2,635 research outputs found
Schmidt, Touch, Neitz, Neitz (2016). J Vis
No full textColor appearance, genetic and optical data. Notes: L cone sensitivities were based on the sequence of each subjects L pigment. Amino acids reported: exon 2—65, 111, 116; exon 3—153, 171, 174, 180; and exon 4—230, 233, 236. For females with two L sequences, the peak sensitivity of both pigments was averaged to compute the reported peak L cone sensitivity. All subjects had M cone peak values of 530 nm. All subjects identified as Caucasian except subjects U12 and U13, who were of Asian ethnicity.Data were published in the appendix of Schmidt, Touch, Neitz, Neitz (2016). "Circuitry to explain how the relative number of L and M cones shapes color experience." They published here for easier access.</div
Representation of color in the human retina
No full textThesis (Ph.D.)--University of Washington, 2015-12Preceding the development of modern biological techniques, psychophysical experimentation and careful reasoning alone yielded an accurate account of human color perception predicated upon three opponent processes: blue versus yellow, red versus green and white versus black (Hurvich and Jameson, 1957). That is, when one of the opponent pairs, say blue, is perceived the other, yellow, is necessarily absent. The discovery, nearly five decades ago, by De Valois, Abramov and Jacobs of neurons early in the visual pathway with spectral characteristics similar to the theorized opponent interactions provided a plausible neurobiological substrate for hue perception (De Valois et al., 1966). In the decades since De Valois and colleagues published their seminal findings (De Valois et al., 1966), discrepancies between the properties of the lateral geniculate nucleus (LGN) cells reported and behavioral evidence have weakened the interpretation that these early visual cells directly map to human color perception (Stockman and Brainard, 2010). In particular, the contribution of S-cones to each opponent system has continued to be the subject of considerable experimental attention (Neitz and Neitz, 2011; Solomon and Lennie, 2007). On the basis of these discrepancies, De Valois and De Valois proposed a cortical transformation of LGN signals amounting to a rotation of the color axes (De Valois and De Valois, 1993). In light of evolutionary constraints and evidence from the genetic introduction of a third class of cones to a dichromatic retina (Mancuso et al., 2009), a simplied version of the De Valois model has been proposed (Neitz and Neitz, 2011; Mancuso et al., 2010; Schmidt et al., 2014). This model posits that the spectral opponency necessary to account for hue perception is already present in a subset of midget ganglion cells. Early reports from de Monasterio et al. (1975; 1978) described such retinal cells, with more recent support from a large sample of LGN neurons taken by Tailby et al. (2008). The goal of the research presented here was to directly test the hypothesis that hue perception is mediated by a small subset of midget ganglion cells that receive S-cone input via H2 horizontal cells
Author Under Sail The Imagination of Jack London, 1893-1902
No full textIn Author Under Sail, Jay Williams offers the first complete literary biography of Jack London as a professional writer engaged in the labor of writing. It examines the authorial imagination in London's work, the use of imagination in both his fiction and nonfiction, and the ways he defined imagination in the creative process in his business dealings with his publishers, editors, and agents. In this first volume of a two-volume biography, Williams traverses the years 1893 to 1902, from London's "Story of a Typhoon" to The People of the Abyss. The Jack London who emerges in the pages of Author Under Sail is a writer whose partnership with publishers, most notably his productive alliance with George Brett of Macmillan, was one of the most formative in American literary history. London pioneered many author models during the heyday of realism and naturalism, blurring the boundaries of these popular genres by focusing on absorption and theatricality and the representation of the seen and unseen. London created an impassioned, sincere, and extremely personal realism unlike that of other American writers of the time. Author Under Sail is a literary tour de force that reveals the full range of London as writer, creative citizen, and entrepreneur at the same time it sheds light on the maverick side of machine-age literature.Intro -- Title Page -- Copyright Page -- Dedication -- Contents -- Acknowledgments -- Introduction -- 1. Spirit Truth -- 2. From Absorption to Theatricality and Back Again -- 3. "I Will Build a New Present" -- 4. Sons as Authors -- 5. Fathers as Publishers -- 6. The Daughter as Author -- 7. Lovers as Authors -- 8. At Sea with the Family -- 9. Yellow News, Yellow Stories -- 10. The Return Home -- Notes -- Bibliography -- Index -- About Jay WilliamsIn Author Under Sail, Jay Williams offers the first complete literary biography of Jack London as a professional writer engaged in the labor of writing. It examines the authorial imagination in London's work, the use of imagination in both his fiction and nonfiction, and the ways he defined imagination in the creative process in his business dealings with his publishers, editors, and agents. In this first volume of a two-volume biography, Williams traverses the years 1893 to 1902, from London's "Story of a Typhoon" to The People of the Abyss. The Jack London who emerges in the pages of Author Under Sail is a writer whose partnership with publishers, most notably his productive alliance with George Brett of Macmillan, was one of the most formative in American literary history. London pioneered many author models during the heyday of realism and naturalism, blurring the boundaries of these popular genres by focusing on absorption and theatricality and the representation of the seen and unseen. London created an impassioned, sincere, and extremely personal realism unlike that of other American writers of the time. Author Under Sail is a literary tour de force that reveals the full range of London as writer, creative citizen, and entrepreneur at the same time it sheds light on the maverick side of machine-age literature.Description based on publisher supplied metadata and other sources.Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, YYYY. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries
