1,721,017 research outputs found
Can COVID 2019 disease induce a specific cardiovascular damage or it exacerbates pre-existing cardiovascular diseases?
No full textA novel coronavirus SARS-CoV-2 causes acute respiratory distress syndrome (ARDS) with cardiovascular and multiple organ failure till death. The main mechanisms of virus internalization and interaction with the host are down-regulation or upregulation of the ACE2 receptor, the surface glycoprotein competition mechanism for the binding of porphyrin to iron in heme formation as well as interference with the immune system. The interference on renin-angiotensin-aldosterone system (RAAS) activation, heme formation, and the immune response is responsible for infection diffusion, endothelial dysfunction, vasoconstriction, oxidative damage and releasing of inflammatory mediators. The main pathological findings are bilateral interstitial pneumonia with diffuse alveolar damage (DAD). Because ACE receptor is also present in the endothelium of other districts as well as in different cell types, and as porphyrins are transporters in the blood and other biological liquids of iron forming heme, which is important in the assembly of the hemoglobin, myoglobin and the cytochromes, multiorgan damage occurs both primitive and secondary to lung damage. More relevantly, myocarditis, acute myocardial infarction, thromboembolism, and disseminated intravasal coagulation (DIC) are described as complications in patients with poor outcome. Here, we investigated the role of SARSCoV-2 on the cardiovascular system and in patients with cardiovascular comorbidities, and possible drug interference on the heart
Medical legal consideration in ultrasound diagnostics of fetal osteopathology
No full textThe provision of complete, updated and understadble information (of which there must be a written record) is an indispensable prerequisite for any medical act; it has considerable importance in the obstetric-gynecological field in consideration of the time limits imposed by the legislature to proceed with the voluntary interruption of pregnancy in the presence of significant malformation anomalies of the unborn child. The pregnant woman must be informed about the possibility of a late onset (after birth) of the osteopathy or its worsening during gestation, the degree of diagnostic accuracy of the ultrasound examination in identifying these malformations and the impossibility of this investigation to detect associated functional anomalies (metabolism disorders, hemopathies, mental retardation), evidence that the majority of osteopathies are identifiable only through molecular genetic investigation and that only the geneticist is able to predict the prognosis. In the presence of osteopathy on ultrasound examination, the operator must request specialist opinions, first of all genetic counseling, to better characterize the anomaly. The healthcare professional must update their scientific knowledge and behave in accordance with the most recent acquisitions in the medical field
The regulations relating to heterologous artificial insemination following the ruling of the constitutional court [La disciplina della fecondazione eterologa dopo la pronuncia della Consulta]
No full textReporting
No full textDrafting an exam comprehensively requires the acquisition of: Personal data. Anamnesis. Indication for examination (specifying if the investigation is aimed at screening or if there is a specific indication). The execution of the examination starts with the observation of uterine morphology, the number of fetuses, and study of fetal anatomy and biometrics. It is necessary to study all the fetal system and characteristics of the placenta and umbilical cord. The fetal measurements should be included in growth nomograms and evaluated in centiles. At the end of the report the sonographer must express his diagnostic consideration and, sometimes, request other consultancy. It is useful to indicate the number of images given and when a new check is useful. It is useful to archive a copy of the entire examination
Doubt: Recognition or diagnostic accuracy?
No full textWe evaluate if it is correct to express the concept of diagnostic accuracy as it is almost always considered, i.e., as the sonographer's ability to recognize that specific malformation in a specific age of gestation (for example in mid-gestation). Since the malformation almost always manifests itself in a different manner as from anatomical point of view and above all in the time. In fact, the same malformation sometimes becomes visible early, sometimes late, sometimes grossly, and sometimes minimally. For this reason it is believed that the method of diagnostic accuracy used up to now must be changed and indicate how many times that anomaly is already present in that gestational age. The sonographer is also invited to always document the anatomical and biometric well-being and always keep the images or film of the ultrasound examination in the archive so as to be able to demonstrate, in medical-legal litigation, whether that fetal malformation was already present at the moment when the ultrasound examination was performed
Il carattere multidimensionale della povertà alla luce della pandemia
No full textL'articolo mette in luce le diverse situazioni di povertà di natura non economica o non esclusivamente economica scaturite o aggravate (ove preesistenti) dall'emergenza sanitaria provocata dalla pandemia da Covid-19 e dall'adozione delle conseguenti misure di confinamento. La riflessione conduce, essenzialmente, a rimarcare il carattere multifattoriale della povertà.The article highlights the different situations of poverty of a non-economic or not exclusively economic nature that the health emergency caused by the Covid-19 pandemic and the adoption of the consequent confinement measures have provoked or aggravated (if pre-existing). Reflection essentially leads to stressing the multifactorial character of poverty
La rivoluzione scientifica nelle acquisizioni etiopatogenetiche in tema di paralisi cerebrale infantile: significato clinico e valenze medico-legali
No full text
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
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