234 research outputs found
Folio
No full textZahoor Hussain Chohan-Editorial; Riaz Hussain-Article-Muhammad (SAW) and the People of India and Pakistan. pp. 7-11; Ahsan Waseem-Poetry-The Land of the Pious. pp. 11; Sultan Khan-Article-Quaid as a Political Philosopher. pp. 12-14; Aniza Zaheer-Article-Building-Up the National Fiber. pp. 15-19; Muhammad Tanvir-Essay-Importance of Discipline. pp. 19-20; Hameed Nizamee, Edited by Saleem Mansur Khalid-Article-Iqbal and his Urdu Poetry a General Survey Based on his Urdu Works. pp. 21-33; Amjad Ali Bhatti-Essay-The Prophet's Message to the Muslims. pp. 34-36; Arif Qureshi-Poetry-Salute to the Quaid. pp. 36; Tahir Kamran-Essay-Rise of Muslim History Writing. pp. 37-39; Muhammad Ahsan Pasha-Essay-Where do we Stand. pp. 40-42; Irshad-ul-Hasan-Poetry-The Walls of Glass. pp. 43-44; Rubina Nazir Chohan-Poetry-Gift. pp. 44; Sohail Ahmad Sharyar-Essay-What Is Literature. pp. 45-47; Muhammad Ahsan Pasha-Poetry-A Funny Commentary on Chaucer. pp. 47-48; Irshad-ul-Hasan-Article-Symbolism. pp. 49-61; Gilani Kamran-Essay-Discovering Folklore. pp. 62-64; Mohammad Tanvir Butt-Essay-Father of the Nation. pp. 65-67; Tariq Hameed Rathore-Poetry-Pleasant Manner. pp. 68; Syed Saadat Mehdi-The Days at College. pp. 68-69; Muhammad Akmal-Three Narrations. pp. 69-70; Wasif Rashid-Friendship & Friends. pp. 71; Ateeq-ur-Rahman-May You Have. pp. 71; Ali Awais-Quotes. pp. 72; Hammad Raza-Definitions. pp. 72; Akhlaque Ahmad-Mind and its Problems. pp. 73-74; Kamran Mahboob-Notice for the Students. pp. 75; Sana-ur-Rahman-Article-Emancipation of Women. pp. 76-80; Dalip Kumar Rajpoot-Best Use of Youth. pp. 80; Akhtar Ali Khan-Essay-Way to Economic Progress. pp. 81-82; Zia-ul-Haq-Essay-The World First Democracy. pp. 82-83; Zahor Hussain Chohan-On the Eve of Retirement. pp. 84; Folio [Urdu]. 272 p.College Buildings. after English title; Quaid-e-Azam. after contents; Allama Iqbal. 1 page after contents; Dr Shaukat Ali, Principal. 2 pages after contents; Prof Talat Mahmood. 3 pages after contents; Students Union 1988-1989. after page 84; Editorial Board 1988-89. after editorial Urdu pag
Drought Resilience of Wheat Genotypes Through Microbial Biostimulants Under Water Deficit Regimes
No full textABSTRACT Drought resilience strategies are needed to tackle the escalating issue of water scarcity and to sustain crop productivity under water deficit conditions. There is a gap in identifying the most effective consortium of microbial biostimulants and understanding the underlying physiological and antioxidant mechanisms involved in the drought resilience of wheat ( Triticum aestivum L.) crop. To address this, three experiments were carried out in laboratory and wire house conditions to identify and optimise the response of drought‐tolerant microbial biostimulants for wheat genotypes. Three drought‐tolerant microbial biostimulants: Bacillus subtilis , Bacillus megaterium and Trichoderma harzianum were selected from a laboratory study. The two wheat genotypes: Dilkash‐2021 and Bakhar Star (drought tolerant and sensitive, respectively) were selected from a wire house experiment. Afterwards, the response of individual and consortium of selected drought‐tolerant microbial biostimulants was evaluated in drought‐tolerant and sensitive wheat genotypes under well‐watered and water deficit regimes. Results indicated that seed inoculation of drought‐tolerant genotype with the microbial consortium of Bacillus subtilis , Bacillus megaterium and Trichoderma harzianum significantly increased relative water contents (58%), stomatal conductance (39%), sub‐stomatal conductance (70%), water use efficiency (38%) and net leaf photosynthetic rate (34%) as compared with the un‐inoculated control under water deficit. Furthermore, a significant reduction in malondialdehyde concentration (36%) and an improvement in proline contents (77%), superoxide dismutase (82%) and peroxidase (51%) were observed with this microbial consortium under water deficit. Therefore, seed inoculation of drought‐tolerant wheat genotypes with the microbial consortium might be considered in formulating the best agricultural practices for alleviating the adverse effects of water deficit on the wheat crop
Random forest models for motorcycle accident prediction using naturalistic driving based big data
No full textMotorcycle accident studies usually rely upon data collected from road accidents collected through questionnaire surveys/police reports including characteristics of motorcycle riders and contextual data such as road environment. The present study utilizes big data, in the form of vehicle trajectory patterns collected through GPS, coupled with self-reported road accident information along with motorcycle rider characteristics to predict the likelihood of involvement of a motorcyclist in an accident. Random Forest-based machine learning algorithm is employed by taking inputs based on a variety of features derived from trajectory data. These features are mobility-based features, acceleration event-based features, aggressive overtaking event-based features and motorcyclists socio-economic features. Additionally, the relative importance of features is also determined which shows that aggressive overtaking event-based features have more impact on motorcycle accidents as compared to other categories of features. The developed model is useful in identifying risky motorcyclists and implementing safety measures focused towards them
