180 research outputs found
Transitioning to CCWIS Compliance for NYS: Go or No Go?
No full textIn June 2016, the federal Administration for Children and Families, Department of Health and Human Services (ACF) published a new federal rule defining the Comprehensive Child Welfare Information System (CCWIS) initiative which governs state and tribal Child Welfare (CW) information systems for the foreseeable future. In general, these CCWIS regulations, which are optional, allows state CW agencies greater flexibility to develop systems consistent with their practices and business needs by moving away from “data capture” to a “data maintenance” philosophy, as long as a copy of the data is stored and maintained in CCWIS, which must be the source of all data and reporting requirements. The primary features of the CCWIS regulations include a new level of emphasis on data exchange capability and data quality (rather than on the specific functionality to be provided) and on modularity as a development principle. The new system places greater emphasis on bi-directional data exchanges between CW-related programs in the state agencies that administer health, justice, labor, education, and local agencies as well as other organizations who provide services to children and families.In June of 2017, the New York State (NYS) Office of Children and Family Services (OCFS) launched a nine-month assessment of the investments required for enhanced program development and the impact of CCWIS compliance on NYS CW programs and services.This report presents the results of the nine-month assessment undertaken by OCFS to gather information necessary to inform their decision regarding commitment to CCWIS compliance and, given that a “Go” decision was made, to set a course for continued planning and implementation
L'amplification religieuse du quotidien dans le minimalisme positif francophone : En vie d'Eugène Savitzkaya et Célébration du quotidien de Colette Nys-Mazure
No full textIn this article, the author develops the narrative, stylistic and thematic strategies implementedin two novels published by two contemporary Belgian Francophone novelists: EugèneSavitzkaya En vie and Colette Nys-Mazure Célébration du quotidien. These two texts belongto a movement of contemporary narrative fiction that is related to the taxonomy of "positiveminimalism" promoted by Rémi Bertrand, and the major features of which are much related toeveryday life
ELABELA/TODDLER a new tumor suppressor and marker for tumor progression and angiogenesis : Therapeutic and prognostic strategies developmement
No full textInitialement identifiée comme ARN non codant, Elabela est le second ligand peptidique du récepteur de l’Apeline (APJ/ APLNR), un récepteur couplé aux protéines G. Largement distribuée dans l’organisme, l’Apeline est impliquée dans de nombreuses fonctions physiologiques et physiopathologiques allant du développement embryonnaire jusqu' aux pathologies cardiovasculaires et le cancer. L’expression d’Elabela est, elle, beaucoup plus restreinte, elle est exprimée par les cellules souches endothéliales et joue un rôle critique dans le développement cardiovasculaire et chez l’homme adulte elle est exprimée principalement par le rein et la prostate. Elabela joue un rôle important dans divers processus physiologiques tels que le contrôle de la pression artérielle, la morphogenèse cardiaque, l'apoptose, l'angiogenèse, la prolifération cellulaire, la migration. Elle est également impliquée en lors de pathologies comme l’insuffisance cardiaque, l'hypertension, les maladies rénales, certains troubles du Système Nerveux Central, et récemment elle a été identifiée comme étant impliquée dans le cancer.Ce travail présente différents aspects de la fonction d’Elabela au cours de l’angiogenèse et du cancer du pancréas.Notre équipe ayant récemment mis en évidence un rôle antitumoral d’Elabela dans le cancer du rein bien qu’ayant qu’Elabela présente aussi une fonction pro-angiogénique, une première étude a été menée sur l’angiogenèse en utilisant le modèle de la régénération de la nageoire caudale du poisson zèbre adulte. Ce modèle présente l’avantage d’être un modèle d’angiogenèse in vivo avec une régénération en quelques jours. Il a ainsi pu être montré qu’Elabela était impliquée dans la maturation des vaisseaux sanguins lors de l’angiogenèse régénérative. Son expression est rapidement et fortement induite après amputation de la nageoire avec un maximum d’expression 3 jours post amputation. De plus l’inhibition de son expression par des morpholinos provoque un net retard de la maturation des vaisseaux sanguins. Cette étude met en