69 research outputs found
Effect of lumbar-pelvic control on functionality in children with spastic cerebral palsy
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Effect of lumbar-pelvic control on functionality in children with spastic cerebral palsy
No full textLack of pelvic control is a common functional impairment in children with spastic cerebral palsy (CP), so pelvic stability may be critical to improvecontrolled movements and activities in these children.The aim of this randomized controlled trialwas to evaluate the effect of physical therapy programs combined with pelvic control exercises on controlled hip, knee, and ankle movements and gross motor functions in children with spastic CP. Thirty-two children diagnosed with spastic cerebral palsy at levels II and III on the gross motor functional classification system participated in this study. Theywere randomly and equally divided by a computerized program into control and study groups. The control group (eight boys and eight girls) received the designed therapy program for one hour. The study group (four boys and twelve girls) received lumbar-pelvic control exercises for 20 minutes in addition to 40 minutes of a physical therapy program. The program for both groups was applied three times per week for twelve weeks. After twelve weeks of treatment, the controlled movement, functional ability plus a joint range of motion of the hip, knee, and ankle were assessed by selective motor control scale, Peabody scales, and Kinovia software program, respectively.All statistical measures were performed through the Statistical Package for Social Studies (SPSS) version 20 for windows (SPSS, Inc., Chicago, IL). The results of our studyshowed a statistically significant improvement in median selective motor control, the Z score of Peabody scale, and the mean angle of hip, knee, and ankle range of motion after the treatment program in the study group compared with the control group (p < 0.05).Lumbar-pelvic control exercises are useful in improving the controlled movement and functional abilities in children with spastic diplegiaCP when combined with a physical therapy program
Muhammed El-Kefevî ve Hâşiye Ala Şerhi’l-İstiâre isimli eserinin tahkiki / حاشية الكفوي على استعارة العصام
No full textÖZETBu çalışma kültürü ihya etme, el yazması bir eseri karanlıktan aydınlığa çıkartma ve kütüphane raflarından okuyucunun hizmetine sunma amacı gütmektedir. Bu yüzden, Osmanlı âlimlerinden çok değerli bir âlimin bir kitabını tahkik etmeye karar verdik. Bu âlim, Akkirmanî olarak tanınan Muhammed b. Mustafa Hamid el-Kefevî el-Hanefî’dir. Bu âlimin, beyan ilmiyle ilgili Hâşiye Alâ Şerhi İsam alâ Risâleti’l-İstiâre li’s-Semerkandi eseri tahkik çalışmamızın konusunu oluşturmaktadır.İlgili eserin, üçü Süleymaniye Kütüphanesi, biri de Suudi Arabistan’daki Kral Suud Üniversitesinde olmak üzere dört nüshasını karşılaştırdım.Çalışma bir giriş ve beş bölümden oluşmaktadır:Giriş: Bu çalışmanın özet ve çevirisinden bahsedilmiş, daha sonra önsöz, sembol ve işaretleri ele alınmıştır.Metin sahibi Ebü’l-Kāsım b. Ebî Bekr el-Leysî es-Semerkandî ve şerhi yapan Ebû İshâk İsâmüddîn İbrâhîm b. Muhammed b. Arabşâh el-İsferâyîn tanıtılmıştır. bunun akabinde Hâşiye’nin sahibi el-Kefevî’nin hayatı detaylı bir şekilde ele alınmıştır.İkinci Bölüm: Eser tanıtılmıştır (adı, telif nedeni, nüshalar arasındaki farklar, içeriği, müellifin bilgileri işleme yöntemi, son olarak ta Haşiye’de Kefevî’nin yararlandığı kaynaklar).Üçüncü Bölüm: Tahkik esnasında izlenen yöntem açıklanmıştır. El yazması eserin dört nüshasından örnek ve resimler eklenmiştir.Dördüncü Bölüm: Bu bölümde Semerkandi’nin İstiâre ile ilgili metni yer almaktadır.Beşinci Bölüm: Bu bölümde Hâşiye’nin tahkiki, ayet ve hadislerin tahrici, eserde geçen şiirleri sahiplerine isnat etme, kapalı ve anlaşılması güç sözcükleri açıklama, ilgili eserde adı geçen kişilerin tanıtımı, mesel ve veciz sözlerin açıklanması, nüshaların karşılaştırılması yer almaktadır. El yazmanın kenarlarında geçen yorumları dipnotlara aldım. İsâmüddîn’ın sözlerini el-Kefevî’nin sözlerinden ayırdım. Bu bölümün sonunda da kaynaklar ve ndeksini zikrettim. İÇİNDEKİLERIÖZETIIIAbstractIVGİRİŞ- 1 -ÖZET(ARAPÇA)- 1 -ÖNSÖZ- 2 -KISALTMALAR DİZİNİ- 4 - Semerkandî ’nin ANLATIMI- 5 -Şerh Sahibi İsameddin el-İsferâyînî Anlatımı- 7 - KEFEVİ’nin Anlatımı- 10 -YETİŞTİĞİ YER- 10 -KIRIM’IN TARİHİ- 10 -AKKIRMAN ŞEHRİNİ TARİHİ- 11 -KIRIM ALİMLERİNDEN BAZILARI- 13 -İSMİ VE LAKABI- 15 -DOĞDUĞU VE AİT OLDUĞU YER- 15 -HAYATI VE GÖREVLERİ- 16 -Şahsiyeti- 17 -Düşüncesi VE MEZHEBİ- 17 -İLMİ ÇALIŞMALARI- 18 -ESERLERİ........................................................................................................................