113 research outputs found
The issues of youth political participation (Case study: Municipality of Kamnik)
No full textPolitična participacija je izjemno širok ter kompleksen pojem, ki se venomer razvija ter spreminja glede na čas ter skupek dejavnikov, ki nanj vplivajo. V sledeči diplomski nalogi sem se osredotočil na novejše teoretične pristope k politični participaciji, še posebej pri politični participaciji mladih. Novejše teorije se oddaljujejo od konvencionalnih oblik politične participacije ter se vedno bolj osredotočajo na alternativne pristope, ki jih uporabljajo mladi. Mladi politično participacijo razumejo na drugačen način, zato ni prav, da so mlajše generacije označene za politično nepismene ter apatične. Čeprav po tradicionalnih pokazateljih, kot sta spremljanje ter aktivnost v institucionalni ter strankarski politiki mladih, kažejo nižje stopnje zanimanja, se pokaže, da so izjemno aktivni na področjih, ki jih zanimajo, ko vštejemo druge dejavnike ter načine, na katere participirajo. Prihodnost politične aktivnosti mladih se zagotovo skriva v novih oblikah participacije, ki jih je s seboj prinesla nova doba priložnostnih politik ter aktivizma.Political participation is an extremely broad and complex concept that constantly develops and changes over time and with the factors that influence it. In the following thesis, I have focused on new theoretical approaches to political participation, especially in the political participation of young people. New theories distance themselves from conventional forms of political participation and increasingly focus on alternative approaches used by young people. Young people understand political participation in a different way, so younger generations should not be characterised as politically illiterate and apathetic. Although, according to traditional indicators, such as activity in institutional and party politics, young people show lower levels of interest, it turns out that they can also extremely active in the fields that interest them, once other factors and the ways in which young people participate are taken into account. The future of youth political participation is to be found in new forms of participation brought about by the new era of one-time politics and activism
Youth and environmental activism as a form of political participation: an overview of Podnebni štrajk 2023
No full textV sodobnem svetu so mladi okoljski aktivisti postali ključna politična sila. V magistrskem delu sem analizirala vključevanje mladih v okoljski aktivizem s posebnim poudarkom na slovenskem okviru, s primerom Podnebnega štrajka 2023. Izpodbijam splošno razširjeno prepričanje, da današnje mlade zaznamuje politična apatičnost, če ne celo popolna apolitičnost, saj se delo poglablja v zapletene interakcije med mladimi, političnim udejstvovanjem in okoljskim aktivizmom. To argumentiram z orisom novih repertoarjev političnega udejstvovanja, ki dopolnijo ali nadomestijo konvencionalne oblike, in z empirično podlago, pridobljeno z opazovanjem z udeležbo, polstrukturiranimi intervjuji ter strukturiranimi intervjuji. S predstavitvijo zgodovinskega ozadja in opisom različnih oblik in vzrokov okoljskega aktivizma mladih je to delo podlaga za celovito analizo sodobnega vključevanja mladih v okolijski aktivizem. Omenjeni metodološki instrumenti ponujajo vpogled v odnos mladih aktivistov do okolja in podnebnih sprememb ter v prakse, ki jih uporabljajo za doseganje svojih ciljev. Namen te študije je zagotoviti vpogled v spreminjajočo se naravo političnega udejstvovanja mladih in njihovo zmožnost, da bistveno spremenijo okoljevarstvo.In the modern world, young environmental activists have become a key political force. In my master’s thesis I analyse the involvement of young people in environmental activism with a particular focus on the Slovenian context, with the case of the Podnebni štrajk 2023. I challenge the widely held belief that today\u27s young people are characterised by political apathy, if not outright apoliticality, as the thesis delves deeper into the complex interactions between young people, political participation, and environmental activism. I argue for this by outlining new repertoires of political participation that complement or replace conventional forms, and by drawing on empirical evidence from participant observation, in-depth interviews, and a planned survey. By presenting the historical background and describing the different forms and causes of youth environmental activism, this work provides the basis for a comprehensive analysis of contemporary youth involvement in environmental activism. The methodological instruments mentioned above offer insights into the attitudes of young activists towards the environment and climate change and the practices they use to promote their goals. This study aims to provide insights into the changing nature of young people\u27s political participation and their capacity to make a significant difference to environmentalism
Scientific and professional activity of professor Jelenko M. Mihailović (1869-1956)
No full textThe Scientific and professional activity of distinguished seismologist,
Professor Jelenko M. Mihailović is presented, and his bibliography is listed.