évidence un rôle important d’Elabela au cours de la maturation vasculaire.Une seconde étude porte sur le rôle d’Elabela au cours du cancer du pancréas. Alors qu’à ce jour non décrit dans la littérature nous avons pu mettre en évidence la présence d’Elabela dans le pancréas et par screening par RT-qPCR d’échantillons de pancréas sains ou tumoraux de patients, l'expression des différents composants du système apelinergique : le récepteur APJ et ses deux ligands : l'Apeline et Elabela. Il est apparu que l’expression d’Elabela était diminuée dans les échantillons tumoraux. La restauration de l’expression d’Elabela dans différentes lignées cellulaires cancéreuses du pancréas a permis de diminuer la croissance tumorale de la xénogreffe chez l’embryon de poisson zèbre avec également une forte inhibition des capacités métastatiques cancéreuses.Ces travaux ont permis de mettre en évidence le rôle d’Elabela dans la maturation des vaisseaux, suggérant ainsi qu’Elabela constitue un élément clef de la normalisation des vaisseaux tumoraux permettant un meilleur accès aux agents thérapeutiques. Au cours du cancer du pancréas, Elabela pourrait constituer un nouveau marqueur de ce cancer de très mauvais pronostique et pourrait permettre le développant d’outils thérapeutiques.Ce travail met en évidence le rôle d’Elabela comme étant une nouvelle cible thérapeutique.Initially identified as a non-coding RNA, Elabela is the second peptide ligand of the apelin receptor (APJ/APLNR), a G-protein-coupled receptor. Widely expressed in the body, Apelin is involved in various physiological and physiopathological functions from embryonic development to cardiovascular pathologies and cancer. Elabela’s expression is more restricted, Elabela is expressed by endothelial stem cells and plays an important role in cardiovascular development and in adult humans, is mainly expressed in kidney and prostate. Elabela plays an important role in various physiological process such as blood pressure control, cardiac morphogenesis, apoptosis, angiogenesis, cell proliferation, migration. Elabela is also involved in pathologies such as heart failure, hypertension, kidney disease, central nervous system disorders, and recently it has ben identified as being involved in cancer.This work presents different aspect of Elabela function during angiogenesis and pancreatic cancerOur team has recently demonstrated an antitumoral role of Elabela in kidney cancer although Elabela also has a pro-angiogenic function. A first study was carried out on angiogenesis using the regeneration model of the caudal fin of the adult zebrafish. This model has the advantage of being an in vivo angiogenesis model with regeneration in a few days. It has been shown that Elabela is involved in the maturation of blood vessels during regenerative angiogenesis. Its expression is rapidly and strongly induced after fin amputation with maximum of expression 3 days post amputation. In addition, the inhibition of its expression by morpholinos causes a marked delay in the maturation of blood vessels. This study highlights an important role of Elabela during vascular maturation.A second study focuses on the role of Elabela in pancreatic cancer. While to date not described in the literature, we have been able to demonstrate the presence of Elabela in the pancreatic cancer and by screening by RT-qPCR of healthy or tumorous pancreas from patients, the expression of the various components of the apelinergic system: APJ receptor and its 2 ligands: Apelin and Elabela. It appeared that the expression of Elabela was decreased in pancreatic tumor samples. Restoration of the expression of Elabela in different pancreatic cell lines has reduced the tumor growth of the xenograft in the zebrafish embryo with also a strong inhibition of metastatic capacities.This work highlights the role of Elabela in vessels maturation, suggesting that Elabela is a key element in tumoral vessels normalization allowing better access to therapeutic agents. In pancreatic cancer, Elabela could constitute a new marker for this poor prognosis cancer and could allow therapeutics tools development. This work emphasis the role of Elabela as a new therapeutic target
Royal Commission on Human Relationships
No full textThis controversial Royal Commission from the 1970s found that many Australian families were failing to protect their most valuable members, and helped change the shape of public discussion around families, gender and sexuality.
This is the first time a digitised version of the Royal Commission on Human Relationships\u27 five-volume final report has been made publically available.
