1,720,989 research outputs found
Una interpretación de a-ka-na-jo ( a3-ka-na-jo)
Full text linkThe author studies the word a-ka-na-jo in the PY Cn 328 tablet and taking into account some factors she proposes αγναιος as the reading of this word.The author studies the word a-ka-na-jo in the PY Cn 328 tablet and taking into account some factors she proposes αγναιος as the reading of this word
YU NA JO
No full text학위논문(석사)--아주대학교 일반대학원 :의생명과학과,2015. 2위암 (Gastric cancer) 은 매년 전세계에서 암 사망률의 주요 원인 중 하나이다. 위암과 관련된 여러 가지 새로운 종양 유전자와 종양 억제 유전자를 찾는 것은 조기 진단과 표적 치료의 발전을 위해 도움이 될 수 있다. 그 중 Poly (ADP-ribose) polymerase1 (PARP1) 은 많은 암 종류에서 항암치료의 타겟으로 보고되어 왔으며 PARP1억제제를 이용한 임상시험이 다양한 암 종을 바탕으로 진행되었으며 현재까지 수행되고 있다. 하지만, PARP1을 저해하게 되면 종양 발달이 어떻게 억제가 되는지 충분히 설명되어지지 않고 있다. 따라서, 위암 세포를 이용하여 PARP1 저해제인 올라파립 (Olaparib) 뿐만 아니라 PARP1 siRNA를 가지고 PARP1의 저해가 암세포의 성장을 어떻게 조절하는지를 보여주었으며 PARP1저해에 의한 FOXO3의 발현 증가를 통해 종양을 억제하는 효과를 가져온다. 뿐만 아니라, 166개의 tumor stage-matched 위암 환자 샘플을 사용하여 PARP1과 FOXO3 발현을 조직 마이크로 어레이로 평가하였다. 다변량 분석을 통해 PARP1 및 FOXO3 의 발현 차이에 따른 생존 곡선을 비교한 결과, 전체 생존 기간 (overall survival, PARP1; P = 0.021, FOXO3; P = 0.001) 및 무 재발 생존 기간 (relapse-free survival, PARP1; P = 0.021, FOXO3; P = 0.001) 의 영향을 주는 요인으로써 암의 독립적인 예후 지표로 활용 가능하다는 것을 확인하였다. 결론적으로, 우리의 결과는 PARP1- FOXO3 신호는 임상적인 의미와 암세포의 성장에 중요한 역할을 한다는 것을 입증하였고, 이는 암 치료에 있어 PARP1-FOXO3신호는 새로운 메커니즘과 임상 통찰력을 제안 할 수 있다.차 례
국문요약 ⅰ
차례 ⅲ
그림 차례 ⅴ
표 차례 ⅵ
Ⅰ. 서론 1
Ⅱ. 재료 및 방법 7
A. 위암세포 배양 7
B. 약물처리 7
C. siRNA Transfection 8
D. MTT(3-(4,5-dimethylthiazol-2-yl)-2,5-diphenylteteazolium bromide)assay 8
E. Cell counting 8
F. Colony forming assay 9
G. Western blotting 9
H. 환자 및 표본 10
I. Tissue microarray 11
J. RNA 분리 및 real-time PCR 12
K. 통계처리 13
Ⅲ. 결과 15
A. 위암 세포에서 PARP1의 억제의 세포 성장 억제 15
B. PAPR1의 억제는 FOXO3의 발현 유도 19
C. PARP1과 FOXO3의 발현과 위암 환자 임상결과 2 1
D. PARP1과 FOXO3 발현은 위암 환자의 생존율에 영향 32
Ⅳ. 고찰 38
Ⅴ. 결론 44
참고문헌 45
ABSTRACT 56Maste
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
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