He was coworker of Milan Nedeljković the founder of Belgrade Astronomical
Observatory from 1893 up to 1906. During this time Mihailovi´c was his
assistant working on Belgrade Astronomical Observatory and even on the post
of vice director
Untersuchung der N-terminalen regulatorischen Domänen der Phosphodiesterasen 1, 4, 5 und 10 mit einer Adenylatcyclase als Reporter
No full textAlpha-helical linker regions between tandem GAF domains in PDE5 and 10 are essential for intramolecular signal transmission through subtle interactions between upstream and downstream GAF domains. Mutations within the first ten amino acids of the linker region S231-A366 of PDE10 into corresponding amino acids of PDE5 resulted in enzyme activation and loss of cAMP regulation. C240Y mutation was identified as one of them responsible for this effect and probably for the specific interactions within GAF tandem domains.
Beside tandem GAF domains from PDE2, 5, 10 and 11, N-terminal tandem domains from PDE1 – CaM-binding domains and PDE4 – UCR domains can regulate CyaB1 AC. PDE1A3-CyaB1 AC chimera was 2.1 and PDE1B1-CyaB1 AC was 4.4-fold stimulated by CaM, what is similar to the already reported values for CaM stimulation of these holoenzymes. PDE4A4-, B1- and D3- CyaB1 AC chimeras were activated by phosphomimetic mutation of serine from the phosphorylation motif at the beginning of UCR1, 2, 2.1, and 3.8-fold, respectively, similarly as the reported activation of the holoenzymes by serine phosphorylation.
Successful substitutions of tandem GAF domain from cyanobacterial AC by different tandem domains of human PDEs indicates that molecular mechanisms which regulate enzyme activity upon modifications from N-terminal domains are conserved and similar in all PDEs and established early in the evolution. Recently solved crystal structure of near full length hPDE2 helped in elucidating this mechanism. It is possible that N-terminal domains of different PDEs regulate access to the substrate binding pocket as the way of regulation catalytic activity.Alpha-helicale Linkerregionen zwischen Tandem GAF-Domänen in PDE5 und 10 sind unerlässlich für die intramolekulare Signalweiterleitung aufgrund der fein abgestimmten Interaktionen zwischen vor- und nachgeschalteten GAF-Domänen. Mutationen im Bereich der ersten 10 Aminosäuren der Linkerregion S231-A366 von PDE10 in die entsprechenden Aminosäuren von PDE5 hatten Enzymaktivierung und Verlust der cAMP-Regulierung zur Folge. Die Mutation C240Y hat sich als für diesen Effekt verantwortlich herausgestellt und ist möglicherweise auch für die spezifischen Interaktionen innerhalb der Tandem GAF-Domänen verantwortlich.
Neben der Tandem GAF-Domänen von PDE2, 5, 10 und 11 können auch N-terminale Tandem-Domänen von CaM-Bindedomänen aus PDE1 und UCR-Domänen aus PDE4 die AC von CyaB1 regulieren. Die Chimäre PDE1A3-CyaB1 AC zeigte 2,1-fache und PDE1B1-CyaB1 AC 4,4-fache Stimulierung durch CaM, was mit den bereits bekannten Werten für CaM-Stimulierung dieser Holoenzyme übereinstimmt. PDE4A4-, B1- und D3- CyaB1 AC-Chimären konnten durch phosphomimetische Mutation von Serin im Phosphorylierungs-Motiv am Anfang der UCR1-Domäne 2-fach, 2,1-fach bzw. 3,8-fach aktiviert werden, was der beschriebenen Aktivierung der Holoenzyme durch Serin-Phosphorylierung entspricht.
