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Fig. 2 in Diterpenoids from Zhumeria majdae roots as potential heat shock protein 90 (HSP90) modulators
No full textFig. 2. Comparison of experimental and in silico calculated ECD spectra of compounds 1–3 and 19 in MeOH.Published as part of Zadali, Reza, Nejad-Ebrahimi, Samad, Hadjiakhoondi, Abbas, Fiengo, Lorenzo, D'Ambola, Massimiliano, Vita, Simona De, Tofighi, Zahra, Chini, Maria Giovanna, Bifulco, Giuseppe & Tommasi, Nunziatina De, 2021, Diterpenoids from Zhumeria majdae roots as potential heat shock protein 90 (HSP90) modulators, pp. 1-8 in Phytochemistry (112685) 185 on page 3, DOI: 10.1016/j.phytochem.2021.112685, http://zenodo.org/record/825973
Fig. 3 in Diterpenoids from Zhumeria majdae roots as potential heat shock protein 90 (HSP90) modulators
No full textFig. 3. Effect of 20 on HSP90α client protein levels in MCF7 cells after treatment with 20 (18 μM) for 48 h. Equal amounts (30 μg) of total protein lysate were separated on SDS-PAGE and client proteins were visualized by Western Blot analysis. α-tubulin and GAPDH were used as loading controls. The blots are representative of three different experiments with similar results. Numbers above each lane represent the densitometric values.Published as part of Zadali, Reza, Nejad-Ebrahimi, Samad, Hadjiakhoondi, Abbas, Fiengo, Lorenzo, D'Ambola, Massimiliano, Vita, Simona De, Tofighi, Zahra, Chini, Maria Giovanna, Bifulco, Giuseppe & Tommasi, Nunziatina De, 2021, Diterpenoids from Zhumeria majdae roots as potential heat shock protein 90 (HSP90) modulators, pp. 1-8 in Phytochemistry (112685) 185 on page 5, DOI: 10.1016/j.phytochem.2021.112685, http://zenodo.org/record/825973
Fig. 4. Binding mode between 20 and the C in Diterpenoids from Zhumeria majdae roots as potential heat shock protein 90 (HSP90) modulators
No full textFig. 4. Binding mode between 20 and the C-terminal domain of HSP90. The two chains of the protein are colored differently (blue and red). The hydrogen bond is represented with a blue dotted line, the salt bridge with a pink dotted line, and interacting hydrophobic residues are labeled in black with the corresponding chain explicated. (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)Published as part of Zadali, Reza, Nejad-Ebrahimi, Samad, Hadjiakhoondi, Abbas, Fiengo, Lorenzo, D'Ambola, Massimiliano, Vita, Simona De, Tofighi, Zahra, Chini, Maria Giovanna, Bifulco, Giuseppe & Tommasi, Nunziatina De, 2021, Diterpenoids from Zhumeria majdae roots as potential heat shock protein 90 (HSP90) modulators, pp. 1-8 in Phytochemistry (112685) 185 on page 5, DOI: 10.1016/j.phytochem.2021.112685, http://zenodo.org/record/825973
Drug Affinity Responsive Target Stability (DARTS) Identifies Laurifolioside as a New Clathrin Heavy Chain Modulator
Get PDFFive new diterpenes (1-5) and a megastigmane derivative (6) were isolated from the aerial parts of Euphorbia laurifolia, along with several known compounds. Their structures were elucidated by NMR, MS, and ECD and by chemical methods. A chemical proteomics drug affinity responsive target stability (DARTS) approach to investigate the lathyrane diterpene 1, laurifolioside, on its putative cellular target(s) was performed. Clathrin heavy chain 1, a protein mainly involved in selective uptake of proteins, viruses, and other macromolecules at the plasma membrane of cells, was identified as the major interaction partner of compound 1. The modulation of clathrin activity by 1 was studied through microscopy, molecular docking, and molecular dynamics studies, suggesting a new activity of lathyrane diterpenes in the modulation of trafficking pathways
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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