117,827 research outputs found
Pricing Chinese rain: a multi-site multi-period equilibrium pricing model for rainfall derivatives
No full textMany industries are exposed to weather risk which they can transfer on financial markets via weather derivatives. Equilibrium models based on partial market clearing became a useful tool for pricing such kind of financial instruments. In a multi-period equilibrium pricing model agents rebalance their portfolio of weather bonds and a risk free asset in each period such that they maximize the expected utility of their incomes constituted by possibly weather dependent profits and payoffs of portfolio positions. We extend the model to a multisite version and apply it to pricing rainfall derivatives for Chinese provinces. By simulating realistic market conditions with two agent types, farmers with profits highly exposed to weather risk and a financial investor diversifying her financial portfolio, we obtain equilibrium prices for weather derivatives on cumulative monthly rainfall. Dynamic portfolio optimization under market clearing and utility indifference of these representative agents determines equilibrium quantity and price for rainfall derivatives.rainfall derivatives, equilibrium pricing, space-time Markov model
A new fetal RHD genotyping test : costs and benefits of mass testing to target antenatal anti-D prophylaxis in England and Wales
No full textBackground
Postnatal and antenatal anti-D prophylaxis have dramatically reduced maternal sensitisations and cases of rhesus disease in babies born to women with RhD negative blood group. Recent scientific advances mean that non-invasive prenatal diagnosis (NIPD), based on the presence of cell-free fetal DNA in maternal plasma, could be used to target prophylaxis on "at risk" pregnancies where the fetus is RhD positive. This paper provides the first assessment of cost-effectiveness of NIPD-targeted prophylaxis compared to current policies.
Methods
We conducted an economic analysis of NIPD implementation in England and Wales. Two scenarios were considered. Scenario 1 assumed that NIPD will be only used to target antenatal prophylaxis with serology tests continuing to direct post-delivery prophylaxis. In Scenario 2, NIPD would also displace postnatal serology testing if an RhD negative fetus was identified. Costs were estimated from the provider's perspective for both scenarios together with a threshold royalty fee per test. Incremental costs were compared with clinical implications.
Results
The basic cost of an NIPD in-house test is £16.25 per sample (excluding royalty fee). The two-dose antenatal prophylaxis policy recommended by NICE is estimated to cost the NHS £3.37 million each year. The estimated threshold royalty fee is £2.18 and £8.83 for Scenarios 1 and 2 respectively. At a £2.00 royalty fee, mass NIPD testing would produce no saving for Scenario 1 and £507,154 per annum for Scenario 2. Incremental cost-effectiveness analysis indicates that, at a test sensitivity of 99.7% and this royalty fee, NIPD testing in Scenario 2 will generate one additional sensitisation for every £9,190 saved. If a single-dose prophylaxis policy were implemented nationally, as recently recommended by NICE, Scenario 2 savings would fall.
