1,720,991 research outputs found
Adrenergic regulation of vascular smooth muscle tone in calf digital artery
No full textRadioligand binding studies and functional assays on isolated smooth muscle
preparations were performed in order to obtain a biochemical and functional
characterization of the b-adrenoceptor (b-AR) subtypes involved in regulation
of the smooth muscle relaxation of the calf’s common digital artery. The results
indicate that the common digital artery possesses two b-AR populations (40%
b1 and 60% b2) and the b2-subtype appears to predominate as far as function is
concerned. Only the b2-AR agonists clenbuterol and fenoterol caused doserelated
relaxant effects, antagonized by propranolol, when tested in preparations
precontracted both with PGF2a (1.4 · 10)5
M) and noradrenaline
(1.2 · 10)6
M). In noradrenaline precontracted preparations the b1-AR
selective agonists dobutamine and xamoterol caused vasodilation which was
not antagonized by (±)propranolol. While the functional relaxant effects of
dobutamine may be attributed to its potent competitive a-AR blocking activity,
further investigations are required to explain the effect of xamoterol. The
vasodilator effect of (±)isoproterenol was irregular. The recorded contractile
effects, mainly at dosages greater than 10)6
M, suggest the loss of drug
selectivity for b-AR and a-AR activation. Indirect evidence indicates that the aadrenoceptor
(a-AR) population in this tissue which produces a strong
contraction is functionally dominant over the b-AR, suggesting limited
therapeutic benefit for b-AR drugs to control blood flow disorders in the calf’s
distal limb
Caratterizzazione e distribuzione dei sottotipi recettoriali a-adrenergici nell'apparato genitale di bovina
No full textCaratterizzazione funzionale dei sottotipi recettoriali α-adrenergici del miometrio di bovino
No full text(selezionato per pubblicazione nel Volume: Annual Meeting Selected Abstracts, 2001; Anno III; pp. 114-115; lingua Inglese: "Functional characterization of α-adrenoceptor subtypes in isolated bovine myometrium"
Are veterinary students using technologies and online learning resources for didactic training? A mini-meta analysis.
No full textOver the last years, there has been an increase in online educational resources and media de-vice use for educational purposes in veterinary settings. However, an overall analysis of these studies providing measurements of the use of learning resources and media devices could be particularly useful for veterinary teachers. The evolution of technology, coupled with the ad-vent of pandemic-related restrictions in person lessons, has made it imperative that educa-tors consider how students may access educational material, as well as what type of educa-tional material may be available to them. Databases including PubMed, Scopus, CAB Ab-stracts, and Web of Sciences were searched for relevant studies from January 2012 to June 2022. A mini-meta-analysis for proportions was performed using RStudio. Results highlight a high use of portable media devices with differences among countries, continued good use of traditional textbooks, moderate use of online tools, and low use of research papers. The re-sults suggest that despite living in a technologically advanced world, veterinary students have attitudes towards digital resources that cannot be assume
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Identificazione di recettori beta-adrenergici funzionali in una linea cellulare di carcinoma intestinale umano (CACO-2)
No full textBeta-adrenergic regulation of lipolysis in the subcutaneous adipose tissue of food producing animals
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