1,720,955 research outputs found
Rayos X provenientes de equipos odontológicos inducen cambios en la expresión de Hsp70, p53, caspasa-8 y caspasa-3 y/o muerte celular por apoptosis en leucocitos humanos
Get PDFX-rays are used in dental offices for diagnostic purposes, where the POE receives a dose of exposure that causes a stochastic damage that is not report, but is cumulative. Therefore, a relationship between leukopenia and exposure to ionizing radiation has been reported, in such a way that leukocytes are an ideal biological model. Cell damage is manifested through the expression of bioindicators such as Hsp70 or cell death, process that must be studied for the degree of homeostatic tolerance with different degrees of radiation. The aim of this work was to evaluate the changes in the expression of proteins Hsp70, p53, caspase-8 and caspase-3 and / or cell death by apoptosis in human leukocytes exposed to X-rays from dental equipment. Leukocytes in whole blood were exposed at different doses of X-rays. Subsequently, cell viability was assessed by Wright's stain. Following this, the proteins Hsp70, p53, caspase-8 and caspase-3 were identified by Western-blot. A decrease of living cells from 97.5% to 39.5% was observed with respect to the different exposure doses. The behavior of Hsp70 and caspase-8 was similar, in such a way that for the third dose the expression increased and for the highest dose it decreases. The p53 protein increased its expression in the first dose and then decreased in the following ones. The expression of caspase-3 for each dose increased. The percentage of cell death was dependent on the dose of exposure. The data obtained determine that Hsp70 is a bioindicator of cellular stress, while p53, caspase-8 and caspase-3 are bioindicators of apoptosis. The cellular damage of leukocytes exposed to X-rays, provides relevant information to implement protection mechanisms in the area of radiological safety.Los rayos X son utilizados en consultorios odontológicos con fines de diagnóstico, donde el POE recibe dosis de exposición ocasionando un daño estocástico que comúnmente no es considerado, pero es acumulable. Por lo anterior, se ha reportado una relación entre leucopenia y exposición a radiación ionizante, de tal manera que los leucocitos son un modelo biológico idóneo. El daño celular se manifiesta a través de expresión de bioindicadores como Hsp70 o con muerte celular, proceso que debe ser estudiado para ver el grado de tolerancia homeostática con diferentes grados de radiación. El objetivo de este trabajo fue evaluar los cambios en la expresión de las proteínas Hsp70, p53, caspasa-8 y caspasa-3 y/o muerte celular por apoptosis en leucocitos humanos expuestos a rayos X provenientes de equipos odontológicos. Leucocitos en sangre total fueron expuestos a dosis diferentes de rayos X. Posteriormente, se evaluó la viabilidad celular mediante tinción Wright. Seguido a esto se procedió a identificar las proteínas Hsp70, p53, caspasa-8 y caspasa-3 por Western-blot. Se observó una disminución de células vivas de 97.5% a 39.5% respecto a las diferentes dosis de exposición. El comportamiento de Hsp70 y caspasa-8 fue similar, de tal manera que para la tercera dosis la expresión incrementó y para la dosis más alta esta disminuye. La proteína p53 incrementó su expresión en la primera dosis para luego disminuir en las siguientes. La expresión de caspasa-3 para cada dosis fue incrementando. El porcentaje de muerte celular fue dependiente de la dosis de exposición. Los datos obtenidos determinan que Hsp70 es un bioindicador de estrés celular, mientras que p53, caspasa-8 y caspasa-3 son bioindicadores de apoptosis. El daño celular de los leucocitos expuestos a rayos X, provee información relevante para implementar mecanismos de protección en el área de seguridad radiológica
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
Author Under Sail The Imagination of Jack London, 1893-1902
No full textIn Author Under Sail, Jay Williams offers the first complete literary biography of Jack London as a professional writer engaged in the labor of writing. It examines the authorial imagination in London's work, the use of imagination in both his fiction and nonfiction, and the ways he defined imagination in the creative process in his business dealings with his publishers, editors, and agents. In this first volume of a two-volume biography, Williams traverses the years 1893 to 1902, from London's "Story of a Typhoon" to The People of the Abyss. The Jack London who emerges in the pages of Author Under Sail is a writer whose partnership with publishers, most notably his productive alliance with George Brett of Macmillan, was one of the most formative in American literary history. London pioneered many author models during the heyday of realism and naturalism, blurring the boundaries of these popular genres by focusing on absorption and theatricality and the representation of the seen and unseen. London created an impassioned, sincere, and extremely personal realism unlike that of other American writers of the time. Author Under Sail is a literary tour de force that reveals the full range of London as writer, creative citizen, and entrepreneur at the same time it sheds light on the maverick side of machine-age literature.Intro -- Title Page -- Copyright Page -- Dedication -- Contents -- Acknowledgments -- Introduction -- 1. Spirit Truth -- 2. From Absorption to Theatricality and Back Again -- 3. "I Will Build a New Present" -- 4. Sons as Authors -- 5. Fathers as Publishers -- 6. The Daughter as Author -- 7. Lovers as Authors -- 8. At Sea with the Family -- 9. Yellow News, Yellow Stories -- 10. The Return Home -- Notes -- Bibliography -- Index -- About Jay WilliamsIn Author Under Sail, Jay Williams offers the first complete literary biography of Jack London as a professional writer engaged in the labor of writing. It examines the authorial imagination in London's work, the use of imagination in both his fiction and nonfiction, and the ways he defined imagination in the creative process in his business dealings with his publishers, editors, and agents. In this first volume of a two-volume biography, Williams traverses the years 1893 to 1902, from London's "Story of a Typhoon" to The People of the Abyss. The Jack London who emerges in the pages of Author Under Sail is a writer whose partnership with publishers, most notably his productive alliance with George Brett of Macmillan, was one of the most formative in American literary history. London pioneered many author models during the heyday of realism and naturalism, blurring the boundaries of these popular genres by focusing on absorption and theatricality and the representation of the seen and unseen. London created an impassioned, sincere, and extremely personal realism unlike that of other American writers of the time. Author Under Sail is a literary tour de force that reveals the full range of London as writer, creative citizen, and entrepreneur at the same time it sheds light on the maverick side of machine-age literature.Description based on publisher supplied metadata and other sources.Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, YYYY. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries
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