908 research outputs found
D.H. Lawrence, La Volpe, traduzione e cura di Stefania Michelucci, edizione bilingue
No full textIt is the bilingual and critical edition of D.H. Lawrence's The Fox in the series, Elsinore, Collana di Classici Inglesi, edited and translated by Stefania Michelucci
The volume consists of a long introduction to the text, pp 11-37, of a biographical article on the author and his work (l'autore e l'opera), pp. 39-45), of a note to the text (pp. 47-48) (English and Italian, page to page, pp. 49-227) of explicatory notes (pp. 229-243) and of a biographical section (pp. 245-252)
Ricordo di Stefania Rossi Minutelli
No full textThe author commemorates Stefania Rossi Minutelli – librarian at the Marciana National Library from 1971 to 2005, who died on october 10th, 2008 – remembering her professional career and her role within the Italian Library Association.L'autore ricorda con affetto e stima professionale Stefania Rossi Minutelli – bibliotecaria marciana dal 1971 al 2005, scomparsa nell'ottobre 2008 – ripercorrendo il tratto di strada fatto insieme all'interno dell'Associazione Italiana Biblioteche e del mondo bibliotecario italiano
Adipose-derived Stem/Stromal Cell secretome blunts TNFα-induced hypertrophy on human primary articular chondrocytes
No full textOBJECTIVE: Up to now several clinical trials have shown the safety and efficacy of the intra-articular injection of Adipose-derived Mesenchymal Stem/Stromal Cells (ASCs) in contrasting osteoarthritis. Since ASCs act predominantly through paracrine mechanisms, their secretome represents a promising cell-free alternative. The aim of our study was to invetigate anti-hypertrophic and anti-catabolic effects of ASC conditioned medium (ASC-CM) on TNFα-stimulated human primary articular chondrocytes (CHs).
MATERIALS AND METHODS: CHs were treated with 10ng/ml TNFα and/or ASC-CM administered at a 1:5 recipient:donor cell ratio. Cell viability was assessed up to day 9. The activity, expression and/or release of hypertrophy markers (MMP-13, Collagen X and Osteocalcin), catabolic mediators (MMP-3) and cartilage-protective factors were assessed up to day 3 by enzymatic assays, qRT-PCR, Western Blot and multiplex immunoassays.
RESULTS: ASC-CM blunted TNFα-induced hypertrophy, reducing the enhanced levels of MMP-13 activity (-61%), Osteocalcin (-37%) and Collagen X (-18%). In addition, also MMP-3 activity was diminished by -59%. We associated the observed reduction of MMP-3 and MMP-13 activity to the abundancy of TIMPs (Tissue Inhibitors of MMPs) in ASC secretome, rather than to a direct down-modulation of their expression and/or release. Moreover, ASC-CM contains high levels of OPG and DKK-1, other known chondroprotective factors.
CONCLUSION: ASC-CM is rich in cartilage-protective factors and exerts anti-hypertrophic and anti-catabolic effects on TNFα-stimulated CHs. These evidences open the way for its possible clinical use as a cell-free approach in contrasting osteoarthritis. We are currently investigating through a differential proteomic analysis if the recognized chondroprotective effectors are enriched in the vesicular rather than the soluble component of the secretome
Human Adipose-derived Stromal Cell secretome beneficial potential in contrasting osteoarthritis
No full textOBJECTIVE: Adipose-derived Stromal Cells (ASCs) possess a strong anti-inflammatory potential, which is mediated by a wide array of released bioactive factors. The use of conditioned medium (CM) instead of cells presents substantial advantages especially in terms of handling and safety. The purpose of this study is to investigate the potential of hASC secretome in contrasting osteoarthritis (OA), an inflammatory disease characterized by hypertrophic differentiation of chondrocytes (CHs) and extracellular-matrix-degrading proteases production.
