1,721,031 research outputs found
Effectiveness and Safety of Pixantrone for the Treatment of Relapsed or Refractory Diffuse Large B-Cell Lymphoma in Every-Day Clinical Practice: The Italian Cohort of the PIXA Registry
No full textTreatment of relapsed/refractory (R/R) diffuse large B-cell lymphoma (DLBCL) represents a challenge for clinicians due to the lack of therapeutic options. DLBCL is not a rare disease in Italy. Pixantrone is an aza-anthracenedione, which, when compared to anthracyclines and anthracenediones, has a significantly reduced cardiotoxicity while maintaining good anti-tumor activity. However, the evidence on the use of pixantrone in the context of daily clinical practice is scarce
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Circulating Endothelial Cell Levels Correlate with Treatment Outcomes of Splanchnic Vein Thrombosis in Patients with Chronic Myeloproliferative Neoplasms
Full text linkCirculating endothelial cells (CECs) are viable, apoptotic or necrotic cells, identified by
CD 146 surface antigen expression, considered a biomarker of thrombotic risk, given their active
role in inflammatory, procoagulant and immune processes of the vascular compartment. Growing
evidence establishes that CECs are also involved in the pathogenesis of several hematological and
solid malignancies. The primary aim of this study was to verify if CEC levels could predict both the
course and treatment responses of splanchnic vein thrombosis (SVT), either in patients affected by
myeloproliferative neoplasms (MPNs) or liver disease. Thus, a retrospective multicenter study was
performed; fifteen patients receiving anticoagulant oral treatment with vitamin k antagonists (VKA)
for SVT were evaluated. Nine patients were affected by MPN, and all of them received cytoreduction
in addition to anticoagulant therapy; four of these patients had primary myelofibrosis (PMF) and
were treated with ruxolitinib (RUX), and one patient with primary myelofibrosis, two patients with
essential thrombocythemia (ET), and two patients with polycythemia vera (PV) were treated with
hydroxyurea (HU). Six patients affected by liver diseases (three with liver cirrhosis and three with
hepatocellular carcinoma) were included as the control group. CECs were assayed by flow cytometry
on peripheral blood at specific time points, for up to six months after enrollment. The CEC levels were
related to C-reactive protein (CRP) levels, splenic volume reduction, and thrombus recanalization,
mainly in MPN patients. In patients with liver cirrhosis (LC) and hepatocellular carcinoma (HCC),
for which the mechanism of SVT development is quite different, the relationship between CEC and
SV reduction was absent. In conclusion, the CEC levels showed a significant correlation with the
extent of venous thrombosis and endothelial cell damage in myeloproliferative neoplasm patients
with splanchnic vein thrombosis. Although preliminary, these results show how monitoring CEC
levels during cytoreductive and anticoagulant treatments may be useful to improve SVT outcome in
MPN patients
Clinical and biological data on the use of hydroxychloroquine against SARS-CoV-2 could support the role of the NLRP3 inflammasome in the pathogenesis of respiratory disease
No full textThe use of hydroxychloroquine (HCL) has been very common in countries with a rapid spread of coronavirus disease 2019 (COVID-19), although controversial and the subject of heated scientific discussions with implications for the whole society. This article is protected by copyright. All rights reserved
La versione provenzale della Vindicta Salvatoris e la sua tradizione gallo-romanza (con edizione e traduzione del testo: ms. Paris BNF fr. 25415)
No full textLa tesi prende in esame un argomento di per sé vasto, ossia lo studio dei vangeli apocrifi, focalizzandosi sul solo Ciclo di Pilato e sulla Vindicta Salvatoris in esso inclusa e, ancora più specificatamente, nelle sue redazioni nei vernacoli romanzi con particolare riguardo alla versione provenzale di inizio XIV secolo contenuta nel BNF fr. ms. 25415. Lo studio può essere suddiviso in due sezioni: nella prima si affronta l’intricato confronto tra il Nuovo Testamento - lo sviluppo del canone, la creazione quasi naturale di una gerarchia testuale, la sua evoluzione e poi affermazione, le particolarità - e i Vangeli Apocrifi - la loro origine di natura popolare, la loro diffusione collaterale alle narrazioni canoniche, come si presentano e l’influenza che hanno avuto nella cultura posteriore.
Partendo da questo fondamentale quadro generale, si inizia a scendere nel particolare, analizzando, tra gli Apocrifi della Passione e Risurrezione, il Ciclo e la figura di Ponzio Pilato; esposto questo si passa alla Vindicta Salvatoris, al suo contenuto, alla reale vicenda storica da cui si ispira, alle vicende relative alla tradizione latina in primis e a quelle romanze - nello specifico quelle italiane, catalana, spagnola e portoghese - di seguito.
Infine, per quanto riguarda la prima sezione, vi è un approfondimento delle redazioni gallo-romanze della Vindicta. Iniziando dalla presentazione della cospicua tradizione manoscritta, si giunge a quella delle principali edizioni dei testi medievali in versi e in prosa, sviluppando poi un confronto parallelo tra i contenuti di queste per meglio delineare l’evolversi della leggenda.
La seconda parte della tesi è ovviamente incentrata sull’analisi del testo occitanico. Si apre con una descrizione del manoscritto preso in considerazione e con le note linguistiche guida, utili per determinare l’area di sviluppo e diffusione del testo.
L’ultimo e più corposo capitolo è composto da un'analisi del contenuto e delle fonti della leggenda e poi dall’edizione del testo ritrascritto e commatizzato - controllato sia con il manoscritto che con la sola precedente trascrizione di fine ‘800 - e dalla traduzione; a questo vengono fatti seguire un indice dei luoghi e personaggi principali e una tavola delle numerose miniature presenti nel corpo del codice. Infine è presente la bibliografia con i principali testi di riferimento consultati
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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