648 research outputs found
Nathan Perlmutter (1923-1987) papers, 1934-1989, 1949-1987.
No full textThis collection consists of the papers of Nathan Perlmutter, a lawyer, lecturer, author, political activist, and a long-time leader of the American Jewish community. It contains certificates, newspaper clippings, correspondence—including numerous condolence cards and letters sent to his family after his death—manuscripts and drafts of Perlmutter’s writings, obituaries, printed materials, programs, and subject files relating to topics he was interested in and that he wrote about.Published citations should take the following form: Identification of item, date (if known); Nathan Perlmutter (1923-1987) Papers; P-1012; box number; folder number; American Jewish Historical Society, New York, NY, and Boston, MA.Donated by Ruth Ann Perlmutter
From Paralysis to Progress: The (Useful) Art of Copyright Pragmatism
No full textAmericans want the nation’s copyright laws to make sense, be fair, and reflect the technologies in use, argued Shira Perlmutter, chief policy officer and director for international affairs, United States Patent and Trademark Office. Her April 15 lecture at Catholic University’s law school noted that for some reason, Congress and regulatory oversight bodies have historically had a hard time meeting that reasonable expectation. Her remarks were presented as the 2014 Dean William Callyhan Robinson Intellectual Property Lecture, a series named after the author the founding dean of the law school at The Catholic University of America
Rethinking the value of initial claims as a forecasting tool
Get PDFThe weekly numbers on initial claims for unemployment insurance convey key information about the labor market. But how reliable are claims in predicting changes in the much anticipated monthly employment report? According to a simple forecasting model, claims consistently send an accurate signal about employment during recessions but not during expansions.Unemployment insurance ; Forecasting ; Employment (Economic theory)
The influence of positively charged nitrogen species on compound accumulation and activity in gram-negative bacteria
Get PDFMultidrug resistant Gram-negative bacterial infections are on the rise, and with no FDA approvals for new classes of broad-spectrum antibiotics in over 50 years, these infections constitute a major threat to human health. A significant challenge is the inability of most compounds to accumulate in Gram-negative bacteria. Recently developed predictive guidelines called the eNTRy rules show that appending a primary amine to an appropriately shaped compound can enhance Gram-negative accumulation and antibacterial activity. However, in certain cases addition of a primary amine resulted in the disruption of target engagement. Therefore, it would be advantageous to have alternate functional groups that facilitate accumulation in Gram-negative bacteria but offer different interactions with a given target protein.
Here we report that other positively charged nitrogen functional groups, namely N-alkyl guanidiniums and pyridiniums, can also facilitate compound uptake into Gram-negative bacteria. Accumulation of a set of 60 non-antibiotic compounds, consisting of 20 primary amines derived from the Complexity-to-Diversity strategy and their corresponding guanidiniums and pyridiniums, was assessed in Escherichia coli. We also installed these alternate functional groups onto six antibiotic scaffolds and assessed their accumulation and antibacterial activity in Gram-negative bacteria. In addition, computational studies were performed to predict whether additional charged functional groups will be able to facilitate Gram-negative uptake. The results suggest that other positively charged, nitrogen-containing functional groups should be considered when designing antibiotics with Gram-negative activity.
Finally, retrospective analysis of commercial screening libraries showed a lack of compounds containing primary amines. This is likely a major reason for the failures within the pharmaceutical industry to find lead compounds with whole cell activity from high throughput screening campaigns. Here strategies for addressing this problem through efficient amine installation strategies are discussed and applied to compounds from the CtD collection and their antimicrobial activity assessed.Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2022-12-01The student, Sarah Perlmutter, accepted the attached license on 2020-11-23 at 12:13.The student, Sarah Perlmutter, submitted this Dissertation for approval on 2020-11-23 at 13:00.This Dissertation was approved for publication on 2020-11-25 at 11:56.DSpace SAF Submission Ingestion Package generated from Vireo submission #15939 on 2021-03-04 at 16:19:47Made available in DSpace on 2021-03-05T21:42:39Z (GMT). No. of bitstreams: 7
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Previous issue date: 2020-11-25Embargo set by: Seth Robbins for item 117210
Lift date: 2023-03-05T21:43:00Z
Reason: Author requested U of Illinois access only (OA after 2yrs) in Vireo ETD systemAuthor requested U of Illinois access only (OA after 2yrs) in Vireo ETD systemU of I Onl
Molecular data confirm the position of Flakea papillata in the Verrucariaceae
