1,721,025 research outputs found
Plasma MicroRNA Profiling Reveals Loss of Endothelial MiR-126 and Other MicroRNAs in Type 2 Diabetes.
No full textRationale: MicroRNAs (miRNAs) have been implicated in the epigenetic regulation of key metabolic, inflammatory, and antiangiogenic pathways in type 2 diabetes (DM) and may contribute to common disease complications.
Objective: In this study, we explore plasma miRNA profiles in patients with DM.
Conclusions: We reveal a plasma miRNA signature for DM that includes loss of endothelial miR-126. These findings might explain the impaired peripheral angiogenic signaling in patients with DM
The role of insulin in age-related sex differences of cardiovascular risk profile and morbidity.
No full textDistinct risk profiles of early and advanced atherosclerosis. Prospective results from the Bruneck Study
No full textImpaired glucose tolerance, type 2 diabetes mellitus and carotid atherosclerosis. Prospective results from the Bruneck Study
No full textPrevalence, ancillary clinical features and cardiovascular disease in the metabolic syndrome: The Bruneck study
No full textThe present study aimed at evaluating the prevalence of the Metabolic Syndrome, as assessed by WHO criteria, its ancillary clinical features and its risk of atherosclerosis and cardiovascular disease. We examined a population-based sample of 888 subjects, aged 40–79 years, living in Bruneck (northeastern Italy), among whom we identified subjects fulfilling the WHO criteria for diagnosing the Metabolic Syndrome. In these subjects and in the rest of the sample (Controls), several metabolic and nonmetabolic biochemical parameters were compared, and the 5-year change in carotid atherosclerosis (CA), and incident fatal and nonfatal coronary heart disease (CHD) were determined. The prevalence of the Metabolic Syndrome was 34.1%. Subjects with the Syndrome showed higher levels of oxidized low-density lipoprotein (LDL), apolipoprotein B, urate, leptin, fibrinogen, leukocytes, erythrocyte sedimentation rate (ESR), GOT, gamma-GT and soluble endothelial adhesion molecules (E-selectin, Vascular Adhesion Molecule-1/VCAM-1 and Intercellular Adhesion Molecule-1/ICAM-1), and lower apolipoprotein A concentrations. Insulin resistance increased with the increase in the number of abnormalities composing the Syndrome. Subjects with insulin resistance had more pronounced abnormalities in several classic and nonclassic parameters. Subjects with the Metabolic Syndrome had an increased 5-year incidence and progression of CA and incidence of CHD. The Metabolic Syndrome, in which insulin resistance plays a major role, occurs very frequently in the general population, has several ancillary features and is burdened by an increased risk of atherosclerosis and cardiovascular disease. © 2003, Elsevier B.V
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
The metabolic syndrome: epidemiology and more extensive phenotypic description. Cross-sectional data from the Bruneck Study.
No full textOBJECTIVES: The present study aimed at evaluating the prevalence of the Metabolic Syndrome and at identifying its additional clinical features.
RESEARCH DESIGN AND METHODS: Within a prospective population-based survey examining 888 subjects aged 40–79 y,
subjects were identified fulfilling the WHO and the National Cholesterol Education Program-Adult Treatment Panel III (NCEPATPIII) criteria for diagnosing the Metabolic Syndrome. In these subjects and in the rest of the sample (controls), several
metabolic and nonmetabolic biochemical parameters were compared.
RESULTS: The prevalence of the Metabolic Syndrome by WHO criteria was 34.1% (95% CI 31.0–37.2) and by NCEP-ATPIII
criteria 17.8% (15.5–20.3). The prevalence was significantly higher in older subjects and in those less physically active. Subjects with the Metabolic Syndrome either by WHO or by NCEP-ATPIII criteria showed higher levels of oxidized low-density
lipoprotein, apolipoprotein B, urate, leptin, fibrinogen, leukocytes, erythrocyte sedimentation rate, GOT, gamma-GT and
soluble endothelial adhesion molecules (E-selectin, vascular adhesion molecule-1 and intercellular adhesion molecule-1) and
lower apolipoprotein A concentrations. Insulin resistance, as assessed by the Homeostasis Model Assessment, increased with the increase in the number of traits composing the syndrome found within the single individual. Subjects with insulin resistance had more pronounced abnormalities in several parameters, including the additional features of the syndrome (eg fibrinogen and soluble adhesion molecules).
CONCLUSIONS: The Metabolic Syndrome occurs very frequently in the general population aged 40–79 y, and is associated with
several additional metabolic and nonmetabolic abnormalities that likely contribute to an increased cardiovascular risk. Insulin
resistance seems to play a major role in classic and additional abnormalities featuring the Metabolic Syndrome
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
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