916 research outputs found
Emerging Diplomatics Studies. I, Atti del convegno internazionale (Milano, 30 giugno - 1 luglio 2022), a cura di P. Buffo - G. Capriolo - C. Drago Tedeschini - M.L. Mangini - M. Modesti - V. Ruzzin
No full textAtti della prima edizione del convegno internazionale EDIS. Emerging DIplomatics Studies (30 giugno – 1° luglio 2022, Università degli Studi di Milano Statale) promosso dal Centro Studi Interateneo Notariorum Itinera con il contributo dei progetti di ricerca LIMEN. Linguaggi della mediazione notarile (secc. XII-XV) Seal of Excellence del Bando Straordinario per
Progetti Interdipartimentali dell’Università degli Studi di Milano 2020 e NOTMed. El notariat pùblic en la Mediterrània Occidental: escriptura, institucions, societat i economia, segles XIII-XV dell’Universidad de Barcelona e con il patrocinio della Commission Internationale de Diplomatique e dell’Associazione Italiana dei Paleografi e Diplomatisti
Carex modesti (Cyperaceae), a new species from southern Tanzania
No full textA new species of Carex (Cyperaceae), Carex modesti, is described from southern Tanzania. It grows on stream sides and peat bogs at about 2750 m in the Kitulo Plateau. It is morphologically distinct from the similar species C. vallis-rosetto by its creeping rhizomes, coriaceous leaves and solitary spikes arising in each node.
Carex modesti is included in Carex sect. Spirostachyae subsect. Elatae together with other Carex species from the tropical African mountains
Direct numerical simulation of forced thermal convection in square ducts up to
No full textWe carry out direct numerical simulation (DNS) of flow in a turbulent square
duct by focusing on heat transfer effects, considering the case of unit Prandtl
number. Reynolds numbers up to are considered which are
much higher than in previous studies, and which yield clear scale separation
between inner- and outer-layer dynamics. Close similarity between the behavior
of the temperature and the streamwise velocity fields is confirmed as in
previous studies related to plane channels and pipes. Just like the mean
velocity, the mean temperature is found to exhibit logarithmic layers as a
function of the nearest wall, however with a different slope. The most
important practical implication is the validity of the traditional hydraulic
diameter as the correct reference length for reporting heat transfer data, as
we rigorously show here. Temperature and velocity fluctuations also have
similar behavior, but apparently logarithmic growth of their inner-scaled peak
variances is not observed here unlike in canonical wall-bounded flows. Analysis
of the split contributions to the heat transfer coefficient shows that mean
cross-stream convection associated with secondary motions is responsible for
about of the total. Finally, we use the DNS database to highlight
shortcomings of traditional linear closures for the turbulent heat flux, and
show that substantial modeling improvement may be in principle obtained by
retaining at least the three terms in the vector polynomial integrity basis
expansion
Reduced expression of thyroid hormone receptors and beta-adrenergic receptors in human failing cardiomyocytes.
No full textAn altered thyroid hormone profile has been reported in patients with congestive heart failure. However, information regarding the status of thyroid hormone receptors in human failing cardiomyocytes is lacking. Therefore the expression of thyroid hormone and beta-adrenergic receptors was investigated in human ventricular cardiomyocytes isolated from patients with end-stage heart failure (FM, n=12), or from tentative donors (C, n=4). The expression of thyroid (TRalpha1, and TRbeta1) and beta-adrenergic receptors (ARB1 and ARB2) was measured at both the gene, and at the protein level. In FM the reduced mRNA expression of ARB1 (p<0.05, -37\%) and ARB2 (p<0.05, -42\%) was associated with a reduction of the messenger for TRalpha1 (p<0.05, -85\%) and TRalpha2 (p<0.05, -73\%). These findings were confirmed at the protein level for ARB1, ARB2 and TRalpha1. These data reveal that in human heart failure the reduction of beta-adrenergic receptors is associated with reduced expression of both TRalpha1 and TRalpha2 isoforms of thyroid hormone receptors
A utility measure for finding multiobjective shortest paths in urban multimodal transportation networks
No full text
Reduced expression of thyroid hormone receptors and beta-adrenergic receptors in human failing cardiomyocytes
No full textAn altered thyroid hormone profile has been reported in patients with congestive heart failure. However, information regarding the status of thyroid hormone receptors in human failing cardiomyocytes is lacking. Therefore the expression of thyroid hormone and beta-adrenergic receptors was investigated in human ventricular cardiomyocytes isolated from patients with end-stage heart failure (FM, n=12), or from tentative donors (C, n=4). The expression of thyroid (TRalpha1, and TRbeta1) and beta-adrenergic receptors (ARB1 and ARB2) was measured at both the gene, and at the protein level. In FM the reduced mRNA expression of ARB1 (p<0.05, -37%) and ARB2 (p<0.05, -42%) was associated with a reduction of the messenger for TRalpha1 (p<0.05, -85%) and TRalpha2 (p<0.05, -73%). These findings were confirmed at the protein level for ARB1, ARB2 and TRalpha1. These data reveal that in human heart failure the reduction of beta-adrenergic receptors is associated with reduced expression of both TRalpha1 and TRalpha2 isoforms of thyroid hormone receptors
Differential Influence of Physical Activity on Cardiopulmonary Performance and Stroke Volume Assessed at Cardiopulmonary Exercise Test in Pectus Excavatum: A Pilot Study
No full textBackground: Exercise training increases muscle VO2 by increasing O2 transport and O2 uptake while cardiac output increase might be limited by the conformation of the chest in subjects with pectus excavatum (PE). Aims: The aim of the present study was to investigate the influence of physical activity (PA) on functional parameters of cardiopulmonary performance and stroke volume obtained at Cardiopulmonary Exercise Test (CPET) in PE. Methods and Procedures: A cohort of adolescents (15 with PE and 15 age- and sex-matched healthy controls, HC) underwent Cardiopulmonary Exercise Test (CPET) and administration of the International Physical Activity Questionnaire – Short Form (IPAQ-SF) with estimation of weekly PA (METs h–1⋅week–1). Determinants of CPET parameters were investigated with multivariable linear regression analysis. Results: As expected, when compared to HC, PE had lower VO2 max (37.2 ± 6.6 vs. 45.4 ± 6.4 mL⋅kg–1⋅min–1, p < 0.05), and VO2/HR max (O2 pulse, 12.1 ± 2.4 vs. 16.2 ± 3.6 mL⋅min–1⋅bpm–1, p < 0.05). Importantly, physical activity level was a predictor of VO2 max (adjusted for sex, body mass index, FEV1%, and presence of PE, β = 0.085; 95% Cl 0.010 to 0.160, p = 0.029) whereas O2 pulse was independent from PA level (β = 0.035; 95% Cl −0.004 to 0.074). Conclusion: Physical activity is a determinant of VO2 max (cardiopulmonary performance), whereas it appears not to affect O2 pulse (a measure of stroke volume at peak exercise) related to constrained diastolic filling in PE
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