.A. Soltys, L.S. Kalacheva
Volgograd State Medical University, Volgograd, Russian Federation
The prevalence of iron-deficiency anemia (IDA) is steadily increasing. IDA is more common in women of reproductive age, pregnant women, and adolescent girls thus accounting for the importance of this issue in obstetrics and gynecology. Abnormal uterine bleeding (AUB) is one of the most common causes of IDA both in the puberty and reproductive period which requires hemostasis as well as addressing iron deficiency. A high rate of IDA was also reported in women with pelvic inflammatory diseases; this should considered when managing this large group of gynecological patients. The treatment for anemia or latent iron deficiency is performed for a long time, therefore, the selection of a medication is particularly important. Peroral Tardyferon® containing 80 mg of iron meets all modern-day requirements for anti-anemic drugs and is recommended for anemia resulting from AUB both in women of reproductive age and adolescent girls. Case studies illustrate high efficacy and good tolerability of this medication.
Keywords: iron-deficiency anemia, pregnancy, abnormal uterine bleeding in puberty, heavy menstrual bleeding, genital inflammation, high efficacy, compliance.
For citation: Selikhova М.S., Soltys P.A., Kalacheva L.S. Prevention and treatment for iron-deficiency anemia in obstetrical gynecological practice. Russian Journal of Woman and Child Health. 2020;3(4):276–281. DOI: 10.32364/2618-8430-2020-3-4-276-281.
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Hormonal contraception and its role for the maintenance of reproductive potential in women with pelvic inflammatory disease
No full textHormonal contraception and its role for the maintenance of reproductive potential in women with pelvic inflammatory disease
M.S. Selikhova, P.A. Soltys, A.A. Smol’yaninov
Volgograd State Medical University, Volgograd, Russian Federation
Aim: To study the effect of pelvic inflammatory disease (PID) on female reproductive functions and the importance of hormonal contraception for the rehabilitation of these women.
Patients and Methods: The study included two steps. During step 1, 117 women with acute manifestations of PID were examined. These women were subdivided into 2 groups. Group 1 included 36 women (30.8%) with acute PID diagnosed for the first time. Group 2 included 81 women with exacerbations of chronic PID (69.2%). During step 2, the effects of combined oral contraceptive pills (COCPs) on the rehabilitation of 87 women were analyzed.
Results: Our findings demonstrate that PID is diagnosed in the active reproductive age (29.4±4.9 years). In a half of these women, reproductive function was not realized. Adequate antibiotic therapy considering antibiotic susceptibility does not provide complete rehabilitation after the disease. In the second stage 87 women took part, 21 of them women received COCPs (Midiana®) for a year after PID, 47 — for 6 months, 8 — for 3 months, 11 — did not received COCs. In 3 women who did not received COCPs (27.3%), inflammation has exacerbated. Menstrual disorders were reported in 5 women (45.5%).
Conclusions: Combined single-phase low-dose contraceptive containing 30 μg of ethinylestradiol and 3 mg of drospirenone (Midiana®) provides rehabilitation after PID thus preventing PID recurrences within a year, regaining regular menstrual cycle, and restoring reproductive potential.
Keywords: active reproductive age, pelvic inflammatory disease, rehabilitation, single-phase low-dose contraceptive, decrease in recurrence rate, regaining menstrual cycle, contraception.