MATERIALS AND METHODS: CM was collected from hASCs derived from subcutaneous adipose tissue, cultured for 72 hours in starving conditions. The CM was then concentrated trough Amicon Ultra-15 Centrifugal Filter Unit (Merck-Millipore) of about 46±10-folds (n=26). Hypertrophy was induced in vitro in human primary articular chondrocytes with 10ng/ml TNFα. CM (ratio 5:1, hASCs:hCHs) effect on cell proliferation (up to 9 days) was assessed by AlamarBlue. Gene and protein expression of MMPs and other hypertrophic markers were evaluated (24 and 72 hours) by RT-PCR, Western blot and multiplex immunoassay.
RESULTS: hCH proliferation was prompted (+40%) by a 9-day-treatment with 10 ng/ml TNFα, suggesting the induction of a hypertrophic growth status. Despite the lack of CM effect on CH proliferation, the conditioned medium treatment reverted the TNFα–induced significant increase in MMP3 and MMP13 expression (-50% and -30%, respectively), after 24 hours. The reduction in MMP13 protein expression was also evident after both 24 and 72 hours. Moreover, hASC conditioned medium inhibited TNFα-mediated osteocalcin release. The effect of CM on other OA and hypertrophic markers, in TNFα-inflamed CHs, is currently under investigation.
CONCLUSION: Our data reinforce the idea that ASC secretome might be considered a promising source of factors for future therapeutic applications in the OA treatment. The analysis of CM sub-components (EVs and soluble factors) and the comparison of ASC secretome with CM from cells lacking this therapeutic potential, might allow us to reveal the factors responsible for secretome beneficial action
Adipose-derived Stem/Stromal Cell secretome, containing both soluble factors and extracellular vesicles, exerts chondroprotective effects in vitro
No full textIntroduction
Up to now several clinical trials have shown the safety and efficacy of the intra-articular injection of Adipose-derived Mesenchymal Stem/Stromal Cells (ASCs) in contrasting osteoarthritis. Since ASCs act predominantly through paracrine mechanisms, their secretome represents a promising cell-free alternative. Here we identified anti-hypertrophic and anti-catabolic effects of ASC conditioned medium (ASC-CM) on TNFα-stimulated human primary articular chondrocytes (CHs).
Methods
CHs were treated with 10ng/ml TNFα and/or ASC-CM administered at a 1:5 recipient:donor cell ratio. Cell viability was assessed up to day 9. The activity, expression and/or release of hypertrophy markers (MMP-13, Collagen X and Osteocalcin), catabolic mediators (MMP-3) and cartilage-protective factors were assessed up to day 3 by enzymatic assays, qRT-PCR, Western Blot and multiplex immunoassays.
Results
ASC-CM blunted TNFα-induced hypertrophy, reducing the enhanced levels of MMP-13 activity (-61%), Osteocalcin (-37%) and Collagen X (-18%). In addition, also MMP-3 activity was diminished by -59%. We associated the observed reduction of MMP-3 and MMP-13 activity to the abundancy of TIMPs (Tissue Inhibitors of MMPs) in ASC secretome, rather than to a direct down-modulation of their expression and/or release. Moreover, ASC-CM contains high levels of OPG and DKK-1, other known chondroprotective factors.
Conclusions
ASC-CM is rich in cartilage-protective factors and exerts anti-hypertrophic and anti-catabolic effects on TNFα-stimulated CHs. These evidences open the way for its possible clinical use as a cell-free approach in contrasting osteoarthritis. We are currently investigating through a differential proteomic analysis if the recognized chondroprotective effectors are enriched in the vesicular rather than the soluble component of the secretome
The Global Art Gallery Report with Richard Taittinger, Magnus Resch, Stefania Bortolami, and James Fuentes
No full textModerator: Magnus Resch Book Author and Art Entrepreneur
Panelists:
Stefania Bortolami, Gallery Owner
James Fuentes, Gallery Owner
Richard Taittinger, Gallery Owner
The Global Art Gallery Report is the first and the most wide-ranging report on today\u27s commercial art galleries. Published by Phaidon, it is the first insight of its kind, presenting a detailed and comprehensive portrait of today\u27s gallery scene. In a panel discussion, Magnus Resch will discuss his findings with gallerists Jeffrey Deitch, Stefania Bortolami and James Fuentes. Panelists will shine a light on the future of the art gallery.
