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Hubungan Kadar Pentraxin 3 pada Pasien Penyakit Ginjal Kronik yang Menjalani Hemodialisa dengan Lamanya Pasien Menjalani Hemodialisa
No full textLatar Belakang : Penyakit ginjal kronik saat ini menjadi masalah kesehatan
masyarakat di dunia. Penyakit ini berjalan progresif, sehingga fungsi ginjal akan
terus menurun dari waktu ke waktu dan berakhir dengan gagal ginjal. Perjalanan
penyakit ginjal kronik terkait dengan penurunan fungsi ginjal yang progresif dan
ireversibel. Peradangan dianggap memainkan peran yang relevan untuk terjadinya
atherogenesis dan terjadinya PGK. bahwa PTX3 adalah penanda yang cepat dan
sensitive pada peradangan pasien dengan PGK. Tinggi level PTX3 secara sistemik
dikaitkan dengan peningkatan risiko morbiditas dan mortalitas kardiovaskular
pada pasien dengan PGK
Metode : Penelitian ini mengambil sample darah pasien yang menjalani
Hemodialisa di RSUP.H. Adam Malik. Medan sebanyak 30 pasien. Sample
diperiksa untuk PTX3, BUN, Ureum,Kreatinin dan dihitung lamanya pasien
menjalani Hemodialisa. Penelitian dilaksanakan setelah mendapat ethical approval
dan informed consent.
Hasil dan Pembahasan : 40 orang laki-laki (80%) dan 10 orang wanita (20%)
dengan rata-rata usia 58,96 tahun. uji Mann Whitney untuk menilai perbandingan
Kadar Pentraxin 3 dengan lamanya pasien menjalani hemodialisa di dapatkan nilai
p=0.029. Ini menunjukkan bahwa terdapat perbedaan yang signifikan antara kadar
Pentraxin 3 dengan lamanya menjalani Hemodialisa 5 tahun.
Simpulan dan saran: Terdapat korelasi yang signifikan antara Kadar Pentraxin 3
dengan tingkat lamanya pasien menjalani Hemodialisa.Background: Chronic kidney disease is currently a public health problem in the
world. The disease is progressive, so kidney function will continue to decline over
time and end in kidney failure. The course of chronic kidney disease is associated
with a progressive and irreversible decline in kidney function. Inflammation is
considered to play a relevant role for the occurrence of atherogenesis and the
occurrence of CKD. that PTX3 is a fast and sensitive marker of inflammation in
patients with CKD. High PTX3 levels are systemically associated with an
increased risk of cardiovascular morbidity and mortality in patients with CKD.
Methods: This study took blood samples from patients undergoing hemodialysis
at RSUP.H. Adam Malik. Medan as many as 30 patients. Samples were examined
for PTX3, BUN, Ureum, Creatinine and the number of times the patient
underwent hemodialysis. The study was conducted after obtaining ethical
approval and informed consent.
Result And Discussion: 40 men (80%) and 10 women (20%) with an average age
of 58.96 years. Mann Whitney test to assess the comparison of Pentraxin 3 levels
with the length of time the patient underwent hemodialysis obtained p = 0.029.
This shows that there is a significant difference between Pentraxin 3 levels and the
duration of hemodialysis 5 years.
Conclusion and Suggestion: There was a significant correlation between
Pentraxin 3 levels and the length of time the patient underwent hemodialysis.90 HalamanTesis Magiste
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Kolonisasi Bakteri pada Kavum Nasal Pasien Gagal Ginjal Terminal yang Menjalani Hemodialisis Regular dan Staf di Instalasi Hemodialisa RSUP H. Adam Malik Medan
No full textLatar Belakang : Kolonisasi adalah keberadaan dan pertumbuhan
mikroorganisme pada kulit atau membran mukosa tubuh tanpa disertai tanda
infeksi. Mikroorganisme yang berkolonisasi umumnya flora normal yang terdapat
dalam tubuh seseorang tapi bisa juga mikroorganisme yang ada di RS yang
berkolonisasi dalam tubuh beberapa hari sejak mereka masuk ke RS. Semakin
lama seseorang dirawat di RS semakin besar kemungkinan terkolonisasi dengan
mikroorganisme yang terdapat di rumah sakit.
