1,720,973 research outputs found
Sebaceous carcinoma of the lip.
No full textSebaceous carcinoma (SC) is an uncommon neoplasm. To date fewer than 400 cases have been reported in literature. Due to the low incidence and the not universally accepted histopathological classification, it presents diagnostic problems1. Generally, the lesions arise in the meibomian glands of the eyelid. However, extra-ocular localisation in the head and neck region have been reported. While several reports have documented sebaceous adenomas arising from sebaceous glands of the oral cavity, oral sebaceous carcinomas are extremely rare. To date only six cases have been described2. The salivary glands too are considered an uncommon site, even if some cases arising in the parotid gland were recognised. Herein we reported a case of SC arising in the lateral edge of the lower lip in a 71-year-old men. To the best of our knowledge this is the second case described in lips. The clinical differential diagnosis included squamous cell carcinoma, basal cell carcinoma with sebaceous differentiation (BCCSD) and salivary gland neoplasms.
The operation was performed under local anaesthesia. The lesion was removed with 0.5 cm of free margins and a W shaped wedge. The defect was primarily closed. The post-operative course was uneventful. Although SC may be found among the multiple sebaceous neoplasms occurring in association with multiple visceral carcinomas in the Muir-Torre syndrome, in the present case the lip was the only localisation of SC. SC must be distinguished from basal cell carcinoma with sebaceous differentiation (BCCSD). The diagnosis may be facilitated by lipophylic stains on frozen sections or immunostains for EMA and S-100
Oral tuberculosis: a clinical evaluation of 42 cases
No full textOBJECTIVES:
A retrospective review of a large series of oro-facial cases of tuberculosis to analyse clinical, histopathological, and radiological aspects, as well as those of chemotherapy.
MATERIALS AND METHODS:A total of 42 cases of tuberculosis of the oro-facial region were examined. Thirteen patients had a primary form and 29 a secondary form of the disease. Diagnosis was based on careful clinical examination, Mantoux reaction, histopathological examination, microbiological cultures and immunological investigation with the detection of antibodies against Mycobacteria in the patients' serum (ELISA).
RESULTS: Cases examined consisted of 27 males and 15 females. The age range was 3 to 73 years (mean age 31 years). Clinical manifestations comprised oral ulcers in 69.1%, bone involvement in 21.4%, and salivary gland and/or lymph node involvement in 14.3%. A total of 79.4% patients with secondary disease had pulmonary lesions, 15 of whom showed clinical and radiological signs of activity; there was one case of bilateral renal lesions and two of skin lesions.
CONCLUSIONS:Oro-facial tuberculosis is often difficult to diagnose and it should be an important consideration in the differential diagnosis of lesions that appear in the oral cavity. The most important diagnostic tools remain a careful clinical evaluation, biopsy for histologic study, as well as acid-fast stains, culture, and immunological assays, and skin testing
Calcium sulfate acts on the miRNA of MG63E osteoblast-like cells
No full textCalcium sulfate (CaS) is a highly biocompatible material and enhances bone formation in vivo. However, how CaS alters osteoblast activity to promote bone formation is incompletely understood. We therefore investigated the translation regulation in osteoblasts exposed to CaS by using microRNA microarray techniques. Transduction, transcription, and translation are the three levels of regulation of cell activity. Recently, a new type of translation regulation has been identified: RNA interference (RNAi). RNAi is a process in which microRNA, (miRNA), that is, noncoding RNAs of 19-23 nucleotides can induce sequence-specific mRNA degradation and/or translational repression. The human genome encodes a few hundred miRNAs that can post-transcriptionally repress thousands of genes. The miRNA oligonucleotide microarray provides a novel method of carrying out genome-wide miRNA profiling in human samples. By using miRNA microarrays containing 329 probes designed from Human miRNA sequences, we identified in osteoblast-like cells line (MG-63) cultured with CaS (Surgiplaster, Classimplant, Roma, Italy) several miRNA whose expression is significantly modified. The data reported are, to our knowledge, the first study on translation regulation in osteoblasts exposed to CaS. They could be relevant to a better understanding of the molecular mechanism of bone regeneration and as a model for comparing other materials with similar clinical effects
Epidermal nevus syndrome: epithelial and cutaneous tumours without systemic disorders: a case report
No full textEpidermal nevus syndrome (ENS) is a rare disease characterized by the association of epidermal nevi with abnormalities in other organs and districts affecting prevalently pediatric patients1. The first descriptions of an association of epidermal nevi, neurologic disorders and mental retardation were made by Schimmelpenning in 19572 and extensively reviewed in 1975 by Solomon and Esterly. Central nervous system (cortical atrophy, mental retardation, cerebrovascular malformations and neoplasias), skeletal system (bone cysts, scoliosis syndactyly, polydactyly, chinodacctyly) and eyes (choristomas, bilateral cataracts, colobomas) are most commonly involved while endocrine (hypophosphatemic rickets and precocious puberty), cardio-vascular (aneurysms and malformations), urogenital (testicular adenomas, double ureters), oral and skin lesion other than epidermal nevi were also reported1. It has been determined that there is not just one category of ENS, distinguished from each other by their clinical features and genetic pattern. In 1995, Happle defined six types of ENS but, for the polymorphism showed by the syndrome, different association of anomalies may be present. Sebaceous nevus syndrome, nevus comedonicus syndrome, Becker nevus syndrome, Proteus syndrome, CHILD syndrome are only some examples of the clinical features showed by ENS3. We reported a case of a patients affected by epidermal nevus syndrome with the concomitant presence of oral papillomatosis and cutaneous anomalies including nevi, basal cell carcinoma and siryngocystadenoma without systemic involvement. A concise analysis of the principal epithelial, oral and other lesions associated with ENS and a discussion of the possible relationship between our findings and ENS was performed
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Overexpression of nicotinamide N-methyltransferase in HSC-2 OSCC cell line: effect on apoptosis and cell proliferation
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