803 research outputs found
El Tlacuache Núm. 672 (2015). 672 Año 13 (2015) mayo. El Tlacuache
No full text¿Quién descubrió Chalcatzingo? por Mtro. Pavel Carlos Leiva García. - Las primeras fotografías de Xochicalco por Claudia I. Alvarado León
Pavel Rennenkampf: Unnoticed Decembrist Conspirator
No full textThis article addresses the misidentification of Colonel Pavel Rennenkampf, a member of the Southern Decembrist conspiracy and a colonel in the General Staff (1790-1857), by historians. Through the examination of investigative materials, police reports, official correspondence, and memoirs, the author aims to establish the documentary evidence supporting Pavel Rennenkampf’s involvement in the Decembrist movement. It is concluded that this officer played a significant role in S.I. Muravyov-Apostol’s plans for organizing the uprising of the Chernigov Regiment, dedicated to the secrecy of the military conspiracy and its political goals. The research novelty lies in shedding light on an understudied figure in Decembrist history, previously overlooked by historiography. The relevance of this study lies in its contribution to understanding key events in the Decembrist movement — the Southern conspiracy and uprising. The article discusses why the incriminating evidence indicating P.Ya. Rennenkampf's involvement in clandestine societies was dis-regarded during historical proceedings and remained largely unnoticed by historians. The author provides an explanation for the long-standing misattribution of K.P. Rennenkampf instead of P.Ya. Rennenkampf in historical accounts
Professor Pavel Nikolaevich Napalkov (1900-1988) (on the 120<sup>th </sup> anniversary of the birthday)
No full textProfessor Pavel Nikolaevich Napalkov was born in Moscow on September 30 (October 13), 1900. After graduating from secondary education, Pavel Nikolaevich entered the medical faculty of Don University, where he chose surgery as his future specialty. In 1930, by the invitation of Professor V. A. Oppel, P. N. Napalkov moved to Leningrad, where he began working in the hospital named after I. I. Mechnikov (now Peter the Great). During World War II, Pavel Nikolaevich was in the ranks of the Red Army. P. N. Napalkov summarized the experience of his work in the chapters «Putrid Infection» and «Peritonitis» in the fundamental multi-volume publication «Experience of Soviet Medicine in the Great Patriotic War of 1941-1945». After demobilization, Professor P. N. Napalkov was elected head of the Department of Faculty Surgery of the 2nd Leningrad Medical Institute and headed the department for 28 years - until 1974. Many works, including a dissertation and a monograph, were devoted to ventral hernias. Pavel Nikolaevich was the author and co-author of more than 400 scientific papers and 14 monographs on various sections of specialty surgery, military surgery, traumatology, anesthesiology, and health care organization. Professor P. N. Napalkov died on May 18, 1988 and was buried near Leningrad in the settlement Pesochny
Pavel Koutecky and his film works
No full textWhat in fact is an author?s style? It is the point of view from which an
author sees the given subject. Which style he uses when recording the
action, to which extent he enters into it and tries to influence it, what shooting angles and image interpretation he uses, in what way he works with sound. We can agree upon the fact that only few directors have such a distinct and characterful author?s style as Pavel Koutecký does. He was a director always searching for new possibilities and forms of artistic expression. In my diploma paper I survey his fundamental films and give a general overview of his work
Foreigners at the Court of Pavel I: Reception Ceremonies
No full textАнализируются сведения, содержащиеся в документах Министерства иностранных дел России, камер-фурьерских церемониальных журналах, мемуарах, переписке современников, освещающие церемониал приемов представителей иностранного дипломатического корпуса, коронованных особ и других иностранцев российским императором Павлом I. Показано, что аудиенции иностранцев у Павла I приобрели особую пышность и жесткую регламентацию после получения им титула великого магистра Мальтийского ордена.The author analyzes documents of the Russian Ministry of Foreign Affairs, chamber fourriers’ journals, memoirs, and correspondence containing any information about the ceremonial etiquette at the receptions of foreign diplomats, monarchs and other foreigners at the court of the Russian Emperor Pavel I. The article concludes that Pavel’s audience of foreigners became particularly pompous and strictly regulated after he received the title of Grand Master of the Knights Hospitaller
Regulation des Rezeptor des Stickstoffoxides löslicher Guanylylcyclase
