2,146 research outputs found
Ludwig Fulda Collection 1989
No full textThe Ludwig Fulda collection contains a photograph and two biographical documents.Gaby Fulda, 1964L.H. Niemeyer (p), 1958ProszeniumLibrisRosen AuktionEggertAuthor, 1862-1939Processed for digitizationSent for digitizationReturned from digitizationLinked to online manifestationdigitize
Solothurn, Staatsarchiv, R 1.1.17 : Fulda Legendary
No full textBifolio from the third volume (May-June) of a Fulda Legendary that originally consisted of six volumes, commissioned in 1156 by Rugger, provost of Frauenberg Abbey in Fulda. This fragment contains parts of the vita of Boniface by Otloh of St Emmeram; it was written by Eberhard von Fulda. The legendary was still used in the middle of the 16th century in Fulda by Georg Witzel (1501-1573) for his Hagiologium seu de sanctis ecclesiae (Mainz 1541) as well as for his Chorus sanctorum omnium. Zwelff Bücher Historien Aller Heiligen Gottes (Köln 1554). Other fragments from this third volume are in Basel and Nuremberg. It shows that this volume, and at least the 6th volume (November-December) of the legendary as well, reached Basel, where both evidently were used as manuscript waste around 1580. The P-initial 1r has a representation of Boniface inside the bowl of the initial; below that is Rugger, who commissioned the legendary.Online Since: 2017-12-1
Temporalization?
No full textDaniel Fulda evaluates Lessing’s Laocoon against the backdrop of contemporary historiography. Fulda explains that Lessing’s prescriptions about painterly ‘space’ and poetic ‘time’ are also shaped by debates on how to write history—discussions that themselves stretch all the way back to Graeco-Roman antiquity. Ultimately, Fulda argues, Lessing’s prescriptions about the proper ‘limits’ of ‘poetry’ and ‘painting’ respond to what was seen as a weakness of German historiography in the eighteenth century: namely, its struggle to reconcile a conflict between the spatial and temporal dimensions of historical writing.</p
Regulation of cell death in cancer - possible implications for immunotherapy
No full textSince most anticancer therapies including immunotherapy trigger programmed cell death in cancer cells, defective cell death programs can lead to treatment resistance and tumor immune escape. Therefore, evasion of programmed cell death may provide one possible explanation as to why cancer immunotherapy has so far only shown modest clinical benefits for children with cancer. A better understanding of the molecular mechanisms that regulate sensitivity and resistance to programmed cell death is expected to open new perspectives for the development of novel experimental treatment strategies to enhance the efficacy of cancer immunotherapy in the future
How to target apoptosis signaling pathways for the treatment of pediatric cancers
No full textApoptosis represents one of the most important forms of cell death in higher organisms and is typically dysregulated in human cancers, including pediatric tumors. This implies that ineffective engagement of cell death programs can contribute to tumor formation as well as tumor progression. In addition, the majority of cytotoxic therapeutic principles rely on the activation of cell death signaling pathways in cancer cells. Blockade of signaling networks that lead to cell death can therefore confer treatment resistance. A variety of genetic and epigenetic events as well as dysfunctional regulation of signaling networks have been identified as underlying causes of cell death resistance in childhood malignancies. Apoptosis pathways can be therapeutically exploited by enhancing proapoptotic signals or by neutralizing antiapoptotic programs. The challenge in the coming years will be to successfully transfer this knowledge into the development of innovative treatment approaches for children with cancer
Shifting the balance of mitochondrial apoptosis: therapeutic perspectives
No full textSignaling via the intrinsic (mitochondrial) pathway of apoptosis represents one of the critical signal transduction cascades that control the regulation of cell death. This pathway is typically altered in human cancers, thereby providing a suitable target for therapeutic intervention. Members of the Bcl-2 family of proteins as well as cell survival signaling cascades such as the PI3K/Akt/mTOR pathway are involved in the regulation of mitochondria-mediated apoptosis. Therefore, further insights into the molecular mechanisms that form the basis for the control of mitochondria-mediated apoptosis will likely open new perspectives to bypass evasion of apoptosis and treatment resistance in human cancers
Die räumliche Rekonstruktion der Bibliothek von Fulda
No full textThe preserved booklists of the monastery of Fulda mark the two central periods in the history of the library of Fulda, the ninth century and the tum of the 15th to the 16th century. We point out certain structures and compare different passages in the later group of lists which enable us to draw some conclusions on the arrangement of the books in the shelves. Our knowledge is also based on archaeological research by Josef Leinweber and the wood-engraving of Hans Brosamer of 1542
Arabidopsis acyl-acyl carrier protein synthetase AAE15 with medium chain fatty acid specificity is functional in cyanobacteria
No full textCyanobacteria are potential hosts for the biosynthesis of oleochemical compounds. The metabolic precursors for such compounds are fatty acids and their derivatives, which require chemical activation to become substrates in further conversion steps. We characterized the acyl activating enzyme AAE15 of Arabidopsis encoded by At4g14070, which is a homologue of a cyanobacterial acyl-ACP synthetase (AAS). We expressed AAE15 in insect cells and demonstrated its AAS activity with medium chain fatty acid (C10-C14) substrates in vitro. Furthermore, we used AAE15 to complement a Synechocystis aas deletion mutant and showed that the new strain preferentially incorporates supplied medium chain fatty acids into internal lipid molecules. Based on this data we propose that AAE15 can be utilized in metabolic engineering strategies for cyanobacteria that aim to produce compounds based on medium chain fatty acids
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