1,721,124 research outputs found
In limine. Forme marginali e discorsi di confine, a cura di MARGHERITA DE BLASI, GIULIA IMBRIACO, FELICE MESSINA, SALVATORE ORLANDO, VALENTINA SCHETTINO, Università degli studi di Napoli “L’Orientale”, Napoli, 2018 (ISBN 978-88-6719-160-4)
No full textInappropriate prescribing in elderly patients
No full textPotential inappropriate prescriptions (PIPs) in elderly population are a source of additional clinical and economic burden on healthcare systems. PIPs can derive from inappropriate dosage or duration of treatment, off-label use, use in contraindicated circumstance and in particular
drug-drug interactions (DDIs). PIPs are associated with an increased risk of drug–related adverse events, especially in the elderly population, including hospitalization and mortality. Furthermore, older patients are more at risk for PIPs because they are often treated with complex drug regimens.
The age-related changes in drug pharmacokinetics and pharmacodynamics can raise the risk of PIPs. Polypharmacy is common in the elderly population, with more than 60% receiving a simultaneous prescription of five drugs or more. There is a strong relationship between the
number of dispensed drugs and the probability of potential DDIs. The use of administrative databases signifies a significant step forward, representing a valuable tool to estimate the prevalence of clinically relevant potential DDIs as well as to examine possible predictors of
potential DDI exposure. The results show that the elderly population has a high risk of DDIs, also highlighting a very high rate of suboptimal drug prescribing in the elderly. As physicians still have some difficulty in managing this problem, the urgent implementation of national educational programs is essential, in order to highlight factors that raise the risk of DDIs and to increase an appropriate use of drugs
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Iolascon G, Capaldo A, Orlando V, Menditto E. Persistence with antiosteoporotic drugs: a retrospective population-based color study
No full textThe study of adherence to therapy is a field of study of particular relevant today. In chronic conditions, the adherence to therapy is never greater than 50% Which leads to an increase in both morbidity and mortality. The use of administrative databases represents an excellent tool for indirect measurement of levels of persistence to evaluate the effectiveness of therapy. Osteoporosis is a major cause of disability with high costs to the health service. Persistence to drug therapy of less than 6 months has absolutely no benefit to the patient. The analysis performed in Campania region by using retrospective health administrative databases confirms inadeguate persistence of therapy: about 70% of patients interrupt treatment at 6 months and only 14% are persistent after 1 year. Moreover, half of incident users are spot therapy. The greatest factor which influences persistence is the complexity of administration: Ibandronate and Risedronate which are taken monthly are the most compliant
Economic Evaluation of Treatments for Migraine: An Assessment of the Generalizability Following a Systematic Review
No full textAll health economics reviews on chronic and episodic migraine published to date underline the heterogeneity of results. Currently, the need for the generalizability of economic evaluations across different jurisdictions is considered a key issue to avoid unnecessary overlaps and to minimize the time to reimbursement decisions
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