1,721,887 research outputs found
NKI-related immediate toxicity profiles in 19 NKIs.
No full textNKI-related immediate toxicity profiles in 19 NKIs.</p
Fastighetsbranschens användande av NKI-undersökningar
No full textSYFTE: Syftet med uppsatsen är att undersöka hur fastighetsföretagen använder sig av NKI-undersökningar samt hur processen ser ut från analys till implementering av resultaten i verksamheten.
TEORI: För att läsaren ska få en förståelse för bakgrunden till användandet av NKI-undersökningar behandlas, förutom strukturen på NKI, i teorin även sambandet mellan kvalitetsförbättringar, kundnöjdhet och lönsamhet.
SLUTSATS: Främsta anledningen till att fastighetsföretagen använder sig av NKI-undersökningar är för att erhålla hyresgästers åsikter om företagets åtagande. Undersökningen ligger sedan som grund inför förbättringsarbeten i verksamheten som syftar till att hålla eventuella vakanser nere. Fastighetsföretagen som medverkat i undersökningen har insett vikten av NKI som verktyg och ingen ser några problem kring implementeringen av förändringarna
Immune reconstitution after NKI following haplo-SCT.
No full text(A) Immune reconstitution after NKI following haplo-SCT in six patients who completed three scheduled NKIs. Median values for cell numbers are presented. (B) The number of NK cells was higher until day 60 in the study cohort compared to the reference cohort, who underwent haplo-SCT without NKI.</p
The NKI-Rockland Sample: A Model for Accelerating the Pace of Discovery Science in Psychiatry
No full textThe National Institute of Mental Health strategic plan for advancing psychiatric neuroscience calls for an acceleration of discovery and the delineation of developmental trajectories for risk and resilience across the lifespan. To attain these objectives, sufficiently powered datasets with broad and deep phenotypic characterization, state-of-the-art neuroimaging, and genetic samples must be generated and made openly available to the scientific community. The enhanced Nathan Kline Institute Rockland Sample (NKI-RS) is a response to this need. NKI-RS is an ongoing, institutionally-centered endeavor aimed at creating a large-scale (N>1000), deeply phenotyped, community-ascertained, lifespan sample (ages 6-85 years old) with advanced neuroimaging and genetics. These data will be publically shared, openly and prospectively (i.e., on a weekly basis). Herein, we describe the conceptual basis of the NKI-RS, including study design, sampling considerations, and steps to synchronize phenotypic and neuroimaging assessment. Additionally, we describe our process for sharing the data with the scientific community while protecting participant confidentiality, maintaining an adequate database, and certifying data integrity. The pilot phase of the NKI-RS, including challenges in recruiting, characterizing, imaging, and sharing data, is discussed while also explaining how this experience informed the final design of the enhanced NKI-RS. It is our hope that familiarity with the conceptual underpinnings of the enhanced NKI-RS will facilitate harmonization with future data collection efforts aimed at advancing psychiatric neuroscience and nosology
NKi-2 cells maintain kidney function when grown in 3D tissues.
No full text<p>(A) Adenylate cyclase activity in NKi-2 cells within the bioengineered 3D tissue upon treatment with ADH or PTH. Treatment with forskolin acted as a control for production of cAMP. n = 4. (<b>B</b>) Na<sup>+</sup> dependent glucose uptake in NKi-2 cells within the bioengineered 3D tissues. Tissues were exposed to 2-DG with or without Na<sup>+</sup> in the form of NaCl. *p<0.05, n = 5. (C) RT-PCR of drug tranporters found in kidney epithelial cells using RNA from both NKi-2 cells and 4 week 3D tissues. (<b>C</b>) RT-PCR of different transport proteins found in human kidney cells in both NKi-2 cells (2D) and 4 week old 3D tissues.</p
Comparision of NKI 70-gene signature with SCoR derived 69-gene signature.
No full text<p>(a), cluster heatmap of gene expression using SCoR generated prognostic probes from NKI-295 dataset with blowup views of genes inside the center of poor and good prognosis gene clusters, probes matching the NKI 70-genes were marked in black lines on the right side of the heatmap. Patient survival is marked in blue (>5yr), red (dead in 2yr), or otherwise cyan. ER status is marked in red (ER-) or cyan (ER+). Molecular subtypes are marked in blue (luminal A), green (luminal B), red (basal), ERBB2 (pink), or cyan (normal-like). NKI 70-gene prediction is marked in red (poor prognosis) or cyan (good prognosis). (b), Kaplan Meier plots of patient survivals stratified by either the NKI 70-gene signature or the SCoR 69-gene signature.</p
Changes in granulocyte-derived MDSCs after NKI following haplo-SCT.
No full textThe number of granulocyte-derived MDSCs decreased after NKI. In two patients (patient #3 and #4), the number of granulocyte-derived MDSCs increased from day 90 and tumor relapse/progression had occurred at the six-month tumor evaluation. On the other hand, the number of granulocyte-derived MDSCs did not increase in patient #7, who remained progression-free.</p
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
No full text“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
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