Rational engineering of Escherichia coli strain for stable and enhanced biosynthesis of pinene
No full textMonoterpene α-pinene exhibits significant potential as an alternative fuel, widely recognized for its affordability and eco-friendly nature. It demonstrates multiple biological activities and has a wide range of applications. However, the limited supply of pinene extracted from plants poses a challenge in meeting the needs of the aviation industry and other sectors. Considering this, the microbial cell factory is the only viable option for achieving sustainable pinene production. This study employed a rational design model to optimize the copy number and integration site for the heterogenous pinene expression pathway in Escherichia coli (E. coli). The integrated strain with the best pinene pathway PG1 was selected. Subsequently, the resulting strain, E. coli HSY009, accumulated 49.01 mg/L of pinene after 24 h fermentation in the flask culture. To further enhance production, pinene expression cassette PG1 was sequentially integrated into three non-essential regions (44th, 58th, 23rd), resulting in an improved pinene titer. Then, the fermentation process under optimized conditions enhanced the production of pinene to 436.68 mg/L in a 5 L batch fermenter with a mean productivity of 14.55 mg/L/h. To the best of our knowledge, this work represents the maximum mean pinene productivity based on the currently available literature. The findings of this work provide valuable insights for optimizing E. coli to produce other valuable terpenoids that share the same intermediates, IPP and DMAPP. Conclusively, this research validates the model’s universality and highlights its potential for application as cutting-edge biofuel precursors
Modifier genes in microcephaly: a report on WDR62, CEP63, RAD50 and PCNT variants exacerbating disease caused by biallelic mutations of ASPM and CENPJ
No full textCongenital microcephaly is the clinical presentation of significantly reduced head circumference at birth. It manifests as both non-syndromic - microcephaly primary hereditary (MCPH) - and syndromic forms and shows considerable inter- and intrafamilial variability. It has been hypothesized that additional genetic variants may be responsible for this variability, but data are sparse. We have conducted deep phenotyping and genotyping of five Pakistani multiplex families with either MCPH (n = 3) or Seckel syndrome (n = 2). In addition to homozygous causal variants in ASPM or CENPJ, we discovered additional heterozygous modifier variants in WDR62, CEP63, RAD50 and PCNT - genes already known to be associated with neurological disorders. MCPH patients carrying an additional heterozygous modifier variant showed more severe phenotypic features. Likewise, the phenotype of Seckel syndrome caused by a novel CENPJ variant was aggravated to microcephalic osteodysplastic primordial dwarfism type II (MOPDII) in conjunction with an additional PCNT variant. We show that the CENPJ missense variant impairs splicing and decreases protein expression. We also observed centrosome amplification errors in patient cells, which were twofold higher in MOPDII as compared to Seckel cells. Taken together, these observations advocate for consideration of additional variants in related genes for their role in modifying the expressivity of the phenotype and need to be considered in genetic counseling and risk assessment
Optimizing the phosphorus use in cotton by using CSM-CROPGRO-cotton model for semi-arid climate of Vehari-Punjab, Pakistan
No full textRahman, Muhammad Habib ur/0000-0002-2823-9959; Jabran, Khawar/0000-0001-8512-3330; Hakeem, Khalid Rehman/0000-0001-7824-4695; Amin, Asad/0000-0003-2242-8377; Ata-Ul-Karim, Syed Tahir/0000-0001-5233-4502; Jatoi, Ghulam Hussain/0000-0002-7266-1567; Rehmani, M.I.A./0000-0001-7922-1233; Bajwa, Ali/0000-0002-7171-3118; Nadeem, Muhammad/0000-0002-7426-1196; Ata-Ul-Karim, Syed Tahir/0000-0001-5233-4502; Ameen, Asif/0000-0002-3982-7000; Islam, Faisal/0000-0002-1471-1570WOS: 000397013000067PubMed: 28054268Crop nutrient management is an essential component of any cropping system. With increasing concerns over environmental protection, improvement in fertilizer use efficiencies has become a prime goal in global agriculture system. Phosphorus (P) is one of the most important nutrients, and