Die Tandem GAF-Domäne der cyanobakteriellen AC konnte erfolgreich durch verschiedene Tandem-Domänen der humanen PDEs ersetzt werden. Dies deutet darauf hin, dass molekulare Mechanismen, die die Enzymaktivität durch Modifizierung der N-terminalen Domänen regulieren, konserviert und in allen PDEs ähnlich sind und sich früh in der Evolution ausgebildet haben. Die kürzlich gelöste Kristall-Struktur der fast kompletten hPDE2 war bei der Aufklärung dieses Mechanismus hilfreich. Möglicherweise regulieren N-terminale-Domänen verschiedener PDEs die Zugänglichkeit zur Substrat-Bindetasche über die Regulierung der katalytischen Aktivität
Youth Athletes’ Perception of Existence and Prevalence of Aggression and Interpersonal Violence and Their Forms in Serbia
No full textAggression and interpersonal violence (IV) against children and youth are issues in con-temporary society. The current study reports on the youth athletes’ perception of the aggression and IV prevalence and its manifestation forms in a Serbian context. The sample included athletes (N = 2091) between the age of 11 and 18 years. Data were collected through an ad-hoc questionnaire created by the authors. Respondents’ answers to introductory questions about the frequency of IV indicated its absence (78.1%). However, the answers to the questions about specific forms of violent peer behavior indicated forms as well as the time and place where IV most often occurs. They underlined that IV takes place mainly after training or competition and during sports camps; and that the dressing room is the most favorable place for these behaviors. They also confirmed that the most prevalent subtypes of IV are psychological (roughly 40%) and physical (approximately 30%). The respondents’ opinions and experiences about IV (psychological, physical, sexual) revealed that factors such as gender, location, and parents’ education level may influence the IV manifestation. Highlighting the prevalence and the most frequently manifesting types of aggression and IV could help in awareness-raising of these social issues
Synthesis, structure and properties potential biologically active N-aryl-2,2-disubstituted succinimides
No full textУ оквиру овог рада, са циљем испитивања утицаја структуре на биолошку
ативност, први пут су синтетисане три различите серије једињења деривата
сукцинимида (пиролидин-2,5-дионa), и то: N-(3- и 4-супституисани фенил)-2-етил-2-
метилсукцинимиди, N-(3- и 4-супституисани фенил)-2-фенил-2- метилсукцинимиди
и N-(3- и 4-супституисани фенил)-2-(4-хлорфенил)-2-метилсукцинимиди.
Свих 34 једињења су синтетисана према модификованим поступцима из
литературе, а структура и чистоћа су потврђена применом одговарајућих
спектроскопских метода.
Ефекти солватације растварача различитих поларности на електронска
својства деривата N-арил-2,2-дисупституисаних сукцинимида су проучавани
снимањем UV-Vis апсорпционих спектара у опсегу таласних дужина 200 ̶400 nm.
Урађени су квантнохемијски прорачуни, коришћењем програмског пакета
Gaussian 09 применом DFT методе. У циљу проналажења најстабилнијих
конформера, урађена је конформациона анализа. Одређена је мапа молекулског
електростатичког потенцијала деривата и анализа енергија граничних молекуларних
орбитала (HOMO и LUMO), као и енергетска разлика између њих, применом B3LYP
и М06-2Х/6-311++G(d,p) методе.