Tujuan : Untuk mengetahui perbedaan proporsi kolonisasi dan sensitivitas
antimikroba terhadap bakteri di kavum nasal pasien yang menjalani hemodialisis
regular dan staf di Instalasi Hemodialisa RSUP HAM.
Metode : Penelitian bersifat analitik observasional dengan metode potong lintang,
dilakukan di Departemen Patologi Klinik RSUP HAM bekerjasama dengan
Instalasi Hemodialisa RSUP HAM dari bulan Agustus 2016 sampai Oktober
2016. Sampel yang digunakan swab kavum nasal anterior kemudian dilakukan
identifikasi bakteri dan uji kepekaan.
Hasil : Total yang mengikuti penelitian 46 orang dimana pasien dan staf samasama
berjumlah 23 orang. Kolonisasi bakteri terbanyak pada kavum nasal pasien
hemodialisis regular dan staf di Instalasi Hemodialisa : Staphylococcus
epidermidis 9(39.13%) dan 12(52.17%); Staphylococcus aureus 4(17.39%) dan
3(13.04%); Staphylococcus saprophyticus 2(8.70%) dan 2(8.70%). Dijumpai 3
(tiga) bakteri MRSA dari total 23 bakteri (13.04%) pada pasien hemodialisis
regular. Sedangkan pada staf tidak ada dijumpai MRSA.
Diskusi : MRSA pada pasien hemodialisis regular sesuai dengan penelitian
Gasemian yang menemukan kolonisasi Staphylococcus aureus pada kavum nasal
pasien hemodialisis regular sebesar 36.9% dimana MRSA sebesar 74.2%.
Kesimpulan : Dijumpai kolonisasi MRSA pada pasien hemodialisis regular
dengan tingkat sensitifitas terhadap Vancomycin sebesar 50%.Background: Colonization is the presence and growth of microorganism on the
skin or mucous membrane of body without any sign of infection. Commonly
colonized microorganisms are normal flora within a person's body but can also be
microorganism in hospital that colonize within the body a few days after they
enter the hospital. The longer a person hospitalized the more likely to be
colonized with the microorganism in the hospital.
Objective: To determine the difference of proportion of colonization and
antimicrobial sensitivity to bacteria in nasal cavity of regular hemodialysis
patients and staffs in Hemodialysis Installation of RSUP HAM.
Method: The study was analytic observational with cross sectional method,
conducted in Department of Clinical Pathology of RSUP HAM together with
Hemodialysis Installation of RSUP HAM from August 2016 - October 2016.
Sample is anterior nasal cavity swab which then identification and sensitivity
test is done.
Result: Total number of participants followed the study was 46 people where
patients and staffs were equal to 23 people. Most bacterial colonization of the
nasal cavity of patients and staffs: Staphylococcus epidermidis 9 (39.13%) and 12
(52.17%); Staphylococcus aureus 4 (17.39%) and 3 (13.04%); Staphylococcus
saprophyticus 2 (8.70%) and 2 (8.70%). There were 3 MRSA from total of 23
bacteria (13.04%) in regular hemodialysis patients.
Discussion: MRSA in regular hemodialysis patients same with the study of
Gasemian which found 36.9% colonization of Staphylococcus aureus where
MRSA was 74.2%.
Conclusion: MRSA colonization was found in regular hemodialysis patients with
50% sensitivity level of Vankomycin.143 HalamanTesis Magiste
The Effect of Indoxyl Sulfate Levels on the Functional Capacity of End-Stage Renal Disease Patients Undergoing Regular Hemodialysis Using The Karnofsky Performance Scale at Haji Adam Malik General Hospital, Medan
No full textIntroduction. PGTA is a burdensome disease with high prevalence, mortality, and treatment costs. Indoxyl sulphate is one of the most studied solutes that accumulates in plasma when the kidneys fail. Clinical studies have shown that indoxyl sulphate can predict the prognosis of CKD and CVD in CKD patients. Serum levels of IS are associated with all cause mortality and cardiovascular mortality in CKD patients. The general objective of this study was to determine the relationship of indoxyl sulfate levels to the functional ability of CKD patients undergoing regular haemodialysis using the Karnofsky scale measuring instrument at the Haji Adam Malik Central General Hospital Medan.