For citation: Selikhova M.S., Soltys P.A., Smol’yaninov A.A. Hormonal contraception and its role for the maintenance of reproductive potential in women with pelvic inflammatory disease. Russian Journal of Woman and Child Health. 2019;2(2):102–106.<br
Review of <em>Advancing Global Education: Patterns of Potential Human Progress</em>
No full textDennis Soltys reviews the second volume of a five-part series that will further comprise health, infrastructure, and governance. The first volume, on poverty, was reviewed by this author in the No. 2, 2010, issue of the journal of Poverty & Public Policy.Education, education, global, poverty, development
Review of <em>Reducing Global Poverty: Patterns of Potential Human Progress, Vol. 1</em>
No full textDennis Soltys, author of <em>Education for Decline: Soviet Vocational and Technical Schooling from Khrushchev to Gorbachev</em> (Toronto: University of Toronto Press, 1997), reviews this book that discusses poverty and the human condition in many of the poorest regions around the globe.Poverty, global poverty, policymaking, human potential
Renaissance of the vaginal microbiota: reframing clinical paradigms
No full textG.N. Minkina1, K.R. Bondarenko2, M.S. Selikhova3, P.A. Soltys3
1A.I. Yevdokimov Moscow State University of Medicine and Dentistry, Moscow, Russian Federation
2Pirogov Russian National Research Medical University, Moscow, Russian Federation
3Volgograd State Medical University, Volgograd, Russian Federation
One of the promising options for reducing the prevalence of inflammatory diseases of the genital organs and preventing their recurrence is to achieve and maintain a normal vaginal microbiome as the first line of natural protection against infections. Medications comprising antibacterial and/or antifungal agents which are widely used in the treatment of abnormal vaginal discharges may cause a substantial decrease in woman’s own lactobacilli. Over the last decade, researchers have focused on probiotics which increase the efficacy of treatment and reduce the rate of disease recurrences. As known, the human gut microbiota plays a central role in the development of healthy microbiome of its host and biotopes of various locations. Thus, the currently preferred oral probiotics include combination products for oral intake which contain multiple symbiont bacterial strains and prebiotic components. An oral probiotic comprising a combination of two lactic acid bacteria wi th synergistic effect, Lactobacillus rhamnosus HN001 and Lactobacillus acidophilus La-14 that remain viable after passing through the gastrointestinal tract and maintain ability to colonize the vagina as well as other organs and are characterized by a high level of adhesion to vaginal epithelial cells, helps to increase the lactobacilli count, normalizing microbiome in the woman’s vagina. The recent clinical trials have demonstrated the efficacy of oral administration of the combination of two strains of lactic acid bacteria, L. rhamnosus HN001 and L. acidophilus La-14, in the prevention of recurrences of bacterial vaginosis and vulvovaginal candidiasis with the aim of maintaining and normalizing vaginal microbiome; this combination is approved for taking during pregnancy and breastfeeding.
Keywords: vaginal infections, microbiome, probiotics, oral intake, symbiont bacterial strains, normal vaginal biocenosis.
For citation: Minkina G.N., Bondarenko K.R., Selikhova M.S., Soltys P.A. Renaissance of the vaginal microbiota: reframing clinical paradigms. Russian Journal of Woman and Child Health. 2022;5(4):303–308 (in Russ.). DOI: 10.32364/2618-8430-2022-5-4-303-308.
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Gel'mintofauna volkov (Canis lupus L.)