У наставку истраживања урађена је процена потенцијалне биолошке
активности проучаваних једињења. Експериментално је одређена антимикробна
активност синтетизованих деривата сукцинимида методом микродилуције, на осам
бактеријских врста и осам гљивичних врста.In this paper, three different series of compounds of succinimide derivatives
(pyrrolidine-2,5-dione) were synthesized for the first time to investigate the effect of the structure on biological activity: N-(3- and 4-substituted phenyl)-2-ethyl-2-methylsuccinimides, N-(3- and 4-substituted phenyl)-2-phenyl-2-methylsuccinimides and N-(3- and 4-substituted phenyl)-2-(4-chlorophenyl)-2-methylsuccinimides. All 34 compounds were synthesized according to modified literature procedures, and the structure and purity were confirmed using appropriate spectroscopic methods.
The effects of the solvation of solvents of different polarities on the electronic properties of N-aryl-2,2-disubstituted succinimide were studied by recording UV-Vis absorption spectra in the wavelength range of 200-400 nm.
Quantum-chemical calculations were made using the Gaussian 09 software
package using the DFT method. In order to find the most stable conformers, a
conformational analysis was made. A map of the molecular electrostatic potential of the derivatives and the analysis of the energy of Frontier Molecular Orbitals (HOMO and LUMO), as well as the energy difference between them, was determined using the B3LYP and M06-2H / 6-311 ++ G (d, p) methods.
In the continuation of the research, an assessment was made of the potential
biological activity of the compounds studied. The antimicrobial activity of the synthesized succinimide derivatives was experimentally determined by microdilution method, eight bacterial species and eight fungal species.Experimental antimicrobial activity was determined by microdilution method
Synthesis, structure and properties potential biologically active N-aryl-2,2-disubstituted succinimides
No full textУ оквиру овог рада, са циљем испитивања утицаја структуре на биолошку
ативност, први пут су синтетисане три различите серије једињења деривата
сукцинимида (пиролидин-2,5-дионa), и то: N-(3- и 4-супституисани фенил)-2-етил-2-
метилсукцинимиди, N-(3- и 4-супституисани фенил)-2-фенил-2- метилсукцинимиди
и N-(3- и 4-супституисани фенил)-2-(4-хлорфенил)-2-метилсукцинимиди.
Свих 34 једињења су синтетисана према модификованим поступцима из
литературе, а структура и чистоћа су потврђена применом одговарајућих
спектроскопских метода.
Ефекти солватације растварача различитих поларности на електронска
својства деривата N-арил-2,2-дисупституисаних сукцинимида су проучавани
снимањем UV-Vis апсорпционих спектара у опсегу таласних дужина 200 ̶400 nm.
Урађени су квантнохемијски прорачуни, коришћењем програмског пакета
Gaussian 09 применом DFT методе. У циљу проналажења најстабилнијих
конформера, урађена је конформациона анализа. Одређена је мапа молекулског
електростатичког потенцијала деривата и анализа енергија граничних молекуларних
орбитала (HOMO и LUMO), као и енергетска разлика између њих, применом B3LYP
и М06-2Х/6-311++G(d,p) методе.
У наставку истраживања урађена је процена потенцијалне биолошке
активности проучаваних једињења. Експериментално је одређена антимикробна
активност синтетизованих деривата сукцинимида методом микродилуције, на осам
бактеријских врста и осам гљивичних врста.In this paper, three different series of compounds of succinimide derivatives
(pyrrolidine-2,5-dione) were synthesized for the first time to investigate the effect of the structure on biological activity: N-(3- and 4-substituted phenyl)-2-ethyl-2-methylsuccinimides, N-(3- and 4-substituted phenyl)-2-phenyl-2-methylsuccinimides and N-(3- and 4-substituted phenyl)-2-(4-chlorophenyl)-2-methylsuccinimides. All 34 compounds were synthesized according to modified literature procedures, and the structure and purity were confirmed using appropriate spectroscopic methods.
The effects of the solvation of solvents of different polarities on the electronic properties of N-aryl-2,2-disubstituted succinimide were studied by recording UV-Vis absorption spectra in the wavelength range of 200-400 nm.