The Royal Commission was initiated in 1974, following a failed attempt by the Whitlam government to reform abortion law. The terms of reference were:
To inquire into and report upon the family, social, educational, legal and sexual aspects of male and female relationships, so far as those matters are relevant to the powers and functions of the Australian Parliament and Government, including powers and functions in relation to the Territories:
To give particular emphasis to the concept of responsible parenthood, to have regard to experience in other countries and to include in your inquiry the following aspects of the said matters:
(a) the extent of relevant existing education programs, including sex education programs, and their effectiveness in promoting responsible sexual behaviour and providing a sound basis in the fundamentals of male and female relationships in the Australian social environment;
(b) the extent of relevant existing programs in medical schools and their adequacy to provide comprehensive medical training in contraceptive techniques, in the physical, psychological and sexual problems experienced by women in adapting to marriage and before, during and after menstruation and in matters relating to pregnancy, fertility control, spontaneous and induced abortions and childbirth and to encourage acceptance by the medical profession of its responsibilities in the field of contraceptive counselling;
(c) the provision, adequacy and effectiveness of existing family planning facilities, educational and activational information on family planning and methods of evaluation of all family planning techniques;
(d) the social, economic, psychological and medical pressures on women in determining whether to proceed with unplanned or unwanted pregnancies, having regard to:
(i) the adequacy of housing, child-minding centres, pre-school centres, domestic assistance for families and working mothers, assistance to single parent families, other forms of assistance for mothers employed in industry, and adoption procedures;
(ii) the disabilities of families with handicapped children; and
(iii) the social status of women in the community; the social, psychological and medical results of termination of, or and failure to terminate such pregnancies;
(e) the adequacy and effectiveness of existing medico-legal determinations in relation to termination of pregnancy, the incidence of such terminations, the factors influencing their occurrence, the adequacy of medical training in an evaluation of methods of termination, consultative rights of the family or other persons concerned and the adequacy and effectiveness of pregnancy support services; and
(f) any other matters in relation to the family, social, educational, legal and sexual aspects of male and female relationships to which the attention of the Commission is directed by the Prime Minister in the course of the inquiry.
To make recommendations as to measures that are desirable with respect to the foregoing matters under existing or future laws of the Australian Parliament or of the Territories (including laws providing for grants to the States) and to indicate whether these measures should be implemented through existing bodies or through government instrumentalities to be created.
The final report, presented to Governor-General John Kerr in 1977, contained over 500 recommendations relating to "contraception (access and use), unwanted pregnancies, childbirth, attitudes to sexuality, sexual knowledge, sex education, domestic violence, rape and the police and courts’ treatment of rape victims, the changing roles of women, child care, child abuse, and homosexuality – especially discrimination faced by gays and lesbians."
The report was highly controversial when released and many of its recommendations were not acted on. However, the Royal Commission had a lasting influence. It was said to have brought taboo topics like abortion, rape and child abuse into public discussion, and to have opened up conversations about private life to this day.
---------------
Part of the Policy History Collection. Digitisation of this report has been supported by the National Library of Australia.
Reproduced with permission of the Department of Prime Minister and Cabinet
Human rights-based approach to the provision of supportive housing for mentally ill homeless people
No full textThesis: M.C.P., Massachusetts Institute of Technology, Department of Urban Studies and Planning, 2015.Cataloged from PDF version of thesis.Includes bibliographical references (pages 52-54).Despite its cost-effectiveness, supportive housing is grossly underprovided. In this paper, I build a rights-based strategy for supportive housing advocates, specifically structured around meeting the needs of mentally ill homeless people. A rights-based strategy, emanating from constitutional law, is the most robust way to secure this support. The failure of New York State to provide supportive housing for mentally ill homeless people is a prima facie violation of human rights under domestic law (specifically, NYS constitution Article 17, Section 1) and various international treaties. The government has enforced a property ownership and regulatory regime that interferes with mentally ill citizens' ability to satisfy their basic needs and therefore must provide a publicly-financed remedy for their condition. This thesis identifies the best legal strategy by which activists can secure this remedy. To make this is case, it is necessary to circumvent resistance from federal courts to affirmative welfare policy. I do this by identifying the state law basis of the right to adequate housing. Once it has been established as a right at the state level, federal attitudes take a different character as federal courts treat welfare entitlements as property-and federal courts vigorously defend property.by Christian Nicolas Desrosiers.M.C.P
Passive maternal exposure to environmental microbes selectively modulates the innate defences of chicken egg white by increasing some of its antibacterial activities.
