170,370 research outputs found
BALB-neuT regenerated fibers have a better fitting than those of BALB/c in their uninjured predictive area.
No full text<p>Comparison of BALB-neuT with BALB/c uninjured fibers (A) and respective injured versus uninjured condition (B, BALB/c; C, BALB-neuT). Yellow fields correspond to the predictive area of reference condition (A-B, BALB/c uninjured; C, BALB-neuT uninjured) bounded by 95% prediction interval of regression line and ±2σ (2 standard deviations –95% of cases) of axon diameter. Percentages represent the fiber amount of considered group fitting the predictive area.</p
The number of Schwann cells is comparable between BALB/c and BALB-neuT mice.
No full text<p>A, histognams showing the number of Schwann cells counted at electron microscopy. B, C representative electron images of transverse sections of uninjured median nerves of BALB/c and BALB-neuT mice respectively. Magnification: 10000×.</p
Electron-nucleus scattering in the NEUT event generator
No full textThe NEUT event generator is a widely-used tool to simulate neutrino
interactions for energies between 10s of MeV and a few TeV. NEUT plays a
crucial role in neutrino oscillation analyses for the T2K and Hyper-K
experiments, providing the primary simulation of the neutrino interactions
whose final-state products are measured to infer the oscillation parameters.
NEUT is also capable of simulating nucleon decay and hadron scattering. These
proceedings present an expansion of NEUT to simulate electron scattering before
showing comparisons to experimental measurements and using discrepancies to
derive an empirical correction to NEUT's treatment of nuclear removal energy.Comment: 5 pages, 3 figures. NuFact2022 proceedings submissio
Picking up myelodysplastic syndromes and megaloblastic anemias on peripheral blood: Use of NEUT-X and NEUT-Y in guiding smear reviews
No full textPicking up myelodysplastic syndromes and megaloblastic anemias on peripheral blood: Use of NEUT-X and NEUT-Y in guiding smear review
Picking up myelodysplastic syndromes and megaloblastic anemias on peripheral blood: Use of NEUT-X and NEUT-Y in guiding smear reviews
No full textPicking up myelodysplastic syndromes and megaloblastic anemias on peripheral blood: Use of NEUT-X and NEUT-Y in guiding smear review
Curcumin enhances the antitumoral effect induced by the recombinant vaccinia Neu Vaccine (rV-neuT) in mice with transplanted salivary gland carcinoma cells
No full textThe survival rate for head and neck cancer patients has not substantially changed in the last two decades. We previously showed that two rV-neuT intratumoral injections induced an efficient antitumor response and rejection of transplanted Neu (rat ErbB2/neu oncogene-encoded protein)-overexpressing salivary gland tumor cells in BALB-neuT mice (BALB/c mice transgenic for the rat ErbB2/neu oncogene). However, reiterated poxviral vaccinations increase neutralizing antibodies to viral proteins in humans that prevent immune response against the recombinant antigen expressed by the virus. Curcumin (CUR) is a polyphenol with antineoplastic and immunomodulatory properties. The aim of this study was to employ CUR administration to boost the anti-Neu immune response and anticancer activity induced by one rV-neuT intratumoral vaccination in BALB-neuT mice. Here, we demonstrated that the combined rV-neuT+CUR treatment was more effective at reducing tumor growth and increasing mouse survival, anti-Neu humoral response, and IFN-γ/IL-2 T-cell release in vitro than the individual treatment. rV-neuT+CUR-treated mice showed an increased infiltration of CD4+/CD8+ T lymphocytes within the tumor as compared to those that received the individual treatment. Overall, CUR enhanced the antitumoral effect and immune response to Neu induced by the rV-neuT vaccine in mice. Thus, the combined treatment might represent a successful strategy to target ErbB2/Neu-overexpressing tumors
BALB-neuT mice express higher levels of ErbB2 protein in peripheral nerves.
No full text<p>A: Western blot analysis showing ErbB2 expression in mammary gland and in uninjured peripheral nerves. β-actin was used as a loading control. Mammary gland from BALB-neuT mice was used as positive control for ErbB2 overexpression. The ErbB2 level is higher in BALB-neuT mice compared to BALB/c mice. B–C.</p
The number of Schwann cells is higher in BALB-neuT mice after regeneration.
No full text<p>A, histognams showing the number of Schwann cells counted at electron microscopy. B, C representative electron images of transverse sections of regenerated median nerves of BALB/c and BALB-neuT mice respectively. Magnification: 10000×. Statistical significance: *p<0.05.</p
14 days after the injury, grasping strength is greater in BALB-neuT than in BALB/c mice.
No full text<p>Graph showing the performance of the mice in the grasping test after normalizing the recorded values with the animal body weights. Data are reported as means ± SEM (*BALB/c vs BALB-neuT; # regenerating vs pre-injury wild-type, p<0.05).</p
2 days after the crush injury, BALB-neuT mice express higher levels of ErbB2 protein.
No full text<p>Western blot analysis showing ErbB2 expression in crushed nerves 2-days after injury. β-actin was used as a loading control. The ErbB2 expression is higher in BALB-neuT mice compared to BALB/c mice.</p
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