Conclusions
Currently, NIPD testing to target anti-D prophylaxis is unlikely to be sufficiently cost-effective to warrant its large scale introduction in England and Wales. Only minor savings are calculated and, balanced against this, the predicted increase in maternal sensitisations may be unacceptably high. Reliability of NIPD assays still needs to be demonstrated rigorously in different ethnic minority populations. First trimester testing is unlikely to alter this picture significantly although other emerging technologies may
Difference based Ridge and Liu type Estimators in Semiparametric Regression Models
No full textWe consider a difference based ridge regression estimator and a Liu type estimator of the regression parameters in the partial linear semiparametric regression model, y = Xβ + f + ε. Both estimators are analysed and compared in the sense of mean-squared error. We consider the case of independent errors with equal variance and give conditions under which the proposed estimators are superior to the unbiased difference based estimation technique. We extend the results to account for heteroscedasticity and autocovariance in the error terms. Finally, we illustrate the performance of these estimators with an application to the determinants of electricity consumption in Germany.Difference based estimator; Differencing estimator, Differencing matrix, Liu estimator, Liu type estimator, Multicollinearity, Ridge regression estimator, Semiparametric model
The meaning of handicrafts of children aged 4 to 5 in development of the fine motor skills
No full textDarba temats: Rokdarbu nozīme 4 - 5 gadus vecu bērnu sīkās motorikas attīstībā. Balstoties uz aktualitātēm izglītībā, personisko pieredzi, tika izvēlēts Pētījuma mērķis: Pētīt rokdarbu nozīmi sīkās motorikas apguvē 4 – 5 gadus veciem bērniem. Darbs sastāv no trijām nodaļām ar apakšnodaļām. Darbā tika analizētas pedagogu un psihologu atziņas par sīkās pirkstu muskulatūras attīstību vidējā pirmsskolas vecumā. Tāpat tika skatīts jautājums par 4 – 5 gadus vecu bērnu psiholoģiskajām īpatnībām, attīstību. Tika izpētīti materiāli rokdarbu nodarbību plānošanai un izstrādātas rekomendācijas darbam ar 4 – 5 gadus veciem bērniem rokdarbu nodarbībās. Tika veikts pētījums. Pētījumā izmantotas daudzveidīgas metodes. Darba vadītāja ir mag. paed., lektore: Ineta Aizporiete Darbs balstās uz ārzemju (Gabbard C., Rodrigies L., Козырева E., Вавилова А.Jermakovas un c.), kā arī uz Latvijas pedagogu un psihologu (D.Lieģenieces, D.Dzinteres, Šternfeldes I, Vidneres M., Ozoliņas I., Aizporietes I., Volānes E., I.Šternfelde un c.) teorētiskajām atziņām par bērna sīkās pirkstu muskulatūras attīstību un rokdarbu nozīmi 4 – 5 gadus veca bērna personības izaugsmē. Praktiskajā daļā veikti pedagoģiskie novērojumi, skolotāju intervijas, iegūto rezultātu analīze. Kvalifikācijas darbs sastāv no trīs nodaļām, 43 lpp, 4 pielikumiem, 5 attēliem, 43 literatūras avotiem.The title of qualification paper is „ The meaning of handicrafts of children aged 4 to 5 in development of the fine motor skills.” The author of the paper is Santa Osipenko, a student of the part – time first level professional study programme „Preschool education teacher” within the Faculty of Pedagogy of Riga, University of Latvia. The supervisor: Mg.paed., lect. Ineta Aizporiete. The aim of the research paper: to research the importance of the fine motor skills education for children aged 4 to 5. The paper consists of two main parts: theoretical and practical part. The research consists of three divisions with subdivisions. During the research the information made by educators and psychologists about the fine motor skills development and psyshological characteristics of children aged 4 to 5. Materials about lessons of handicraft planning werw researched. Based on the research there were made recommendations for work with children aged 4 to 5 during handicrafts lessons. The research was made using different kinds of methods. The theoretical part is based on the theoretical findings of both the foreign (Gabbard C., Rodrigies L., Козырева E., Вавилова А. ) and the Latvian pedagogues and psychologists (V. Hibnere, V.Jonīte, D.Lieģiniece, D.Dzintere ,E. Volāne, I.Šternfelde) about the development of childrens. The practical part is based on pedagogical observations, interview of teachers and analysis of results. The qualification paper consists of 3 chapters, 43 pages, 5 illustrations, literature and information – latvian and english authors, russian authors - 43
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Square Dancing with the Stars to Enhance Dynamic Hirschman Linkages?