Founded in 1969, the Sotheby’s Institute of Art is the first and foremost graduate school for the study of art and its markets. With more than 6,000 alumni working internationally in art fairs, galleries, museums, auction houses, and nonprofits, the Institute’s alumni are shaping the future of the art industry. Past guest speakers at the Institute have included artists, such as: Ulay and Jaša, Dan Graham, Alexandre Singh, Glenn Ligon, Sanford Biggers, Carolee Schneemann, Dara Birnbaum, Alfredo Jaar, Ahmed Alsoudani; and art industry experts from Sotheby’s, Art Basel, Paddle8, Auctionata, Armory Show, Artsy, Whitney Museum, Swiss Institute, MoMA, and others.https://digitalcommons.sia.edu/speaker/1007/thumbnail.jp
A Human Rights Approach to Environmental Health
No full textThis chapter explores the interface between health and the environment through the human rights prism, focusing on the environmental dimension of the right to health and on the now widely recognized right to a healthy, safe and clean environment. To this end, the chapter intends to offers a comprehensive analysis of the relevant provisions contained in human rights treaties and the obligations stemming therefrom. The review of these legal sources is completed by a critical assessment of the case law produced by regional human rights bodies and their evolutive interpretation of individual rights and corresponding State obligations in this field, with a special focus on the case law of the European Court of Human Rights. The aim of this legal analysis is to evaluate the added value of a human rights approach to environmental health litigation, with a view to best achieving the overarching goal of public health protection from environmental harm. The author highlights that human rights can be used in court as effective tools to protect public health against the adverse effects of environmental degradation and severe pollution. She also stresses that the potential of human rights bodies in the field of environmental health is yet fully unexpressed, but further positive developments towards the protection of collective and intergenerational rights related to the environment and human health can be achieved thanks to the dynamic and evolutive approach adopted by these bodies and through the virtuous circle created by judicial cross-fertilization
A Multitude of Women: The Challenges of the Contemporary Italian Novel
No full textA Multitude of Women looks at the ways in which both Italian literary tradition and external influences have assisted Italian women writers in rethinking the theoretical and aesthetic ties between author, text, and readership in the construction of the novel. Stefania Lucamante discusses the valuable contributions that Italian women writers have made to the contemporary novel and illustrates the relevance of the novelistic examples set by their predecessors. She addresses various discursive communities, reading works by Di Lascia, Ferrante, Vinci, and others with reference to intertextuality and the theories of Elsa Morante and Simone de Beauvoir.
This study identifies a positive deviation from literary and ideological orthodoxy, a deviation that helps give meaning to the Italian novel and to transform the traditional notion of the canon in Italian literature. Lucamante argues that this is partly due to the merits of women writers and their ability to eschew obsolete patterns in narrative while favoring forms that are more attuned to the ever-changing needs of society. She shows that contemporary novels by women authors mirror a shift from previous trends in which the need for female emancipation interfered with the actual literary and aesthetic significance of the novel. A Multitude of Women offers a new epistemology of the novel and will appeal to those interested in women's writing, readership, Italian studies, and literary studies in general
Stefania Poznanska (1923-2010) : a teacher, nursing tutor
No full textStefania Poznańska, PhD, was one of five managers of the school, which informal name was Cracow School of Nurses. The School was
founded on 5 November 1911 under the name of School of Professional Nursing, also called the "old Cracow school". Its successor i.e. the
University School of Nurses and Health Carers later Hygienists was opened on 10 December 1925. The abovementioned term also refers to
the following nursing schools: University School of Nursing and Midwifery (1946-1951), Public School of Nursing and Midwifery (1949-1951), Public School Of Nursing (1950-1964), Public Medical School of Nursing (1964-1971), Department of Nursing of the Medical Vocational
College No 1 (1971-1981), and Anna Rydlówna Department of Nursing of the Medical Vocational College No 1 (1982-2001). The
school was localised in Cracow, 25 Kopernika St. until 1975, and then was moved to a new location - 12 Michałowskiego St. The aim of the study was the recollection of Stefania Poznańska, PhD, a nurse, teacher, tutor of nursing, author of multiple research studies
and publications, a person dedicated to the development of modern nursing, and last but not least, a great fiend.
