4,341 research outputs found
Letter to Charles P. Clever from Frederick Muller
No full textLetter dated October 1, 1861 to Charles P. Clever from Frederick Muller, Taos, New Mexico. Letter difficult to read. HL introduction page overlaid by document. Letter in German, handwritten, 1pp/fr
Letter to Charles P. Clever from Frederick Muller
No full textLetter dated October 1, 1861 to Charles P. Clever, Adjutant General, Militia, Santa Fe from Frederick Muller, Fernandez de Taos, San Fernando de Taos, New Mexico, saying he was resigning as Brigadier General of the Militia of New Mexico, due to health reasons. Civil War. HL introduction page overlaid by document. Letter in English, handwritten, 1pp/fr
Copying, Moving and Borrowing semantics
No full textIn this paper we discuss primitives for mobilising code and communications. We distinguish three types of semantics for mobility: copying (where an identical copy is created remotely), moving (where the original is destroyed), and borrowing (where the original is moved to the target and back to where it came from at defined moments). We discuss these semantics for mobile code and mobile channels. We have implemented Icarus, a language that uses borrowing semantics for mobile code (the on-statement) and moving semantics for mobile channels (first class channels).In this paper we discuss primitives for mobilising code and communications. We distinguish three types of semantics for mobility: copying (where an identical copy is created remotely), moving (where the original is destroyed), and borrowing (where the original is moved to the target and back to where it came from at defined moments). We discuss these semantics for mobile code and mobile channels. We have implemented Icarus, a language that uses borrowing semantics for mobile code (the on-statement) and moving semantics for mobile channels (first class channels)
Performances of the HL (Hyperloop) transport system
No full textThis paper deals with an analysis of performances of the HL (Hyperloop) transport system considered as an advanced transport alternative to the existing APT (Air Passenger Transport) and HSR (High Speed Rail) systems. The considered performances are operational, financial, social and environmental. The operational performance include capacity and quality of service provided to the system’s users-passengers with attributes such as door-to-door travel time consisting of the access and egress time, schedule delay, in-vehicle time, and interchange time. The economic performances embrace the costs and revenues of operating the system. The costs include that for infrastructure, vehicles, traffic management facilities and equipment, and employees. The revenues embrace earnings from pricing users/passengers. The environmental performances include energy consumption and related emissions of GHGs (Green House Gases), and land use. The social performances are considered to be noise and safety. The analytical models of indicators of these performances are developed and applied to the scenario of operating the HL system on the short- to medium-haul travel distances/routes. These are then compared to the corresponding performances of the HSR and APT. This comparison has shown that the HL system may possess some advantages but also disadvantages regarding particular performances.Transport and PlanningOLD Urban and Regional Developmen
Analysis and modelling of performances of the HL (Hyperloop) transport system
No full textIntroduction: Hyperloop (HL) is presented as an efficient alternative of HSR (High Speed Rail) and APT (Air Passenger Transport) systems for long-distance passenger transport. This paper explores the performances of HL and compares these performances to HSR and APT. Methods: The following performances of the HL system are analytically modeled and compared to HSR and APT: (i) operational performance; (ii) financial performance; (iii) social/environmental performance. Results: The main operational result is that the capacity of HL is low which implies a low utilization of the infrastructure. Because the infrastructure costs dominate the total costs, the costs per passenger km are high compared to those for HSR and APT. The HL performs very well regarding the social/environmental aspects because of low energy use, no GHG emissions and hardly any noise. The safety performance needs further consideration. Conclusions: The HL system is promising for relieving the environmental pressure of long-distance travelling, but has disadvantages regarding the operational and financial performances.Transport and PlanningOLD Urban and Regional Developmen
Does Fluctuating Light Affect Crop Yield? A Focus on the Dynamic Photosynthesis of Two Soybean Varieties
No full textIn natural environments, plants are exposed to variable light conditions, but photosynthesis has been mainly studied at steady state and this might overestimate carbon (C) uptake at the canopy scale. To better elucidate the role of light fluctuations on canopy photosynthesis, we investigated how the chlorophyll content, and therefore the different absorbance of light, would affect the quantum yield in fluctuating light conditions. For this purpose, we grew a commercial variety (Eiko) and a chlorophyll deficient mutant (MinnGold) either in fluctuating (F) or non-fluctuating (NF) light conditions with sinusoidal changes in irradiance. Two different light treatments were also applied: a low light treatment (LL; max 650 μmol m−2 s−1) and a high light treatment (HL; max 1,000 μmol m−2 s−1). Canopy gas exchanges were continuously measured throughout the experiment. We found no differences in C uptake in LL treatment, either under F or NF. Light fluctuations were instead detrimental for the chlorophyll deficient mutant in HL conditions only, while the green variety seemed to be well-adapted to them. Varieties adapted to fluctuating light might be identified to target the molecular mechanisms responsible for such adaptations
Impact of hyperglycemia on phospholipase C and phospholipase D expression in neutrophil-like HL-60 cells
No full textPLEASE NOTE: This work is protected by copyright. Downloading is restricted to the BU community: please log in with a valid BU account to access and click Download. If you are the author of this work and would like to make it publicly available, please contact [email protected] (MSD) --Boston University, Henry M. Goldman School of Dental Medicine, 2011 (Department of Periodontology and Oral Biology).Includes bibliography: leaves 80-96.Diabetes mellitus is a metabolic disease characterized by functional abnormalities of polymorphonuclear neutrophils (PMN) and inflammation. The aim of this study was to define the impact of diabetic control on the expression of phosphoinositide-specific phospholipase C (PLC) and phosphatidylcholine-specific phospholipase D (PC-PLD) in neutrophils.Testing diabetic conditions requires prolonged incubation periods to expose cells to hyperglycemia and advanced glycation endproducts (AGE). This is not possible for neutrophils because they are terminally differentiated cells with a lifespan of 24 to 48 hours. Therefore, superoxide (O2[-]) production, a measurement of basic cytotoxic PMN function and expression levels of target molecules and expression of PLC and PLD were evaluated in human pro-myelocytic leukemic cells (HL-60) which can be cultured and differentiated into neutrophil-like cells.