- 19 -EL YAZMA ESERLERİ- 19 -BASILMIŞ ESERLERİ- 22 -İKİNCİ BÖLÜM KİTABIN TANITIMI- 24 -KİTABIN İSMİ TELİF NEDENİ VE TARİHİ- 24 -Kitabın İçeriği- 25 -Kitabın Kaynakları- 26 -FAYDALANDIĞI KAYNAKLAR- 28 -KİTABIN BELAGAT İLMİNDEKİ YERİ- 34 -KİTABIN NÜSHALARI- 35 -ÜÇÜNCÜ BÖLÜM Tahkikin Yöntemi ve Metodolojisi- 38 -DÖRDÜNCÜ BÖLÜM SEMERKANDİ’NİN İSTİARE METNİ- 43 -TAHKİK’İN SONUÇ- 47 -BEŞİNCİ BÖLÜM- 47 -KEFEVİ ’NİN HAŞİYESİ- 47 -KEFEVİ’NİN ÖNSÖZÜ- 48 -İSAMUDDİN’İN ÖNSÖZÜNE KEFEVİ’NİN HAŞİYESİ - 50 -MECAZ TÜRÜNDE BİRİCİ IKID- 62 -Birinci Feride mecaz müfredin anlatımı ve mecaz Mürsel ve istia’reye ayrımı- 64 -İkinci Feride istia’renin asliyye ve tebaiyye ye ayrımı- 73 -Nisbeye göre fiilde istia’re - 79 -Istia’renin harflerde gerçekleşmesi- 85 -Üçüncü Feride istia’renin tahkikiyye ve tahyiyliyye ayrılmasI- 88 -Dördüncü Feride istia’renin Mutlaka Müreşşaha ve Mücerrede ye ayrılması - 89 -Beşinci Feride- 96 -Altıncı Feride: Mecaz Murekkeb- 99 - İkinci İkid:istia’re bil kinaye nin tahkiki- 111 -İkinci Feride: Sekaki mezhebinde istia’re Mekniye - 123 -Üçüncü Feride: El Hatip mezhebinde istia’re Mekniye - 128 -Isamuddin ve istia’re Mekniye- 131 -Dördüncü Feride - 132 -Birinci Feride Önceki alimlerin istia’re Tayiliyye ile ilgili Mezhepleri- 135 -İkinci Feride: Zamahşeri ve karine i Mekniye - 137 -Üçüncü Feride: Essekaki ve karine i Mekniye....................................................................-139-Dördüncü Feride: SEMERKANDİ ve Karine Mekniye ile ilgili seçimleri- 141 -Beşinci Feride; Terşhlerle alakalı- 143 -Kaynak ve referanslar- 146 -AbstractThis research falls under the scope of knowledge revival, which aims at bringing it out of the darkness and back into the light, and out of library shelves and back into the hands of the readers. For this reason, we chose to investigate a book of one of the leading scholars of the High Ottoman Empire that is Imam Muhammed Bin Mustafa Hamid, Al-Kafawyi, Al-Hanafi, known as Al-Akramany. For this research, we choose to investigate – and one's choice reflects their thinking – his Footnotes on Al-Essam's Explanation of the Manuscript of Samarqandiyyeh which falls under the Science of Rhetoric. Our investigation includes the following:- I compared and contrasted four copies of this work. Three of which were available in the Sulaymaniyyeh Library, and one in King Saud University, KSA.This research is divided into an introduction and seven chapters:Introduction: discusses the abstract of this research with its translation, introduces this work, and explains the terms and symbols used in it.Chapter 1: provides biographies of the author of the original book, Al-Samarqandiy, the author of its explanation, Al-Essam, and a detailed biography of Al-Kafawyi, author of the footnotes. Chapter 2: this division introduces the book: its name, reason of its composition, the difference between its copies, its content, its method of discussing information, and finally, the references which Al-Kafawyi used in writing the Footnotes. Chapter 3: introduces the research methods adopted in this investigation, and provides models and images of the manuscript in its four copies. Chapter 4: contains the text of Samarqandiyyeh In Metaphor.Chapter 5: Contains investigation of the Footnotes, and refers to the Quran verses and Hadiths as mentioned in their original scripts.s Moreover, this chapter refers to the authors of poetry lines mentioned, explains obscure vocabulary and terms, provides biographical information about some of the leading figures mentioned, explains proverbs and sayings of wisdom mentioned, compares and contrasts the four copies, and refers to the differences among them. In this chapter, the comments mentioned in the margins of the manuscripts are provided, and we clarified which are the words of Al-Kafawyi and which of Al-Essam. Finally, this chapter is followed by a list of references, and a list of conten
