172 research outputs found
Sexual dysfunction and other distressful symptoms in cervical cancer survivors
No full textBackground: The majority of cervical cancer survivors are young or middle-aged women who will live many years with their treatment-induced sequelae. The effects of preoperative brachytherapy are unclear and treatment traditions vary - in Sweden and internationally. The relative occurrence of long-term distressful symptoms related to different treatments and the extent to which the women want to trade off optimal survival chances are not known.Methods: The effects of radical hysterectomy were studied in a comparison with population controls, and the effects of additional brachytherapy could be studied due to various treatment policies at different centres. We used an anonymous postal questionnaire, studying the nature, occurrence and intensity of the symptoms and, separately, the corresponding symptom-induced distress.Results: We obtained information from 256 of 332 (77%) cervical cancer survivors and 350 of 495 (72%) population controls. Radical hysterectomy alone caused insufficient lubrication (relative risk [RR] 2.8 as compared to controls), reduced genital swelling at arousal (RR 1.5), reduced vaginal length (RR 6.1) and vaginal elasticity (RR 7.1), dyspareunia (RR 4.4), straining to void (RR 21.8), lymphoedema (RR 8.1) and distress from vaginal changes (RR 3.0). The addition of preoperative brachytherapy yielded RR 3.1 for defecation urgency, RR 8.5 for frequent nocturia and RR 1.6 for moderate and severe anxiety, but no excess risk concerning vaginal changes. The addition of external radiotherapy yielded, e.g., RR 13.1 for frequent nocturia and RR 4.8 for frequent defecation. A history of sexual abuse and cervical cancer gave RR 30.0 for superficial dyspareunia as compared to population controls with no history of sexual abuse. The majority of women were not prepared to forgo brachytherapy (even at a possible risk of 1% decreased survival) to avoid its long-term side effects.Conclusion: Sexual dysfunction is the most distressful symptom in cervical cancer survivors, thus emphasising efforts to avoid it and interventions to relieve it. The excess risk of distressful treatment- induced symptoms from preoperative brachytherapy is low, if any, and the majority of women prioritise optimal survival over freedom from treatment-induced symptoms. To meet the needs of women with early cervical cancer, a valid (randomised) study of the effects of preoperative brachytherapy is warranted. The long-term situation for cervical cancer survivors can be improved by clinical application of the data from this and other studies, and a number of areas for future research that may better the situation even more have been specified.List of scientific papersI. Bergmark K, Avall-Lundqvist E, Dickman PW, Henningsohn L, Steineck G (1999). Vaginal changes and sexuality in women with a history of cervical cancer. N Engl J Med. 340(18): 1383-9. https://pubmed.ncbi.nlm.nih.gov/10228188II. Bergmark K, Avall Lundqvist E, Dickman PW, Henningsohn L, Steineck G (2002). Patient-rating of distressful symptoms after treatment for early cervical cancer. Acta Obstetrica et Gynecologica Scandinavica. [Accepted]III. Bergmark K, Avall Lundqvist E, Dickman PW, Henningsohn L, Steineck G (2002). Long-term symptom prevalence after radical hysterectomy for early cervical cancer and among population controls. [Submitted]IV. Bergmark K, Avall Lundqvist E, Dickman PW, Henningsohn L, Steineck G (2002). Distressful symptoms in cervical cancer survivors after radical hysterectomy with or without preoperative brachytherapy. [Submitted]V. Bergmark K, Avall Lundqvist E, Dickman PW, Henningsohn L, Steineck G (2002). Sexual abuse: Long-term effect on sexuality and well-being, and relation to cervical cancer. [Submitted]VI. Steineck G, Bergmark K, Henningsohn L, al-Abany M, Dickman PW, Helgason A (2002). Symptom documentation in cancer survivors as a basis for therapy modifications. Acta Oncologica. [Accepted]</p
Oral history interview with Alexander Forger, conducted by Martha Bergmark
No full textA graduate of Princeton University School of Public and International Affairs, Alexander Forger earned his law degree at Yale Law School. He was a Partner with Milbank, Tweed, Hadley & McCloy LLP since 1958, and served as Chairman of the Firm from April 1984 through April 1992. He now serves as Special Counsel to the Firm. Mr. Forger has extensive experience in trusts and estates and in domestic relations and personal law. He is a Fellow of the American College of Trust and Estate Counsel and the International Academy of Estate and Trust Law. As a member of the American Bar Association, Mr. Forger has served as the New York Delegate to the House of Delegates; as a member of the Comprehensive Legal Needs Study, the Advisory Committee to the Immigration Pro Bono Development Project and the Commission on Legal Problems of the Elderly. He also is Trustee-Emeritus of the National Conference of Bar Foundations. As a member of the Association of the Bar of the City of New York, he has served on the Committee to Enhance Professional Opportunities for Minorities, the Committee on Lesbians and Gay Men in the Profession and currently serves on the Special Commission on Campaign Finance Reform. As a member of the New York State Bar Association, he served as President from 1980 to 1981, and is a member of the House of Delegates. Mr. Forger was a Director of the Legal Aid Society from 1976 to 1993, President from 1977 to 1979 and Chairman of the Board from 1984 to 1993. He served as President of the Legal Services Corporation from 1994 to 1997. He currently serves as a member of the Board of the Lawyers Committee for Civil Rights under Law, Chair of the Volunteer Lawyers Aids project, Vice President and Director of the Dorothea L. Leonhardt Foundation, Board of the Children's Advocacy Center, Director of The Gerard B. Lambert Memorial Foundation, Inc. and as National Chairman of the Advisory Committee of the Inter Press Alliance. Mr. Forger is Trustee-Emeritus of The Rockefeller University and Trustee and former Chairman of the Board of New York Law School.
