1,667 research outputs found
Plasmodium mexicanum sex ratios and genotypes from natural infections collected 2007-2009
No full textCompiled data on naturally-occuring infections of the lizard malaria parasite Plasmodium mexicanum in its host, the lizard Sceloporus occidentalis, including sex ratio and parasitemia counts and alleles observed at 4 microsatellite loci. Data was collected for the current study (Testing sex ratio theory with the malaria parasite Plasmodium mexicanum in natural and experimental infections) from samples collected by Allison Neal, Jennifer Fricke, and Anne Vardo-Zalik. Contribution of other dataset authors is outlined in ReadMe file, as well as more detailed inforamtion about the study and data set
Distribution of Plasmodium mexicanum clones among hosts
No full textData, metadata and R code to accompany the manuscript "Distribution of clones among hosts for the lizard malaria parasite Plasmodium mexicanum" (author: AT Neal; in review at PeerJ
Distribution of Plasmodium mexicanum clones among hosts
No full textData, metadata and R code to accompany the manuscript "Distribution of clones among hosts for the lizard malaria parasite Plasmodium mexicanum" (author: AT Neal; in review at PeerJ
Distribution of Plasmodium mexicanum clones among hosts
No full textData, metadata and R code to accompany the manuscript "Distribution of clones among hosts for the lizard malaria parasite Plasmodium mexicanum" (author: AT Neal; in review at PeerJ
Dr. Scott Allison and Dr. Al Goethals – Faculty Author Interview
No full textDr. Scott Allison, Professor, Department of Psychology and Dr. Al Goethals, Professor, Jepson School of Leadership Studies discuss their recent book, Heroes: What They Do and Why We Need Them. Published by Oxford University Press, the book offers a stimulating tour of the psychology of heroism, shedding light on what heroism and villainy mean to most people and why heroes — both real people and fictional characters — are so vital to our lives. For more information on the book and project, connect to the “Heroes” blog
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Exploiting knowledge of immune selection in HIV-1 to detect HIV-specific CD8 T-cell responses
No full textSince HLA-restricted cytotoxic T-cell responses select specific polymorphisms in HIV-1 sequences and HLA diversity is relatively static in human populations, we investigated the use of peptide epitopes based on sites of HLA-associated adaptation in HIV-1 sequences to stimulate and detect T-cell responses ex vivo. These "HLA-optimised" peptides captured more HIV-1 Nef-specific responses compared with overlapping peptides of a single consensus sequence, in interferon-γ enzyme linked immunospot assays. Sites of immune selection can reveal more immunogenic epitopes in HLA-diverse populations and offer insights into the nature of HLA-epitope targeting, which could be applied in vaccine design
Modulation of antigen-specific T-cells as immune therapy for chronic infectious diseases and cancer
No full textCopyright: © 2014 Li, Symonds, Miao, Sanderson and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.This article has been made available through the Brunel Open Access Publishing Fund.T-cell responses are induced by antigen presenting cells (APC) and signals from the microenvironment. Antigen persistence and inflammatory microenvironments in chronic infections and cancer can induce a tolerant state in T-cells resulting in hyporesponsiveness, loss of effector function, and weak biochemical signaling patterns in response to antigen stimulation. Although the mechanisms of T-cell tolerance induced in chronic infection and cancer may differ from those involved in tolerance to self-antigen, the impaired proliferation and production of IL-2 in response to antigen stimulation are hallmarks of all tolerant T cells. In this review, we will summarize the evidence that the immune responses change from non-self to “self”-like in chronic infection and cancer, and will provide an overview of strategies for re-balancing the immune response of antigen-specific T cells in chronic infection and cancer without affecting the homeostasis of the immune system.Arthritis Research UK and Medical Research Council UK
Sum of Every Lost Ship
No full textAllison Titus is the author of Sum of Every Lost Ship (Cleveland State University Poetry Center, 2010), the novel The Arsonist\u27s Song Has Nothing To Do With Fire (Etruscan, 2014) and the forthcoming book of poems, The True Book of Animal Homes. She teaches in the low-res M.F.A. program at New England College.
“Sum of Every Lost Ship navigates what is haunting, strange, and unknowable grief and disappearances, fragments and histories. Reading, we are deftly balanced on the shores of mystery, a mystery fathomed by a keen instinct for metaphor. Allison Titus is a writer exquisitely attuned to compassion, isolation, and the sometimes overlooked details of this sturdy and tenuous world goats hearts, schooners, cabinets, arctic realities. This is a startling and moving collection.” –Talvikki Ansel
“The pilgrim heart, as one of Allison Titus’ exquisite phrasings has it, requires an unmooring, a letting go, into a world marked by passing journeys, passing architectures, almost-lost motels for intimates to get lost in a hardscrabble world rich with leavings. An internality emerges, sets out, to congress with the obstinate, the creaturely. This poetry’s experiment takes us to the fact that the everyday is also experimental, in that, familiar as it is, it can never, if it is seen intensely enough to be durably writ, be wholly predicted. So fine a lyric sensibility as the reader will find in these poems is all the more compelling for acknowledging the human limits of the lyric, for making hard choices, even refusals, and for never romanticizing omission i.e., obliteration but testing it at every step with earthly perceptions. Allison Titus’ s Sum of Every Lost Ship presents readers with a striking new poetry, and a beautiful and truly original voice.” –William Olsen
“‘We choose / what soothes us,’ writes Allison Titus in this intricate collection, and yet I don t quite believe her; Titus’s choices here are invariably brave and unflinching, thus wonderfully jarring. She pays careful attention, and her sights land on deafening gallops, shipwrecked utterances, waking night terrors. This close-up looking reminds us of our essential predicament ‘What we need / is a surefire way to strap the bed / onto the trembling boat,’ she tells us and yet, in Titus s steady hands, capsize seems not only necessary danger but uncanny adventure.” –Kerri Webster
More Information:
Allison Titus Website
Octopus Magazine
Blackbird
The Voltahttps://engagedscholarship.csuohio.edu/clpc_bks/1136/thumbnail.jp
South African responses to Open Access publishing: a survey of the research community
No full textOpen access publishing offers wide benefits to the scholarly community and may also afford relief to financially embattled academic libraries. The progress of the open access model rests upon the acceptance and validation of open access journals and open archives or institutional repositories by the academic mainstream, particularly by publishing researchers. To what extent are the key actors in the South African research system aware of the advantages of open access? This article reports on the findings of a recent survey undertaken to assess the current awareness, concerns and depth of support for open access amongst local researchers, research managers and policy makers in South Africa. The study focuses on issues of quality, article or author charges and the established academic reward system. It concludes that within the prevailing framework, there is little prospect that academics would choose to publish within open access
journals. Recommendations for advocacy by the library community are proposed
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