224 research outputs found
[Monday Afternoon, 3:55]
No full textMessage by Chuck Colson, author/speaker from Washington DC. SBC Pastors Conference, Georgia World Congress Center, Atlanta, GA, June 3, 1991
Genetics of Menstrual Migraine: The Molecular Evidence
No full textMigraine is considered to be a multifactorial disorder in which genetic, environmental, and, in the case of menstrual and menstrually related migraine, hormonal events influence the phenotype. Certainly, the role of female sex hormones in migraine has been well established, yet the mechanism behind this well-known relationship remains unclear. This review focuses on the potential role of hormonally related genes in migraine, summarizes results of candidate gene studies to date, and discusses challenges and issues involved in interpreting hormone-related gene results. In light of the molecular evidence presented, we discuss future approaches for analysis with the view to elucidate the complex genetic architecture that underlies the disorder.Griffith Health, School of Medical ScienceFull Tex
A pharmacogenomic evaluation of migraine therapy
No full textMigraine is a common idiopathic primary headache disorder with significant mental, physical and social health implications. Accompanying an intense unilateral pulsating head pain other characteristic migraine symptoms include nausea, emesis, phonophobia, photophobia and in approximately 20-30% of migraine cases, neurologic disturbances associated with the aura phase. Although selective serotonin (5-HT) receptor agonists (i.e., 5-HT(1B/1D)) are successful in alleviating migrainous symptoms in < or = 70% of known sufferers, for the remaining 30%, additional migraine abortive medications remain unsuccessful, not tested or yet to be identified. Genetic characterization of the migrainous disorder is making steady progress with an increasing number of genomic susceptibility loci now identified on chromosomes 1q, 4q, 5q, 6p, 11q, 14q, 15q, 17p, 18q, 19p and Xq. The 4q, 5q, 17p and 18q loci involve endophenotypic susceptibility regions for various migrainous symptoms. In an effort to develop individualized pharmacotherapeutics, the identification of these migraine endophenotypic loci may well be the catalyst needed to aid in this goal. In this review the authors discuss the present treatment of migraine, known genomic susceptibility regions and results from migraine (genetic) association studies. The authors also discuss pharmacogenomic considerations for more individualized migraine prophylactic treatments.Griffith Health, School of Medical ScienceNo Full Tex
Clément Colson et le développement de l'économie mathématique et de la statistique en France
No full textInternational audienceThe aim of the paper is to analyse the role of Clement Colson in the development of economic calculus in France. First of all this study demonstrates that he is one of the few French liberal economists of the early 20th century to use mathematics. Then this article shows that he is one of the pioneers of the use of statistics in economics. Finally, his simultaneous use of statistics and mathematics allows to consider him as an author facilitating the first project of econometrics diffusion in France.L’objectif de l’article est d’analyser le rôle de Clément Colson dans le développement du calcul économique en France. L’étude montre d’abord qu’il est l’un des rares économistes libéraux français du début du xxe siècle à utiliser les mathématiques. Elle démontre ensuite qu’il est l’un des pionniers de l’utilisation des statistiques en économie. Enfin, l’article permet de comprendre qu’il peut être considéré comme un auteur facilitant la diffusion du projet initial de l’économétrie en France
Migraine genetics and prospects for pharmacotherapy
No full textMigraine is a common complex neurological disorder with a well-known but poorly characterized genetic liability. The search for migraine susceptibility genes has been the focus of intense research. It is now believed that common migraine is not a single gene disorder, but attributable to several potentially interacting genetic variants. These variants may differ in each sufferer and interact with environmental factors to set the individual migraine threshold. This genetic liability may play an important role in the clinical heterogeneity seen in migraine and also in the variability of treatment response. This review will look at genetic loci implicated in migraine to date and consider their current or prospective role in migraine therapy. To elucidate the complex nature of migraine genetic liability, approaches that consider detailed endophenotypic profiles that encompass treatment response may provide much more relevant information than simple end diagnosisGriffith Health, School of Medical ScienceNo Full Tex
The role of vascular and hormonal genes in migraine susceptibility
No full textMigraine is a primary headache disorder that involves both genetic and environmental components. Migraine is considered to be a polygenic disorder with a number of susceptibility genes having a minor but nonetheless significant impact on susceptibility. Migraine candidate gene studies have concentrated mainly on genes involved in neurotransmitter pathways, however evidence also exists for a role for alterations in vascular and hormonal function in migraine susceptibility. We present here a mini-review of genetic studies, investigating the potential role of vascular and hormonal gene variants, and discuss how vascular and hormonal dysfunction may impact on migraine susceptibility. We propose that the potential role of vascular and hormonal genes in this disorder warrants further investigation.Griffith Health, School of Medical ScienceNo Full Tex
Role of anthocyanins in attenuating obesity and obesity-induced inflammation
No full textThe incidence of obesity and its related metabolic diseases, such as diabetes, cardiovascular disease and hypertension, has escalated dramatically over the past decades worldwide, so much so that it has reached epidemic proportions. It has become a significant public health issue and a massive burden to the health-care system in developed and developing countries. Obesity is the fifth leading risk for human mortality around the globe, resulting in 2.8 million adult deaths each year. Another alarming fact is that childhood obesity has increased dramatically since 1990. Childhood obesity is one of the serious public health challenges of the 21st century, with there expected to be about 60 million obese children by 2020 globally. Obesity is connected with chronic low-grade inflammation manifested by increased circulatory levels of several cytokines and acute phase proteins associated with inflammation. While many are secreted by adipocytes, it is believed that increased adipose tissue mass is either directly or indirectly associated with the increased production of inflammation-related factors. Several therapeutic options have been used for short-term treatment of obesity, however many of these cause unpleasant side-effects, including dizziness, headache, anxiety, elevated heart rate and gastro-intestinal issues. There is strong evidence supporting the therapeutic use of polyphenols such as stilbenes, flavonoids and curcuminoids, given that they show potential in the prevention and/or treatment of obesity and its metabolic complications. [...]Thesis (PhD Doctorate)Doctor of Philosophy (PhD)School of Medical ScienceGriffith HealthFull Tex