Forger provided crucial leadership in the early days of the AIDS epidemic in establishing legal services for people with HIV/AIDS. In 2011, the American Bar Association established the Alexander D. Forger Award to recognize and celebrate lawyers and legal service providers who have demonstrated a sustained commitment to the advancement of the rule of law for individuals living with HIV and to the provision of direct legal services to individuals infected with, and affected by, HIV. Mr. Forger received the Whitney N. Seymour, Sr. Award, presented by the Federal Bar Council in recognition of public service by a member of the private bar; the Treat Award for Excellence, presented by the National College of Probate Judges in recognition of contributions to the improvement of the law in the probate field; the Servant of Justice Award for the Legal Aid Society, and honorary degrees from Widener University School of Law and the New York Law School
Determination of hemoglobin adducts in humans occupationally exposed to acrylamide
No full textHemoglobin (Hb) adduct determinations were used to monitor occupational exposure to acrylamide (AA) and acrylonitrile (AN). Forty-one workers in a factory in the People's Republic of China who were involved in the synthesis of AA by catalytic hydration of AN and the manufacturing of polyacrylamides were studied. Ten nonexposed workers in the same city served as controls. AA and AN exposures were monitored using the modified Edman degradation procedure for the determination of their respective Hb adducts to N-terminal valine. The adduct levels in the exposed workers were 0.3-34 nmol/g Hb for AA and 0.02-66 nmol/g Hb for AN, as determined by gas chromatography-mass spectrometry (GC-MS). The formation of glycidamide (GA), the epoxide metabolite of AA, in humans was demonstrated by GC-MS analysis of its Hb adduct to N-terminal valine following acid hydrolysis, ion-exchange chromatography, and derivatization. The GA adduct was detected in samples from the exposed persons with levels of 1.6-32 nmol/g Hb. There was a linear relationship between the AA and GA adduct levels (r = 0.96) and the ratio of the in vivo doses of GA and AA was 3:10. These results suggest that AA is metabolized to GA in humans, as had previously been shown in the rat. The high AA adduct levels in the exposed workers, as compared to those expected from air concentrations, indicate that dermal exposure may contribute significantly to the total uptake of AA. The average daily in vivo doses of AA and GA in the highest exposed workers were comparable to the in vivo doses in rats injected with 3 mg/kg AA. Since a regimen of 2 mg/kg/day is known to cause a significant increase of tumors in rats, preventive measures may be necessary for humans exposed to high levels of AA in industrial settings
Profilering i offentliga sektorn : En studie i varför statliga förvaltningsmyndigheter bedriver profileringsarbeten
No full textTitle: Branding the public sector Author: Rasmus Bergmark and David Backman Tutor: Magnus Fredriksson Purpose: The purpose of this thesis was to examine branding in the public sector. The frame extends to government agencies and authorities in the Swedish public sphere, and aims to identify ulterior motives for their work with branding. Method/Material: The material used in this thesis consists 102 graphic manuals for government agencies in the Swedish public sector. The examination was based on an inductive survey where we extracted prominent motives among the graphic manuals. Main results: The main results of this survey shows which ulterior motives are more prominent than others, why they are more prominent and correlations between different motives. Number of pages: 53 Course: Media and Communications studies C University: Division of Media and Communication, Department of Information sience, Uppsala university Period: Fall 2013 Keywords: Corporate branding, public sector, motives, market communicationDenna studies syfte är att undersöka vilka motiv som myndigheter anger vara skäl till att arbeta med profilering och vilka av dessa motiv som är de mest framträdande. Uppsatsen bygger på en övergripande frågeställning och tre stycken mer specificerade frågor som berör den övergripande frågan på en närmare nivå. Den övergripande frågan är: Varför vill man profilera sig som myndighet? Vidare är de tre andra frågorna som uppsatsen ämnar besvara dessa: Hur motiverar svenska myndigheter sitt arbete med profilering? Vilka motiv är vanligast förekommande? Hur beskrivs det att myndigheter arbetar med profilering? Undersökningen baseras på en kvantitativ studie och genomfördes med hjälp av en innehållsanalys. Studien är utförd på samtliga tillgängliga profilmanualer för statliga förvaltningsmyndigheter i Sverige. Utifrån dessa har vi utformat ett eget ramverk med kategorier baserat på vad vi kunnat utläsa ur manualerna. Genom detta ramverk har vi kunnat ta fasta på vad och hur svenska myndigheter motiverar sitt arbete med profilering. Undersökningens resultat visade vad som motiverar svenska myndigheter att bedriva arbete med profilering. Resultatet i underökningen visade i vilken utsträckning myndigheterna angav dessa motiv. Majoriteten angav tydlighet som motiv till att bedriva arbetet med profilering och detta motiv tycks även vara grundläggande för resterande faktorer i deras arbete. Vidare kan vi konstatera att det är viktigt att arbetet bedrivs konsekvent då majoriteten av svenska myndigheter angav detta som ett motiv