Methods. This type of research is an observational analytic study with a cross
sectional design where data collection is taken to record indoxyl sulfate levels in kidney failure patients undergoing haemodialysis at Adam Malik Hospital.
Results. Of all 56 study samples, the mean of the study sample was 49.35 years with a standard deviation of 12.3 years where most patients were dominated by male gender, Batak tribe with PGTA. The mean indoxyl sulphate was 47.32 ug/mL with a standard deviation of 29.19 ug/mL. Basically, most patients came with functional ability calculated by Karnofsky score having category A. The results of analysis with Spearman test showed that there was a moderate negative correlation between indoxyl sulphate levels and functional ability of patients.
Conclusion. Indoxyl sulphate levels can be used as an objective parameter to predict a patient's functional ability.97 PagesTesis Magiste
Hubungan Kadar Magnesium Serum dengan Kalsifikasi Pembuluh Darah pada Pasien Hemodialisis Reguler
No full textLatar belakang: Kalsifikasi pembuluh darah adalah faktor risiko kematian kardiovaskular pada pasien dengan penyakit ginjal kronik yang menjalani terapi hemodialisis. Kadar magnesium yang rendah telah dilaporkan mempunyai hubungan yang kuat dengan kalsifikasi pembuluh darah pada pasien hemodialisis. Tujuan dari penelitian ini untuk melihat hubungan antara kadar magnesium serum dengan kalsifikasi pembuluh darah pada pasien hemodialisis reguler.
Metode: Sampel studi adalah 60 pasien stabil hemodialisis reguler, yang telah menjalani hemodialisis diatas atau sama dengan 3 tahun. Kalsifikasi pembuluh darah dinilai dengan menggunakan foto lateral lumbal. Pemeriksaan darah dilakukan untuk mengukur kadar magnesium serum.
Hasil : Studi melibatkan 60 pasien, pria 38 dan wanita 22, dengan usia antara 25-68 tahun. Kalsifikasi pembuluh darah terjadi pada 65% pasien. Rata-rata kadar magnesium serum 2,12±0,29 mg/dl. Tidak terdapat perbedaan yang signifikan dari kadar magnesium kelompok yang ada kalsifikasi dengan yang tidak ada kalsifikasi pembuluh darah (2,12±0,27 vs 2,13±0,33, p value 0,87 >0,05).
Kesimpulan : Tidak terdapat perbedaan yang signifikan dari kadar magnesium kelompok yang ada kalsifikasi dengan yang tidak ada kalsifikasi pembuluh darah pada pasien hemodialisis regulerIntroduction : Vascular calcification is a risk factor for cardiovascular mortality in hemodialysis patients. Low magnesium levels have been reported to have strong association with vascular calcification in hemodialysis patients. The aims of this study was to examine the association between serum magnesium levels and vascular calcification in hemodialysis patients
Methods : We studied 60 stable patients undergoing maintenance hemodialysis for more than 3 years. Vascular calcification was evaluating using lumbar lateral x-rays. Blood was drawn to measure serum magnesium levels.
Results : This study included 60 patients, 38 male and 22 female, aged 25-68 years. Vascular calcification was present in 65% of the patients. Mean serum magnesium level was 2,12±0,29 mg/dl. Serum magnesium was not statistically lower in patients with vascular calcification than in those without (2,12±0,27 vs 2,13±0,33, p value 0,87 >0,05).
Conclusion : Serum magnesium levels was not statistically different between the group with vascular calcification and without vascular calcification in hemodialysis patients.Tesis Magiste
Perbandingan Glycated Haemoglobin (HbA1c) dengan Glycated Albumin (GA) pada Pasien DM yang Menjalani Hemodialisis Reguler
No full textBackground : DM is diagnosis by blood glucose lwel test.Nowsday there are many report of
HbAlc weakness in blood glucose level monitoring in DM patients with reguler HD. In
regularly hernodialized patieils, HbAlc level me relativly lower thsr they are strppose to be
because RBC life span is shortened in ESRD patients. GA is used as an altemative
monitoring of regutarly hemodialized patients.
