39 research outputs found
The catabolism of glucose by the thermoacidophilic archaebacterium Thermoplasma acidophilum
No full textThe carbon footprint of respiratory treatments in Europe and Canada: an observational study from the CARBON programme
No full textRelievers account for the majority of inhaler use and associated GHG emissions. Implementing treatment guidelines can reduce the unmet need in respiratory care by improving disease control and reducing reliever overuse and the overall carbon footprint. https://bit.ly/3zh3c2
Metabolism of glucose via a modified Entner-Doudoroff pathway in the thermoacidophilic archaebacterium Thermoplasma acidophilum
No full textAbstractIt has been found that the thermoacidophilic archaebacterium, Thermoplasma acidophilum, can metabolise glucose via a modified Entner-Doudoroff pathway involving non-phosphorylated intermediates. Pyruvate and glyceraldehyde are the first products, the glyceraldehyde then being further metabolised to a second molecule of pyruvate via 2-phosphoglycerate. Intermediates of this pathway have been identified by enzymic analysis or by thin-layer chromatography and the individual enzymes involved have been assayed and their kinetic parameters determined. Comparisons are made with the pathways of glucose metabolism in other archaebacteria. p]Archaebacteria(Thermoplasma)Entner-Doudoroff pathwayGlucose metabolis
MASCOT DESIGNER'S GUIDE.
No full textThe author describes the purpose and intended role of the guide, concerns in creating a prototype advisor system, methods for providing metrics which can be applied to a representation of a MASCOT design, and a description of design experiments
Safe and sound: the story of the Justice Institute of British Columbia
No full textINTRODUCTION Jack McGee, President of the JIBC -- The Genesis of the JIBC -- Criminal Justice -- Social Justice -- Health and Pre-Hospital Care -- Public Safety -- Cross-Disciplinary Studies -- The Way of the FutureThis book tells its three-decade saga, enlivened with insights and anecdotes from the Institute’s visionary originators, innovators and present-day faculty and students, illustrated with both archival and exciting new photographs. The story will be of great value to potential, current and former students of the JIBC, to its friends and supporters and to anyone interested in tracing the modern evolution of education and training in the justice and public safety field
Forefoot pathology in rheumatoid arthritis identified with ultrasound may not localise to areas of highest pressure: cohort observations at baseline and twelve months
No full textBackgroundPlantar pressures are commonly used as clinical measures, especially to determine optimum foot orthotic design. In rheumatoid arthritis (RA) high plantar foot pressures have been linked to metatarsophalangeal (MTP) joint radiological erosion scores. However, the sensitivity of foot pressure measurement to soft tissue pathology within the foot is unknown. The aim of this study was to observe plantar foot pressures and forefoot soft tissue pathology in patients who have RA.Methods A total of 114 patients with established RA (1987 ACR criteria) and 50 healthy volunteers were assessed at baseline. All RA participants returned for reassessment at twelve months. Interface foot-shoe plantar pressures were recorded using an F-Scan® system. The presence of forefoot soft tissue pathology was assessed using a DIASUS musculoskeletal ultrasound (US) system. Chi-square analyses and independent t-tests were used to determine statistical differences between baseline and twelve months. Pearson’s correlation coefficient was used to determine interrelationships between soft tissue pathology and foot pressures.ResultsAt baseline, RA patients had a significantly higher peak foot pressures compared to healthy participants and peak pressures were located in the medial aspect of the forefoot in both groups. In contrast, RA participants had US detectable soft tissue pathology in the lateral aspect of the forefoot. Analysis of person specific data suggests that there are considerable variations over time with more than half the RA cohort having unstable presence of US detectable forefoot soft tissue pathology. Findings also indicated that, over time, changes in US detectable soft tissue pathology are out of phase with changes in foot-shoe interface pressures both temporally and spatially.Conclusions We found that US detectable forefoot soft tissue pathology may be unrelated to peak forefoot pressures and suggest that patients with RA may biomechanically adapt to soft tissue forefoot pathology. In addition, we have observed that, in patients with RA, interface foot-shoe pressures and the presence of US detectable forefoot pathology may vary substantially over time. This has implications for clinical strategies that aim to offload peak plantar pressures
Ideas for justice
No full textAs part of the wider ‘What is Justice?’ symposium, the Ideas for Justice project is speaking to people about their understanding and experience of justice today. The interviews are being conducted by Harry Annison and Philippa Budgen. In this update on the ‘Ideas for Justice’ project, we reflect on the interviews that have been published so far
James Joyce and the making of Ulysses With a portr. of James Joyce and 4 drawings to Ulysses by the author
No full textEvolution of Secondary Studies in SE
No full textFor each identified secondary study performed in 2010, 2015 and 2020, we have assessed the type of study (e.g. systematic review, mapping study), whether it is qualitative or quantitative (or methodological), the number of authors performing the study, and rated the experience of the leading author based on their entry in DBLP. This provides a profile of the secondary studies published in these three years (in five leading software engineering journals), enabling an assessment of how the use of secondary studies has evolved in the period 2010-2020.THIS DATASET IS ARCHIVED AT DANS/EASY, BUT NOT ACCESSIBLE HERE. TO VIEW A LIST OF FILES AND ACCESS THE FILES IN THIS DATASET CLICK ON THE DOI-LINK ABOV
The epidemiology and clinical importance of forefoot bursae in patients with rheumatoid arthritis
No full textThe epidemiology of foot complications in patients with rheumatoid arthritis (RA) is poorly understood. A number of patients report ongoing foot-related pain, impairment, footwear restriction and activity limitation, despite developments in pharmacological disease management. Forefoot bursae (fluid filled sacks, FFB) have been previously shown to be highly prevalent and related to foot complications in patients with RA. However, the longitudinal epidemiology and clinical importance of FFB in this patient population remains unclear. It is anticipated that an improved understanding of the mechanisms by which FFB are responsive to, or contribute to, fluctuations in RA disease activity will inform future evaluation of foot health and novel therapeutic targets. Through a series of four experimental studies this work has shown that ultrasound (US) detectable FFB are highly prevalent in patients with RA compared to healthy volunteers (HV) and are clinically relevant. The natural history of FFB remains consistent longitudinally in a cohort of patients with established RA disease at baseline. US-detectable FFB were determined to be significant prognostic indicators of foot-related disability after three years. Furthermore, the distribution of US-detected FFB across forefoot sites was identified as significantly different between HV and patients with predominantly inflammatory or degenerative arthritis; uniquely patients with RA have a number of FFB within the central forefoot region, in addition to those located laterally, which were frequently present in all comparative groups. Thus, in patients with RA ~50% of US-detected FFB may be of greatest clinical relevance, due to their positioning within the central forefoot region. Detection of FFB using MRI defined a series of FFB characteristics of clinical relevance in patients with RA. The presence of plantar forefoot fluid lesions or intermetatarsal soft tissue lesions was significantly related to RA disease activity. The presence of plantar soft tissue lesions was significantly related to increased biomechanical impairment. However, a high proportion of plantar predominantly soft tissue FFB was also noted to be actively inflamed whilst other MRI-based markers of disease activity within the forefoot were minimal