Cytotoxicity by endocrine disruptors through effects on ER Ca 2+ transporters, aberrations in Ca 2+ signalling pathways and ER stress
No full text© 2024 The Author(s). FEBS Open Bio published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies.Concerns regarding man‐made organic chemicals pervading our ecosystem and having adverse and detrimental effects upon organisms, including man, have now been studied for several decades. Since the 1970s, some environmental pollutants were identified as having endocrine disrupting affects. These endocrine disrupting chemicals (EDC) were initially shown to have estrogenic or anti‐estrogenic properties and some were also shown to bind to a variety of hormone receptors. However, since the 1990s it has also been identified that many of these EDC additionally, have the ability of causing abnormal alterations in Ca2+ signalling pathways (also commonly involved in hormone signalling), leading to exaggerated elevations in cytosolic [Ca2+] levels, that is known to cause activation of a number of cell death pathways. The major emphasis of this review is to present a personal perspective of the evidence for some types of EDC, specifically alkylphenols and brominated flame retardants (BFRs), causing direct effects on Ca2+ transporters (mainly the SERCA Ca2+ ATPases), culminating in acute cytotoxicity and cell death. Evidence is also presented to indicate that this Ca2+ATPase inhibition, which leads to abnormally elevated cytosolic [Ca2+], as well as a decreased luminal ER [Ca2+], which triggers the ER stress response, are both involved in acute cytotoxicity.Unfunde
Impacts of Heat Stress on Some Performance Parameters of Broiler Chicken Reared Under Different Stocking Densities
No full textThe current study was designed to investigate the impacts of heat stress (HS) on performance parameters of broiler chicken reared at different stocking densities, also study assessed the effects of anti-stress (vitamin) supplementation in the mitigation of different levels of stress. A total of 720 7th-day-old Cobb ® chicks were randomly distributed into 18 groups, (two replicates within each group). The experiment with a factorial arrangement of treatments (3x3x2), 3 levels of stocking densities (RSD: 10 chicks/m2, MSD: 14 chicks/m2, and HSD: 18 chicks/m2), 2 levels of vitamin supplementation (0 mg/l and combination of 250 mg/l ascorbic acid plus 0.5 ml/l Vit E + Se) and three temperatures (Thermoneutral temperature (TN), sudden chronic heat stress exposure (CHS) and gradual chronic heat stress exposure). Broilers were kept either under thermoneutral conditions (24 ± 1 ºC) during the whole life period or slowly introduced to CHS from 7th to 21st d of age and kept at high temperature thereafter and the third chamber had chicks that were exposed to CHS (32 ± 2 ºC for 8 h/day) during the period from 21st: 42nd day of age. Chicks were reared on a deep litter system and had free access to feed and water. Performance parameters (FI, BW, BWG, and FCR) were determined on the 42nd day of age. The results showed HSD had adverse effects on the growth performance of broilers reared under thermoneutral or CHS conditions where the differences between densities were significant (P<0.05) under TN and sudden CHS conditions and insignificant in case of gradual CHS exposure conditions for most of the performance parameters. Vitamins supplementation had improved growth performance (BW and FCR) of broilers kept under MSD or HSD and exposed to thermoneutral or sudden CHS conditions as compared to corresponding not supplemented birds. While it was effective in combating the adverse effects of gradual HS exposure in RSD and MSD kept broilers only. In addition, there was no significant difference between RSD not supplemented broilers and MSD-supplemented birds under TN conditions; concluding that broilers can be stocked at MSD under thermoneutral conditions if they were supplemented with vitamins.