Methode : This study was an observational analysis with cross sectional design in Haji Adam
Malik public hospital in Medm. From Januari #d fehruari 2016. The research subjects were
patients that were undergoing reguler HD and for patiens who wcre diagnosed DM type 2
with ESRD adn hadn't gone on HD before in HAM hospital were includsd in the control
group.
Result : During this study 27 patients who went on reguler HD and 25 DM type 2 with
ESRD patients who hadn't gone on IID were included. The blood samples were taken for
testing in HAM hospital labomtorium. All groups of [fD patients were compared to the
control group. There were significant differences of the HbAlc levels (6,01t1,06 vs
9,01+2,79; P(0,0O1). The GA levels (17,8Sr5,47 vs 24,85*14,01; P(O022). artd ths uretrm
levels ( 173,49+69,22 vs 133,97*48,05; P(0,022). The mean of HbAlc leveis is+6,01, which
is lower thant the control group's mean +9.01. While in GA patients, the control mean is
relatively higher (+i7.8 ard +24.85). We could conclude that HbAlc in patients who were
undergoing reguler HD were lower. GA is used m an lternative blood glucose level
monitoring in reguarly hemodyalized patients.112 HalamanTesis Magiste
Perbandingan Kadar Serum Gamma Glutamyl Transferase Pada Pasien Penyakit Ginjal Kronik 5D Dengan Penyakit Ginjal Kronik Stadium 3 dan 4
No full textBackground:
CKD is a global public health problem with increased prevalence and incidence of kidney
failure, poor prognosis and high costs. Therefore the aim of this study is to look at the
characteristics of patients with CKD and the comparison of serum GGT levels in patients with
chronic 5D kidney disease. with patients with chronic kidney disease St 3 - 4. So they can find
out the mortality rate of patients with CKD 5D with CKD st 3-4.
Method:
Every CKD patient had venous blood drawn using a 5 mL venoject inserted into the EDTA
vacutainer tube and without anticoagulants then blood samples without anticoagulants were
centrifuged at 3500 rpm for 15 minutes to get serum. Then the serum is used for GGT
examination.
Results:
In this study the characteristics of CKD patients by sex were obtained by men as many as 55
people (56.1%), and female sex as many as 43 people (43.9%). From this study, the age of the
youngest CKD patient was 26 years and the oldest age was 74 years. In this study also found the
cause of CKD was HT as many as 53 patients (54.1%), DM as many as 43 patients (43.9%), and
nephrolithiasis as many as 2 patients (2.0%). And also obtained the results of a significant
difference between the GGT levels of 5D CKD patients and STK 3-4 patients (p = <0.001).
Conclusion:
Characteristics of CKD patients based on sex obtained by men more than women. From this
study also obtained the youngest age of CKD patients is 26 years and the oldest age is 74 years.
There is a significant difference between the GGT levels of patients with CKD 5D and CKD st
3-4.Latar Belakang:
PGK merupakan masalah kesehatan masyarakat global dengan prevalensi dan insidensi gagal
ginjal yang meningkat, prognosis yang buruk dan biaya yang tinggi.. Oleh sebab itu tujuan dari
penelitian ini adalah untuk melihat karakteristik dari pasien dengan PGK dan perbandingan
kadar serum GGT pada pasien penyakit ginjal kronik 5D dengan pasien penyakit ginjal kronis St
3 - 4. Sehingga dapat mengetahui tingkat mortalitas pasien PGK 5D dengan PGK st 3-4.
Metode:
Setiap pasien PGK dilakukan pengambilan darah vena menggunakan venoject sebanyak 5 mL
dimasukkan kedalam tabung vacutainer EDTA dan tanpa antikoagulan lalu sampel darah tanpa
antikoagulan di sentrifugasi 3500 rpm selama 15 menit untuk mendapat kan serum. Kemudian
serum digunakan untuk pemeriksaan GGT.