Endophenotype profiles of MTHFR and ACE gene polymorphisms in migraine susceptibility
No full textBackground Migraine is a debilitating neurological disorder affecting approximately 12% of the Caucasian population. There are two main sub-types of migraine, migraine without aura (MO) and migraine with aura (MA). Migraine exhibits varied phenotypic expression with sufferers experiencing a range of neurological and other symptoms. It is likely that multiple susceptibility genes play a role in this varied phenotypic expression, thus investigation of genotype-phenotype relationships may provide valuable insights into the role of susceptibility genes in this disorder.\ud
Methods This study investigated the links between migraine susceptibility genes, methylenetetrahydrofolate reductase (MTHFR) and angiotensin converting enzyme (ACE), and clinical manifestation through statistical analyses.\ud
Results The result showed that for the MTHFR genotypes, there was a statistically significant correlation with the TT homozygous genotype and visual disturbances, unilateral head pain and physical activity discomforts. It was also found that bilateral head pain was associated with the male gender.\ud
Conclusion From these study results, it is plausible to state that MTHFR genotypes affect the phenotypic expression of migraine disease manifestation
Clément Colson (1853-1939), la science économique de son époque et ses prolongements
No full textSource : ABES [http://www.idref.fr/033702462/id] - theses.fr, 27/01/2022The object of this dissertation is to analyse the contributions of Clément Colson to the economics in order to be better acquainted with his thought, with the French Liberal School at the beginning of the 20th century, to see the influence he had on his main students, Divisia, Roy and Rueff, and to evaluate the actuality of his recomandations. The first chapter develops the Colson’s theoretical contributions.For his students, his main contribution would be the theory of the joint setting of wage and of the interest rate. We will explain this theory is close to the optimal management rule in microeconomics attributed to Clark; we will see we can speak then about multiple discovery.Colson is interesting too from the point of view of the method used. We will see he uses statistics and mathematics in his developments: he makes one of the first assesments of the French income, his lectures develop economics calculus, he can be seen as a precursor of econometrics in France. The second chapter shows that Colson develops the Jules Dupuit pricing method for means of communications exploited by a monopoly by proposing practical way of preferences revelation. We will show too that this theory is used nowadays with the Yield Management and by airline lowcost companies.The third chapter has for purpose to see how Colson takes into account the social question. We will see he argues for a more important State intervention than other liberal economists in order to avoid workers to turn to socialism. The fourth chapter is devoted to the State intervention recommended by Colson in the field of railways. We will see that in this field in which the State is very present, the author wishes to limit it. So he prefers the concession to the public exploitation and wishes construction of new railway lines just if they are profitable. We will see again that the fear of socialism is not stranger to his positions. On each theme, we will see that Colson gives an important place to the practice. At the theoretical level all starts and finishes with the observation, at the practice level he is influenced by the preoccupations of his time.L’objectif de cette thèse est d’analyser les contributions de Clément Colson à la science économique dans le but de mieux connaître sa pensée, de mieux connaître l’École libérale française au début du XXème siècle, d’étudier l’influence qu’a pu avoir cet auteur sur ses principaux élèves, Divisia, Roy et Rueff, et d’évaluer l’actualité de certaines de ses recommandations.Le premier chapitre montre quels sont les apports théoriques de Colson à la science économique.Pour ses élèves, son principal apport serait la théorie de la détermination conjointe du salaire et du taux d’intérêt. Nous montrerons que cette théorie est proche de la règle de gestion optimale en microéconomie attribuée à Clark ; nous verrons alors que l’on peut parler de découverte multiple.Colson est également intéressant au point de vue de la méthode utilisée. Nous verrons alors qu’il utilise les statistiques et les mathématiques dans ses développements : il est à l’origine d’une évaluation pionnière du revenu de la France, son enseignement impulse le calcul économique, il peut être considéré comme un précurseur de l’économétrie en France. Le deuxième chapitre montre que Colson développe la méthode de tarification des voies de communication exploitées en monopole de Jules Dupuit en proposant des moyens pratiques de révélation des préférences. Nous verrons également que cette théorie est reprise de nos jours avec le Yield Management et par les compagnies aériennes à bas coûts. Le troisième chapitre a pour but de voir comment Colson prend en compte la question sociale. Nous verrons qu’il défend une intervention de l’État plus importante que d’autres économistes libéraux afin d’éviter que les ouvriers ne se tournent vers le socialisme. Le quatrième chapitre étudie l’intervention de l’État préconisée par Colson dans le domaine des chemins de fer. Nous verrons que dans ce domaine où l’État est très présent, l’auteur souhaite le limiter. Il préfère ainsi la concession à la régie et souhaite la construction de nouvelles lignes uniquement si elles sont rentables. Nous verrons qu’à nouveau, la crainte du socialisme n’est pas étrangère à ses positions. Sur chacun des thèmes, nous verrons que Colson accorde à la pratique une place importante. Au niveau théorique tout part de l’observation et se termine par l’observation, au niveau pratique il est marqué par les préoccupations de son époque
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