Quantum-chemical calculations were made using the Gaussian 09 software
package using the DFT method. In order to find the most stable conformers, a
conformational analysis was made. A map of the molecular electrostatic potential of the derivatives and the analysis of the energy of Frontier Molecular Orbitals (HOMO and LUMO), as well as the energy difference between them, was determined using the B3LYP and M06-2H / 6-311 ++ G (d, p) methods.
In the continuation of the research, an assessment was made of the potential
biological activity of the compounds studied. The antimicrobial activity of the synthesized succinimide derivatives was experimentally determined by microdilution method, eight bacterial species and eight fungal species.Experimental antimicrobial activity was determined by microdilution method
Women\u27s question in socialism: political thought of Alexandra Kollontai in Yugoslav feminist discourses
No full textPričujoče magistrsko delo obravnava politično misel ruske teoretičarke Aleksandre Kollontaj v jugoslovanskih feminističnih diskurzih. S tem namenom delo umestimo v foucaultovski arheološki pristop, ki naš teoretsko-metodološki okvir opremi s konceptoma diskurza ter avtor-funkcije. V skladu s konceptom diskurza socialistični feminizem opredelimo kot diskurz in preko metafore nesrečnega zakona izpostavimo njegove ključne elemente. V obravnavi socialističnega feminizma kot diskurza se kot ena izmed ključnih lastnosti kažejo paradigmatske omejitve, ki jih implicira uvedba spola kot analitične kategorije. Koncept avtor-funkcije služi obravnavi vloge Aleksandre Kollontaj v jugoslovanskih feminističnih diskurzih. Pri tem stičišča obravnavanih feminističnih tokov opazujemo na dveh mestih. Na prvem mestu gre tu za tematska stičišča, kjer primerjamo delovanje dveh ženskih organizacij - sovjetskega Ženotdela in jugoslovanske Antifašistične fronte žensk. V obravnavi le-teh kot pomembno stičišče prepoznamo vprašanje o pogojih emancipacije žensk. V sklopu tematskih stičišč prav tako obravnavamo področje komodifikacije (ženske) seksualnosti, kjer prepoznamo podobnosti v obravnavanju fenomena kot družbeno situiranega. Na drugem mestu obravnavamo okoliščine prevoda zbirke Ženska v socializmu (1982), ki predstavlja prvi slovenski prevod del Aleksandre Kollontaj. V tej obravnavi ugotavljamo, da je Aleksandra Kollontaj v lokalni feministični prostor vstopila preko klasikov marksizma, in ne preko feminističnih tokov. Hkrati ugotavljamo, da je Aleksandra Kollontaj v slovenskem feminističnem prostoru predstavljala novost, in ne ene izmed ključnih referenčnih točk.The present master’s thesis deals with the political thought developed by the Russian theoretician Alexandra Kollontai and its integration to Yugoslav feminist discourses. The work is situated within a Foucauldian archaeological approach which grounds our theoretical and methodological framework in the concepts of discourse and author-function. In line with the concept of discourse, we delineate socialist feminism as a discourse and underline its key elements through the unhappy marriage metaphor. Here, the paradigmatic limitations implied by the introduction of gender as an analytical category emerge as one of its key features. The concept of author-function serves to address the role of Kollontai in Yugoslav feminist discourses. In doing so, the intersections of the discussed feminist currents are observed in two instances. Firstly, we discuss thematic intersections and compare two women’s organisations - the Soviet Zhenotdel and the Yugoslav Antifascist Women’s Front. Here, the question of the condition of the emancipation of women is identified as an important point of convergence. We also consider the subject of the commodification of (female) sexuality and recognise similarities in the treatment of this phenomenon as socially situated. Secondly, we look at the context of the translation of the volume Ženska v socializmu (1982), which represents the first Slovenian translation of Kollontai’s works. In this analysis, we note that Kollontai was introduced to the local feminist space through the classics of Marxism, rather than through feminist currents. We conclude that Alexandra Kollontai represented a novelty in the Slovenian feminist space, and not one of the key reference points
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