sj-pdf-1-vmj-10.1177_1358863X241228542 – Supplemental material for Methods, design, and initial results of an angiographic core lab from VOYAGER-PAD
No full textSupplemental material, sj-pdf-1-vmj-10.1177_1358863X241228542 for Methods, design, and initial results of an angiographic core lab from VOYAGER-PAD by R Kevin Rogers, Joerg Herold, Nicholas Govsyeyev, Roberto Iezzi, Justin Morrison, Shea E Hogan, Mark Nehler, Rory Bricker, Brice Andring, Brian Bergmark, Matt Cavender, Emily Malgor, Donald Jacobs, Michael N Young, Warren Capell, Joseph W Yčas, Sonia S Anand, Scott D Berkowitz, E Sebastian Debus, Lloyd P Haskell, Eva Muehlhofer, Manesh R Patel, Connie N Hess, Rupert M Bauersachs, Victoria Anderson and Marc P Bonaca in Vascular Medicine</p
Visualizing the Marrow of Science
No full textThis study proposes a new methodology that allows for
the generation of scientograms of major scientific domains,
constructed on the basis of cocitation of Institute
of Scientific Information categories, and pruned using
PathfinderNetwork, with a layout determined by algorithms
of the spring-embedder type (Kamada–Kawai),
then corroborated structurally by factor analysis. We
present the complete scientogram of the world for the
Year 2002. It integrates the natural sciences, the social
sciences, and arts and humanities. Its basic structure
and the essential relationships therein are revealed,
allowing us to simultaneously analyze the macrostructure,
microstructure, and marrow of worldwide scientific
output
'Living lightly on the Earth': Building an ark for Prince Edward Island, 1974–76 by Steven Mannell (review)
No full textLiving Lightly on the Earth is a shining example of publicly engaged scholarship in the environmental humanities. Steven Mannell, an architect and director of Dalhousie University’s College of Sustainability, is not a historian but, rather, a public scholar, and, like the college, this book is an accomplishment in interdisciplinary public teaching and research. Mannell curated an exhibit at the Confederation Centre of the Arts in Charlottetown in the months prior to the book’s publication. The book’s “project team” lists three members, including Mannell as author and exhibit curator, Lukas Bergmark as assistant curator, and Megan Peck as research and curatorial assistant. Full credit is also given to the two original architects, two curators at the Confederation Centre, one additional writer (historian Daniel A. Barber wrote a short introduction), and four other collaborators. The ratio of authors to words published is thus substantially higher than most of the books reviewed in this journal, but the result is a richly illustrated, well-researched, and deeply personal account of this unique moment in architectural and environmental history
Will I see you at work? Ethnic workplace segregation in Sweden 1985–2002*
No full textWe study ethnic workplace segregation in Sweden using linked employer-employee data covering the entire working-age Swedish population during 1985–2002. Segregation is measured as overexposure to a particular group, taking into account the distribution of human capital, industry and geography. We find considerable workplace segregation between immigrants and natives but the results differ substantially between ethnic groups. Segregation has increased during the period, mainly due to changes in the ethnic composition. Immigrants are particularly overexposed to workers from their own birth region but also to other immigrants. Children to immigrants are only overexposed to immigrants from their parents region of birth. Segregation—particularly in the immigrant-native dimension—is in general negatively correlated with economic status.Workplace segregation; ethnic minorities; immigrant assimilation
Analytical study of contents of LANL physics and cross-listed e-print archives, 1994-2002
No full textThe frontiers of physics and cross-listed e-print archives posted during the years 1994-2002 at http://www.arxiv.org/archives/physics web service of Los Alamos National Laboratory (LANL) are explored from 7770 submissions. E-print archives posted to top most six physics-cross-listed research categories besides physics (5390) are: Condensed matter (754), Quantum physics (279), Astrophysics (222), Chemical physics (129), High energy physics - Phenomenology (118), and High energy physics-Theory (100). Prominent contributors are B.G. Sidharth (India), V.V. Flambaum (Australia), Antonina N. Fedorova (Russia), and Michael G. Zeitlin (Russia). Most preferred journals for rechannelising e-print archives are Physical Review Letters, Physical Review A, Physical Review E, Nuclear Instruments and Methods A, and Journal of Chemical Physics
A new technique for building maps of large scientific domains based on the cocitation of classes and categories
No full textOur objective is the generation of schematic visualizations as interfaces for scientific domain analysis. We propose a new technique that uses thematic classification (classes and categories) as entities of cocitation and units of measure, and demonstrate the viability of this methodology through the representation and analysis of a domain of great dimensions. The main features of the maps obtained are discussed, and proposals are made for future improvements and applications
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