No full textThe author examined the internal parasites of 18 wolves hunted down on the terrain of the Lublin province during the period 1950-1956. To this material were included also tapeworms from 14 wolves from the Białowieża virgin forest (Puszcza Białowieska) (1941-1943). The infection of the wolves from the Lublin province with worms amounted to 100 per cent. In the collected material the author differentiated 5 species of worms: Alaria alata (Goeze, 1782), Krause, 1914, Taenia hydatigena Pallas, 1766, Uncinaria stenocephala (Railliet, 1884), Crenosoma vulpis (Dujardin, 1845) and Trichinella spiralis (Oven, 1835) Railliet, 1895. The wolf proved to be a new host to Crenosoma vulpis (Dujardin, 1845). In the material collected in Białowieża the author found the following taeniae: Taenia hydatigena Pallas, 1766 and Mesocestoides lineatus Goeze, 1872. The highest number of species of parasites in the wolves was demonstrated in the Soviet Union. Their number reaches 15 species. Exclusively for this area were demonstrated out of the trematodes only Alaria alata, of the tapeworms: Diphyllobothrium decipens, Dipylidium pasquala, Taenia krabei and Taenia polyacantha. The followin nematodes were isolated: Toxocara leoninu, Ancylostoma caninum, Spirocerca lupi , Eucoleus aerophilus and Dioctophyme renale. Out of the Acanthocephala was isolated Ancicola skrjabini. On the Alaska terrains were isolated 8 species of worms out of them only the trematode Alaria canis was exlusive for Alaska. In Poland 6 species of worms were found. Up to the present time were demonstrated for Poland exclusively 3 species. They are Euparyphium malis, Crenosoma vulpis and Thominx böhmi
The Problems of Strategic and Spatial Planning in the Management of Metropolitan Areas Development
No full textThe aim of the work is recognizing and systemizing of the problems related to planning of a complex management strategy of metropolitan area development as well as preparation of a spatial development plan for such areas. The problems of planning are defined as the difficulties, dilemmas and doubts about different aspects of the planning process. The author is referring to the features of metropolitan areas and typical problems which are solved in the planning process of their development. In extent justified by the content, the author uses the analogies with problems of planning on the local level. The problems discussed in the paper tackle (inter alia): defining the subject of a metropolitan areas strategic plan, participation of variety of actors in the planning process, enhancing strategic features of spatial planning of metropolitan areas as well as the definition of the range of issues a strategic plan decide on. The author is also analyzing the causes of the problems and showing some of the possibilities of solving them
Process of Emergence of Smart Specialisation in Pomeranian Voivodeship in Poland
No full textAbstractThe European Commission puts a growing emphasis on the smart specialization as a tool of regional development. This term is present in a number of strategic development documents in the European Union, including Europe 2020, published by the European Commission in 2010. It implies the need for countries and regions to specialize as well as focus the development of innovation on areas that are consistent with their endogenous potentials.Objectives of this paper are: (1) to present the method and results of the process of identifying smart specialization in Pomeranian Voivodship; (2) to analyse evolution of the fields of smart specialization; (3) to identify problems and challenges which occurred during this process. In this research, following methods have been applied: (1) analysis of existing documents including application forms for the competition of Pomeranian smart specialization, (2) individual in-depth interviews with members of partnerships and representatives of the Voivodeship Marshal's Office, (3) authors’ observations while participating in this process. The authorities of the Pomeranian Voivodeship see the smart specialization as an area with high potential, relevant to the development of the Voivodeship, based on the unique resources of the Region and their innovative use. It is assumed that, among others, implementation of R & I is contributing to the development of existing economic specialization and having an impact on the growth of competitiveness of the Pomeranian Region on the national and international arena. The process of identification of smart specialization has been implemented in three phases
Fair Ranking in Competitive Bidding Procurement: A Case Analysis