No full textFlakea papillata is a predominantly tropical, widespread lichen characterized by flake-like thalli of narrowly arranged, irregularly wrinkled, small bluish-green lobes, whose taxonomic position was unclear. The lichen shows superficial similarity with either algal colonies, bryophytes or fern prothallia, but the production of zeorin and other triterpenoids supports its inclusion in the ascomycetes. Analysis of the nuclear large and small subunits rRNA sequence data of samples from different origins supports the position of F. papillata within the Verrucariaceae: it forms its own supported clade not related to the core of Agonimia, in which it has been previously placed
Deliverable 2: Report on the production of GIF by turbot, the effects on growth performance of turbot of local GIF production within RAS and the presence of GIF at commercial farm level
No full textOne of the working hypotheses of this project is that growth retardation of turbot cultured in recirculating aquaculture systems (RAS) is caused by the accumulation of growth inhibiting factors (GIF) produced by the turbot themselves in the culture water. Our first goal was to demonstrate the production of growth inhibiting factors by turbot following the methodology of Yurl and Perlmutter. A series of successive experiments was performed. Extracts from turbot culture water were tested for GIF presence in early life stage tests using eggs and larvae and small scale growth trials with juveniles. Our second goal was to demonstrate the transfer of GIF between tanks. Four experiments involving the integration of experimental tanks in a farm scale setting were performed. Our third goal was to demonstrate the presence of GIF at commercial farms. Two juvenile growth trials were performed
Freedom Now: A New Look at the Impulse Approximation
No full textRecent work on a field-theoretic impulse approximation is described. The operator product expansion is organized according to powers of g(Q2), the effective coupling constant appropriate to momentum transfer Q^2, instead of asymptotic dimensional analysis. This allows the calculation of all quark and target mass dependence of lepton-hadron inclusive scattering, order by order in g(Q^2). To O(g°), there is scaling in a mass dependent variable, ξ. The correct incorporation of quark masses into the renormalization group analysis is presented; the consequences include the relation of constituent masses to current algebra and the magnitude and shapes of the parton distribution functions for gluons, antiquarks, and heavy quarks
O avanço de Oblíquos em Panará
Get PDFO objetivo desta comunicação é mostrar que, em Panará, certas posposições, ao se incorporarem ao núcleo verbal para formar construções aplicativas, não provocam, aparentemente, qualquer mudança nas relações gramaticais entre o verbo e os seus argumentos. Estratégias de relativização (Keenan & Comrie 1977), no entanto, demonstram que o objeto da posposição incorporada é promovido a objeto direto (Perlmutter & Postal 1974). Tais termos compõem uma série distinta dos termos básicos de referência e vocativos. Demonstram um requinte lógico, preenchendo uma lacuna semântica que falta em línguas como inglês ou português. Manifestam noções de geometria (ou etno-matemática), demonstrando, no caso Me)bengôkre, a sofisticação d
Cosmological parameter estimation using Very Small Array data out to ℓ= 1500
No full textWe estimate cosmological parameters using data obtained by the Very Small Array (VSA) in its extended configuration, in conjunction with a variety of other cosmic microwave background (CMB) data and external priors. Within the flat Λ cold dark matter (ΛCDM) model, we find that the inclusion of high-resolution data from the VSA modifies the limits on the cosmological parameters as compared to those suggested by the Wilkinson Microwave Anisotropy Probe (WMAP) alone, while still remaining compatible with their estimates. We find that Ωbh2= 0.0234+0.0012−0.0014, Ωdmh2= 0.111+0.014−0.016, h= 0.73+0.09−0.05, nS= 0.97+0.06−0.03, 1010AS= 23+7−3 and τ= 0.14+0.14−0.07 for WMAP and VSA when no external prior is included. On extending the model to include a running spectral index of density fluctuations, we find that the inclusion of VSA data leads to a negative running at a level of more than 95 per cent confidence ( nrun=−0.069 ± 0.032 ), something that is not significantly changed by the inclusion of a stringent prior on the Hubble constant. Inclusion of prior information from the 2dF galaxy redshift survey reduces the significance of the result by constraining the value of Ωm. We discuss the veracity of this result in the context of various systematic effects and also a broken spectral index model. We also constrain the fraction of neutrinos and find that fν < 0.087 at 95 per cent confidence, which corresponds to mν < 0.32 eV when all neutrino masses are equal. Finally, we consider the global best fit within a general cosmological model with 12 parameters and find consistency with other analyses available in the literature. The evidence for nrun < 0 is only marginal within this model
Stereoselective intermolecular oxymercurations of allylic ethers.
No full textThe influence of alkene geometry and allylic substitution on the stereochemical outcome of intermolecular oxymercurations of allylic ethers is described. (C) 1997 Published by Elsevier Science Ltd.PT: J; CR: BRATT K, 1996, J ORG CHEM, V61, P2109 CHAMBERLIN AR, 1984, TETRAHEDRON, V40, P2297 EVANS DA, 1990, J AM CHEM SOC, V112, P7001 FUJIOKA H, 1993, HETEROCYCLES, V35, P665 GARAVELAS A, 1995, TETRAHEDRON LETT, V36, P463 GIESE B, 1985, TETRAHEDRON LETT, V26, P1197 MAVROPOULOS I, 1996, TETRAHEDRON LETT, V37, P3751; NR: 7; TC: 3; J9: TETRAHEDRON LETT; PG: 4; GA: WT464Source type: Electronic(1
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