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PMCA Applications for Prion Detection in Peripheral Tissues of Patients with Variant Creutzfeldt-Jakob Disease
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PMCA Applications for Prion Detection in Peripheral Tissues of Patients with Variant Creutzfeldt-Jakob Disease
by Giorgio Giaccone
and Fabio Moda
* [ORCID]
Fondazione IRCCS Istituto Neurologico Carlo Besta, Division of Neurology 5—Neuropathology, 20133 Milan, Italy
*
Author to whom correspondence should be addressed.
Biomolecules 2020, 10(3), 405; https://doi.org/10.3390/biom10030405
Submission received: 13 February 2020 / Revised: 2 March 2020 / Accepted: 5 March 2020 / Published: 5 March 2020
(This article belongs to the Special Issue Prion Disease Biomarkers: Recent Advances)
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Abstract
Prion diseases are neurodegenerative and invariably fatal conditions that affect humans and animals. In particular, Creutzfeldt-Jakob disease (CJD) and bovine spongiform encephalopathy (BSE) are paradigmatic forms of human and animal prion diseases, respectively. Human exposure to BSE through contaminated food caused the appearance of the new variant form of CJD (vCJD). These diseases are caused by an abnormal prion protein named PrPSc (or prion), which accumulates in the brain and leads to the onset of the disease. Their definite diagnosis can be formulated only at post-mortem after biochemical and neuropathological identification of PrPSc. Thanks to the advent of an innovative technique named protein misfolding cyclic amplification (PMCA), traces of PrPSc, undetectable with the standard diagnostic techniques, were found in peripheral tissues of patients with vCJD, even at preclinical stages. The technology is currently being used in specialized laboratories and can be exploited for helping physicians in formulating an early and definite diagnosis of vCJD using peripheral tissues. However, this assay is currently unable to detect prions associated with the sporadic CJD (sCJD) forms, which are more frequent than vCJD. This review will focus on the most recent advances and applications of PMCA in the field of vCJD and other human prion disease diagnosis
Comparative efficacy of sciatic obturator and femoral nerve block technique with that of adductor canal block in patients undergoing elective knee surgeries: a prospective, randomized, double-blind study
No full textBackground: Knee surgery necessitates adequate analgesia to reduce postoperative complications and promote early recovery. This study aimed to compare the efficacy of the SOFT block (a single-puncture technique to block the sciatic, obturator, and femoral nerves) and the adductor canal block for improved postoperative analgesia and early ambulation. Materials and Methods: In total, 60 patients posted for elective knee surgeries under spinal anesthesia were included. Postoperatively, they were divided into two groups. The SOFT block was administered to Group S with 45 mL of 0.2% ropivacaine and 8 mg of dexamethasone. Meanwhile, the adductor canal block was provided to subjects in Group A with 30 mL of 0.2% ropivacaine and 8 mg dexamethasone. Subjects were then reassessed at 0, 6, 12, 24, and 36 h for heart rate, mean arterial pressure, visual analog score, duration of analgesia, early mobilization, satisfaction score, and adverse events. Results: The mean duration of analgesia of the SOFT block and adductor canal block were 14.62 ± 4.50 and 11.68 ± 2.48 min, respectively (P = 0.003). The mean mobilization time was significantly shorter in Group S (19.96 ± 1.64 vs. 21.77 ± 2.34 min, P = 0.002). The patient satisfaction score was better in the SOFT block than in the adductor canal block (P < 0.001). Hemodynamic parameters and adverse events were comparable. Conclusion: SOFT block with 45 mL of 0.2% ropivacaine and 8 mg dexamethasone provides a longer duration of postoperative analgesia and early mobilization than adductor canal block with 30 mL of 0.2% ropivacaine and 8 mg dexamethasone in patients undergoing elective knee surgeries
Moda Fluida e Harry Styles: expressão e transgressão na moda
Get PDFThis final project aims to present a fashion brand called Volare, created by the author, whose intention is to enter the fluid fashion niche. It also involves the development of a capsule collection with 12 looks inspired by the binary style of British singer Harry Styles, mainly in his distinct stage costumes. Based on bibliographic studies by authors such as Diana Crane (2006), Lipovetsky (2009), Reed, and Young (2022), among others, the binary notion of wearables and some approximations and divergences of genders over the centuries were identified. Finally, a fashion editorial will be produced with the pieces of 3 looks created and developed by the author, proposing to enhance transgression in fashion, freedom of experimentation and identity, and communication through wearables.O presente trabalho de conclusão de curso tem como objetivo a apresentação de uma marca de moda denominada Volare criada pela autora, cuja intenção é a inserção no nicho de moda fluida. Ainda, envolve o desenvolvimento de uma coleção cápsula com 12 looks, inspirada no estilo binário do cantor britânico Harry Styles, principalmente, em seus figurinos de palco distintos. Com base em estudos bibliográficos de autores como Diana Crane (2006), Lipovetsky (2009), Reed e Young (2022), entre outros, foram identificadas a noção binária dos vestíveis e algumas aproximações e divergências dos gêneros ao longo dos séculos. Por fim, será realizado um editorial de moda com as peças de 3 looks criados e desenvolvidos pela autora, propondo potencializar a transgressão na moda, liberdade de experimentação e identidade, e comunicação através dos vestíveis
