2,238 research outputs found
Progesterone receptor targets play critical roles in maintaining pregnancy and disease prevention
No full textThe ovarian hormone progesterone influences many facets of uterine physiology through the transcriptional activity of progesterone receptor (PR). This body of work investigates the role of progesterone receptor targets heart and neural crest derivatives expressed 2 (HAND2) and insulin receptor substrate 2 (IRS2) in regulating uterine functions. Our lab has previously shown that the PR target HAND2 is a negative regulator of uterine epithelial proliferation and is hypermethylated and silenced in uteri from women diagnosed with endometrial hyperplasia and cancer. The study presented in chapter 2 demonstrates that exposure to the environmental toxicant bisphenol-A (BPA) causes increased methylation at the Hand2 promoter and reduced HAND2 expression. BPA also stimulated expression of fibroblast growth factors (FGF), stromal derived factors that drive uterine epithelial proliferation. Increased expression of the pro-proliferative FGFs coupled with decreased expression of the anti-proliferative HAND2 led to aberrant epithelial proliferation. This is notable in the uterine glands, the site of origin for endometrial hyperplasia and cancer, suggesting that environmental BPA exposure poses as a risk factor for these uterine conditions.
We recently identified IRS2 as a direct target of PR in human endometrial stromal cells. IRS2 serves as an adaptor molecule for insulin and IGF1 receptors (IR and IGF1R, respectively). The study presented in chapter 3 explores the function of IRS2 during stromal differentiation. We find that IRS2, acting downstream of IR, is critical for inducing the expression of decidual markers and the changes in cell morphology characteristic of stromal differentiation. We also show that IRS2 promotes expression and membrane localization of glucose transporters (GLUT), allowing for increased glucose movement into the cell to meet the metabolic demands of differentiation. This work provides insight into the metabolic shifts in differentiating stromal cells and the hormone regulated factors that mediate it. These findings may also shed light on the mechanisms underlying the infertility associated with conditions presenting with peripheral insulin resistance, such as polycystic ovarian syndrome.Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2021-08-01The student, Alison Neff, accepted the attached license on 2019-07-02 at 14:29.The student, Alison Neff, submitted this Dissertation for approval on 2019-07-02 at 14:57.This Dissertation was approved for publication on 2019-07-05 at 15:14.DSpace SAF Submission Ingestion Package generated from Vireo submission #14134 on 2019-11-26 at 14:00:48Made available in DSpace on 2019-11-26T20:58:36Z (GMT). No. of bitstreams: 5
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Previous issue date: 2019-07-05Embargo set by: Seth Robbins for item 113038
Lift date: 2021-11-26T20:58:44Z
Reason: Author requested closed access (OA after 2yrs) in Vireo ETD systemEmbargo set by: Seth Robbins for item 113038
Lift date: 2021-11-26T20:59:54Z
Reason: Author requested closed access (OA after 2yrs) in Vireo ETD systemLimited Restriction Lifted for Item 113038 on 2021-11-27T10:15:34Z
Repositioning the graphic designer as researcher
No full textIn academic terms, the discipline of graphic design is relatively young. Consequently the position of the discipline within academic territory, and the role of the designer, continue to be debated. In part, these debates have been a product of attempts to define and defend the discipline’s borders from within, in order to establish a sense of the role of graphic design and the graphic designer as commensurate with other disciplines both within and beyond art and design. In recent years graphic designers have variously been defined as ‘authors’, ‘producers’ and ‘readers’, yet none of these definitions seem to have provided any kind of productive or lasting impact within the academy. This paper suggests that rather than continue to seek territorial definitions and positions from within, it could be more productive to look beyond the confines of the discipline. Gaining a broader, interdisciplinary perspective on, and understanding of, qualitative research methods from other disciplines may enable the graphic designer to more fully position his or her practice within the wider academy. Such a perspective could help facilitate the repositioning and redefinition of the graphic designer as ‘researcher’ - a move that would be productive in relation to the future development of postgraduate research within the discipline