No full textAbstractFair and transparent procurement procedures are a cornerstone of a well functioning free-market economy. In particular, bidding is a mechanism whereby companies compete for contracts; when functioning well, the process rewards both the quality of the proposal, and the “reasonableness” of the quote. This way, both the company and the public win. The bidding process requires a fair and transparent ranking procedure. Once the parameters of the competition are established, the company issuing the bid is required by law to abide by those parameters. Not surprisingly, opposing interests may try to “game the system.” The more complex the service, the harder it is to rank competing bids. Complex services require complex ranking, which in turn makes undue influence more difficult to uncover. In this paper we analyze the case of two companies, Reilly Security and Contemporary Security, bidding for the contract of providing security during the Pan American games ([1]) in Toronto 2015: The Pan Am Games are the world's third largest international multi-sport Games; they are only surpassed in size and scope by the Olympic Summer Games and the Asian Games. We argue that the ranking procedures did not reflect the quality of the bids, resulting in one of the companies submitting a substantially more expensive bid, and still winning the competition. The reader may gain information on this contentious matter by reading a number of newspaper articles: [2–5]. Article [5] mentions the results presented in this paper. The author consulted for Executek International on this matter
Validação de métodos analíticos, estudos de estabilidade e desenvolvimento de uma suspensão contendo deflazacorte
No full textDissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde. Programa de Pós-graduação em farmáciaO Deflazacorte (DFZ) é um glicocorticóide derivado da prednisolona indicado no tratamento de doenças reumáticas, dermatológicas, alérgicas, do tecido conjuntivo, gastrointestinais, transplante de órgão entre outras. Apresenta a vantagem da redução significativamente menor na perda óssea, manutenção dos níveis de colesterol, menor efeito diabetogênico e menor perda de massa muscular quando comparado a outros glicocorticóides. Apesar de seu amplo uso na terapêutica, não há registros de monografias farmacopeicas descrevendo métodos para quantificação de DFZ em suspensão, e há escassas informações sobre a estabilidade do fármaco. Os objetivos deste trabalho foram desenvolver, otimizar e validar métodos para análise qualitativa e quantitativa em suspensão oral; avaliar a estabilidade do fármaco, isolar e identificar o principal produto de degradação; avaliar a atividade antiinflamatória e desenvolver suspensão oral contendo DFZ. A caracterização do DFZ foi realizada através de estudos termoanalíticos, espectroscópicos e cromatográficos. Este foi devidamente caracterizado e apresentou uma pureza de 98,98 %. Foram desenvolvidos e validados os métodos espectrofotométricos (UV e Vis) e cromatografia líquida de alta eficiência (CLAE) para a análise do DFZ em suspensão. Para o controle de qualidade do DFZ em suspensão oral, os métodos que demonstraram maior eficiência foram UV e CLAE. O estudo de estabilidade do DFZ foi realizado em meio ácido (HCl 0,1N), alcalino (NaOH 0,1N) e em co-solventes farmacêuticos; tampão acetato, tampão fosfato, glicerina, sorbitol e PEG-400). Nos estudos de estabilidade foi demonstrado que o DFZ degrada mais rapidamente em meio alcalino, e com menor degradação em tampão acetato pH 5,0 com a adição de PEG-400. O principal produto de degradação (DDP1) foi isolado a partir da hidrólise em meio alcalino e foi identificado através de técnicas espectroscópicas como 21-hidroxideflazacorte. DDP1 foi testado comparativamente com DFZ em modelos animais de inflamação aguda in vivo, e ensaios em cultura celular in vitro. Os ensaios farmacológicos demonstraram que o DFZ e o seu metabólito 21-hidroxideflazacorte apresentam efeito antiinflamatório in vivo e in vitro. Além disso, foram desenvolvidas quatro suspensões contendo DFZ, que foram avaliadas quanto à estabilidade acelerada. Nestes ensaios, as formulações F1 e F2 contendo carboximetilcelulose sódica como espessante foram mais estáveis que as formulações F3 e F4 contendo hidroxipropilmetilcelulose. Baseado nestes resultados foi possível concluir que o DFZ foi identificado e quantificado através de técnicas termoanalíticas, espectroscópicas e CLAE, possibilitando usá-lo como substância química referência. Estes métodos também demonstraram ser reprodutíveis para o controle de qualidade do DFZ em suspensão oral. Através do estudo de estabilidade química do DFZ em meio aquoso foi demonstrado que a degradação é dependente de pH e o uso de co-solventes farmacêuticos interferem diretamente na estabilidade do DFZ. Nos ensaios farmacológicos, o 21-hidróxideflazacorte demonstrou efeito antiinflamatório in vivo e in vitro superior ao DFZ. Na avaliação da estabilidade das formulações desenvolvidas, F1 foi considerada mais estável, mantendo os parâmetros dentro do limite de 5 % e conferindo um prazo de validade de 24 meses. Os resultados obtidos contribuem para o estabelecimento de métodos analíticos para o controle de qualidade de formas farmacêuticas contendo DFZ, especialmente em suspensões