The study material is based on a review of personal notes and archive materials gathered by the Institute of Nursing and Midwifery,
Faculty of Health Sciences, Medical Collage, Jagiellonian University in Cracow. Also, personal recollections of multiple encounters
with Stefania Poznańska were taken into account. A biography-historical method as well as the review of documents were applied by
the authors. A significant contribution of Stefania Poznańska to the development of modern nursing must be emphasized. This contribution included her
work for the Programme Committee in Cracow for nursing education curriculum at university level as well as specific detailed programs regarding nursing history and ethical issues in nursing care, and the publication of a series of articles on new concept for teaching nursing
profession. Stefania Poznańska was a person open to another human being
La Globalidad de Lenguajes. Semiótica, antropología, psicología. Cuicuilco Revista de la Escuela Nacional de Antropología e Historia: Análisis del discurso y semiótica de la cultura: perspectivas analíticas para el tercer milenio Tomo I. Num. 24 (2002) Vol. 9 enero-abril
No full textLa Globalidad de Lenguajes es una disciplina de comunicación y expresión con todos los lenguajes; es de carácter teórico-práctico e integra distintos campos como la antropología, la semiología, la psicología y la pedagogía, con aplicaciones en la investigación, la educación y la terapia. Ha sido elaborada desde 1970 en Italia por Stefania Guerra Lisi y se enseña y aplica en muchos contextos científicos, pedagógicos y terapéuticos en distintos países. Su paradigma incluye valores, conceptos, principios, teorías y métodos articulados y entrelazados.The Globalism of Languages is a multidimensional discipline of communication and expression, related to anthropology, semiotics, psychology and pedagogy. In Italy, Stefania Guerra Lisi has been developed it since 1970. Its teaches and used to scientific, pedagogic and therapeutic contexts on different countries. Its paradigm includes values, concepts, principles, theories and methods articulated and intercrossed.Arnheim, Rudolf. 1969. Verso una psicologia dell ´arte, Torino, Einaudi.Bachelard, Gaston. 1973. La poetica della rêverie, Bari, Dedalo.Barthes, Roland. 1985. L´ovvio e l´ ottuso, Torino, Einaudi.Bateson, Gregory. 1984. Mente e natura, Adelphi, Milano.Bion, Wilfried R. 1972. Apprendere dall´esperienza, Roma, Armando.Dogana, Fernando. 1990. Le parole dell´incanto.Esplorazioni dell´iconismo linguistico, Milano, F. Angeli.Eco, Umberto. 1990. I limiti del l´interpretazione, Milano, Bompiani.Ehrenzweig, Anton. 1977. La psicoanalisi della percezione nella musica e nelle arti figurative, Roma, Astrolabio.Goethe Wilhelm, Friedrich. 1981. La teoria dei colori, Milano, Il Saggiatore.Gombrich E., Hochberg J., Black M. 1978. Arte percezione e realtà, Come pensiamo le immagini, Torino, Einaudi.Guerra Lisi, Stefania. 1980 Comunicazione ed espressione nella globalità dei linguaggi, Roma, Il Ventaglio.Guerra Lisi, 1983. Integrazione interdisciplinare dell ´handicappato, Roma, Il Pensiero Scientifico, (traducción al español: La integración interdisciplinar del deficiente, Barcelona, CEAC, 1988).Guerra Lisi, 1985. Il metodo della globalità dei linguaggi, Roma, Borla.Guerra Lisi, 1986. Come non spezzare il filo, Roma, Borla.Guerra Lisi, 1987. Psiche suono corpo-movimento musica-danza, Assisi, Edizioni Musicali PCC.Guerra Lisi, 1990. Ri-uscire, Roma, Borla.Guerra Lisi, 1992. Il racconto del corpo, Roma, Borla.Guerra Lisi, 1993. Continuità 1 e 2, Roma, Borla.Guerra Lisi, 1996. La trans-formazione possibile. Globalità dei Linguaggi e Analisi Transazionale, Pisa, Ediciones del Cerro.Guerra Lisi, 1996. Sinestesi Arti, Bologna, Fuori Thema.Guerra Lisi, 1997. Viaggio nel ritardo mentale, Pisa, Ediciones del Cerro.