COMBINED USE OF VIDEO LARYNGOSCOPY AND FIBEROPTIC FOR AIRWAY MANAGEMENT IN A PATIENT WITH FIXED CERVICAL SPINE
Get PDFAirway management may be difficult in patients with fixed cervical spine who have undergone previous spine surgery. Among the various techniques, fiber-optic intubation is a preferred method for securing the airway in such situation. However, it has some limitations also like identification of landmarks, especially in a case of distorted anatomy of the airway. To overcome this inadequacy, we used video laryngoscopy as a complement, to guide the tip of bronchoscope beneath the epiglottis into the trachea and thus achieving the goal. We present a case of difficult airway of fixed cervical spine with distorted anatomy in which combined use of fiberoptic and video laryngoscopy was performed to secure the airway. In our opinion, this technique can be utilized for other difficult airway case scenario also
La moda en el museo. El caso de la moda argentina
Get PDFFashion had a more frequent appearance in museums and spaces for the exhibition of art in recent years. In the fashion shows, the culture of the past and present is collected, exhibited and investigated. This essay narrates the interest of museums in fashion and puts the experience of Argentine fashion in context, with references to exhibitions by Fridl Loos, Dalila Puzzovio, Mary Tapia, Gino Bogani, the under movement, the generation of author design and the case of Malba Moda in order to explore the potential of fashion in museums to reflect on history through the ages and its creators.La moda tuvo una aparición más frecuente en los museos y espacios destinados a la exhibición de arte en los últimos años. En las muestras de moda se recopila, exhibe e investiga la cultura del pasado y del presente. Este ensayo narra el interés de los museos por la moda y pone en contexto la experiencia de la moda argentina, con referencias a las exhibiciones de Fridl Loos, Dalila Puzzovio, Mary Tapia, Gino Bogani, el movimiento under, la generación de diseño de autor y el caso de Malba Moda a modo de explorar el potencial de la moda en los museos para reflexionar la historia a través de las épocas y sus creadores.A moda teve um aparecimento mais frequente em museus e espaços de exposição de arte nos últimos anos. Nos desfiles, a cultura do passado e do presente é coletada, exibida e investigada. Este ensaio narra o interesse dos museus pela moda e contextualiza a experiência da moda argentina, com referências a exposições de Fridl Loos, Dalila Puzzovio, Mary Tapia, Gino Bogani, o submovimento, a geração do design autor e o caso da Malba Moda como forma de explorar as potencialidades da moda nos museus para refletir sobre a história ao longo dos tempos e seus criadores
Derecho de la moda: un concepto entre varios conceptos
No full textThis paper seeks to achieve a definition of Fashion Law. For this, the author has chosen to deconstruct the different elements of the term, explaining each one of them. The deconstruction determines what is Law for the author, what is Fashion and the use of connectors. To specify the task, the Fashion industry and the meaning generated by the use of binding prepositions in the case of Fashion Law and Fashion Law are analyzed. Thoughts, definitions and opinions of the legal sector around the world are collected as an additional contribution. The conclusion provided by the explanation comes from the construction of a concept with the chosen elements of deconstruction.En este trabajo se busca lograr una definición del Derecho de la Moda. Para ello el camino elegido es la deconstrucción de los distintos elementos del término explicando cada uno de ellos. Se determina qué es para la autora el Derecho, qué es la Moda y el uso de los conectores. Para concretar el cometido se analiza la industria de la Moda y el significado que genera el uso de preposiciones vinculantes en el caso de Derecho de Moda y Derecho a la Moda. Se recogen pensamientos, definiciones y opiniones del sector jurídico de alrededor del mundo como aporte adicional. La conclusión que provee la definición del Derecho de la Moda proviene de la construcción de un concepto con los elementos elegidos de la deconstrucción
Consumo de Moda: A Relação Pessoa-Objeto
Get PDFThis is an interview with Prof. Ana Paula Celso de Miranda on the launch of the second edition of the book “Fashion Consumption: a Person-Object Relationship”. The author talks about her motivation for this work and her 20 years of academic trajectory in the field of fashion. The news this edition brings are flagged by Ana Paula in the interview. In addition to the partnership with the stylist Ronaldo Fraga, in this edition the author counts with the contribution of Prof. Olga Pepece and Profº Eduardo Maciel. The author indicates who is meant to read her book, points out some paths in fashion research and talks about the work she has been developing.Esta é uma entrevista com a Profª Ana Paula Celso de Miranda sobre o lançamento da segunda edição do livro “Consumo de Moda: a Relação Pessoa-Objeto”. A autora fala sobre sua motivação para a escrita dessa obra e seus 20 anos de trajetória acadêmica no campo da moda. As novidades que a edição traz são sinalizadas por Ana Paula na entrevista. Além da parceria com o estilista Ronaldo Fraga, nessa edição a autora conta com a contribuição da Profª Olga Pepece e do Profº Eduardo Maciel. A entrevistada indica a quem se destina a leitura de seu livro, aponta caminhos para a pesquisa de moda e fala sobre o trabalho que vem desenvolvendo
¿Puede la semiótica contribuir a la comprensión de la moda?
