1,216 research outputs found
Novitsky Vyacheslav Viktorovich (to 70th birthday)
No full textThe biography of famous native scientist, doctor of medical sciences, academician of the Russian Academy of Sciences, head of Pathophysiology Department of Siberian State Medical University Professor V.V. Novitsky, has been prezented. The main directions of scientific and public activity of the scientist are shown
Новицкий Вячеслав Викторович (к 70-летию со дня рождения)
No full textThe biography of famous native scientist, doctor of medical sciences, academician of the Russian Academy of Sciences, head of Pathophysiology Department of Siberian State Medical University Professor V.V. Novitsky, has been prezented. The main directions of scientific and public activity of the scientist are shown.Представлена биография известного отечественного ученого – доктора медицинских наук, академика РАН, заведующего кафедрой патофизиологии Сибирского государственного медицинского университета В.В. Новицкого. Отражены основные направления научной и общественной деятельности ученого
The 85th Anniversary of Academician V.V. Alekseev
No full textIn the article dedicated to the 85th anniversary of Doctor of Historical Sciences, Professor and Academician of the Russian Academy of Sciences Veniamin V. Alekseev, the author traces the main milestones of the scientific biography of the prominent historian who is a well-known specialist in the field of national history and the theory of historical process and the founder of the Institute of History and Archaeology of the Ural Branch of the Russian Academy of Sciences. The paper considers the main stages of the formation of the scientist, his scientific, organizational and administrative activities in the field of historical science. The author highlights the scientific results of Academician V.V. Alekseev that made him well known in Russia and abroad, his theoretical and methodological studies and such large blocks of scientific research as the history of Russian modernizations, the phenomenon of Russian regionalism, the history of metallurgy of the Urals and industrial heritage. The article also focuses on the features of the scientific method of V.V. Alekseev and his merits in the formation of the documentary base for historical research
The game space and its attributive characteristic in the novel "The defence" by V.V. Nabokov
No full text© Journal of Language and Literature. The article deals with the analysis of game space and its attributive characteristic in the novel "The Defence" by V.V. Nabokov. The author provides a review of the most interesting and significant works, devoted to the study of game phenomenon in the creative work by V.V. Nabokov. Besides, the meaning of notion "game text" is expanded in the work; there are also made the conclusions about lexical organization of the novel game space (it is a chessboard in this case) and about ways of characterization of this space: 1) direct characterization (through description); 2) indirect characterization (through the comparison with another subject)
The game space and its attributive characteristic in the novel "The defence" by V.V. Nabokov
No full text© Journal of Language and Literature. The article deals with the analysis of game space and its attributive characteristic in the novel "The Defence" by V.V. Nabokov. The author provides a review of the most interesting and significant works, devoted to the study of game phenomenon in the creative work by V.V. Nabokov. Besides, the meaning of notion "game text" is expanded in the work; there are also made the conclusions about lexical organization of the novel game space (it is a chessboard in this case) and about ways of characterization of this space: 1) direct characterization (through description); 2) indirect characterization (through the comparison with another subject)
Trips Of The Orientalist V.V. Barthold To Bukhara And Their Scientific Significance
No full textThis article discusses the trips of Academician V.V. Barthold to Bukhara to get acquainted with medieval monuments of writing, as well as scientific expeditions of Russian orientalists in the late 19th– early 20th centuries. The author analyzes the scientist's attitude to the issue of studying the history of Bukhar
Functional polymorphism of the pro-inflammatory cytokine genes in pulmonary tuberculosis [Функциональный полиморфизм генов провоспалительных цитокинов при туберкулезе легких]
No full textIn the present time, incidence of pulmonary tuberculosis (TB) becomes broader, due to spreading resistance of Mycobacterium tuberculosis (MBT) to anti-tuberculosis drugs and infection with highly virulent strains of M. tuberculosis. The MBT antigens can cause dysfunction of the receptors and modulate the cytokine secreting function of immunocompetent cells. Polymorphic genes of pro-inflammatory cytokines involved in the mechanisms of defense responses of innate immunity, determine the degree of resistance to individual mycobacterial infection, as well as severity and duration of the disease in cases of clinical manifestations. The aim of the study was to investigate the connections between allelic polymorphisms of IL2, IFNG and TNFA genes and changes in secretion of the corresponding