1,720,998 research outputs found
Cell delivery of the Met docking site peptide inhibits angiogenesis and vascular tumour growth
No full textINFLAMMATION AND INFLAMMATORY PROCESSES IN TUMOR ANGIOGENESIS AND METASTASIS, MECHANISMS AND PREVENTION
No full textMacrophage production of IL-12 is required for inhibition of angiogenesis by angiostatin: the innate immunity as a key target for endogenous angiogenesis inhibitors
No full textThe SARS‐CoV‐2 receptor, ACE‐2, is expressed on many different cell types: implications for ACE‐inhibitor‐ and angiotensin II receptor blocker‐based cardiovascular therapies (Reply Letter).
No full textThis is a "Reply Letter" addressing an ad hoc "Letter to the Editor", which was focused on our previously published IAEM article, entitled "The SARS-CoV-2 receptor, ACE-2, is expressed on many different cell types: Implications for ACE-inhibitor- and angiotensin II receptor blocker-based cardiovascular therapies"
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Tumor microenvironment of colorectal cancer: toll like receptor 4 (TLR4) as a marker of progression
No full textMATRIGEL PROMOTES RETINOBLASTOMA CELL-GROWTH INVITRO AND INVIVO
No full textCells derived from retinoblastomas grow slowly in vitro and only very rarely form tumors in nude mice. Matrigel, a mixture of components normally found in basement membranes, promotes the growth of Y-79 and WERI-RbI retinoblastoma (Rb) cells when added to suspension cultures of the 2 Rb cell lines. It also substantially increases cell adhesion in vitro. Y-79 cells, seeded into a Matrigel matrix, form round colonies over a 3-week period similar to those of control, weakly metastatic murine melanoma cells. In vivo, s.c. co-injection of Matrigel with either Y-79 or WERI-RbI cells into nude mice promotes retinoblastoma tumor formation. Transplantation of as few as 1,000 cells allows for xenografting under these conditions, while no tumors were observed in the absence of Matrigel, even at 10 x 10(6) cells/inoculum. The tumors produced have the expected morphology and express an mRNA for a highly specific retina/retinoblastoma marker protein, the interphotoreceptor retinoid-binding protein. Thus, the xenografts obtained maintain the original morphological and molecular characteristics of the injected cells and represent a useful model for in vivo studies of retinoblastoma growth and treatment
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