No full textBackground Egg defence against bacterial contamination relies on immunoglobulins (IgY) concentrated in the yolk and antimicrobial peptides/proteins predominantly localized in the egg white (EW). Hens contaminated with pathogenic microorganisms export specific IgYs to the egg (adaptative immunity). No evidence of such regulation has been reported for the antimicrobial peptides/proteins (innate immunity) which are preventively secreted by the hen oviduct and are active against a large range of microbes. We investigated whether the egg innate defences can be stimulated by the environmental microbial contamination by comparing the antimicrobial activity of EW of hens raised in three extreme breeding conditions: Germ-free (GF), Specific Pathogen Free (SPF) and Conventional (C) hens. Results The difference in the immunological status of GF, SPF and C hens was confirmed by the high stimulation of IL-1β, IL-8 and TLR4 genes in the intestine of C and SPF groups. EW from C and SPF groups demonstrated higher inhibitory effect against Staphylococcus aureus (13 to 18%) and against Streptococcus uberis (31 to 35%) as compared to GF but showed similar activity against Salmonella Enteritidis, Salmonella Gallinarum, Escherichia coli and Listeria monocytogenes. To further investigate these results, we explored putative changes amongst the three main mechanisms of egg antimicrobial defence: the sequestration of bacterial nutrients, the inactivation of exogenous proteases and the direct lytic action on microorganisms. Lysozyme activity, chymotrypsin-, trypsin- and papain-inhibiting potential of EW and the expression of numerous antimicrobial genes were not stimulated suggesting that these are not responsible for the change in anti-S. aureus and anti-S. uberis activity. Moreover, whereas the expression levels of IL-1β, IL-8 and TLR4 genes were modified by the breeding conditions in the intestine of C and SPF groups they were not modified in the magnum where egg white is formed. Conclusions Altogether, these data revealed that the degree of environmental microbial exposure of the hen moderately stimulated the egg innate defence, by reinforcing some specific antimicrobial activities to protect the embryo and to insure hygienic quality of table eggs
Technical improvements in 19th-century Belgian window glass production
No full textGlass was used since the Roman age in the building envelope, but it became widely applied together with iron since the 19th century. Belgium was a major producer of window glass during the nineteenth century and the majority of the produced window glass was exported all over the world. Investigating the literature on the development of 19th century Belgian window glass production is therefore internationally relevant. In the 17th century, wood was replaced as a fuel by coal. In the 19th century, the regenerative tank furnace applied gas as a fuel in a continuous glass production process. The advantages were a clean production, a more constant and higher temperature in the furnace and a fuel saving. The French chemist Nicolas Leblanc (1787-1793) and later the Belgian chemist Ernest Solvay (1863) invented processes to produce alkali out of common salt. The artificial soda ash improved the quality and aesthetics of the glass plates. During the 19th century, the glass production was industrialized, influencing the operation of furnaces, the improvement of raw materials as well as the applied energy sources. Although the production process was industrialized, glassblowing was still the work of an individual. By improving his work tools, he was able to create larger glass plates. The developments in the annealing process followed this evolution. The industry had to wait until the invention of the drawn glass in the beginning of the 20th century to fully industrialise the window glass manufacture process
Physical and antimicrobial protection of the hen’s egg throughout the extended laying cycle
No full textInternational audienc
Computers and Computer Software - Microsoft Office
No full textThe documents are designed to be generic; with time, location, institution, and instructor information to be added when implemented as a specific school. As such they are as complete as possible but will need some editing when a school or instructor implements the course. For example insertion or editing of instructor name and contact information, dates, etc. With that said they are meant to be “picked up” by an instructor and delivered with as little editing as possible. In this respect, some course authors either templates others samples for these editable documents. Templates simply have an empty space where information needs to be added, samples have sample information that needs to be replaced. • Some courses are stand alone, with no added materials needed, while others are built around a specific text or ebook. This was left to the discretion of the subject matter expert as long as the course covered the required NYS apprenticeship competencies and was OSCQR compliant. For courses with a linked text, eBook, online resource etc., this is listed in the syllabus. For those that did not require a connected resource, the syllabus will say ‘none required’ or ‘tbd’ under the text book portion. In the latter case a text can be added by the local instructor but is not needed and could be left out. • You should both have access to the courses in FLCC’s blackboard system. You can use this to see what the .zip files “look like” if you haven’t already. Zip folders aren’t much to look at! If you don’t have or don’t recall your login information please let me know and I will have Jeff or Ashley send you login instructions.Each course has a syllabus in template form. A planning document formally links the NYS Occupations, associated Apprenticeship competencies, learning outcomes, course assessments and activities together.NAN/ASUNY Finger LakesN/
Machining Machine tools Cutting Tools Course Outline and Syllabus rev A
No full textThe documents are designed to be generic; with time, location, institution, and instructor information to be added when implemented as a specific school. As such they are as complete as possible but will need some editing when a school or instructor implements the course. For example insertion or editing of instructor name and contact information, dates, etc. With that said they are meant to be “picked up” by an instructor and delivered with as little editing as possible. In this respect, some course authors either templates others samples for these editable documents. Templates simply have an empty space where information needs to be added, samples have sample information that needs to be replaced.Each course has a syllabus in template form. A planning document formally links the NYS Occupations, associated Apprenticeship competencies, learning outcomes, course assessments and activities together.NASUNY Finger LakesN/
- …
