87,411 research outputs found
Emerging roles of 3D-culture systems in tackling tumor drug resistance
No full textDrug resistance that affects patients universally is a major challenge in cancer therapy. The development of drug resistance in cancer cells is a multifactor event, and its process involves numerous mechanisms that allow these cells to evade the effect of treatments. As a result, the need to understand the molecular mechanisms underlying cancer drug sensitivity is imperative. Traditional 2D cell culture systems have been utilized to study drug resistance, but they often fail to mimic the 3D milieu and the architecture of real tissues and cell-cell interactions. As a result of this, 3D cell culture systems are now considered a comprehensive model to study drug resistance in vitro. Cancer cells exhibit an in vivo behavior when grown in a three-dimensional environment and react to therapy more physiologically. In this review, we discuss the relevance of main 3D culture systems in the study of potential approaches to overcome drug resistance and in the identification of personalized drug targets with the aim of developing patient-specific treatment strategies that can be put in place when resistance emerges
Simulazione numerica dei fenomeni aerodinamici prodotti da treni ad alta velocità in tunnel di forma complessa
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Collation Model for Ms. Codex 65: La vita de Sancto Orso
No full textLife of Saint Ursus (or Orso), venerated in Santorso, near Venice in the province of Vicenza. The text was translated from Latin into Italian by Alberto Bischazza, archpriest of Rovigo (f. 1v). Also includes a prayer to Saint Ursus, in different ink in a different, possibly later hand, on the verso of the second flyleaf. Colophon in Latin (f. 14r) contains the notarial statement, without seal of signature, by the notary Ioannes Franciscus de Platea of Vicenza. The lack of a seal or date, added to the evidence of the corrected error of duplication in the explicit, indicates that this is a copy of a notarial copy.https://repository.upenn.edu/sims_models/1091/thumbnail.jp
Peppa Pig e Masha e Orso: modelli educativi a confronto
No full textinevitabilmente e spesso inconsapevolmente, i cartoon sono educativi; a prescindere dalla connotazione delle proposte: anche un pessimo cartone animato, infatti, propone un modello educativo nel quale i piccoli spettatori e le piccole spettatrici possono rispecchiarsi, se assomiglia a quello sperimentato in ambito famigliare, o immedesimarsi conoscendo situazioni altre, nel caso se ne discosti. Si tratta di prospettive significativamente diverse. Le serie animate Peppa Pig e Masha e Orso rappresentano in maniera esemplare le due tipologie – quella confermativa e quella “divergente” – rispetto al modello educativo in uso nella generalità delle famiglie italiane. La scelta di prendere in considerazione queste serie tv è dettata dalla notorietà di entrambe: anche chi non ha a che fare con l’infanzia conosce Peppa Pig e Masha attraverso le pubblicità, i gadget, gli accessori che ne garantiscono la permanenza nell’immaginario
Metanalysis of results of Interferon (IFN) treatment in children affected by chronic hepatitis B (CHB).
No full textEconomics of Adverse Childhood Treatment
No full textThe individuals’ well-being throughout their entire lives depends on their initial inherited endowments, on their/their parents’ subsequent investments and actions as well as on the environment in which they grow, act, and live. The recent literature in various fields, starting with the epidemiological/psychological one but also the sociologic and economic research, point out that early life (childhood and adolescence) is crucial in determining a set of late life outcomes, from health to education, socioeconomic status, income, etc. In this sense, adverse events/trauma in these life stages become of paramount importance since, from an economics perspective, they can be assimilated to “negative” investments. Indeed, a continuously extending literature documents that adverse childhood and adolescence experiences (ACEs) are associated with poor physical and mental health, unhealthy life styles, poor schooling performances, lower levels of education, higher unemployment, and lower income, with extremely high economic burden for the individuals and the society. Such evidence calls for sound and targeted policy interventions that to prevent adverse events in early offspring’s lives and to mitigate and correct as much as possible the negative effects for those children that were subject to trauma
Lung Ultrasound Score in Critically Ill COVID-19 Patients: A Waste of Time or a Time-Saving Tool?
No full textHemodynamic goals in sepsis and septic shock resuscitation: An umbrella review of systematic reviews and meta-analyses with trial sequential analysis
No full textObjective: The objective of this study was to verify whether any parameter among those used as the target for haemodynamic optimisation (e.g., mean arterial pressure, central venous oxygen saturation, systolic or diastolic dysfunction, CO2 gap, lactates, right ventricular dysfunction, and PvaCO2/CavO2 ratio) is correlated with mortality in an undifferentiated population with sepsis or septic shock. Methods: An umbrella review, searching MEDLINE, the Cochrane Database of Systematic Reviews, Health Technology Assessment Database, and the JBI Database of Systematic Reviews and Implementation Reports, was performed. We included systematic reviews and meta-analyses enrolling a population of unselected patients with sepsis or septic shock. The main outcome was mortality. Two authors conducted data extraction and risk-of-bias assessments independently. We used a random-effects model to pool binary and continuous data and summarised estimates of effect using equivalent odds ratios (eORs). We used the ROBIS tool to assess risk of bias and the assessment of multiple systematic reviews 2 score to assess global quality. Data synthesis: 17 systematic reviews and meta-analyses (15 828 patients) were included in the quantitative analysis. Diastolic dysfunction (eOR: 1.42; 95% confidence interval [CI]: 1.14–1.76), PvaCO2/CavO2 ratio (eOR: 2.15; 95% CI: 1.37–3.37), and CO2 gap (eOR: 1.86; 95% CI: 1.07–3.25) showed a significant correlation with mortality. Lactates were the parameter with highest inconsistency (I2 = 92%). Central venous oxygen saturation and right ventricle dysfunction showed significant statistical excess test of significance (p-value = 0.009 and 0.005, respectively). None of the considered parameters showed statistically significant publication bias. Conclusions: According to this umbrella review, diastolic dysfunction is the haemodynamic variable that is most closely linked to the prognosis of septic patients. The PvaCO2/CavO2 ratio and the CO2gap are significantly related to the mortality of septic patients, but the poor quality of evidence or the low number of cases, studied so far, limit their clinical applicability. Clinical trial registration: PROSPERO: International prospective register of systematic reviews, 2023, CRD42023432813 (Available from: https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42023432813)
Dangerous Goods Transportation by Road: a Risk Analysis Model and a Global Integrated Information System to Monitor Hazardous Materials Land Transportation in Order to Protect Territory
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