360 research outputs found
The impact of pregnancy on peak flow values in women with asthma
No full textAsthma is the most common respiratory complication of pregnancy and affects approximately four per cent of all pregnant women. The purpose of this study was to establish normative data regarding how peak flow values change during gestation in pregnant women with asthma. Eighteen pregnant women with asthma were recruited and completed dally logs throughout their pregnancies. The findings suggest there is a difference in peak flow values in different trimesters. Specifically peak flow values were highest in the second trimester with significant differences between the second and third trimesters. While the sample size is small it does provide longitudinal data that suggest changes in asthma as the pregnancy progresses. This study represents a logical next step in identifying the impact of pregnancy on asthma.Peer reviewe
Peak Flow Values by Gestation in Women with Asthma
No full textAsthma is one of the most common medical complications of pregnancy. Control of asthma is associated with improved perinatal outcomes compared with pregnancies of women whose asthma is not controlled. Peak flow measures have been recommended to determine the status of asthma yet norms for peak flow values in women with asthma are missing from the literature. The purpose of this prospective, longitudinal study was to determine average peak flow values in pregnant women with asthma. Forty three women were recruited into the study prior to the twentieth week of pregnancy. Demographic data including age, ethnic background, and number of pregnancies were collected. Type and severity of asthma, medications used for asthma, and past hospitalizations for asthma was recorded. Peak flow values increased across the three trimesters. Significant differences were found in peak flow values between the first and third trimesters (>0.001) and the second and third trimesters (>0.007). Findings from the present study contradict those of studies on pregnant women without asthma. Since hormonal levels change during pregnancy and hormones are thought to influence the status of asthma, the interaction of hormonal changes of pregnancy and asthma warrant further study.Peer reviewe
The Role of Coordination and Cooperation for Bt-maize cultivation in Brandenburg, Germany
No full textSince 2006, several varieties of transgenic Bt-maize are approved for commercial cultivation in Germany. The German regulatory framework for growing these crops comprises ex-ante regulations as well as ex-post liability rules to protect conventional and organic farming from possible negative side effects of transgenic plants and to ensure co-existence. Public regulation is also suspected to impose additional costs to those farmers who intend to plant Bt-maize. We address the question how Bt-maize growing farmers perceive the additional costs of regulation and whether coordination or cooperation takes place in order to diminish these costs. In 2006, we carried out a case study in the Oderbruch region (Brandenburg, Germany) comprising eight Bt-maize growing farmers and six adjacent neighbours. The predominantly large farms chose intrafarm coordination to manage the construction of buffer zones within their own fields and to avoid the planting of Bt-maize close to their neighbours. Inter-farm coordination or cooperation with adjacent farmers was not regarded necessary to achieve co-existence.Coordination, Cooperation, Bt-maize, Crop Production/Industries,
Faculty Perception of Bullying in Schools of Nursing
No full textAims: This paper is a report of a study of conducted to determine the prevalence of bullying among faculty members in Schools or Colleges of Nursing.
Background: The issue of bullying of nursing faculty in the academic setting is of interest in terms of recruitment, retention, job satisfaction, and the overall quality of the work environment.
Method: This cross-sectional, descriptive study of faculty in three northeastern states of the U.S. was carried out in 2010. The Negative Acts Questionnaire-Revised was used to survey faculty members in Schools of Nursing who award a baccalaureate degree (or higher) in nursing.
Results: 473 faculty members met the inclusion criteria and responded to the NAQ-R. An iterative exploratory principal components analysis with orthogonal rotation was performed. Thirteen of the original 22 items were retained to measure the experiences of negative acts in the nursing faculty workplaces. The mean total score for the 13 item instrument was 17.90 (SD 6.07) and ranged from 13 to 56. The resulting components structure produced three clear subscales identifying the experiences of: Verbal abuse, Physical abuse, and Devaluing. The revised 13 item instrument had a Cronbach’s alpha value of 0.88. Experiences of bullying were reported in 169 of the 473 (36%) respondents. A significant correlation was found between meeting frequency and the report of bullying (r = 0.18, p ≤ 0.001). Administrators and senior faculty were more likely than expected to be the perpetrators of bullying.
Discussion: If the leaders are identified as bullies, the environment cannot be perceived as supportive and healthy. These unhealthy environments may have serious consequences related to retaining nursing faculty.Peer reviewe
A dance or a marriage? The relationship between education and the law in South Africa some personal observations from two vantage points
No full textThis article deals with the debate in education and law circles about the convergence of the two fields of knowledge in an area conveniently called education law. It recognises that there is no universal acknowledgement of the existence of such a discipline.
