725 research outputs found
Supplemental material for Brain endothelial specific gene therapy improves experimental Sandhoff disease
No full textSupplemental Material for Brain endothelial specific gene therapy improves experimental Sandhoff disease by Godwin Dogbevia, Hanna Grasshoff, Alaa Othman, Anke Penno and Markus Schwaninger in Journal of Cerebral Blood Flow & Metabolism</p
A half-century of metal and metalloid-containing polymers
No full textAlaa S. Abd-El-Aziz ... [et al.]; Includes bibliographical references and indexes.; Editor, Alaa S. Abd-El-Aziz, is currently President of the University of Prince Edward Island.Source type: Electronic(1
Personal Identification Using Ears Based on Statistical Features
Get PDFAdvisor/s: Atalla I. Hashad, Gouda I. Salama. Date and location of PhD thesis defense: May 2014, AASTMTBiometrics is an automated method of recognizing a person based on a physiological (e.g. face, iris, or retina) or behavioral (e.g. gait, signature, or dynamic keystrokes) characteristics. Ear recognition is one of the physiological biometrics' types that have been interested in the recent years. Ear recognition, achieves good accuracy and has many advantages such as it doesn't affected by expressions, health, and more stable than many other biometrics. However, it has many challenges such as the pose of the face, lighting variation, occlusion with hair or clothes. In this research, four proposed models are used to identify people using ear images. The first model used single feature extraction method based on single classifier. While, the second model used single feature extraction method based on multi-classifiers. The third model used feature combination techniques (parallel or serial) based on single classifier. Finally, in the fourth model multi-features and multi-classifiers are used. In this research, there are four methods that are used to extract the features, namely, \textit{Principal Component Analysis} (PCA), \textit{Linear Discriminant Analysis} (LDA), \textit{Independent Component Analysis} (ICA), and \textit{Discrete Cousin Transform} (DCT). Neural networks, decision tree, and minimum distance classifiers are used to classify the unknown samples. The occlusion problem with hair or scarves is one of the big challenges of the ear recognition systems. In this research, segmentation technique is proposed to neglect the occluded part and solve the occlusion problem. The idea of the segmentation technique is based on dividing the ear images into different parts. The occluded part/s is neglected and the rest of the parts are used to identify people based on features fusion and classifiers fusion. The segmentation technique consists of two main types, namely, uniform or non-uniform segmentation techniques. In this research, the uniform segmentation technique is used for many experiments (horizontal, vertical, and grid). All the four proposed models are applied to all ear segments to investigate the power of each model and to achieve a high accuracy. In this research, ear database images is used. The ear dataset consists of 102 grayscale images (6 images for each of 17 subjects) in PGM format [1]. The proposed models are achieved good identification rates using ear images. In the first model, the best accuracy achieved using LDA and neural network classifier. The results of the first model ranged from 64.12\% to 100\%. In the second model, many classifiers are fused to increase the recognition rate. In this method, two methods are used, namely, Borda count and majority voting. The results of this model ranged from 94.12\% to 96.08\%. The third model, the features using two different methods, namely serial and parallel are combined. The results of this model prove that the serial combination is more powerful than parallel combination. Finally, in the fourth model, two features and two classifiers are fused to get one decision. The accuracy of this model is approximately the same of the third model, and it does not achieve good results because there is a diversity between different classifiers. Moreover, the proposed segmentation model achieved good results when some parts of the ear images are occluded
R02. HIV-1 Tat Promotes Age-Related Anxiety-like, Antinociceptive, and Neuromuscular Impairments in Aged Male Mice
Get PDFCorresponding author (BioMolecular Sciences): Alaa Qrareya, [email protected]://egrove.olemiss.edu/pharm_annual_posters/1001/thumbnail.jp
Dibenzyl ferrocene-1,1&#8242;-dicarboxylate
No full textIn the title compound, [Fe(C13H11O2)2], there are markedly different orientations of the two phenylmethoxycarbonyl substituents [O&#8212;C&#8212;C&#8212;C torsion angles = 84.5&#8197;(3) and 139.6&#8197;(2)&#176;]. These orientations are mediated by a number of intermolecular C&#8212;H...O interactions, which result in a one-dimensional hydrogen-bonded network of molecules
Pobreza y sexo en "La colmena" de Camilo José Cela y "El edificio Yacobian" de Alaa Al-Aswany