No full textSoluble guanylyl cyclase (sGC) is the best established receptor for nitric oxide (NO) and regulates a great number of important physiological functions. Surprisingly, despite the wellappreciated roles of this enzyme in regulation of vascular tone, smooth muscle cell proliferation, platelet aggregation, renal sodium secretion, synaptic plasticity, and other functions, extremely little is known about the regulation of sGC activity and protein levels. To date, the only well-proven physiologically relevant sGC regulator is NO. In the present study, some additional possibilities for sGC regulation were shown. Firstly, we evaluated the ability of different NO donors to stimulate sGC. Significant differences in the sGC stimulation by SNP and DEA/NO were found. DEA/NO stimulated sGC much stronger than did SNP. Interestingly, no correlation between the sGC protein and maximal activity distribution was found in rat brain regions tested, suggesting the existence of some additional regulatory mechanisms for sGC. The failure of SNP to stimulate sGC maximally might be one of the reasons why the lack of correlation between the distribution of sGC activity and proteins in brain was not detected earlier. Prolonged exposure of endothelial cells to NO donors produced desensitization of the cGMP response. This desensitization cannot be explained by increased PDE activity, since PDE inhibitors were not able to prevent the NO donor-induced decrease of the maximal cGMP response in endothelial cells. The failure of SH-reducing agents to improve the cGMP response after its desensitization by NO suggests that a SH-independent mechanism mediates NO effects. Demonstration that the potency of the recently described activator of oxidized (heme-free) sGC, BAY58-2667, to stimulate sGC increases after prolonged exposure of the cells to an NO donor, DETA/NO, suggests that oxidation of heme may be a reason for NOinduced desensitization of sGC and decrease in sGC protein level. Indeed, the well-known heme-oxidizing agent ODQ produces a dramatic decrease in sGC protein levels in endothelial cells and BAY58-2667 prevents this effect. Although the mechanism of sGC activation and stabilization by BAY58-2667 is unknown, this substance is an interesting candidate to modulate sGC under conditions where sGC heme iron is oxidized. Very little is known about regulation of sGC by intracellular localization or translocation between different intracellular compartments. In the present study, an increase in sGC sensitivity to NO under membrane association was demonstrated. Treatment of isolated lung with VEGF markedly increased sGC in membrane fractions of endothelial cells. Failure of VEGF to stimulate sGC membrane association in cultured endothelial cells allows us to propose a complex mechanism of regulation of sGC membrane association and/or a transient character of sGC membrane attachment. A very likely mechanism for the attachment of sGC to membranes is via sGCinteracting proteins. These proteins may participate also in other aspects of sGC regulation. The role of the recently described sGC interaction partner, Hsp90, was investigated. Shortterm treatment of endothelial cells with an Hsp90 inhibitor does not affect NO donor or calcium ionophore-stimulated cGMP accumulation in the cells. However, inhibition of Hsp90 results in a rapid and dramatic decrease in sGC protein levels in endothelial cells. These effects were unrelated to changes in sGC transcription, since inhibition of transcription had much slower effect on sGC protein levels. In contrast, inhibitors of proteasomes abolished the reduction in sGC protein levels produced by an Hsp90 inhibitor, suggesting involvement of proteolytic degradation of sGC proteins during inhibition of Hsp90. All these data together suggest that Hsp90 is required to maintain mature sGC proteins. In conclusion, in the present study it was demonstrated that multiple mechanisms are involved in the regulation of sGC activity and its sensitivity to NO. Oxidation of sGC heme by NO seems to be one of the mechanisms for negative regulation of sGC in the presence of high or prolonged stimulation with NO. Another possible means of regulating sGC sensitivity to NO is via the intracellular translocation of the enzyme. It has been also demonstrated here that attachment of sGC to the membrane fraction results in an apparent increase in the enzyme sensitivity to NO. Additionally, Hsp90 was required to maintain sGC protein in endothelial and other cell types. However, we could not find any acute affect of Hsp90 on sGC activity, as reported recently. All these findings demonstrate that the regulation of sGC activity and protein level is a much more complex process than had been assumed earlier.Lösliche Guanylylcyclase (sGC) ist der Hauptrezeptor für Stickstoffmonooxid (NO), der sich an der Regulation zahlreicher physiologischer Funktionen beteiligt. Trotz ihrer sehr gut untersuchten Rolle in der Regulation der Blutgefässenrelaxation, synaptische