Although the article does not present a full scale analysis of the relationship between education and law, it does present some views emerging from the existence and functioning of two organisations in South Africa namely the South African Education Law Association (SAELA) and the Interuniversity Centre for Education Law and Policy (CELP). Both of the organisations aim to promote education law research and training. In light of the existing literature the relationship is likened to a marriage of convenience or a dance in which the quality of the relationship between the two fields varies.
The author examines and concurs with opinions that there are grounds to support the notion that a discrete field of inquiry named education law does exist in South Africa. However, the relationship still needs to be developed for the field to mature as an academic discipline. Among the problems that have to be addressed are the lack of interest in universities (especially law faculties at former English universities) in this field, the subsequent imbalance between educators and jurists active in the field and the failure of educational administrators to abide by the law even if they are aware of what the law requires. Added to this failure is a lack of knowledge among administrators of education law and the presence of a phenomenon termed the use of imagined power among them.
The article concludes that there are indications that the relationship between education and the law can lead to the development and promotion of a discrete field of law named education law
Differentiation of human embryonic stem cells to hepatocytes
No full textMany liver diseases involve hepatocyte malfunction. In most cases, transplantation of corrected hepatocytes would correct for disease symptoms. Liver donor shortage and hepatocyte inability to proliferate in vitro accentuate this problem. Embryonic stem and induced pluripotent stem cells proliferate indefinitely and have the capacity to differentiate into every cell type of the body. They could thus represent a solution to this organ donor shortage. In this project, we aim to differentiate ES and iPS cells to hepatocytes. First, we consider an approach to select the ES/iPS cell line showing the best potential to generate liver lineage using teratomas as a selection tool. Then we use lentiviral vectors to transduce this selected cell line with essential liver-‐specific development factors to help differentiation efficiency. Next, we developed an in vitro differentiation protocol based on existing protocols and developmental clues of liver development to generate a pool of hepatocyte precursors. Later on, we injected these differentiated cells in mice liver of Fah-‐, Rag2-‐ and Il-‐2rγ-‐deficient mice to check for engraftment and liver marker expression. Our findings show, after checking for hepatocyte-‐ specific markers in the differentiated cells, that our previous selection for the potentially best cell line seems correct. We also find that the transcription factors involved in liver development appear to have a negative effect in vitro on liver differentiation. Applying our protocol to regular ES cells results on the production of late maturity hepatocyte markers, showing correct differentiation and maturation of newly formed hepatocytes. Finally, mouse in vivo liver transplantation of these differentiated cells gives us human albumin expression detectable in blood serum of said miceSSVLaboratory of Genetics, Salk Institute for Biological Studies, La Jolla, Californi
Multiscale Approaches to Complex Human Diseases
No full textElucidating the fundamental biological mechanisms underlying complex diseases remains, to date, a challenging task. Genetic approaches have been used to implicate genes and pathways in disease, but classical (reverse) and population (forward) genetic approaches have fallen short of bringing new understanding to multi-factorial disorders. With the emergence of rapidly advancing, new technologies and the dramatic reduction of their costs, new algorithms and analytical models that maximally leverage the data these technologies generate, are being developed to uncover novel biological insights for complex traits. Furthermore, the integration of multiple strata of biological information permits the creation of better representations of disease. This thesis aims to leverage some of these models on novel multi-scale datasets to explore the mechanisms of Alzheimer’s disease and the variability of induced pluripotent stem cells
Islamic Law, Adat and State Law Franz Von Benda-Beckmann on Systems of Property and Inheritance in Minangkabau
No full textFranz von Benda-Beckmann is a famous figure in the field of legal pluralism. He is one among scholars who propose to understand the plurality of norms in a society. Among his many works, those on Minangkabau are well-known in the study of Anthropology of Law (Rechtsethnologie). This article attempts to analyse his ideas in a book entitled Property in Social Continuity: Continuity and Change in the Maintenance of Property Relationships through Time in Minangkabau, West Sumatra published in 1979. It has its relevance in the seminar Anthropology of Islamic Law, especially when the book talked about the pluralistic situation of laws in Minangkabau on problems of property and inheritance. Because the book is predominantly about Minangkabau adat, the author focuses on adat's relation with Islamic law and more specifically on the problem of inheritance which has been a source of much “competition” between both systems to regulate the society
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