31,707 research outputs found
Sherlock Holmes on Reasoning
No full textIn this paper, I will show that Sherlock Holmes was a good logician, according to the standard of the 19th century, both in his character and knowledge (sections 2 and 3). Holmes, in all probability, knew William Stanley Jevons’ clarification of deductive reasoning in terms of “logical alphabets” (section 4). And in view of his use of “analytic-synthetic” distinction and “analytic reasoning,” I will argue that Holmes knew rather well philosophy too, as far as logic and methodology are concerned (section 5). Further, I have argued that Holmes introduced new twists (presumably, following Jevons) into analytic reasoning: application to reasoning as regards causal sequences, and probabilistic elimination of hypotheses (sections 6 and 7). Also, in this context, I will clarify the significance of Holmes’ metaphor of the “little attic”: without fine assortment in your brain, it is hard to devise promising hypotheses (section 8). Finally, presenting a simple model of probabilistic inference, which became prevalent in the 19th century (section 9), I claim that the essence of Holmes’ reasoning consists of probabilistic inferences, “balance probabilities and choose the most likely,” which is nothing but probabilistic elimination of hypotheses in the light of evidence. I also argue that my claim fits in well with the text of Holmes stories (section 10)
Certificate of Death: Holmes, Author
No full textState of Florida death certificate for [Arthur] Holmes, age 38. Handwritten notes on the back
An ethic for researching multilingually in transnational, multilingual, multidisiplinary research teams
No full textWorking in a multilingual, multinational, and multidisciplinary project invites questions concerning the role of languages among the researchers, participants and stakeholders involved in the project. In this chapter, we attempt to explore how colleagues in the network project understood the role of their own linguistic resources, and those of others included in their research: for example, decisions about using multiple languages in literature searches and reviews; linguistic decisions in the field when working with the multiple languages of participants and other stakeholders; in collaborations within the research team; and in producing academic and stakeholder outputs. In previous work, Holmes and colleagues had come to realise that decisions concerning how researchers draw on their linguistic resources in their research are largely made tacitly; or decisions may be shaped by structural and linguistic hegemonies, often in ways that go uncontested or cannot be contested, in the contexts where the research is produced, or later, where it is to be published (Holmes et al., 2013; Andrews et al., 2020; Holmes et al., 2022). Furthermore, Meyer Pitton and Schedel (2022, in press) comment that decisions about language choice and publication within research teams are rarely discussed. In this chapter, we draw on the experiences of the researchers who were part of our transnational network to explore processes of researching multilingually in an attempt to uncover researchers’ perspectives on these matters. Our aim is to provide an ethical stance towards multilingual researcher practices in a multilingual network of researchers, who in this case, are working in contexts of conflict, forced migration, economic marginalisation, and occupation. First, we discuss the research context and chapter aims, followed by our research method. We then present the researchers’ responses (the languages in the project, and participants’ experiences of drawing on multiple linguistic resources during various phases of the project. We finish with conclusions and recommendations to other researchers on incorporating an ethic of researching multilingually in their work
William Holmes McGuffey portrait
No full textThis is a photographic reproduction of an engraved portrait depicting William Holmes McGuffey. McGuffey, who was from Tuscarawas County, Ohio, was a professor at Miami University from 1826 to 1836. Between 1836 and 1845 he served as president of three Ohio institutions: Cincinnati College, Ohio University and Woodward College in Cincinnati. In 1845 McGuffey became a professor at the University of Virginia, where he taught until his death in 1873. He is best known as the author of the popular series of children's textbooks called McGuffey Readers
DataSheet1_CRISPR-HOLMES-based NAD+ detection.docx
No full textStudies have indicated that the intracellular nicotinamide adenine dinucleotide (NAD+) level is associated with the occurrence and development of many diseases. However, traditional nicotinamide adenine dinucleotide (NAD+) detection techniques are time-consuming and may require large and expensive instruments. We recently found that the clustered regularly interspaced short palindromic repeat (CRISPR)-Cas12a protein can be inactivated by AcrVA5-mediated acetylation and reactivated by CobB, using NAD+ as the co-factor. Therefore, in this study, we created a CRISPR-Cas12a-based one-step HOLMES(NAD+) system for rapid and convenient NAD+ detection with the employment of both acetylated Cas12a and CobB. In HOLMES(NAD+), acetylated Cas12a loses its trans-cleavage activities and can be reactivated by CobB in the presence of NAD+, cutting ssDNA reporters to generate fluorescence signals. HOLMES(NAD+) shows both sensitivity and specificity in NAD+ detection and can be used for quantitative determination of intracellular NAD+ concentrations. Therefore, HOLMES(NAD+) not only provides a convenient and rapid approach for target NAD+ quantitation but also expands the application scenarios of HOLMES to non-nucleic acid detection.</p
Correspondence: Chase Ambler to state geologist, December 1900
No full textIn this 3 pages of letters, J. A. Holmes and Chase Ambler discuss a visit by Holmes to meet with the members of the Appalachian National Park Association. Chase P. Ambler (1865-1932) was a founding member and long-time secretary of the Appalachian National Park Association. Joseph Austin Holmes (1859-1915) was the North Carolina State Geologist
Dataset for: Self-assembled axicon lens in integrated optical fiber
No full textData supporting the published paper: Holmes, C., & Smith, P. G. R. (2019). Self-assembled axicon lens in integrated optical fiber. Optics Letters, 44(14), 3506-3509. DOI: 10.1364/OL.44.003506
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Gifford Lectures webpage: Holmes Rolston III
No full textDr. Rolston delivered the Gifford Lectures at the University of Edinburgh, Academic Year 1997-1998, in November 1997, with the title "Genes, Genesis and God".Author biography of Dr. Holmes Rolston on the online Gifford Lectures database
Correspondence with state geologist
No full textIn this 3 pages of letters, J. A. Holmes and Chase Ambler discuss a meeting at Blowing Rock. Chase P. Ambler (1865-1932) was a founding member and long-time secretary of the Appalachian National Park Association. Joseph Austin Holmes (1859-1915) was the North Carolina State Geologist
Book design: David Holmes – A Brush with the Music of Time
No full textDavid Holmes: Book author
Phil Cleaver: As the designer of this book I conceived the size of the book, the way the book is bound, and the slip case. I laid out the order of the work as the art editor, authored the work and inserts of text on smaller page size, conceived numbering the page numbers backwards, typeset the text and did the whole print production of the book. It won Best book in Britain award 2017/18
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