No full textEn "¿Es la moda un síntoma de la cultura?", Lucia Santaella nos ofrece una obra que explora la profunda intersección entre moda y cultura desde una perspectiva semiótica peirceana. La autora, conocida por sus estudios en semiótica y comunicación, investiga cómo la moda trasciende su papel como prenda de vestir y se convierte en una expresión compleja y multifacética de la sociedad. A través de un apasionante enfoque teórico, Santaella analiza las dinámicas culturales, sociales e históricas que dan forma a la moda contemporánea.Em A Moda é Sintoma da Cultura?, Lucia Santaella nos oferece uma obra que explora a profunda intersecção entre moda e cultura a partir de uma perspectiva da semiótica peirceana. A autora, conhecida por seus estudos em semiótica e comunicação, investiga como a moda transcende seu papel de vestimenta e se torna uma expressão complexa e multifacetada da sociedade. Por meio de uma abordagem teórica de folego, Santaella analisa as dinâmicas culturais, sociais e históricas que moldam a moda na contemporaneidade.In "A Moda é Sintoma da Cultura?", Lucia Santaella offers us a work that explores the profound intersection between fashion and culture from a Peircean semiotic perspective. The author, known for her studies in semiotics and communication, investigates how fashion transcends its role as clothing and becomes a complex and multifaceted expression of society. Through a deep theoretical approach, Santaella analyzes the cultural, social and historical dynamics that shape fashion in contemporary times
Editorial de moda
No full textTrabalho de Projeto apresentado à Escola Superior de Artes Aplicadas do Instituto Politécnico de Castelo Branco para cumprimento dos requisitos necessários à obtenção do grau de Mestre em Design do Vestuário e Têxtil,Aplicação do n.º 3 do art.º 2.º da Política de Depósito de Documentos do IPCB.O projeto desenvolvido teve como objetivo explorar e investigar a problemática do consumo conspícuo de moda na Europa, onde a perceção da empresa e do
consumidor estiveram interligadas, de forma a encontrar possíveis soluções que trouxessem benefícios e consciencializassem ambos. Esta problemática abrangeu várias temáticas e foi contextualizada através das mesmas, seja a nível ambiental, social ou na moda, onde se inseriu. Através desta problemática, a autora pretendeu criar um editorial de moda para abordar as causas, os efeitos e as temáticas associadas ao consumo conspícuo.
Pretendeu-se neste projeto a criação de um editorial de moda que mostrasse a realidade do consumismo conspícuo e da busca dos consumidores pela validação e da pressão para permanecer nas tendências.
A metodologia utilizada teve uma abordagem mista, envolvendo elementos qualitativos.Abstract: The developed project aimed to explore and investigate the issue of conspicuous fashion consumption in Europe, where the perception of the company and the consumer were interconnected, in order to find possible solutions that could bring benefits and raise awareness for both. This issue encompassed various themes and was contextualized through them, whether at an environmental, social, or fashion level, where it was situated. Through this issue, the author intended to create a fashion editorial to address the causes, effects, and themes associated with conspicuous consumption.
This project sought to create a fashion editorial that would depict the reality of conspicuous consumerism, the pursuit of validation by consumers, and the pressure to stay on-trend.
The methodology used had a mixed approach, involving qualitative elements
Arte, moda y consumo cultural
No full textThe artistic and cultural value of fashion productions has increased in the last years.
The author design stores , the museum, the cultural center and even the runway and the shopping mall offer spaces for dialogue between market, fashion and art. Languages like those of the
installation, the performance and the intervention are the most usual when locating clothing
in an artistic space. Simultaneously, these resources are taken by creators in the runway and
in the windows of the author design establishments. This article aims to analyze the different
meanings that in present societies empower the way in which the dress appears, is appreciated
and recognized visually by the spectator like part of the legitimate culture.En los últimos años se ha acentuado el valor artístico y cultural de las producciones
de moda. Las tiendas del diseño de autor, el museo, el centro cultural e incluso la pasarela y el
shopping disponen múltiples espacios para el diálogo entre el mercado, la moda y el arte. Lenguajes como los de la instalación, la performance y la intervención suelen ser los más usuales al
momento de situar al indumento en el espacio artístico. Simultáneamente, estos recursos son
apropiados por los creadores en la pasarela y en las vidrieras de los emprendimientos comerciales
del diseño de autor. Este artículo se propone analizar las diversas lógicas de significación que en
las sociedades actuales potencian el modo en que el vestido se presenta, es apreciado y reconocido visualmente por el espectador como parte de la cultura legítima
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