 
Prevalence and correlates of complementary and alternative medicine use among diabetic patients in Beirut, Lebanon: A cross-sectional study
No full textBackground: Patients with Type 2 Diabetes Mellitus (T2DM) are increasingly using complementary and alternative medicine (CAM) therapies due to difficulty in adhering to the therapeutic regimens and lifestyle changes necessary for disease management. Little is known about the prevalence and mode of CAM use among patients with T2DM in Lebanon.Objective: To assess the prevalence and modes of CAM use among patients with T2DM residing in Beirut, Lebanon.Methods: A cross-sectional survey of T2DM patients was conducted on patients recruited from two major referral centers in Beirut- a public hospital and a private academic medical center. In a face-to-face interview, participants completed a questionnaire comprised of three sections: socio-demographic, diabetes characteristics and types and modes of CAM use. Descriptive statistics, univariate and multivariate logistic regression analyses were utilized to assess the prevalence and correlates of CAM use, as well as whether the use was complementary or alternative to mainstream medicine. The main outcome in this study, CAM use, was defined as using CAM at least once since diagnosis with T2DM.Results: A total of 333 T2DM patients completed the survey (response rate: 94.6percent). Prevalence of CAM use since diagnosis with the disease was 38percent. After adjustment, CAM use was significantly associated with a married status, a longer duration of T2DM, the presence of disease complications, and a positive family history of the disease. Folk foods and herbs were the most commonly used CAM followed by natural health products. One in five patients used CAM as alternative to conventional treatment. Only 7percent of CAM users disclosed the CAM use to their treating physician. Health care practitioners were the least cited (7percent) as influencing the choice of CAM among users.Conclusion: The use of CAM therapies among T2DM patients in Lebanon is prevalent. Decision makers and care providers must fully understand the potential risks and benefits of CAM therapies to appropriately advise their patients. 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A Novel Autosomal Recessive, Progeroid Syndrome with Short Stature, Mandibular Hypoplasia, Osteoporosis and Short Eyebrows Due to a Homozygous Mutation in PRRT3
No full textA homozygous p.Glu394Lys mutation in PRRT3 causes a novel autosomal recessive, progeroid syndrome with short stature, mandibular hypoplasia, osteoporosis, short eyebrows and mild GH deficiency.This submission meets the Extended Data Sets and Supplemental Materials requirements that are included in author guidelines for Journal of Clinical Endocrinology and Metabolism (Print ISSN 0021-972X, Online ISSN 1945-7197).CONTEXT: Despite considerable progress in elucidating the molecular basis of various progeroid syndromes, some rare patients remain unexplained.
OBJECTIVE: To elucidate molecular genetic basis of a novel autosomal recessive progeroid syndrome.
PARTICIPANTS: A 21-year-old male and his 17-year-old sister with short stature, mandibular hypoplasia, pointed nose, shrill voice, severe osteoporosis, and short eyebrows; and their unaffected siblings and parents belonging to a consanguineous Arab family.
RESULTS: Using exome and Sanger sequencing, we report a novel homozygous p.Glu394Lys disease-causing mutation in proline rich transmembrane protein 3 (PRRT3). PRRT3 belongs to the family of proline-rich proteins containing several repeats of a short proline-rich sequence but its function remains to be determined. Preliminary observations showing co-localization of Prrt3 and synaptophysin support its role in vesicle exocytosis. Consistent with the highest mRNA expression of PRRT3 in the pituitary, both the patients had mild growth hormone deficiency but had near normal reproductive development.
CONCLUSIONS: We conclude that the homozygous p.Glu394Lys mutation in PRRT3 causes a novel autosomal recessive, progeroid syndrome with short stature, mandibular hypoplasia, osteoporosis, short eyebrows and mild GH deficiency. Our findings extend the spectrum of progeroid syndromes and elucidate important functions of PRRT3 in human biology including secretion of growth hormone from the pituitary
Tidal peritoneal dialysis versus ultrafiltration in type 1 cardiorenal syndrome: A prospective randomized study
No full textMeasurement of exclusive Upsilon photoproduction from protons in pPb collisions at root s(NN) = 5.02 TeV (vol 79, 277, 2019)
No full textIn this article the author name Luigi Calligaris was incorrectly written as A. Calligaris. The original article has been corrected
Erratum to: Measurement of exclusive Υ photoproduction from protons in pPb collisions at s NN = 5.02 TeV (The European Physical Journal C, (2019), 79, 3, (277), 10.1140/epjc/s10052-019-6774-8)
No full textIn this article the author name Luigi Calligaris was incorrectly written as A. Calligaris. The original article has been corrected. © CERN for the benefit of the CMS collaboration 2022
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