strategies are required to optimize its use in important arable crops like cotton (Gossypium hirsutum L.) that has great significance. Sustainable P use in crop production could significantly avoid environmental hazards resulting from over-P fertilization. Crop growth modeling has emerged as an effective tool to assess and predict the optimal nutrient requirements for different crops. In present study, Decision Support System for Agro-technology Transfer (DSSAT) sub-model CSM-CROPGRO- Cotton-P was evaluated to estimate the observed and simulated P use in two cotton cultivars grown at three P application rates under the semi-arid climate of southern Punjab, Pakistan. The results revealed that both the cultivars performed best at medium rate of P application (57 kg ha(-1)) in terms of days to anthesis, days to maturity, seed cotton yield, total dry matter production, and harvest index during 2013 and 2014. Cultivar FH-142 performed better than MNH-886 in terms of different yield components. There was a good agreement between observed and simulated days to anthesis (0 to 1 day), days to maturity (0 to 2 days), seed cotton yield, total dry matter, and harvest index with an error of -4.4 to 15%, 12-7.5%, and 13-9.5% in MNH-886 and for FH-142, 4-16%, 19-11%, and 16-8.3% for growing years 2013 and 2014, respectively. CROPGRO-Cotton-P would be a useful tool to forecast cotton yield under different levels of P in cotton production system of the semi-arid climate of Southern Punjab.Government of Australia [4915_2015]; Higher Education Commission (HEC) of PakistanHigher Education Commission of PakistanThe first author is grateful to the International Global Change Institute (IGCI) Hamilton, New Zealand, for providing the software (SimCLIM2013) and the required climatic dataset for future projections with for southern Punjab, Pakistan. The first author is thankful to Prof. Dr. Gerrit Hoogenboom (Ex-Director, AgWeatherNet, Washington State University, USA; Currently: University of Florida-USA), for his technical guidance and support during the entire period of study and modeling work. Furthermore, first author is highly thankful from NASA for weather data of respective years (which was obtained from website http://power.larc.nasa.gov/cgi-bin/cgiwrap). The corresponding author (Wajid NASIM) is highly thankful to Government of Australia, for Endeavor Research Award/Fellowship (No. 4915_2015) to The Commonwealth Scientific and Industrial Research Organization (CSIRO), Sustainable Agriculture, National Research Flagship, Toowoomba-QLD 4350, Australia. Furthermore, co-authors (Wajid NASIM and Shakeel AHMAD) are highly thankful for Higher Education Commission (HEC) of Pakistan for partial funding
Paradox of Credibility
No full textIn an information transmission situation, a senders concern for its credibility could endow itself with an invisible power to control the detected. In this case, the sender can achieve its favored outcome without losing its credibility, which stays true even when the sender and the receiver have contradictory preferences. Therefore, the senders concern for its credibility could result in less truthful signals from the sender and worse payoffs to the receiver. This is the paradox of credibility. This paper models this paradoxical role of the senders credibility concern.Anti-Coordination Game, Credibility, Information Transmission, Hawk-Dove Game, Paradox
Istihsan (juristic preference) : the forgotten principle of Islamic law
No full textEThOS - Electronic Theses Online ServiceGBUnited Kingdo
Emerg Infect Dis
No full textDromedary camels from Africa and Arabia are an established source for zoonotic Middle East respiratory syndrome coronavirus (MERS-CoV) infection among humans. In Pakistan, we found specific neutralizing antibodies in samples from 39.5% of 565 dromedaries, documenting significant expansion of the enzootic range of MERS-CoV to Asia
Changing Oil Prices, Exchange Rates and its Impact on Inflation in Pakistan
No full textPurpose: The key objective of the analysis is to explore the impact of oil prices and exchange rates on the inflation rate in Pakistan by using annual time-series data from the period 1980 to 2020.
Design/Methodology/Approach: The augmented Dickey-Fuller test, bound test approach, and ARDL model are applied to achieve the objectives of the study.
Findings: It is found that the crude oil prices and real effective exchange rate are found to be significant factors that influence the inflation rate in Pakistan. The other findings explored that money supply, exports, and gross fixed capital formation are positively related to the inflation rate.
Implications/Originality: The author’s recommended that policymakers should take steps to control the inflation rate by regulating the fiscal and monetary policy measures in the right direction
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