6 research outputs found
“Hormone replacement therapy, C-reactive protein, and fibrinogen in healthy postmenopausal women”
No full textThe relationship of pentraxin-3 levels with IL-17, fetuin-A, insulin in patients with Behçet's disease
No full textBackground: Pentraxin (PTX) 3 is synthesized by leukocytes, dendritic cells, endothelial cells and monocytes in response to IL-1 and tumor necrosis factor (TNF)-α, and it might be informative regarding local inflammation. In additionally, pentraxin (PTX)-3, produced by endothelial cells in atherosclerotic plaques, acts as a modulator of inflammatory processes and is involved in the development of atherosclerotic lesions.
Objective: This study aimed to identify the levels of proteins, such as PTX and fetuin-A, which are thought to play a role in the progression of atherosclerotic and cardiovascular disorders in patients with BD, and to investigate the relationship of these protein levels with BD activity, inflammatory cytokines, insulin resistance and dyslipidaemia.
Patients and methods: This study included 58 patients (36 females, 22 males) with BD and 20 healthy controls. Serum PTX-3, fetuin-A, interleukin (IL)-17 and insulin concentrations were determined. Homeostasis model of insulin resistance (HOMA-IR) values were calculated, and disease activity was assessed using BD Current Activity Form (BDCAF) scores.
Results: The levels pentraxin-3, fetuin-A, IL-17, insulin and HOMA-IR in patients with BD were found to be higher than control subjects (p 0.05).
Conclusions: Similar to CRP, PTX-3 is an acute-phase reactant that is considered an inflammatory and atherosclerotic biomarker. This study showed that PTX-3 levels can increase, similar to IL-17, but no relationship was detected between disease activity and coronary risk factors such as serum lipids, glucose intolerance and obesity. This was a cross-sectional study; therefore, the patients should be followed in long-term studies to determine whether higher PTX levels in BD patients are associated with a higher incidence of cardiovascular disease
Salivary human beta-defensins and cathelicidin levels in relation to periodontitis and type 2 diabetes mellitus
No full textObjective: Type 2 diabetes mellitus (T2DM) is a well-defined risk factor of periodontitis and it can affect expression of human beta-defensins (hBDs) and cathelicidin (LL-37) as well. The aim of the present study was to evaluate the impact of periodontitis and T2DM on salivary concentrations of these antimicrobial peptides.Material and methods: Unstimulated saliva samples, together with full-mouth periodontal recordings were collected from 92 individuals with periodontitis (63 with T2DM and 21 smokers) and 86 periodontally healthy controls (58 with T2DM and 21 smokers). Salivary hBD-1, -2, -3, LL-37, and advanced glycalization end products (AGE) concentrations were measured by enzyme-linked immunosorbent assay.Results: Among the periodontitis patients, T2DM group demonstrated lower levels of hBD-1 (p = .006), hBD-2 (p p p p = .002) and LL-37 (p Conclusion: In the limits of this study, hyperglycaemia can be proposed as a regulator of salivary hBD and cathelicidin levels. Periodontitis, on the other hand, affects only salivary LL-37 levels.</p
HEPATITIS C TESTING AMONG ADULTS BORN BETWEEN 1945 AND 1965 IN TURKEY: A MULTICENTRE STUDY
No full textConclusions: We determined that the anti-HCV seropositivity rate is significantly higher in adults born between 1945-1965 compared to the younger adults as indicated in the literature. According to data from this study together with the WHO and CDC suggestions, we believe that it is appropriate to offer anti-HCV serology testing for people over 50 years of age since the anti- HCV seroprevalence in this age group is relatively high
Yogun Bakım Unitelerinden izole Edilen Etkenler ve Antibiyotik Duyarlılıklari
No full textYoğun bakım üniteleri (YBÜ), hastanelerin yatak kapasitelerinin %10’unu oluşturmasına karşın, hastane enfeksiyonlarının yaklaşık %25’inin saptandığı birimlerdir. Immun sistemin baskılanması, sık yapılan invaziv girişim— ler, hastanede uzun kalış ve geniş spektrumlu antibiyotik kullanımı YBÜ’lerdeki hastane enfeksiyonlarını artıran önemli nedenlerdir. Bu çalışmada, 2004-2005 yıllarında Pediatri, Dahiliye, Cerrahi yoğun bakım ünitelerinden kültür için gönderilen 164 örneğin mikrobiyolojik sonuçları retrospektif olarak değerlendirilmiş, etkenlerin identifikasyonu ve antibiyotik duyarlılıklarının belirlenmesinde klasik mikrobiyolojik yöntemler, API otomatize identifikasyon ve antibiyogram sistemleri kullanılmıştır. Hastaların 7651 (%46) kadın 88’i (%54) erkek olup yaşla— rı 0-78 yaş arasında değişmekteydi. Toplam 221 suşun 82’si (%37.l) trakeal aspirattan, 76’sı kandan (%344), 30’u idrardan (%13.6), 14’ü venöz kateterden (%63), 12’si yara yerinden (%54), 5’ü dren yeri (%2.2), biri plevral effüzyon diğeri ise balgamdan izole edilmiştir. Örneklerin 144’ü ise Cerrahi YBÜ (%652), 42’si Pediatri YBÜ (%19), 35’i Dahiliye YBÜ’den (%15.8) alınmıştır. İzole edilen etkenlerden 51’i (%23.0) Staphylococcus aureus, 32’si (%14.5) Acinetobacter baumannii, 32’si (%14.5) Pseudomonas aeruginosa, 21’i (%95) E.coli, 21’i (%9.5) Klebsiella spp., 1631 (%72) Koagulaz Negatif Stafılokok(KNS), l4’ü (%6.3) Enterococcus spp, lO’u (%4.5) Candida albicans, 7’si (%3.1) Enterobacter aerogenes ve l7’si (%7.7) diğer mikroorganizmalardır. Gram negatif enterik bakteriler yanı sıra nonfeımentatif Gram negatif basillerde de en etkin antimikrobiyalleıin karbapenenıler olduğu gözlenmiştir. S.aureııs suşlarında glikopeptid direnci gözlenmezken, Candida suşlarının F lucytosine, Amphoten'cin B ve Nystatin’e duyarlı bulunmuştur. Her hastanede sık olarak nozokomiyal enfeksiyon nedeni olan mikroorganizmalar ve antibiyotik duyarlılıklarının belirlenmesi ardı sıra koruyucu önlemlerin alınması hastane enfeksiyonlannın azalmasına katkıda bulunacaktı