Guerra Lisi, Stefania y Gino Stefani. 1997. Musicoterapia nella Globalità dei Linguaggi, Bologna, Fuori Thema.Guerra Lisi, Stefania y Gino Stefani. 1997. In principio era il corpo, Bologna, Fuori Thema.Guerra Lisi, Stefania y Gino Stefani. 1998. L´integrazione: nuovo modello di sviluppo, Roma, Borla.Guerra Lisi, Stefania y Gino Stefani. 1999. Gli Stili Prenatali nelle arti e nella vita, Bologna, CLUEB.Guerra Lisi, Stefania y Gino Stefani.2001. I Quattro Elementi nella Globalità dei Linguaggi, Roma, Borla.Johnson, Mark. 1987. The body in the mind, Chicago y Londres, The University of Chicago Press.Jousse, Marcel. 1979. L´antropologia del gesto, Roma, Edizioni Paoline.Jung, Carl. G. 1984. L´uomo e i suoi simboli, Torino, Einaudi.Kandinsky, Wassily. 1968. Punto, línea, superficie, Milano, Adelphi.Lakoff, George. 1994. Women, fire and dangerous things, Chicago y Londres, The University of Chicago Press.Lapierre, A. y R. Aucouturier. 1979 Simbología del movimiento, Cremona, Edipsicologiche.Leroi Gourhan, André. 1977 Il gesto e la parola, Torino, Einaudi.Marks, L. E. 1978. The unity of the sense: interrelations amongs the modalities, Nueva York, Academic Press.Montagu, Ashley. 1981 Il linguaggio della pelle, Milano, Mondadori.Rascovsky, Andrea. 1980. La vita psichica del feto, Milano, Il Formichiere.Reich, Wilhelm. 1978. Analisi del carattere, Milano, Sugar.Ruggieri, Vezio. 1997. L´esperienza estetica. Fondamenti psicofisiologici per un´educazione estetica, Roma, Armando.Stefani, Gino. 1967. L ´ espressione vocale e musicale nella liturgia, Torino-Leumann, LDC.Stefani, Gino. 1974. Musica barocca. Poetica e ideologia, Milano, Bompiani.Stefani, Gino. 1975. Musica e religione nell´Italia barocca, Palermo, Flaccovio.Stefani, Gino. 1976. Actes du 1er Congrès International de Sémiotique Musicale/Proceedings of the 1st International Congress on Semiotics of Music, Pesaro, Centro di Iniziativa Culturale.Stefani, Gino. 1976. Introduzione alla semiotica della musica, Palermo, Sellerio.Stefani, Gino. 1977. Insegnare la musica, Firenze, Guaraldi.Stefani, Gino. 1978. Capire la musica, Milano, L´Espresso Strumenti.Stefani, Gino. 1987. Il segno della musica, Palermo, Sellerio.Stefani, Gino. 1998. Musica: dall´esperienza alla teoria, Milano, Ricordi.Stefani, Gino. 1996. Intense Emozioni in Musica, Bologna, CLUEB.Stefani, Gino y Stefania Guerra Lisi (eds.). 1999. Sinestesia Arti Terapia, Bologna, CLUEB.Stefani, G., L Marconi, E. Tarasti (eds.). 1998. Musical Signification, between Rhetoric and Pragmatics / La significazione musicale, fra retorica e pragmatica, Bologna, CLUEB.Steiner, Rudolf. 1944. Introduzione alle opere scientifiche di Goethe, Milano, Bocca.Stern, Daniel N. 1991. Diario di un bambino. Da un mese a quattro anni, Milano, Mondadori.Winnicott, David W. 1974. Gioco e realt., Roma, Armando
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