Plastizität, Aggregation der Trombozyten, renale Sekretion und anderen wichtigen Funktionen, ist die Regulation der sGC selber noch nicht ausreichend verstanden. Der einzige, zur Zeit bekannte, physiologische Regulator der sGC ist NO. In der vorgelegten Arbeit wurde die Existenz anderer Möglichkeiten der sGC Regulation gezeigt. Zuerst, wurde die Fähigkeit verschiedener NO Donoren sGC zu stimulieren untersucht. DEA/NO stimulierte sGC viel stärker als SNP. Interessanterweise, wurde keine Korrelation zwischen der Verteilung des sGC Proteins und der Enzymaktivität unter Vmax- Bedingungen in verschiedenen Rattenhirnregionen gefunden. Das deutet auf zusätzliche Regulationsmechanismen hin. Die fehlende Fähigkeit von SNP sGC maximal zu stimulieren könnte ein Grund dafür sein, warum dieses Phänomen nicht schon früher gezeigt wurde. Langfristige Behandlung von Endothelzellen mit NO Donoren produzierte eine Desensitisierung der nachfolgenden cGMP Antwort. Diese Desensitisierung kann nicht durch erhöhte Phosphodiesterase-Aktivität erklärt werden, da Phosphodiesterasenhemmer die durch NO Donor verursachte Abnahme der cGMP Antwort nicht rückgängig macht. SHreduzierende Substanzen waren nicht in der Lage die cGMP Antwort zu verbessern, was zur Annahme führt, dass SH-Gruppenoxidation keine wichtige Rolle bei der Wirkung von NO auf sGC spielt. Es müssen daher andere Regulationsmechanismen vorhanden sein. Oxidation des Häms scheint ein möglicher Mechanismus der NO-induzierten sGC Desensitisierung. Einkürzlich beschriebener Aktivator der oxidierten (bzw. Häm-freien) sGC, BAY58-2667, stimulierte sGC nach Vorbehandlung mit NO Donoreb stärker als ohne Vorbehandlung. Es wird vermutet, dass oxidierte sGC verstärkt abgebaut wird was die durch NO oder Häm oxidierende Substanzen induzierte sGC Proteinabnahme erklären würde. Tatsächlich, nahm sGC Proteinlevel nach der Behandlung mit der Häm oxidierenden Substanz, ODQ, ab. BAY58-2667 verhinderte diesen Effekt. Ferner erhöht die Membranassoziation von sGC derer Empfindlichkeit gegenüber NO. Die Membranassoziation der sGC in Endothelzellen ist reguliert. Behandlung isolierter Lunge mit VEGF erhöht den Anteil an membrangebundener sGC in Endothelzellen dramatisch. In kultivierten Endothelzellen könnte VEGF die Membranassoziation jedoch nicht stimulieren, was einen komplexen Mechanismus der Membranassoziation der sGC in vivo vermuten lässt. Wenig ist bekannt über die Interaktionen von sGC mit anderen Protein und der möglichen Rolle dieser Interaktionen bei der Regulation des Enzyms. Proteininteraktionen scheinen aber ein möglicher Mechanismus für die Membranassoziation der sGC zu sein. Aus diesem Grund wurde die Rolle eines vor kurzem beschriebenen sGC-bindenden Proteins, Hsp90, auf die sGC Regulation untersucht. Kurzfristige Behandlung der Endothelzellen mit Hsp90 Inhibitoren hat keine Auswirkung auf NO Donor- und Calciumionophore-stimulierte cGMP-Produktion. Langfristige Hemmung von Hsp90 führte dagegen zur schnellen und deutlichen Abnahme des sGC Proteins. Dieser Effekt ist nicht durch eine Veränderung der Translation zu erklären, weil Tranlationshemmer einen viel langsameren sGC Abfall verursachten. Im Gegenteil, konnte ein Proteasomeninhibitor, MG132, die Effekte von Hsp90 Hemmern rückgängig machen. Das lässt eine proteolytische Abbau der sGC für die Effekte von Hsp90 Hemmer verantwortlich machen. Diese Daten deuten darauf hin, dass Hsp90 für Aufrechterhaltung des Enzyms notwendig ist. Zusammenfassend, wurde in der vorliegenden Arbeit gezeigt, dass sGC Aktivität und ihre Empfindlichkeit gegenüber ihren Aktivator NO durch multiple Faktoren beeinflusst werden kann. Oxidation des Häms durch NO könnte ein Mechanismus der negativen Regulation der sGC bei dauernd erhöhter Konzentration von NO sein. Ein zusätzlicher Mechanismus der Regulation der Empfindlichkeit der sGC gegenüber NO scheint die intrazellulare Translokation zu sein. Wir konnten hier zeigen, das die Membranassoziation der sGC ihre Empfindlichkeit gegenüber NO erhöht. Auch dieProteinlevel der sGC scheinen unter Kontrolle verschiedener Faktoren zu sein. Einer davon ist Hsp90, der für die Aufrechterhaltung des sGC Proteins sowohl in Endothelzellen als auch in anderen Zelltypen notwendig ist. Alle diese Daten zeigen, dass Regulation der sGC ein viel komplexerer Vorgang ist als bis her angenommen wurde und eröffnen interessante neue Forschungsrichtungen innerhalb dieses wichtigen Signalweges
Music Educationalist Pavel Jurkovič and His Methods of Children´s Musicality Development
