20 research outputs found
Pharmaceutical principles of acid inhibitors: unmet needs
No full textDespite the well-established benefits of currently approved delayed-release proton pump inhibitors (PPIs) in the treatment of acid-related diseases, the unmet needs are still present and although often frustrating, they challenge clinicians. The unmet needs relate to the lack of complete control of acid secretion with oral PPI administration in the management of patients with gastroesophageal symptoms. These substantial groups of patients, who do not respond completely to standard doses of PPIs, are nonresponders, and their lack of response should be considered as PPI failure. Several mechanisms could explain PPI failure: differences in pharmacokinetics, PPI formulation, dosing time and diet, noncompliance, transient lower esophageal sphincter relaxations, esophageal hypersensitivity, and nocturnal acid breakthrough. To increase the quality of life of these patients and avoid multiple medical consultations and unnecessary investigations, we have to go one step forward and use combined therapy or look towards new treatments beyond acid suppression
Дизайн печатного издания «В арбузном сахаре» по мотивам романа Ричарда Бротигана
No full text"ЭТО ВХОД
В ЗАБЫТЫЕ ДЕЛА!
ОСТОРОЖНО!
МОЖНО ПОТЕРЯТЬСЯ!"
В своем романе "В арбузном сахаре" Ричард Бротиган рассказывает о быте и повседневной жизни людей в мире из арбузного сахара. Знакомство читателя с причудами "нововещественной" Вселенной происходит в парадигме повествования от первого лица. Фактически книга представляет собой дневник-расследование о жизни рассказчика, "инкрустированной" в весьма специфичный сюжет.
Однако главной идеей данного проекта становится не иллюстрирование хронологической цепочки событий или определенной образной системы-романа. Основной замысел состоит как раз в том, чтобы отказаться от нарратива, предлагаемого автором, показав собственно мир из арбузного сахара, а не историю, происходящую в нем. И вместе с тем важно отринуть семантические маркеры: своим названием новые вещи восходят лишь к прообразу, к Идее, но никак не к понятию.
Таким образом, разработанное издание представляет собой карту абстрактных графических образов, практически лишенных семантики.
Книга-настроение, книга-бред, книга-мечта.
Уже не дневник-расследование, а своего рода книга-исследование: насколько сильное и понятное зрителю Впечатление о мире из нового Вещества – "арбузного сахара" – возможно передать с помощью беспредметных композиций?"THIS IS THE ENTRANCE
TO THE FORGOTTEN WORKS
BE CAREFUL
YOU MIGHT GET LOST"
In his novel "In Watermelon Sugar", Richard Brautigan depicts the daily life of people in the world of watermelon sugar. The reader is introduced to the peculiarities of the new-mattered Universe in the first-person narrative paradigm. In fact, the book is an investigative diary about the life of the narrator, encrusted in a very specific plot.
However, the main idea of this project is not to illustrate a chronological chain of events or a certain system of images of the novel. The intention is to abandon the narrative proposed by the author, showing the actual world of watermelon sugar, and not the story that takes place in its framework. And at the same time, it is important to abandon any semantic markers: with their names, new things go back only to their prototype, to the Idea, but not to the concept itself.
Thus, this printed matter is a map of abstract graphic images, almost devoid of semantics.
A mood-book, a delirium-book, a dream-book.
No longer an investigative diary, but a kind of book-research: how vivid and understandable of an Impression of the world created from the new Matter - "watermelon sugar" - can be conveyed to the reader through the help of non-objective compositions
Endosonography in patients with recent first attack of mild pancreatitis of unclear etiology
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ESOPHAGEAL STENT PLACEMENT FOR DYSPHAGIA PALLIATION IN LUNG CANCER PATIENTS; A TWO YEAR SINGLE CENTER EXPERIENCE
No full textImpact of trainee involvement on the outcome of ERCP procedures: Results of a prospective multicenter observational trial
No full textBackground Training in advanced endoscopic techniques such as endoscopic retrograde cholangiopancreatography (ERCP) should be driven by key performance measures and standardized competence assessment in order to provide safe and high-quality interventions. We aimed to determine whether the involvement of trainees influences the outcome of the procedure and the incidence of ERCP-related adverse events. Methods This was an international, multicenter, prospective, observational study conducted at six high- and low-volume centers across Europe between October 2016 and October 2018, and included independent operators and their trainees. Standard report forms documenting indication, trainee involvement, technical outcome, and complications over a 30-day follow-up of consecutive ERCP procedures were included in the analysis. Technical success of the procedure and procedure-related adverse events were compared between procedures in the trainee group and the control group using bivariable and multivariable analysis. Results 21 trainees and 16 control endoscopists performed 1843 ERCPs during the study period. Trainee involvement in ERCP procedures did not decrease technical success (92.4% vs. 93.7%; P =0.30) or increase the risk of adverse events (14.7% vs. 14.6%; P >0.99). Conversely, there were significantly more moderate or severe adverse events in the control group compared with the trainee group (6.2% vs. 3.4%, P =0.01). On multivariable analysis, only increased bilirubin levels, time to cannulation, and procedure difficulty level increased the risk of any procedure-related adverse event. Conclusion Trainee involvement in ERCP interventions within a proper teaching setting is safe and does not compromise the success of the procedure
ESTIMATING DIFFICULTY OF ENDOSCOPIC RESECTION WITH SMSA POLYP COMPLEXITY CLASSIFICATION SYSTEM
No full textThe esophagus as a working channel: successful closure of a large Mallory–Weiss tear with clips and an endoloop
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