1,187 research outputs found
Kinetic and thermodynamic analysis of leech-derived tryptase inhibitor interaction with bovine tryptase and bovine trypsin
No full textThe interaction of leech-derived tryptase inhibitor (LDTI) with bovine liver capsule tryptase (BLCT) and bovine trypsin has been studied using both thermodynamic and kinetic approaches. Several differences were detected: (i) the equilibrium affinity of LDTI for BLCT (K-a = 8.9 x 10(5) M-1) is about 600-fold lower than that for bovine trypsin (K-a = 5.1 x 10(8) M-1); (ii) LDTI behaves as a purely non-competitive inhibitor of BLCT, while it is a purely competitive inhibitor of bovine trypsin. These functional data are compared with those previously reported for the LDTI binding to human tryptase, where tight inhibition occurs at two of the four active sites of the tetramer (K-a = 7.1 x 10(8) M-1). Amino acid sequence alignment of BLCT, human beta II-tryptase and bovine trypsin allows us to infer some possible structural basis for the observed functional differences
Albert Russell Ascoli, Dante and the Making of a Modern Author, Cambridge UK, University Press, 2008
No full textHypopituitarism
No full textHypopituitarism is the partial or complete insufficiency of anterior pituitary hormone secretion and may result from pituitary or hypothalamic disease. The reported incidence (12-42 new cases per million per year) and prevalence (300-455 per million) is probably underestimated if its occurrence after brain injuries (30-70% of cases) is considered. Clinical manifestations depend on the extent of hormone deficiency and may be non specific, such as fatigue, hypotension, cold intolerance, or more indicative such as growth retardation or impotence and infertility in GH and gonadotropin deficiency, respectively. A number of inflammatory, granulomatous or neoplastic diseases as well as traumatic or radiation injuries involving the hypothalamic-pituitary region can lead to hypopituitarism. Several genetic defects are possible causes of syndromic and non syndromic isolated/multiple pituitary hormone deficiencies. Unexplained gonadal dysfunctions, developmental craniofacial abnormalities, newly discovered empty sella and previous pregnancy-associated hemorrhage or blood pressure changes may be associated with defective anterior pituitary function. The diagnosis of hypopituitarism relies on the measurement of basal and stimulated secretion of anterior pituitary hormones and of the hormones secreted by pituitary target glands. MR imaging of the hypothalamo-pituitary region may provide essential information. Genetic testing, when indicated, may be diagnostic. Secondary hypothyroidism is a rare disease. The biochemical diagnosis is suggested by low serum FT4 levels and inappropriately normal or low basal TSH levels that do not rise normally after TRH. L-thyroxine is the treatment of choice. Before starting replacement therapy, concomitant corticotropin deficiency should be excluded in order to avoid acute adrenal insufficiency. Prolactin deficiency is also very rare and generally occurs after global failure of pituitary function. Prolactin deficiency prevents lactation. Hypogonadotropic hypogonadism in males is characterized by low testosterone with low or normal LH and FSH serum concentrations and impaired spermatogenesis. Hyperprolactinemia as well as low sex hormone binding globulin concentrations enter the differential diagnosis. Irregular menses and amenorrhea with low serum estradiol concentration (<100 pmol/l) and normal or low gonadotropin concentrations are the typical features of hypogonadotropic hypogonadism in females. In post menopausal women, failure to detect high serum gonadotropin values is highly suggestive of the diagnosis. In males, replacement therapy with oral or injectable testosterone results in wide fluctuations of serum hormone levels. More recently developed transdermal testosterone preparations allow stable physiological serum testosterone levels. Pulsatile GnRH administration can be used to stimulate spermatogenesis in men and ovulation in women with GnRH deficiency and normal gonadotropin secretion. Gonadotropin administration is indicated in cases of gonadotropin deficiency or GnRH resistance but is also an option, in alternative to pulsatile GnRH, for patients with defective GnRH secretion. (copyright) Springer Science + Business Media, LLC 2006
P-adic Ascoli theorems and compactoid polynomials
No full textAbstractWe prove several properties of compactoid sets in some spaces of vector-valued continuous functions. As a consequence we derive some p-adic Ascoli theorems which allow us to answer the question proposed by W.H. Schikhof in [MR.90i 46128]
Ascoli longobarda. Frammenti di archeologia urbana
No full textAggiornamento sulle ricerche di archeologia urbana ad Ascoli Piceno nell'ambito di un progetto promosso nel quadro di una convenzione tra Università di Bologna, Soprintendenza e Comune di Ascoli Piceno. Il progetto ha visto la collaborazione attiva di archeologi della comunità cittadina e viene promosso e presentato all'interno di un convegno organizzato da istituzioni ed enti di ricerca di rilevanza nazionale e locale. vengono presentati dati inediti derivanti da indagini archeologiche d emergenza in collaborazione con gli archeologi professionisti coinvolti nella pubblicazione. Le nuove scoperte si inseriscono nella ricostruzione delle variazioni del paesaggio urbano tra antichità e alto-medioevo. Le dinamiche che caratterizzano il paesaggio urbano di Ascoli divengono occasione per un confronto con fenomeni indagati a scala mediterranea
Note Illustrative della Carta geologica d'Italia alla scala 1:50.000, F. 421 Ascoli Satriano
No full text<p>Note illustrative redatte per il Foglio geologico n. 421 Ascoli Satriano della Carta Geologica d'Italia alla scala 1:50.000. 104 pp.</p>
Towards a partnership between statutory sector and voluntary action? Italian welfare pluralism in the 90s
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