No full textIn this Presidential Address, the author takes the reader on a reconnaissance of his life and time as a regional scientist. He points out scenery he found scintillating along the way, hoping that some may pick up the banner and chew on a few of the ideas for a while. He suggests a revisit to Albert O. Hirschman’s notion of key sectors and more empirical analysis related to Marcus Berliant’s and Masahisa Fujita’s notion of knowledge creation and transfer.Presidential Address, San Antonio, Texas, March 29, 2014 (53rd Meetings of the Southern Regional Science Association
Appropriate Similarity Measures for Author Cocitation Analysis
No full textWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
PHYSICAL REHABILITATION OF CHILDREN WITH MOTOR DISORDERS ON THE EXPERIENCE OF THE ODESSA REGIONAL CHARITY FUND FOR THE REHABILITATION OF DISABLED CHILDREN "FUTURE" / ФІЗИЧНА РЕАБІЛІТАЦІЯ ДІТЕЙ З РУХОВИМИ ПОРУШЕННЯМИ НА ДОСВІДІ ОДЕСЬКОГО ОБЛАСНОГО БЛАГОДІЙНОГО ФОНДУ РЕАБІЛІТАЦІЇ ДІТЕЙ-ІНВАЛІДІВ «МАЙБУТНЄ»
No full textMikhailenko V. E., Mikhailenko V. L., Osipenko A. S. PHYSICAL REHABILITATION OF CHILDREN WITH MOTOR DISORDERS ON THE EXPERIENCE OF THE ODESSA REGIONAL CHARITY FUND FOR THE REHABILITATION OF DISABLED CHILDREN “FUTURE”. Актуальні проблеми транспортної медицини / Actual problems of transport medicine / 2019;4(58):72-81. ISSN 1818-9385
DOI http://dx.doi.org/10.5281/zenodo.3594879
http://aptm.org.ua
PHYSICAL REHABILITATION OF CHILDREN WITH MOTOR
DISORDERS ON THE EXPERIENCE OF THE ODESSA REGIONAL
CHARITY FUND FOR THE REHABILITATION OF DISABLED
CHILDREN “FUTURE”
V. E. Mikhailenko, V. L. Mikhailenko, A. S. Osipenko
Odessa Regional Charitable Foundation for Rehabilitation disabled children
“Future”, Odessa, Ukraine
Odessa National Medical University, Odessa, Ukraine
Reference
The majority of children with musculoskeletal disorders are children with cerebral palsy (89 %). The prevalence of cerebral palsy in Ukraine is 2.5 % per 1,000 newborns. At present, many methods of treatment and rehabilitation of children with central and peripheral nervous system lesions have been proposed, which leads to pronounced motor disorders, but researchers have not reached the common view for optimal selection and combination of rehabilitation methods. The purpose of our work was to trace and identify the most effective methods of physical rehabilitation for children with organic lesions of the central and peripheral nervous system in the form of disorders of the musculoskeletal system of all ages and various motor disorders according to the international classification of large motor functions (GMFCS) that can be adapted and applied in the complex rehabilitation on the basis of the Odessa regional charitable fund for the rehabilitation of disabled children “Future”. We studied the following methods of physical rehabilitation: Vojta-therapy, Bobath-therapy, Neurokinetherapy (Smoljaninov A. method), Sensory integration (SI), Therapeutic physical culture, Rehabilitation cage, Tyrosolution, GEO — system, Lokomat, Lokosistema, Dynamic proprioceptive correction (DPC), Mechanotherapy, Hydrokinesiotherapy, Kinesio taping. It was traced for the rehabilitation of 2012 patients aged 2-16 years old with a diagnosis of cerebral palsy I, II, III, IV levels of motor disorders in the International Classification of Large Motor Functions (GMFCS) for 1 year. Patients during the course of rehabilitation (2 weeks) received complex rehabilitation, observations were carried out at the beginning and at the end of the course of treatment. We have developed and adapted for our center a protocol for the appointment of physical rehabilitation methods. Our conclusions — it is necessary to apply in the treatment of various methods of physical rehabilitation, which allows expanding the range of assistance to patients with damage to the central and peripheral nervous system, which leads to severe motor disorders.
Keywords: cerebral palsy, complex rehabilitation, methods of physical rehabilitation
Letter from unknown writer to Jesse L. Boyce
No full textLetter to Jesse L. Boyce from unknown author (possibly Jack) about the investigation into the powder magazine located in the Grand Canyon. Some personal news is included in the letter such as the writer's marriage to the daughter of C.A. Taylor, former Supervisor of Cochise County
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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