pro-inflammatory cytokines IL-2, IFNγ, and TNFα in vitro in patients with the newly diagnosed pulmonary tuberculosis (TB), depending on the clinical form of the disease. A total of 334 patients (220 men and 114 women) aged 23 to 50 years with newly diagnosed infiltrative and disseminated TB were enrolled into the study. The control group consisted of 183 healthy donors (130 men and 53 women) of corresponding age. The material of the research included DNA extracted from the whole blood and supernatants of culture suspensions of mononuclear leukocytes isolated from venous blood in healthy volunteers and patients with TB. The evaluation of cytokines secretion was performed by measuring their concentration in the blood mononuclear cell culture supernatants. using enzyme-linked immunosorbent assay (ELISA). To study polymorphic regions of cytokine genes, a polymerase chain reaction (PCR) was applied. Analysis of the obtained data was carried out by means of the program Statistica for Windows Version 6.0 (StatSoft Inc., USA). It was found that the imbalance of secretion of pro-inflammatory cytokines in TB patients was associated with the polymorphic variants of genes of these cytokines. It was found that the hypo-secretion of IL-2 is determined by the carriage of the G allele and genotype GG (T-330G) of the IL2 gene in both the control group and in patients with TB, regardless of the clinical form. In patients with DTB carriers of the homozygous genotype TT (T-330G) of the IL2 gene, increased protein secretion was established. The maximum secretion of TNFб was recorded in patients with the AA genotype (G-308A) of the TNFA gene in the control group and in ITB patients; the minimum concentration of TNFα was associated with the carrier of the homozygous GG genotype (G-308A) of the TNFA gene in all the examined groups. In patients with ITB and DTB, an increase in IFNγ secretion by mononuclear blood leukocytes is not associated with the carrier of polymorphism +874A/T of the IFNG gene. Reduced secretion of IL-2 and TNFα in TB patients is associated with polymorphisms of their genes – (T-330G) of IL2 gene and (G-308A) of TNFA gene, respectively. The polymorphism (+874A/T) of the IFNG gene does not have a modulatory effect on the secretion of IFNγ in patients with TB, regardless of clinical form of the disease. © 2019, SPb RAAC
A personality as the focal point of the weltanschauung exploration by V.V. Zen'kovs'ky
No full textУ
статті
показано ключову роль поняття і принципу особистості у становленні та розвиткові системи поглядів В. В. Зенъковського.In the article the author expounds upon the key role of the concept and principle of the personality in the establishment and the development of V.V. Zen 'kovs 'ky 's system of standpoints
Dry eye disease in keratoconus: etiology and medical treatment
No full text
V.V. Averich
Scientific Research Institute of Eye Diseases, Moscow, Russian Federation
This paper reviews published data on the studies on keratoconus associated with dry eye disease (DED) presentations. Despite the lack of a direct correlation between DED and keratoconus, many studies have demonstrated that keratoconus is associated with DED in more than 80% of cases. The author describes major endogenous and exogenous (inflammatory, immune/allergic, mechanical, neuropathic) factors triggering the development and association of these conditions. Approaches to the medical treatment of disorders resulting from the association of these entities are discussed. The primary management strategy implies tear film and ocular surface protection with tear substitutes based on the sodium salt of hyaluronic acid. In the lack of the effect of tear substitutes or in rigid gas permeable contact lens wearers, gel-based dexpanthenol in high concentrations is recommended. This treatment significantly increases drug bioavailability and prolongs the ocular surface reparation. Scleral contact lenses ensuring intact corneal epithelium and high visual acuity in irregular astigmatism caused by keratoconus are also used for corneal protection and DED therapy.
Keywords: keratoconus, keratectasia, dry eye disease, epitheliopathy, tear film.
For citation: Averich V.V. Dry eye disease in keratoconus: etiology and medical treatment. Russian Journal of Clinical Ophthalmology. 2022;22(2):122–126 (in Russ.). DOI: 10.32364/2311-7729-2022-22-2-122-126.
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The support level of V.V. Putin by the Yekaterinburg youth: the 2014 results
No full textThe article presents the data, characterizing the support level of V.V. Putin by the Yekaterinburg youth. The author shows that despite of all problems, existing in the country, Russian President has high level of political credibility and strong electoral supporting among young generation representatives. The presented data are explained.В статье представлены данные, характеризующие уровень поддержки Путина молодежью Екатеринбурга. Показано, что, несмотря на все существующие в стране проблемы, действующий Президент России пользуется высоким политическим доверием и уверенной электоральной поддержкой среди представителей молодого поколения. Приводится объяснение полученных сведений
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