Author Under Sail The Imagination of Jack London, 1902-1907
No full textIn this second volume of Author Under Sail Jay Williams investigates the life of Jack London as a professional writer at the turn of the 1900s, as his publications spanned The Call of the Wild to The Iron Heel and The Road. While documenting key life events, especially his rising fame, this biography explores London's necessity to illustrate the inner workings of his own vast imagination through his socialist essays and fiction.Cover -- Title Page -- Copyright Page -- Contents -- Acknowledgments -- Introduction -- 1. Howl, O Heav'nly Muse! -- 2. Jesus in the Theater of Socialism -- 3. Jack London's Place in American Literature -- 4. Theater of War, Theater at Home -- 5. Revolution, Evolution, and the Scene of Writing -- 6. The Jack London Show Goes on the Road -- 7. Red Atavisms and Revolution -- 8. Earthquake Apocalypse and Building the City, Boat, and House Beautiful -- 9. The Future of Socialism and the Death of the Individual -- 10. The Road Never Ends -- Notes -- Bibliography -- IndexIn this second volume of Author Under Sail Jay Williams investigates the life of Jack London as a professional writer at the turn of the 1900s, as his publications spanned The Call of the Wild to The Iron Heel and The Road. While documenting key life events, especially his rising fame, this biography explores London's necessity to illustrate the inner workings of his own vast imagination through his socialist essays and fiction.Description based on publisher supplied metadata and other sources.Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, YYYY. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries
Writers Talk Featuring Jay Douglas
No full textJay Douglas, author of Everything You Need to Write Great Essays, You Can Learn from Watching Movies, talks about how essays can be written like Hollywood cinema.The media can be accessed here: http://streaming.osu.edu/knowledgebank/cstw12/WT_WCRS_08-27-11_JayDouglas.mp3Ohio State University. Center for the Study and Teaching of Writin
"Overcoming America's Infrastructure Deficit, A Fiscally Responsible Plan for Public Capital Investment"
No full textCondemned bridges, dilapidated school buildings, contaminated water supplies, and other infrastructure shortcomings threaten American growth, productivity, and prosperity. S Jay Levy and Walter M. Cadette propose a plan for financing infrastructure projects that is designed to have minimal effect on the federal budget and to promote sound fiscal operation. Federal zero-interest mortgage loans to state and local governments for capital projects specified by Congress can cut the cost of such projects, achieve needed improvements in the nation's infrastructure, and thereby contribute to the American economy's future.
Psychedelics, psychic phenomena, and encounters with non-human entities
No full textLeading minds discuss psychedelics, shamanism, human evolution, and the ecological crisis. In a series of conversations with Duncan Trussell, Graham Hancock, Grant Morrison, Hamilton Morris, Erik Davis, Julia Mossbridge, Rupert Sheldrake, and others, author David Jay Brown elicits answers to some of the most thought-provoking questions about our origins, ecological consciousness, the potential of psychedelics, and the future of humanity and the Earth
Jay Sarno Roundtable
No full textAudio of the 3/2/2014 UNLV Libraries Jay Sarno Roundtable. Jay Sarno did more than build two of the most iconic casinos in the world, Caesars Palace and Circus Circus. He created the mold for modern Las Vegas. In this panel discussion, those who knew him best will talk about his contributions and his quirks. Panelists include: Oscar Goodman, Mel Larson, Dana Gentry, Jay C. Sarno, September Sarno, Freddie Sarno, and Heidi Sarno Straus. The panel is moderated by CGR Director and Grandissimo author David G. Schwartz
Map of Jay County, Indiana
No full text17 1/4 x 14 1/4 inchesJay County was organized in 1836 and is the only county in the United States named for John Jay, the first Chief Justice of the United States Supreme Court. He was also a co-author of the Federalist Papers and a governor of New York
Spectral tuning of ultraviolet cone pigments: An interhelical lock mechanism
No full textUltraviolet (UV) cone pigments can provide insights into the molecular evolution of vertebrate vision since they are nearer to ancestral pigments than the dim-light rod photoreceptor rhodopsin. While visible-absorbing pigments contain an 11-cis retinyl chromophore with a protonated Schiff-base (PSB11), UV pigments uniquely contain an unprotonated Schiff-base (USB11). Upon F86Y mutation in model UV pigments, both the USB11 and PSB11 forms of the chromophore are found to coexist at physiological pH. The origin of this intriguing equilibrium remains to be understood at the molecular level. Here, we address this phenomenon and the role of the USB11 environment in spectral tuning by combining mutagenesis studies with spectroscopic (UV-vis) and theoretical [DFT-QM/MM (SORCI+Q//B3LYP/6-31G(d): Amber96)] analysis. We compare structural models of the wild-type (WT), F86Y, S90A and S90C mutants of Siberian hamster ultraviolet (SHUV) cone pigment to explore structural rearrangements that stabilize USB11 over PSB11. We find that the PSB11 forms upon F86Y mutation and is stabilized by an "inter-helical lock" (IHL) established by hydrogen-bonding networks between transmembrane (TM) helices TM6, TM2, and TM3 (including water w2c and amino acid residues Y265, F86Y, G117, S118, A114, and E113). The findings implicate the involvement of the IHL in constraining the displacement of TM6, an essential component of the activation of rhodopsin, in the spectral tuning of UV pigments. © 2013 American Chemical Society
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