No full textThe purpose of this article is to analyze and compare the novel by the Spanish writer Camilo José Cela and the Egyptian author Alaa al-Aswany, emphasizing the features of poverty and sex in the two novels: La colmena (1951) and The Yacobian building (2002). We also highlight the causes and circumstances that led some characters to resort to sex as their only alternative and escape route in one society as in the other. Therefore, this research work approach both the Spanish and the Egyptian reality to which the author refers.Este trabajo de investigación consiste en el análisis y la comparación de la novela del escritor español Camilo José Cela y el egipcio Alaa al-Aswany haciendo hincapié en los rasgos de pobreza y sexo en las dos novelas: La colmena (1951) y El edificio Yacobian (2002). También subrayamos las causas y circunstancias que llevaron a algunos personajes en recurrir al sexo como su única alternativa y vía de escape tanto en una sociedad como en la otra. Por ello, la investigación aborda tanto la realidad española como la egipcia a la que se refiere el autor
Poverty and sex in La Colmena by Camilo José Cela and The Yacobian building by Alaa Al-Aswany
Get PDFThe purpose of this article is to analyze and compare the novel by the Spanish writer Camilo José Cela and the Egyptian author Alaa al-Aswany, emphasizing the features of poverty and sex in the two novels: La colmena (1951) and The Yacobian building (2002). We also highlight the causes and circumstances that led some characters to resort to sex as their only alternative and escape route in one society as in the other. Therefore, this research work approach both the Spanish and the Egyptian reality to which the author refersEste trabajo de investigación consiste en el análisis y la comparación de la novela del escritor español Camilo José Cela y el egipcio Alaa al-Aswany haciendo hincapié en los rasgos de pobreza y sexo en las dos novelas: La colmena (1951) y El edificio Yacobian (2002). También subrayamos las causas y circunstancias que llevaron a algunos personajes en recurrir al sexo como su única alternativa y vía de escape tanto en una sociedad como en la otra. Por ello, la investigación aborda tanto la realidad española como la egipcia a la que se refiere el auto
Structure of the connexin-43 gap junction channel in a putative closed state
Get PDF: Gap junction channels (GJCs) mediate intercellular communication by connecting two neighbouring cells and enabling direct exchange of ions and small molecules. Cell coupling via connexin-43 (Cx43) GJCs is important in a wide range of cellular processes in health and disease (Churko and Laird, 2013; Liang et al., 2020; Poelzing and Rosenbaum, 2004), yet the structural basis of Cx43 function and regulation has not been determined until now. Here, we describe the structure of a human Cx43 GJC solved by cryo-EM and single particle analysis at 2.26 Å resolution. The pore region of Cx43 GJC features several lipid-like densities per Cx43 monomer, located close to a putative lateral access site at the monomer boundary. We found a previously undescribed conformation on the cytosolic side of the pore, formed by the N-terminal domain and the transmembrane helix 2 of Cx43 and stabilized by a small molecule. Structures of the Cx43 GJC and hemichannels (HCs) in nanodiscs reveal a similar gate arrangement. The features of the Cx43 GJC and HC cryo-EM maps and the channel properties revealed by molecular dynamics simulations suggest that the captured states of Cx43 are consistent with a closed state
Formation and Investigation of Cell‐Derived Nanovesicles as Potential Therapeutics Against Chronic Liver Disease
Get PDFThis study aims to offer a new therapeutic approach using cell-derived nanovesicles (cdNVs) to overcome the lack of effective treatments for liver fibrosis, a reversible chronic liver disease. To achieve this goal we established the formation and purification of cdNVs from untreated, quiescent-like, or activated LX-2 cells, an immortalized human hepatic stellate cell (HSC) line with key features of transdifferentiated HSCs. Analysis of the genotype and phenotype of naïve and transdifferentiated LX-2 cells activated through transforming growth factor beta 1 (TGF-β1 ), following treatment with cdNVs, revealed a concentration-dependent fibrosis regression. The beneficial fibrosis-resolving effects of cdNVs are linked to their biomolecular corona. Liposomes generated using lipids extracted from cdNVs exhibit a reduced anti-fibrotic response in perpetuated LX-2 cells and show a reduced cellular uptake. However, incubation with soluble factors collected during purification results in a new corona, thereby restoring fibrosis regression activity. Overall, cdNVs display encouraging therapeutic properties, making them a promising candidate for the development of liver fibrosis resolving therapeutics. This article is protected by copyright. All rights reserved
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