322,894 research outputs found
Microbiota modification with probiotics induces hepatic bile acid synthesis via downregulation of the Fxr-Fgf15 axis in mice.
No full textp38 inhibitors in preclinical models of colorectal cancer: chemosensitization and association with molecularly targeted drugs.
No full text
p38 inhibitors in preclinical models of colorectal cancer: Chemosensitization and association whit molecular targeted drugs
No full textHepatic-specific Activation of Peroxisome Proliferator-Activated Receptor γ coactivator-1β Protects Against Steatohepatitis
No full textDevelopment of hepatic steatosis and its progression to steatohepatitis may be the consequence of dysfunction of several metabolic pathways, such as triglyceride synthesis, very low-density lipoprotein (VLDL) secretion, and fatty acid β-oxidation. Peroxisome proliferator-activated receptor γ coactivator-1β (PGC-1β) is a master regulator of mitochondrial biogenesis and oxidative metabolism, lipogenesis, and triglyceride (TG) secretion. Here we generated a novel mouse model with constitutive hepatic activation of PGC-1β and studied the role of this transcriptional coactivator in dietary-induced steatosis and steatohepatitis. Selective activation of PGC-1β within hepatocytes is able to protect the liver from lipid overload and from progression to fibrosis. The protective function exerted by PGC-1β is due to its ability to induce mitochondrial oxidative phosphorylation, fatty acid β-oxidation, and citrate cycle, as well as to decrease oxidative stress and promote TG secretion in the blood stream. These findings bolster the concept that a combined hepatic specific action of PGC-1β on lipid synthesis and secretion, as well as on mitochondrial biogenesis and function, could protect against steatohepatitis
Les parfums, les couleurs et les sons se répondent : les correspondances à l’ère du numérique
No full textL’émergence du numérique dans le domaine culturel est désormais une évidence incontournable, si bien que de nombreux groupes de recherche l'ont désormais pris en compte dans leur approche épistémologique. Toutefois, la simple présence d’un item ou d’une récurrence dans un corpus n’est pas suffisante pour en tirer des conclusions sur la sémantique du texte littéraire, étant donné que celui-ci est son propre contexte et que la dimension stylistique joue un rôle déterminant dans la création du sens. Le numérique offre bien évidemment un grand nombre d’avantages, mais les questions que l’on pose doivent devenir de plus en plus spécifiques et précises. C’est pour cette raison que nous voudrions développer une approche épistémologique nouvelle, conjuguant la profondeur analytique de l’exégèse littéraire et les avancées les plus récentes du multimédia. Une fois établis le corpus littéraire à partir de raisons méthodologiques et scientifiques (Ch. Baudelaire, Fleurs du Mal et Petits poèmes en prose) et le macro-thème dirigeant et justifiant l’analyse (la sensorialité), la méthode sera la suivante : nous sélectionnerons au préalable les éléments significatifs dans le texte et nous établirons les paramètres analytiques et les renvois hypertextuels, lesquels seront ensuite élaborés par un logiciel de recherche sémantique et exploratoire, fondé sur la “graph analytics”, apte à élaborer les données reçues d’une façon non plus statique, mais dynamique et relationnelle.
L’objectif est donc de démontrer comment le langage baudelairien est « hypertextuel » au sens linguistique, mais aussi informatique du mot : il s’agit d’explorer d’une façon innovante et stimulante les « correspondances » de l’écriture baudelairienne, en proposant la coopération du critique littéraire et du développeur informatique
Effect of extra virgin olive oil on experimental thrombosis and primary hemostasis in rats.
No full textDiffusive author(s), cohesive author: Analysis of S/N (1994)
No full textThis study indicates the ways in which various aspects of the author(s) are brought forth in Dumb type’s performance art, the S/N production. Previous research has suggested a non-hierarchical organization of Dumb type and the absence of a “privileged author” in Dumb type’s collaborative work, S/N. However, the results that I have investigated from member’s interviews on the creative process of S/N along with my analysis of the recorded images of S/N, indicate a different aspect of the author(s). First, S/N was created through, so to speak, the collective ideas of the members of Dumb type. Further, S/N has at least nine quotations from previous performances, installations, and printed writings, besides the work-in-progress technique. Explicating one of the “author functions” as given by Michel Foucault, each text has plural subjects of the author. However, it has been revealed from members’ interviews that Teiji Furuhashi had a decision-making role in selecting the members’ ideas within the performance. Since then, S/N has had plural subjects of creation; however, Furuhashi is one of the subjects of creation along with the “privileged author.” S/N has plural authors (diffusive authors) yet at the same time, it has a “privileged author,” Teiji Furuhashi (cohesive author)
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
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