Interview with Alison Frank, September 25, 2009
No full textInterview Themes: How Frank chooses research topics (00:50)
Aspects of her training as a historian Frank found useful (07:00)
Books that have inspired and informed Frank's work (11:11)
On the role of area studies for scholarship on East-Central Europe (14:00)
"Internationalizing" the history of East-Central Europe (19:30)
Advice to young historians/scholars working on the region (22:11)Interview with Alison Frank, John L. Loeb Associate Professor of the Social Sciences at Harvard University. Interview conducted in Ithaca, NY on September 25, 2009. Professor Frank is the author of a number of articles and an excellent book on the oil industry in the Habsburg Monarchy entitled Oil Empire: Visions of Prosperity in Austrian Galicia. She is now working on a project on the coastline of Austria-Hungary.1_9lz5ekh
Veteran Law Students: Institutional Initiatives To Transform Their Law School Experiences
No full textPeer reviewe
Introduction: The Politics of Resilience and Recovery in Mental Health Care
No full textThe articles included in this special issue engage these themes across a number of national settings, institutional spaces, and empirical sites, from universities to mental health commissions, to national policy in an international context. They focus, especially, on Canada, Ireland and the United Kingdom, where recent and significant changes in mental health governance have relied heavily on the notions of recovery and resilience, often to questionable effect. They deal, as we have said, with some of the most central themes in social justice studies. As a collection, the articles help us think through some of the pressing political questions about social justice that have arisen with the adoption of the mantras of resilience and recovery in mental health governance
Negotiating the Culture of Resistance: A Critical Assessment of Protest Politics
No full textBoth for those within the movement and the public at large, the anti-globalization movement has become increasingly defined by large-scale protests such as those opposing the Free Trade Area of the Americas (FTAA) in Quebec City. Such events successfully render visible the strength of the movement, expose an emerging global elite, politicize neoliberal restructuring, and capture the media and public's attention. Yet the privileging of large-scale protest for advancing anti-globalist politics is increasingly being questioned both by those involved in the movement and by the Left in general.Peer reviewe
Supplemental Material - Storage Practices, Devices, and Presence of Children Among Owners of Firearms: Informing Pediatric Firearm Safety
No full textSupplemental Material for Storage Practices, Devices, and Presence of Children Among Owners of Firearms: Informing Pediatric Firearm Safety by Michaela Gaffley, Jessica L. Rauh, Alison Gardner, Rebecca Palmer, Cara Haberman, John K. Petty, and Lucas P. Neff in The American Surgeon</p
Portrait of Alison Dolling, author and historian, Adelaide, 1978 [picture] /
No full textTitle devised by cataloguer from accompanying information.; "Dolling, Alison. Writes under Mary Broughton, Hazel de Berg collection. From Adelaide Festival, South Australia"--Compactus card.; Condition: Scratched.; Also available in an electronic version via the Internet at: http://nla.gov.au/nla.pic-vn4764650; Conversation with Alison Dolling (Mary Broughton); located at; National Library of Australia Oral History collection ORAL TRC1/1067
Podcast: Alison Whittaker’s process
No full text“The logics of law and poetry boil meaning and power down to their barest components.”We’re delighted to be able to bring you an interview with Alison Whittaker, a Gomeroi poet and author of the collections Lemons in the Chicken Wire and Blakwork, shortlisted in the Prime Minister’s Literary Award for Poetry 2019
SuperQueero: Alison Bechdel
No full textThis podcast is a biography of Alison Bechdel, an American author and cartoonist, known for her comic titled Dykes to Watch Out For. In 2006, Bechdel released her critically acclaimed graphic memoir Fun Home that discussed her childhood, coming out as a lesbian, and the death of her closeted father who committed suicide.https://source.sheridancollege.ca/swfhass_projects_superqueero_podcast/1003/thumbnail.jp
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