No full textMy bachelor thesis deals with the personality of Pavel Jurkovič, a music educationalist, a singer, an instrumentalist, an author of compositions for children and the youth and a publicist. It is focused on his educational activity based on the principles of Schulwerk pedagogy of Carl Orff which is built on natural connection between music, speech and dance. I also concentrated on his life's journey and his opinions and attitudes related to his teaching practice. According to Pavel Jurkovič, music education not only represents acquiring musical skills and knowledge, but music also positively affects the human personality. I devoted my bachelor thesis to topics such as voice training, folk song, vocal production for children, rhythmic rhymes and games with music and movement, body percussion, instrumental ensemble and listening to music. I attached pieces of advice and recommendations by Pavel Jurkovič on how to procced in musical activities and how to use his sheet music and methodical manuals
Orthogonality Relations and Cherednik Identities for Multivariable Baker-Akhiezer Functions
No full textAuthor Manuscript 27 Feb 2013We establish orthogonality relations for the Baker–Akhiezer (BA) eigenfunctions of the Macdonald difference operators. We also obtain a version of Cherednik–Macdonald–Mehta integral for these functions. As a corollary, we give a simple derivation of the norm identity and Cherednik–Macdonald–Mehta integral for Macdonald polynomials. In the appendix written by the first author, we prove a summation formula for BA functions. We also consider more general identities of Cherednik type, which we use to introduce and construct more general, twisted BA functions. This leads to a construction of new quantum integrable models of Macdonald–Ruijsenaars type.National Science Foundation (U.S.) (Grant DMS-1000113
Pavel Kohout - officer, dissident and writer
No full textThis diploma work deals with the personal developement of Pavel Kohout - his beliefs and his work. Pavel Kohout has been a Czech and Austrian poet, a representative of the Czech constructive poetry, a playwright, a translator and later an important writer of samizdat (self-publishing) and exile literature. The diploma work is an attempt to make a complete monography of a controversial personality of Czech culture, politics and literature from the 50s of the 20th century to recent time. The first part describes his private life including the social and political consequences - it shows the movement from his political engagement in the Youth Organization called Svazarm to the role of an important representative of the Czech dissent. The second part deals with the interpretation of selected 6 pieces of his work - Verše a písně (Verses and Songs), Záříjové noci (September Nights), Taková láska (Such a Love), Katyně (The Hangwoman), Kde je zakopán pes ( Where the Dog is Burried) and Sněžím (I am Snowing). In these pieces of work, the author of the diploma work tries to show the connections between his lyrical, dramatical and prozaic work influenced with his political engagement. The final part mentions the approach of Pavel Kohout to the theatre - including writing some adaptations and also the stage..
Proceeding of youth play titled "Jurček" (Pavel Golia) in primary school
No full textPoet, playwright and translator Pavel Golia had been an significant author of performances and plays for kids. The main goal of this thesis was to introduce his life and his best known works, together with their appearance in schools. In particular, I was interested with response of students, which I got first hand during tuition in class and through assessment of their written works. Based on this, I was trying to determine the extent to which his work is present in curriculum and student literature.
In first chapter, I introduced in detail Golia`s life and work. Further on, I focused on history of development of youth drama, from its beginning until today. I introduced the basic terms, such as playwright, youth drama and youth literature and described all phases of school interpretation of those.
In practical part I studied drama »Jurček« (»Little George«) with pupils from fifth grade during class, after which we visited local library to further learn about Golia`s life and other notable works. In this thesis I also included preparation and assessment material for studies of Golia with pupils.
In my thesis, I would like to answer following questions
• whether Pavel Golia`s literature is present in national curriculum and in study literature,
• if teachers in local primary school discuss local author with pupils during their literature classes,
• how much students know about Pavel Golia,
• whether the topic of powerty 85 years ago, which was included in Golia`s play »Jurček«, still resonates among young readers of Golia`s works.
Empirical part of the thesis will be done by means of direct observation of students in fifth grade of Trebnje Primary School. Research will be done using descriptive method, with qualitative techniques of data collection (by mean of descriptions). Main tools used during this research will be students` notes, their photographs and their works, completed during classes
- …