Hasil:
Pada penelitian ini karakteristik pasien PGK berdasarkan jenis kelamin diperoleh laki-laki
sebanyak 55 orang (56.1%), dan jenis kelamin wanita sebanyak 43 orang (43.9%). Dari
penelitian ini diperoleh usia pasien PGK termuda adalah 26 tahun dan usia tertua 74 tahun. Pada
penelitian ini juga diperoleh penyebab PGK adalah HT sebanyak 53 pasien (54.1%), DM
sebanyak 43 pasien (43.9%), dan nefrolitiasis sebanyak 2 pasien (2,0%). Dan juga didapatkan
hasil perbedaan yang signifikan antara kadar GGT pasien PGK 5D dengan pasien PGK st 3 - 4
(p = < 0.001).
Kesimpulan:
Karakteristik pasien PGK berdasarkan jenis kelamin diperoleh laki-laki lebih banyak di
bandingkan perempuan. Dari penelitian ini juga diperoleh usia termuda pasien PGK adalah 26
Tahun dan usia tertua 74 Tahun.
Terdapat perbedaan yang signifikan antara kadar GGT pasien PGK 5D dengan PGK st 3 - 4.81 HalamanTesis Magiste
Pengaruh Dosis Eritropoietin Fase Koreksi sebagai Drug Related Problems (DRPs) Terhadap Target Kadar Hemoglobin Pada Pasien Hemodialisis Reguler
No full textPatients with chronic kidney disease who undergo regular hemodialysis often experience anemia. Anemia is a serious problem of maintaining the quality of life of patients with chronic kidney disease. Anemia occurs due to reduced production of erythropoietin. Erythropoietin is a hormone that stimulates the bone marrow to produce red blood cells. The use of erythropoietin if not tightly controlled will cause complications that are bad for the patients.
The purpose of this research was to determine the effect of drug related problems (DRPs) to the target dose of hemoglobin level in reguler hemodialysis patients at correction phase treated with erythropoietin.
This study is a clinical study with a prospective cross-sectional design, using DRP - Registration Form V7.0 (PCNE) against fifty patients. The data were analyzed statistically by using Chi-Square test, paired T-Test sample, independent T test, SPSS version 17 program.
The results of the study of fifty patients, obtained dosing less than 27 patients (100%), who did not the target hemoglobin level of 17 patients (63%). Excessive dosing of 2 patients (100%), who did not the target of hemoglobin 1 patient (50%). Based on the Chi Square test, obtained the p value < 0.05, then there is a significant relationship between the dose and target hemoglobin levels. Based on T test results, p value < 0.05, then there is a difference in hemoglobin concentration target after being given significant erythropoietin therapy between the dose of less and excess.
Based on the description, it can be concluded that there is an effect of drug related problems (DRPs) related to excessive dosage; less dose to target hemoglobin level with significant value, so drug related problems (DRPs) associated dose affect the target hemoglobin level.Patients with chronic kidney disease who undergo regular hemodialysis often experience anemia. Anemia is a serious problem of maintaining the quality of life of patients with chronic kidney disease. Anemia occurs due to reduced production of erythropoietin. Erythropoietin is a hormone that stimulates the bone marrow to produce red blood cells. The use of erythropoietin if not tightly controlled will cause complications that are bad for the patients.
The purpose of this research was to determine the effect of drug related problems (DRPs) to the target dose of hemoglobin level in reguler hemodialysis patients at correction phase treated with erythropoietin.
This study is a clinical study with a prospective cross-sectional design, using DRP - Registration Form V7.0 (PCNE) against fifty patients. The data were analyzed statistically by using Chi-Square test, paired T-Test sample, independent T test, SPSS version 17 program.
The results of the study of fifty patients, obtained dosing less than 27 patients (100%), who did not the target hemoglobin level of 17 patients (63%). Excessive dosing of 2 patients (100%), who did not the target of hemoglobin 1 patient (50%). Based on the Chi Square test, obtained the p value < 0.05, then there is a significant relationship between the dose and target hemoglobin levels. Based on T test results, p value < 0.05, then there is a difference in hemoglobin concentration target after being given significant erythropoietin therapy between the dose of less and excess.
Based on the description, it can be concluded that there is an effect of drug related problems (DRPs) related to excessive dosage; less dose to target hemoglobin level with significant value, so drug related problems (DRPs) associated dose affect the target hemoglobin level.Tesis Magiste
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
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