6,834 research outputs found
Genetic polymorphisms and the risk of coronary artery disease
No full textBackground: Myocardial infarction involves the three processes of atheroma development, plaque rupture and formation of a thrombus. Proliferation of smooth muscle cells and vasoconstriction are important aspects of atheroma formation and are influenced by the renin-angiotensin system. Angiotensin converting enzyme (ACE) pivotal to this system has recently been shown to be influenced by an insertion/deletion (I/D) polymorphism in the ACE gene. Patients homozygous for the D allele have the highest circulating levels. Inhibition of fibrinolysis through raised levels of plasminogen activator Inhibitor (PAI- 1) has also been shown to be under the control of a PAI-1 promoter single nucleotide insertion/deletion (4G/5G) polymorphism. Patients homozygous for the 4G allele have the highest levels of circulating PAI-1. Aims: The aim of this thesis, was to investigate the role of both polymorphisms in relation to atherothrombosis in subjects with coronary artery disease (CAD). Results: 609 Caucasian patients (420 males 189 females) admitted for angiography for known or suspected coronary artery disease were recruited from two centres. Patients were classified as having no significant coronary artery disease (20%), single (21%), double (21%) and triple vessel disease (38%) on the basis of 50% stenosis. Both the ACE genotype and the PAI-1 genotype were associated with their respective circulating levels (P= 0.0008) and (P = 0.0001) respectively. There was no relationship between the ACE genotype or levels with either the degree of coronary stenosis or a history of MI. In contrast, the 4G/4G genotype was significantly related to a history of myocardial infarction, an association which was stronger in the group with pre-existing significant atheroma. Conclusions: These data suggests that the ACE genotype-activity does not influence the atherothrombotic process, whereas the PAI-1 promoter polymorphism influences the development of myocardial infarction through its effects on thrombus formation in patients with pre-existing atheroma. Conclusions These data suggests that the ACE genotype-activity does not influence the atherothrombotic process, whereas the PAI-1 promoter polymorphism influences the development of myocardial infarction through its effects on thrombus formation in patients with pre-existing atheroma
Interview with Nicholas Christopher, author of Somewhere in the Night: Film Noir and the American City
No full textInterview with Nicholas Christopher, author of Somewhere in the Night: Film Noir and the American Cit
Resurrecting the Author
No full textPresentation of Nicholas Wolterstorff\u27s Paper Resurrecting the Author with time after for questions beginning at 18:00
Heritability and Linkage Analysis of Appendicitis Utilizing Age at Onset
No full textAppendicitis usually afflicts the young, but there is a large tail in the distribution of onset age. The genetics of this disease are still not well understood. A heritability analysis and genome wide linkage analysis of a large twin dataset was undertaken. Treating age of onset of appendicitis as a censored survival trait revealed a heritability of 0.21, and found evidence of linkage to Chromosome 1p37.3. Author(s): Christopher Oldmeadow 1 * | Kerrie Mengersen 2 | Nicholas Martin 3 | David L. Duffy
Sex Differences in Coagulation and Fibrinolysis in Subjects with Coronary Artery Disease
No full textSummaryWomen with coronary artery disease (CAD) have a prognosis at least as bad and possibly worse than men. Differences in classical risk factors do not fully account for these findings and there is evidence that circulating levels of haemostatic factors may predict CAD risk. In this study sex differences in haemostatic risk factors were examined in relation to coronary stenosis.609 (420 men, 69%) subjects admitted for coronary angiography for suspected CAD were recruited. Levels of Factor VII:C (FVII:C), fibrinogen, plasminogen activator inhibitor-1 (PAI-1) and von Willebrand factor (vWF) were estimated in 296 subjects from one centre. Of these, women (n = 107) had higher levels of FVII:C (134% vs 117%, p <0.0005), and fibrinogen (3.4 g/l vs 3.2 g/l p = 0.01) than men (n = 189) and these differences remained after adjusting for other covariates. In subjects with angiographically significant atheroma these differences in haemostatic factors (n = 50 for women vs n = 147 for men) were exaggerated, (FVII:C 139% vs 117, p <0.0001, fibrinogen 3.7 g/l vs 3.3 g/l p = 0.003), PAI-1 (26.2 ng/ml vs 19.7 ng/ml, p = 0.02) with a trend towards higher levels of vWF in the women. Women with significant atheroma at angiography (n = 50) had higher levels of PAI-1 (25.0 ng/ml vs 13.4 ng/ml p <0.0001) and vWF (1.25 IU/ml vs 1.06 IU/ml, p = 0.02) and a trend towards higher levels of both fibrinogen and FVII:C than women with normal or in significant coronary vessel disease (n = 57).Elevated circulating levels of PAI-1, vWF, fibrinogen and FVII:C in women with angiographically proven CAD may contribute to an adverse cardiovascular risk factor profile and the poorer prognosis in females than male patients with proven coronary artery disease.</jats:p
Nicholas de Monchaux: Local Code / Real Estates
No full textNicholas de Monchaux is an architect and urbanist whose work explores the intersections between nature, technology, and the city. He is the author of Spacesuit: Fashioning Apollo (MIT Press, 2011), an architectural history of the Apollo 11 spacesuit. He is Assistant Professor of Architecture and Urban Design at UC Berkeley. The work of his design studio has been exhibited widely and is currently being featured in the US Pavillion of the 13th Venice Biennale
Nicholas Meyer: 10-31-1979
No full textNicholas Meyer is a screenwriter, producer, director, and author, and a graduate of the University of Iowa. He is the author of the screenplay the Seven Per Cent Solution and co-author of The Black Orchid. He begins the interview by discussing his professional career as both a film writer/director and a novelist. He then talks about how he began writing novels, and discusses the research that goes into his novels. Meyer continues by discussing his movie Time After Time and concludes the interview by listing prominent teachers and writing influences.Archived web contentSUNY BrockportWriters Forum Video
Nicholas Meyer: 10-31-1979
No full textNicholas Meyer is a screenwriter, producer, director, and author, and a graduate of the University of Iowa. He is the author of the screenplay the Seven Per Cent Solution and co-author of The Black Orchid. He begins the interview by discussing his professional career as both a film writer/director and a novelist. He then talks about how he began writing novels, and discusses the research that goes into his novels. Meyer continues by discussing his movie Time After Time and concludes the interview by listing prominent teachers and writing influences.https://digitalcommons.brockport.edu/writers_videos/1022/thumbnail.jp
Interview with Nicholas Wade by Marni Siegel, November 8, 2007
No full textThe interview was a project of the Center for Public Genomics (http://www.genome.duke.edu/centers/cpg/).Nicholas Wade is a science writer for the New York Times and author of several books, including LifeScripts, about genetics and genomics. He also covered the Asilomar Conference for Science magazine.Funded by a grant from the National Human Genome Research Institute and the US Department of Energy (P50 HG003391)
LSE festival Beveridge 2.0 preview: the five giants by Nicholas Timmins
No full textOn Monday 19 February, LSE Festival opened with ‘The Five Giants and the Ministers Who Made a Difference’. Chaired by LSE Director Minouche Shafik, Nicholas Timmins, author of The Five Giants: A Biography of the Welfare State, and Professor Sir Julian Le Grand debated the key UK politicians who really made a difference when it came to Beveridge’s ‘Five Giants’: listen to the podcast here. Ahead of the event, Nicholas Timmins gives insight into the reception and impact of Beveridge’s 1942 report, as well as its enduring significance in today’s global, 21st-century context
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