The cells were cultured in diabetic conditions by adding 25 mM glucose to replicate hyperglycemia and S100B RAGE ligand to simulate the effects of AGE. Superoxide release assays were carried out after corroborating the differentiation of HL-60 cells into neutrophil like cells; an increase of 20% in mean optical density values during 5 minutes was seen on the diabetic samples versus the control. This increase in O2[-] production is consistent with previous reports and most likely due to the priming of the neutrophils because of the diabetic conditions [1].
Expression of PLC and PLD isoforms were measured at protein level. PLC[Beta]1 demonstrated a slight decrease in expression levels. However, PLC[Beta]2 1evels were cleary shown to be elevated over one and a half times the control values in the diabetic groups. PLC[Beta] levels increase cytosolic Ca++ influx thus resulting in increased PKC phosphorylation [2]. Both PLCy1 and PLCy2 were elevated in diabetes, PLCy1 showed a more dramatic increase than PLCy2. PLD catalyzes the hydrolysis of the terminal diester bond of glycerophospholipids, resulting in the formation of phosphatidic acid, which can be converted by diacylglycerol (DAG) kinase into DAG and then phosphorylate protein kinase C (PKC). PA can also activate p47[phox] and subsequently NADPH oxidase directly, resulting in O2[-] production [3, 4]. PLD1 has been shown to regulate motility and adhesion of phagocytes in response to fMLP and IL-8 [5, 6]. The role of PLD2 is not well understood at this time, but it is theorized that it is involved in cell migration as well [6]. The results of this project show a statistically significant increase in expression levels of PC-PLD1 with a decrease in PC-PLD2 levels of almost 50%. Our data shows that diabetes causes an up-regulation of most isoforms and variants of PLC and PLD, which is consistent with elevated O2[-] generation
Heavy flavor jet tagging algorithm developments at CMS for HL-LHC
No full textInternational audienceThe rich physics program at the high luminosity LHC (HL-LHC) requires all final state particles to be reconstructed with good accuracy. However, it also poses formidable challenge of dealing with very high pileup. Different identification algorithms need to be upgraded along with the detectors to improve the overall event reconstruction in such a hostile collision environment. The new timing device in the proposed CMS detector at the HL-LHC allows for the construction of timing observables at the track-level as well as at the jet-level. This information when given as inputs to the deep neural networks, have a potential to improve the existing algorithms used for heavy flavor (HF) jet tagging. In this paper, the latest developments on the studies for HF jet tagging performance at the HL-LHC are presented
The person-based approach to intervention development: application to digital health-related behavior change interventions
No full textThis paper describes an approach that we have evolved for developing successful digital interventions to help people manage their health or illness. We refer to this as the “person-based” approach to highlight the focus on understanding and accommodating the perspectives of the people who will use the intervention. While all intervention designers seek to elicit and incorporate the views of target users in a variety of ways, the person-based approach offers a distinctive and systematic means of addressing the user experience of intended behavior change techniques in particular and can enhance the use of theory-based and evidence-based approaches to intervention development. There are two key elements to the person-based approach. The first is a developmental process involving qualitative research with a wide range of people from the target user populations, carried out at every stage of intervention development, from planning to feasibility testing and implementation. This process goes beyond assessing acceptability, usability, and satisfaction, allowing the intervention designers to build a deep understanding of the psychosocial context of users and their views of the behavioral elements of the intervention. Insights from this process can be used to anticipate and interpret intervention usage and outcomes, and most importantly to modify the intervention to make it more persuasive, feasible, and relevant to users. The second element of the person-based approach is to identify “guiding principles” that can inspire and inform the intervention development by highlighting the distinctive ways that the intervention will address key context-specific behavioral issues. This paper describes how to implement the person-based approach, illustrating the process with examples of the insights gained from our experience of carrying out over a thousand interviews with users, while developing public health and illness management interventions that have proven effective in trials involving tens of thousands of users
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